2007
The resistance to depressive relapse in menopausal women undergoing tryptophan depletion: preliminary findings
Epperson CN, Amin Z, Naftolin F, Cappiello A, Czarkowski KA, Stiklus S, Anderson GM, Krystal JH. The resistance to depressive relapse in menopausal women undergoing tryptophan depletion: preliminary findings. Journal Of Psychopharmacology 2007, 21: 414-420. PMID: 16891341, DOI: 10.1177/0269881106067330.Peer-Reviewed Original ResearchConceptsMenopausal womenTryptophan depletionSelective serotonin reuptake inhibitor fluoxetineAcute tryptophan depletion paradigmSerotonin reuptake inhibitor fluoxetineTryptophan depletion paradigmPathogenesis of depressionReuptake inhibitor fluoxetineMajor depressive episodeAcute tryptophan depletionRelapse of depressionWorsening of moodWeeks of recoveryActive tryptophan depletionWechsler Memory ScaleAssessment of moodDepressive episodeRisk factorsDepressive relapseMajor depressionSignificant worseningNeuroendocrine functionVerbal memorySerotonergic contributionMemory Scale
2006
Estradiol and Tryptophan Depletion Interact to Modulate Cognition in Menopausal Women
Amin Z, Gueorguieva R, Cappiello A, Czarkowski KA, Stiklus S, Anderson GM, Naftolin F, Epperson CN. Estradiol and Tryptophan Depletion Interact to Modulate Cognition in Menopausal Women. Neuropsychopharmacology 2006, 31: 2489-2497. PMID: 16760926, DOI: 10.1038/sj.npp.1301114.Peer-Reviewed Original ResearchConceptsVerbal memory performanceVerbal memory scoresPositive mood effectsVerbal memoryVisuospatial learningMemory performanceVerbal fluencyMemory scoresMood effectsEstrogen treatmentSubjects designCognitionTryptophan depletionMenopausal womenLittle researchSignificant interactionHealthy menopausal womenLast menstrual periodNonreproductive behaviorsInteraction of estrogenActive TrPsOvarian steroidsMenstrual periodProtective effectFluency
1997
Effects of Acute Tryptophan Depletion in Lithium-Remitted Manic Patients: A Pilot Study
Cappiello A, Sernyak M, Malison R, McDougle C, Heninger G, Price L. Effects of Acute Tryptophan Depletion in Lithium-Remitted Manic Patients: A Pilot Study. Biological Psychiatry 1997, 42: 1076-1078. PMID: 9386862, DOI: 10.1016/s0006-3223(97)00329-6.Peer-Reviewed Original Research
1996
Seasonal Variation in Neuroendocrine and Mood Responses to IV L-Tryptophan in Depressed Patients and Healthy Subjects
Cappiello A, Malison R, McDougle C, Vegso S, Charney D, Heninger G, Price L. Seasonal Variation in Neuroendocrine and Mood Responses to IV L-Tryptophan in Depressed Patients and Healthy Subjects. Neuropsychopharmacology 1996, 15: 475-483. PMID: 8914120, DOI: 10.1016/s0893-133x(96)00057-7.Peer-Reviewed Original ResearchConceptsHealthy subjectsTryptophan levelsDrug-free patientsVisual analog scaleL-tryptophanMale patientsAnalog scaleSerum prolactinDepressed patientsMajor depressionSerotonin functionNonpsychotic patientsMood disordersUnipolar patientsPatientsDSM-IIISuch abnormalitiesProlactinCosinor analysisMood responsesDepressionPrevious evidenceSubjectsInfusionNeuroendocrine