Nondisplaceable Binding Is a Potential Confounding Factor in 11C-PBR28 Translocator Protein PET Studies
Laurell G, Plavén-Sigray P, Jucaite A, Varrone A, Cosgrove KP, Svarer C, Knudsen G, Consortium K, Ogden R, Zanderigo F, Cervenka S, Hillmer A, Schain M. Nondisplaceable Binding Is a Potential Confounding Factor in 11C-PBR28 Translocator Protein PET Studies. Journal Of Nuclear Medicine 2020, 62: 412-417. PMID: 32680926, PMCID: PMC8049343, DOI: 10.2967/jnumed.120.243717.Peer-Reviewed Original ResearchConceptsAlcohol use disorderDistribution volumePET studiesParkinson's diseaseFirst-episode psychosis patientsTranslocator proteinAdministration of lipopolysaccharideNondisplaceable bindingFirst-episode psychosisPotential confounding factorsTotal distribution volumeC-PBR28Patient groupPsychosis patientsLipopolysaccharide challengeClinical studiesOutcome measuresTSPO PET studiesUse disordersPET ligandConfounding factorsCorresponding controlsDiseaseDisordersGroup