2004
Addition of the α2-Antagonist Yohimbine to Fluoxetine: Effects on Rate of Antidepressant Response
Sanacora G, Berman RM, Cappiello A, Oren DA, Kugaya A, Liu N, Gueorguieva R, Fasula D, Charney DS. Addition of the α2-Antagonist Yohimbine to Fluoxetine: Effects on Rate of Antidepressant Response. Neuropsychopharmacology 2004, 29: 1166-1171. PMID: 15010697, DOI: 10.1038/sj.npp.1300418.Peer-Reviewed Original ResearchConceptsHamilton depression scale ratingsΑ2-antagonist yohimbineAntidepressant responseClinical Global Impression ratingsBlood pressure changesPercentage of respondersLog-rank testGlobal Impression ratingsMajor depressive disorderMore rapid onsetP subjectsDSM-IV diagnosisSSRI agentsTitrated doseYohimbine doseAntidepressant actionAntidepressant medicationCGI scaleNoradrenergic toneMonoaminergic neurotransmissionΑ2-adrenoceptorsDepressive disorderTreatment periodOutcome measuresSCID interview
1997
Effects of Antiglucocorticoid Treatment on 5-HT1A Function in Depressed Patients and Healthy Subjects
Price L, Cappiello A, Malison R, McDougle C, Pelton G, Schöllnhammer G, Heninger G. Effects of Antiglucocorticoid Treatment on 5-HT1A Function in Depressed Patients and Healthy Subjects. Neuropsychopharmacology 1997, 17: 246-257. PMID: 9326749, DOI: 10.1016/s0893-133x(97)00049-3.Peer-Reviewed Original ResearchConceptsDepressed patientsReceptor functionHealthy control subjectsUnipolar depressed patientsAntiglucocorticoid treatmentAntidepressant actionGlucocorticoid modulationPreclinical findingsAdrenal axisControl subjectsAntidepressant activityClinical studiesTest doseHealthy subjectsReceptor sensitivityIpsapironeCortisol biosynthesisKetoconazoleDepressionPatientsBehavioral responsesSubjectsGlucocorticoidsAgonistsNeuroendocrine