2000
Attenuation of the Neuropsychiatric Effects of Ketamine With Lamotrigine: Support for Hyperglutamatergic Effects of N-methyl-D-aspartate Receptor Antagonists
Anand A, Charney DS, Oren DA, Berman RM, Hu XS, Cappiello A, Krystal JH. Attenuation of the Neuropsychiatric Effects of Ketamine With Lamotrigine: Support for Hyperglutamatergic Effects of N-methyl-D-aspartate Receptor Antagonists. JAMA Psychiatry 2000, 57: 270-276. PMID: 10711913, DOI: 10.1001/archpsyc.57.3.270.Peer-Reviewed Original ResearchMeSH KeywordsAdultAffectBrief Psychiatric Rating ScaleCognition DisordersDouble-Blind MethodExcitatory Amino Acid AntagonistsFemaleGlutamatesHumansKetamineLamotrigineMaleMental DisordersPerceptual DisordersPlacebosPsychiatric Status Rating ScalesReceptors, N-Methyl-D-AspartateSchizophreniaSchizophrenic PsychologyTriazinesVerbal LearningConceptsN-methyl-D-aspartate receptor antagonistNMDA receptor dysfunctionReceptor antagonistNeuropsychiatric effectsGlutamate releaseReceptor dysfunctionSymptom subscalesPlacebo 2 hoursClinician-Administered Dissociative States ScaleAdministration of lamotrigineAdministration of ketamineDouble-blind conditionsNMDA receptor antagonistMood-elevating effectsPositive symptom subscaleBrief Psychiatric RatingNovel therapeutic agentsNegative symptom subscaleHopkins Verbal Learning TestVerbal Learning TestKetamine effectsPsychiatric illnessHealthy subjectsPathophysiologic processesPreclinical studies
1997
Effects of Antiglucocorticoid Treatment on 5-HT1A Function in Depressed Patients and Healthy Subjects
Price L, Cappiello A, Malison R, McDougle C, Pelton G, Schöllnhammer G, Heninger G. Effects of Antiglucocorticoid Treatment on 5-HT1A Function in Depressed Patients and Healthy Subjects. Neuropsychopharmacology 1997, 17: 246-257. PMID: 9326749, DOI: 10.1016/s0893-133x(97)00049-3.Peer-Reviewed Original ResearchConceptsDepressed patientsReceptor functionHealthy control subjectsUnipolar depressed patientsAntiglucocorticoid treatmentAntidepressant actionGlucocorticoid modulationPreclinical findingsAdrenal axisControl subjectsAntidepressant activityClinical studiesTest doseHealthy subjectsReceptor sensitivityIpsapironeCortisol biosynthesisKetoconazoleDepressionPatientsBehavioral responsesSubjectsGlucocorticoidsAgonistsNeuroendocrine
1996
Seasonal Variation in Neuroendocrine and Mood Responses to IV L-Tryptophan in Depressed Patients and Healthy Subjects
Cappiello A, Malison R, McDougle C, Vegso S, Charney D, Heninger G, Price L. Seasonal Variation in Neuroendocrine and Mood Responses to IV L-Tryptophan in Depressed Patients and Healthy Subjects. Neuropsychopharmacology 1996, 15: 475-483. PMID: 8914120, DOI: 10.1016/s0893-133x(96)00057-7.Peer-Reviewed Original ResearchConceptsHealthy subjectsTryptophan levelsDrug-free patientsVisual analog scaleL-tryptophanMale patientsAnalog scaleSerum prolactinDepressed patientsMajor depressionSerotonin functionNonpsychotic patientsMood disordersUnipolar patientsPatientsDSM-IIISuch abnormalitiesProlactinCosinor analysisMood responsesDepressionPrevious evidenceSubjectsInfusionNeuroendocrine