2010
Time-Lag Bias in Trials of Pediatric Antidepressants: A Systematic Review and Meta-Analysis
Reyes MM, Panza KE, Martin A, Bloch MH. Time-Lag Bias in Trials of Pediatric Antidepressants: A Systematic Review and Meta-Analysis. Journal Of The American Academy Of Child & Adolescent Psychiatry 2010, 50: 63-72. PMID: 21156271, PMCID: PMC3645909, DOI: 10.1016/j.jaac.2010.10.008.Peer-Reviewed Original ResearchConceptsSerotonin reuptake inhibitorsPlacebo-controlled trialTime-lag biasMajor depressive disorderYears of ageReuptake inhibitorsAntidepressant trialsPediatric depressionDepressive disorderTreatment respondersMAIN OUTCOMESystematic reviewMeta-AnalysisPositive findingsNegative findingsNegative trialsMedical literatureAntidepressantsTrialsPublication of findingsNegative resultsChild psychiatryEfficacyFindingsPublication time
2006
Selective Serotonin Reuptake Inhibitors and Suicidality in Juveniles: Review of the Evidence and Implications for Clinical Practice
Rey JM, Martin A. Selective Serotonin Reuptake Inhibitors and Suicidality in Juveniles: Review of the Evidence and Implications for Clinical Practice. Child And Adolescent Psychiatric Clinics Of North America 2006, 15: 221-237. PMID: 16321732, DOI: 10.1016/j.chc.2005.08.012.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultDrug TherapyHumansSelective Serotonin Reuptake InhibitorsSuicide, AttemptedConceptsSelective serotonin reuptake inhibitorsSerotonin reuptake inhibitorsReuptake inhibitorsClinical practiceCareful clinical monitoringPharmacologic treatmentMedication complianceManic switchingSevere depressionClinical monitoringSuicidal behaviorBehavioral activationSuicidalityPersonal sufferingDepressionInhibitorsEvidenceNontreatment
2005
Child Psychopharmacology, Effect Sizes, and the Big Bang
Martin A, Gilliam WS, Bostic JQ, Rey JM. Child Psychopharmacology, Effect Sizes, and the Big Bang. American Journal Of Psychiatry 2005, 162: 817-a-817. PMID: 15800175, DOI: 10.1176/appi.ajp.162.4.817-a.Peer-Reviewed Original ResearchSSRIs and the developing brain
Ruchkin V, Martin A. SSRIs and the developing brain. The Lancet 2005, 365: 451-453. PMID: 15705440, DOI: 10.1016/s0140-6736(05)17877-5.Peer-Reviewed Original Research
2004
Age Effects on Antidepressant-Induced Manic Conversion
Martin A, Young C, Leckman JF, Mukonoweshuro C, Rosenheck R, Leslie D. Age Effects on Antidepressant-Induced Manic Conversion. JAMA Pediatrics 2004, 158: 773-780. PMID: 15289250, DOI: 10.1001/archpedi.158.8.773.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge DistributionAntidepressive AgentsAntidepressive Agents, TricyclicAnxiety DisordersBipolar DisorderChildChild, PreschoolDepressionFemaleHumansMaleSelective Serotonin Reuptake InhibitorsUnited StatesConceptsManic conversionAntidepressant classesPatient ageTime-dependent Cox proportional hazards modelsSelective serotonin reuptake inhibitorsCox proportional hazards modelNonbipolar mood disorderSerotonin reuptake inhibitorsProportional hazards modelRisk of conversionAdministrative national databaseEffect of agePharmacy claimsReuptake inhibitorsAntidepressant exposureDrug therapyTricyclic antidepressantsPeripubertal childrenAge effectsBipolar illnessMood disordersHigh riskMental health usersAntidepressant categoryHazards model
2003
Which SSRI? A Meta-Analysis of Pharmacotherapy Trials in Pediatric Obsessive-Compulsive Disorder
Geller DA, Biederman J, Stewart SE, Mullin B, Martin A, Spencer T, Faraone SV. Which SSRI? A Meta-Analysis of Pharmacotherapy Trials in Pediatric Obsessive-Compulsive Disorder. American Journal Of Psychiatry 2003, 160: 1919-1928. PMID: 14594734, DOI: 10.1176/appi.ajp.160.11.1919.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsObsessive-compulsive disorderStandardized mean differenceOutcome measuresMean differenceStudy designSerotonin reuptake inhibitorsDependent outcome measuresAdolescent obsessive-compulsive disorderSystematic literature searchMultivariate regression analysisPediatric obsessive-compulsive disorderTypes of drugsEffect sizePlacebo treatmentMedication trialsReuptake inhibitorsOutcome scoresPharmacological treatmentPharmacotherapy trialsOverall effect sizeInclusion criteriaClinical careDrug effectsMeta-AnalysisLow-Dose Fluvoxamine Treatment of Children and Adolescents with Pervasive Developmental Disorders: A Prospective, Open-Label Study
Martin A, Koenig K, Anderson GM, Scahill L. Low-Dose Fluvoxamine Treatment of Children and Adolescents with Pervasive Developmental Disorders: A Prospective, Open-Label Study. Journal Of Autism And Developmental Disorders 2003, 33: 77-85. PMID: 12708582, DOI: 10.1023/a:1022234605695.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAsperger SyndromeChildChild Behavior DisordersDrug Administration ScheduleFluvoxamineHumansProspective StudiesSelective Serotonin Reuptake InhibitorsTreatment OutcomeConceptsPervasive developmental disorderSelective serotonin reuptake inhibitor responseOpen-label studyOpen-label trialLow-dose fluvoxamineDevelopmental disordersPremature discontinuationClinical responseFluvoxamine treatmentPartial respondersMean ageSerotonin levelsSelect childrenPubertal statusInhibitor responseBehavioral activationFluvoxamineChildrenFurther investigationDisordersTreatmentGender differencesAdolescentsSubjectsTolerability
2000
Pharmacotherapy of Early-Onset Depression Update and New Directions
Martin A, Kaufman J, Charney D. Pharmacotherapy of Early-Onset Depression Update and New Directions. Child And Adolescent Psychiatric Clinics Of North America 2000, 9: 135-157. PMID: 10674194, DOI: 10.1016/s1056-4993(18)30139-1.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAlgorithmsAntidepressive AgentsBrainChildClinical Trials as TopicCombined Modality TherapyDepressive DisorderHumansSelective Serotonin Reuptake InhibitorsTreatment OutcomeConceptsEarly-onset depressionDepressive disorderSafety dataLong-term exposureBrain-derived neurotrophic factor levelsLong-term safety dataEarly-onset depressive disordersAvailable antidepressant agentsRigid treatment guidelinesUseful treatment interventionsNeurotrophic factor levelsLong-term followShort-term efficacyShort-term efficacy dataAtrophic brain changesHigh recurrence ratePsychopharmacology Algorithm ProjectRoutine clinical practiceAlternative treatment strategiesYears of ageShort-term trialsPaucity of dataRisk-benefit analysisLong-term useAntidepressant medication
1998
SSRIs FOR “DIFFICULT” TEMPERAMENT
Landau J, Martin A, Burke M. SSRIs FOR “DIFFICULT” TEMPERAMENT. Journal Of The American Academy Of Child & Adolescent Psychiatry 1998, 37: 1008-1009. PMID: 9785709, DOI: 10.1097/00004583-199810000-00007.Peer-Reviewed Original ResearchAdolescentAdultChildChild Behavior DisordersEthics, MedicalFemaleHumansMaleObsessive BehaviorParentingSelective Serotonin Reuptake InhibitorsTemperament