2010
Time-Lag Bias in Trials of Pediatric Antidepressants: A Systematic Review and Meta-Analysis
Reyes MM, Panza KE, Martin A, Bloch MH. Time-Lag Bias in Trials of Pediatric Antidepressants: A Systematic Review and Meta-Analysis. Journal Of The American Academy Of Child & Adolescent Psychiatry 2010, 50: 63-72. PMID: 21156271, PMCID: PMC3645909, DOI: 10.1016/j.jaac.2010.10.008.Peer-Reviewed Original ResearchConceptsSerotonin reuptake inhibitorsPlacebo-controlled trialTime-lag biasMajor depressive disorderYears of ageReuptake inhibitorsAntidepressant trialsPediatric depressionDepressive disorderTreatment respondersMAIN OUTCOMESystematic reviewMeta-AnalysisPositive findingsNegative findingsNegative trialsMedical literatureAntidepressantsTrialsPublication of findingsNegative resultsChild psychiatryEfficacyFindingsPublication timeAntidepressants and suicide risk: how did specific information in FDA safety warnings affect treatment patterns?
Busch SH, Frank RG, Leslie DL, Martin A, Rosenheck RA, Martin EG, Barry CL. Antidepressants and suicide risk: how did specific information in FDA safety warnings affect treatment patterns? Psychiatric Services 2010, 61: 11-6. PMID: 20044412, PMCID: PMC2801076, DOI: 10.1176/appi.ps.61.1.11.Peer-Reviewed Original ResearchConceptsMajor depressive disorderAntidepressant useTreatment patternsDepressive disorderFDA safety warningsSpecific safety informationThomson Reuters MarketScanUse of paroxetineRisk of suicidalitySafety warningsAntidepressant treatmentOutpatient visitsTreatment episodesTreatment recommendationsPractice patternsNew episodesDrug AdministrationSuicide riskFDA recommendationsDepressed childrenU.S. FoodFDAAntidepressantsChildrenEvidence of increases
2008
Neuropsychiatric Disorders Associated With Streptococcal Infection: A Case-Control Study Among Privately Insured Children
Leslie DL, Kozma L, Martin A, Landeros A, Katsovich L, King RA, Leckman JF. Neuropsychiatric Disorders Associated With Streptococcal Infection: A Case-Control Study Among Privately Insured Children. Journal Of The American Academy Of Child & Adolescent Psychiatry 2008, 47: 1166-1172. PMID: 18724258, PMCID: PMC2783578, DOI: 10.1097/chi.0b013e3181825a3d.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAttention Deficit Disorder with HyperactivityCase-Control StudiesChildChild, PreschoolCross-Sectional StudiesDepressive Disorder, MajorFemaleHealth SurveysHumansIncidenceInsurance, HealthMaleMigraine DisordersNeurocognitive DisordersObsessive-Compulsive DisorderOdds RatioOtitis MediaRiskSinusitisStreptococcal InfectionsTic DisordersTourette SyndromeUnited StatesConceptsMajor depressive disorderAttention-deficit/hyperactivity disorderPrior streptococcal infectionStreptococcal infectionObsessive-compulsive disorderTic disordersTourette syndromeNeuropsychiatric disordersConditional logistic regression modelsStreptococcal sore throatDiagnosis of OCDCase-control studyLogistic regression modelsSore throatIncident diagnosisEpidemiologic evidenceDepressive disorderSubsequent diagnosisNoninfectious conditionsScarlet feverChildren ages 4Immune systemInfectious diseasesInfectionDiagnosis
2006
Neurobiology of Depression in Children and Adolescents
Zalsman G, Oquendo MA, Greenhill L, Goldberg PH, Kamali M, Martin A, Mann JJ. Neurobiology of Depression in Children and Adolescents. Child And Adolescent Psychiatric Clinics Of North America 2006, 15: 843-868. PMID: 16952764, DOI: 10.1016/j.chc.2006.05.010.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdrenocorticotropic HormoneAnxiety DisordersBrainChildCognitive Behavioral TherapyCorticotropin-Releasing HormoneDepressive DisorderEstradiolFemaleHuman Growth HormoneHumansHypothalamo-Hypophyseal SystemMagnetic Resonance ImagingMaleNeurotransmitter AgentsPituitary-Adrenal SystemPrevalencePubertyRisk FactorsTestosterone
2000
Pharmacotherapy of Early-Onset Depression Update and New Directions
Martin A, Kaufman J, Charney D. Pharmacotherapy of Early-Onset Depression Update and New Directions. Child And Adolescent Psychiatric Clinics Of North America 2000, 9: 135-157. PMID: 10674194, DOI: 10.1016/s1056-4993(18)30139-1.Peer-Reviewed Original ResearchConceptsEarly-onset depressionDepressive disorderSafety dataLong-term exposureBrain-derived neurotrophic factor levelsLong-term safety dataEarly-onset depressive disordersAvailable antidepressant agentsRigid treatment guidelinesUseful treatment interventionsNeurotrophic factor levelsLong-term followShort-term efficacyShort-term efficacy dataAtrophic brain changesHigh recurrence ratePsychopharmacology Algorithm ProjectRoutine clinical practiceAlternative treatment strategiesYears of ageShort-term trialsPaucity of dataRisk-benefit analysisLong-term useAntidepressant medication