1991
Enhancement of the Glutamate Response by cAMP-Dependent Protein Kinase in Hippocampal Neurons
Greengard P, Jen J, Nairn A, Stevens C. Enhancement of the Glutamate Response by cAMP-Dependent Protein Kinase in Hippocampal Neurons. Science 1991, 253: 1135-1138. PMID: 1716001, DOI: 10.1126/science.1716001.Peer-Reviewed Original ResearchConceptsProtein kinaseCAMP-dependent protein kinaseGlutamate receptor channelsMonophosphate-dependent protein kinaseReceptor channelsType glutamate receptor channelsAdenylate cyclase cascadeCultured hippocampal pyramidal neuronsSpontaneous excitatory postsynaptic currentsWhole-cell current responsesSingle-channel analysisNeuromodulatory regulationMammalian brainExcitatory postsynaptic currentsHippocampal pyramidal neuronsKinaseLong-term potentiationPyramidal neuronsPostsynaptic currentsGlutamate responseExcitatory neurotransmitterMean open timeHippocampal neuronsAdenylate cyclaseSynaptic events
1990
Calcium/calmodulin-dependent protein kinase II increases glutamate and noradrenaline release from synaptosomes
Nichols R, Sihra T, Czernik A, Nairn A, Greengard P. Calcium/calmodulin-dependent protein kinase II increases glutamate and noradrenaline release from synaptosomes. Nature 1990, 343: 647-651. PMID: 2154695, DOI: 10.1038/343647a0.Peer-Reviewed Original ResearchConceptsNeurotransmitter releaseRat brain synaptosomesSquid giant synapseRelease of neurotransmittersNoradrenaline releaseGlutamate releaseNerve terminalsBrain synaptosomesNervous systemUnidentified neurotransmitterGiant synapseDependent protein kinase IIVertebrate nervous systemRats calciumProtein kinase IINeurotransmittersInduced releasePK IISynaptosomesCalcium-dependent protein phosphorylationGlutamateKinase IIReleaseNoradrenalineInitial rate