2024
Clinical correlates of dopamine transporter availability in cross-sectional and longitudinal studies with [18F]FE-PE2I PET: independent validation with new insights
Honhar P, Sadabad F, Tinaz S, Gallezot J, Dias M, Naganawa M, Yang Y, Henry S, Hillmer A, Gao H, Najafzadeh S, Comley R, Nabulsi N, Huang Y, Finnema S, Carson R, Matuskey D. Clinical correlates of dopamine transporter availability in cross-sectional and longitudinal studies with [18F]FE-PE2I PET: independent validation with new insights. Brain Communications 2024, 6: fcae345. PMID: 39429243, PMCID: PMC11487911, DOI: 10.1093/braincomms/fcae345.Peer-Reviewed Original ResearchDAT availabilityMotor severitySubstantia nigraDopamine transporter availabilityClinical trials of Parkinson's diseaseParkinson's diseaseLongitudinal studyTracking longitudinal changesClinical correlatesVentral striatumTransporter availabilityNigrostriatal regionParkinson's disease patientsPutamenMotor severity scoresAssociated with increasesSubstantiaDATLongitudinal changesTremor scoreNegative associationNigraSubstantia nigra of Parkinson's disease patientsTremor severityPET biomarkers
2020
Nondisplaceable Binding Is a Potential Confounding Factor in 11C-PBR28 Translocator Protein PET Studies
Laurell G, Plavén-Sigray P, Jucaite A, Varrone A, Cosgrove KP, Svarer C, Knudsen G, Consortium K, Ogden R, Zanderigo F, Cervenka S, Hillmer A, Schain M. Nondisplaceable Binding Is a Potential Confounding Factor in 11C-PBR28 Translocator Protein PET Studies. Journal Of Nuclear Medicine 2020, 62: 412-417. PMID: 32680926, PMCID: PMC8049343, DOI: 10.2967/jnumed.120.243717.Peer-Reviewed Original ResearchConceptsAlcohol use disorderDistribution volumePET studiesParkinson's diseaseFirst-episode psychosis patientsTranslocator proteinAdministration of lipopolysaccharideNondisplaceable bindingFirst-episode psychosisPotential confounding factorsTotal distribution volumeC-PBR28Patient groupPsychosis patientsLipopolysaccharide challengeClinical studiesOutcome measuresTSPO PET studiesUse disordersPET ligandConfounding factorsCorresponding controlsDiseaseDisordersGroup