2021
Prostate Cancer Screening and Incidence among Aging Persons Living with HIV
Leapman MS, Stone K, Wadia R, Park LS, Gibert CL, Goetz MB, Bedimo R, Rodriguez-Barradas M, Shebl F, Justice AC, Brown ST, Crothers K, Sigel KM. Prostate Cancer Screening and Incidence among Aging Persons Living with HIV. Journal Of Urology 2021, 207: 324-332. PMID: 34555924, PMCID: PMC8741750, DOI: 10.1097/ju.0000000000002249.Peer-Reviewed Original ResearchConceptsPSA testingHIV statusProstate cancerProstate biopsyCancer incidenceHuman immunodeficiency virus statusProstate-specific antigen (PSA) testingVeterans Aging Cohort StudyProspective national cohortMultivariable Poisson modelsAging Cohort StudySpecific antigen testingHuman immunodeficiency virusProstate cancer screeningUninfected comparatorsCohort studyIncident cancerAntigen testingImmunodeficiency virusMean ageCancer screeningNational cohortCancer stageVirus statusMultivariable modelHIV Infection and the Risk of World Health Organization–Defined Sudden Cardiac Death
Freiberg MS, Duncan MS, Alcorn C, Chang C, Kundu S, Mumpuni A, Smith EK, Loch S, Bedigian A, Vittinghoff E, So‐Armah K, Hsue PY, Justice AC, Tseng ZH. HIV Infection and the Risk of World Health Organization–Defined Sudden Cardiac Death. Journal Of The American Heart Association 2021, 10: e021268. PMID: 34493058, PMCID: PMC8649505, DOI: 10.1161/jaha.121.021268.Peer-Reviewed Original ResearchConceptsHIV viral loadCD4 cell countFirst clinical visitHIV infectionViral loadSCD riskCell countWorld Health OrganizationCopies/Elevated HIV viral loadLow CD4 cell countsSudden cardiac death rateVeterans Aging Cohort StudyCox proportional hazards regressionHealth OrganizationConclusions HIV infectionSCD risk factorsCardiac death rateAging Cohort StudyProportional hazards regressionSudden cardiac deathCells/Mean baseline ageRace/ethnicityCohort study
2020
Genome-wide association study of smoking trajectory and meta-analysis of smoking status in 842,000 individuals
Xu K, Li B, McGinnis KA, Vickers-Smith R, Dao C, Sun N, Kember RL, Zhou H, Becker WC, Gelernter J, Kranzler HR, Zhao H, Justice AC. Genome-wide association study of smoking trajectory and meta-analysis of smoking status in 842,000 individuals. Nature Communications 2020, 11: 5302. PMID: 33082346, PMCID: PMC7598939, DOI: 10.1038/s41467-020-18489-3.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesLarge genome-wide association studiesMillion Veteran ProgramAssociation studiesExpression quantitative trait lociQuantitative trait lociChromatin interactionsComplex traitsFunctional annotationTrait lociSequencing ConsortiumDozen genesSignificant lociSmoking phenotypesLociMultiple populationsNew insightsPhenotypeVeteran ProgramGenetic vulnerabilityGenesTraitsAnnotationEuropean AmericansConsortiumImpact of behavioral and medication treatment for alcohol use disorder on changes in HIV-related outcomes among patients with HIV: A longitudinal analysis
McGinnis KA, Skanderson M, Edelman EJ, Gordon AJ, Korthuis PT, Oldfield B, Williams EC, Wyse J, Bryant K, Fiellin DA, Justice AC, Kraemer KL. Impact of behavioral and medication treatment for alcohol use disorder on changes in HIV-related outcomes among patients with HIV: A longitudinal analysis. Drug And Alcohol Dependence 2020, 217: 108272. PMID: 32971391, PMCID: PMC7757793, DOI: 10.1016/j.drugalcdep.2020.108272.Peer-Reviewed Original ResearchConceptsAlcohol use disorderDetectable VLVisits/monthUse disordersVeterans Aging Cohort Study (VACS) dataCohort study dataRace/ethnicityUndetectable VLMedian ageTreatment initiationMedication treatmentImproved adherenceHIVBehavioral treatmentFirst monthIntensity groupTreatment intensityMonthsImpact of BehavioralOutcomesLinear regression modelsLongitudinal analysisVisitsVLAdherenceReceipt and predictors of smoking cessation pharmacotherapy among veterans with and without HIV
Shahrir S, Crothers K, McGinnis KA, Chan KCG, Baeten JM, Wilson SM, Butt AA, Pisani MA, Baldassarri SR, Justice A, Williams EC. Receipt and predictors of smoking cessation pharmacotherapy among veterans with and without HIV. Progress In Cardiovascular Diseases 2020, 63: 118-124. PMID: 31987807, PMCID: PMC7251937, DOI: 10.1016/j.pcad.2020.01.003.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnti-HIV AgentsCardiovascular DiseasesFemaleHealth StatusHIV InfectionsHIV Long-Term SurvivorsHumansLongitudinal StudiesMaleMiddle AgedPreventive Health ServicesProspective StudiesProtective FactorsRisk AssessmentRisk FactorsRisk Reduction BehaviorSmokersSmokingSmoking CessationSmoking Cessation AgentsTime FactorsTreatment OutcomeUnited StatesVeterans HealthViral LoadConceptsNicotine replacement therapyVeterans Aging Cohort StudyMultivariable log-linear regression modelsPotential treatment disparitiesSmoking cessation pharmacotherapyPatient-level factorsAging Cohort StudyMental health disordersRates of receiptUninfected participantsUninfected patientsCardiovascular riskCessation pharmacotherapyCohort studyCurrent smokingHIV statusMultivariable analysisTreatment disparitiesReplacement therapyRelative riskHealth disordersPharmacotherapyPLWHSmokingHIV
2019
Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations
Kranzler HR, Zhou H, Kember RL, Vickers Smith R, Justice AC, Damrauer S, Tsao PS, Klarin D, Baras A, Reid J, Overton J, Rader DJ, Cheng Z, Tate JP, Becker WC, Concato J, Xu K, Polimanti R, Zhao H, Gelernter J. Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. Nature Communications 2019, 10: 1499. PMID: 30940813, PMCID: PMC6445072, DOI: 10.1038/s41467-019-09480-8.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesAssociation studiesMillion Veteran Program sampleGenetic correlationsWide significant lociSignificant genetic correlationsPolygenic risk scoresCell type groupSignificant lociHeritable traitEnrichment analysisTraitsMultiple populationsLociPhenotypeProgram samplesImproved discrimination of mortality with Veterans Aging Cohort Study (VACS) Index 2.0 in HIV-positive individuals
Tate JP, Sterne JAC, Justice AC. Improved discrimination of mortality with Veterans Aging Cohort Study (VACS) Index 2.0 in HIV-positive individuals. AIDS 2019, Publish Ahead of Print: &na;. PMID: 30649058, PMCID: PMC6749990, DOI: 10.1097/qad.0000000000002140.Peer-Reviewed Original ResearchConceptsWhite blood countC-statisticBlood countVeterans Aging Cohort Study (VACS) IndexAntiretroviral Therapy Cohort CollaborationDiscrimination of mortalityVACS Index 2.0Antiretroviral therapy initiationCD4 cell countHIV-positive populationHarrell's C-statisticHIV-1 RNAHIV-positive individualsKaplan-Meier plotsCohort CollaborationNadir CD4VAC patientsAntiretroviral therapyCause mortalityCD8 ratioTherapy initiationViral suppressionGeneral healthExcess mortalityLaboratory values
2018
Duration of opioid prescriptions predicts incident nonmedical use of prescription opioids among U.S. veterans receiving medical care
Barry DT, Marshall BDL, Becker WC, Gordon AJ, Crystal S, Kerns RD, Gaither JR, Gordon KS, Justice AC, Fiellin DA, Edelman EJ. Duration of opioid prescriptions predicts incident nonmedical use of prescription opioids among U.S. veterans receiving medical care. Drug And Alcohol Dependence 2018, 191: 348-354. PMID: 30176548, PMCID: PMC6596307, DOI: 10.1016/j.drugalcdep.2018.07.008.Peer-Reviewed Original ResearchConceptsPrescription opioid receiptPrescription opioidsMedical careOpioid receiptVeterans Health Administration primary careNonmedical useMultivariable Cox modelInfectious disease clinicProspective cohort studyProportional hazards regressionPrescription opioid medicationsPublic health problemSubstance use disordersMedication-related characteristicsOpioid therapyOpioid medicationsOpioid prescriptionsCohort studyDisease clinicMedian ageHazards regressionEligible participantsPrimary careRisk factorsIncidence rateAUDIT‐C and ICD codes as phenotypes for harmful alcohol use: association with ADH1B polymorphisms in two US populations
Justice AC, Smith RV, Tate JP, McGinnis K, Xu K, Becker WC, Lee K, Lynch K, Sun N, Concato J, Fiellin DA, Zhao H, Gelernter J, Kranzler HR, Program O. AUDIT‐C and ICD codes as phenotypes for harmful alcohol use: association with ADH1B polymorphisms in two US populations. Addiction 2018, 113: 2214-2224. PMID: 29972609, PMCID: PMC6226338, DOI: 10.1111/add.14374.Peer-Reviewed Original ResearchChanges in alcohol use associated with changes in HIV disease severity over time: A national longitudinal study in the Veterans Aging Cohort
Williams EC, McGinnis KA, Bobb JF, Rubinsky AD, Lapham GT, Skanderson M, Catz SL, Bensley KM, Richards JE, Bryant KJ, Edelman EJ, Satre DD, Marshall BDL, Kraemer KL, Blosnich JR, Crystal S, Gordon AJ, Fiellin DA, Justice AC, Bradley KA. Changes in alcohol use associated with changes in HIV disease severity over time: A national longitudinal study in the Veterans Aging Cohort. Drug And Alcohol Dependence 2018, 189: 21-29. PMID: 29859388, PMCID: PMC6344121, DOI: 10.1016/j.drugalcdep.2018.04.022.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAgingAlcohol DrinkingFemaleHIV InfectionsHumansLongitudinal StudiesMaleMiddle AgedSeverity of Illness IndexVeteransConceptsHIV severityAUDIT-C screensViral loadAlcohol useVeterans Aging Cohort Study (VACS) dataPoor HIV controlVeterans Aging CohortHIV disease severityAUDIT-C scoresCohort study dataLow-level drinkingStable drinkingVL analysisHIV controlMean changeAging CohortDisease severityPLWHGreater riskCD4Individual alcohol useSeverityDrinking trajectoriesNational Longitudinal StudyLongitudinal studyMarkers of chronic obstructive pulmonary disease are associated with mortality in people living with HIV
Triplette M, Justice A, Attia EF, Tate J, Brown ST, Goetz MB, Kim JW, Rodriguez-Barradas MC, Hoo GWS, Wongtrakool C, Akgün K, Crothers K. Markers of chronic obstructive pulmonary disease are associated with mortality in people living with HIV. AIDS 2018, 32: 487-493. PMID: 29135579, PMCID: PMC6366454, DOI: 10.1097/qad.0000000000001701.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseRisk of deathStudy participantsVACS IndexPulmonary diseaseComputed tomographyImpact of COPDVeterans Aging Cohort Study (VACS) IndexMultivariable Cox regression modelsBurden of comorbiditiesPredictors of mortalityPulmonary function testingCox regression modelMedian followUninfected subjectsAirflow obstructionCohort studyPulmonary functionPulmonary variablesFunction testingMultivariable modelPLWHCT characteristicsMortality rateAlcohol and Mortality
Eyawo O, McGinnis KA, Justice AC, Fiellin DA, Hahn JA, Williams EC, Gordon AJ, Marshall BDL, Kraemer KL, Crystal S, Gaither JR, Edelman EJ, Bryant KJ, Tate JP. Alcohol and Mortality. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2018, 77: 135-143. PMID: 29112041, PMCID: PMC5762259, DOI: 10.1097/qai.0000000000001588.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAlcoholismBiomarkersFemaleGlycerophospholipidsHIV InfectionsHumansLongitudinal StudiesMaleMiddle AgedSelf ReportConceptsHepatitis C virusAlcohol exposureAlcohol useDirect biomarkerVeterans Aging Cohort Study Biomarker CohortBlood collection dateRecent alcohol exposureHIV viral suppressionUnhealthy alcohol useRelationship of alcoholAUDIT-C scoresViral suppressionC virusHigh riskRisk of harmHIVClinical settingMortalityPEthExposureBiomarkersRiskImproved detectionAuditIndividuals
2017
Multimorbidity Among Persons Living with Human Immunodeficiency Virus in the United States
Wong C, Gange SJ, Moore RD, Justice AC, Buchacz K, Abraham AG, Rebeiro PF, Koethe JR, Martin JN, Horberg MA, Boyd CM, Kitahata MM, Crane HM, Gebo KA, Gill MJ, Silverberg MJ, Palella FJ, Patel P, Samji H, Thorne J, Rabkin CS, Mayor A, Althoff KN, Freeman A, Cescon A, Rachlis A, Rogers B, Rodriguez B, Grasso C, Benson C, Drozd D, Fiellin D, Haas D, Kirk G, Willig J, Globerman J, Brooks J, Eron J, Montaner J, Gabler K, Anastos K, Mayer K, Jacobson L, Kopansky-Giles M, Klein M, Turner M, Mugavero M, Saag M, Harrigan P, Dubrow R, Hunter-Mellado R, Hogg R, Bosch R, McKaig R, Bebawy S, Rourke S, Napravnik S, Boswell S, Sterling T. Multimorbidity Among Persons Living with Human Immunodeficiency Virus in the United States. Clinical Infectious Diseases 2017, 66: 1230-1238. PMID: 29149237, PMCID: PMC5889007, DOI: 10.1093/cid/cix998.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsBlack PeopleCohort StudiesDiabetes Mellitus, Type 2FemaleHeterosexualityHIVHIV InfectionsHomosexuality, MaleHumansHypercholesterolemiaHypertensionLongitudinal StudiesMaleMiddle AgedMultimorbidityRenal Insufficiency, ChronicSexual and Gender MinoritiesUnited StatesWhite PeopleConceptsHuman immunodeficiency virusAdjusted prevalence ratiosAge-associated conditionsImmunodeficiency virusMultimorbidity prevalenceClinical careNorth American AIDS Cohort CollaborationEnd-stage liver diseaseMedian baseline ageHIV outpatient clinicChronic kidney diseaseRobust error varianceConfidence intervalsComplex healthcare needsDemographic subgroupsCohort CollaborationComorbidity preventionCohort studyDiabetes mellitusLiver diseaseOutpatient clinicKidney diseasePrevalence ratiosBaseline ageCare complexityAssociation of Cannabis, Stimulant, and Alcohol use with Mortality Prognosis Among HIV-Infected Men
Adams JW, Bryant KJ, Edelman J, Fiellin DA, Gaither JR, Gordon AJ, Gordon KS, Kraemer KL, Mimiaga MJ, Operario D, Tate JP, van den Berg JJ, Justice AC, Marshall BDL. Association of Cannabis, Stimulant, and Alcohol use with Mortality Prognosis Among HIV-Infected Men. AIDS And Behavior 2017, 22: 1341-1351. PMID: 28887669, PMCID: PMC5881942, DOI: 10.1007/s10461-017-1905-4.Peer-Reviewed Original ResearchConceptsVeterans Aging Cohort StudyLow-risk alcohol useRisk alcohol useMortality riskAlcohol useStimulant useAdjusted longitudinal analysesAging Cohort StudyUnhealthy alcohol useAssociation of cannabisVACS IndexCause mortalityCohort studyPatient populationPrognostic indicatorMortality prognosisHIVStudy periodSubstance useCannabisRiskLongitudinal analysisMenMortalityStimulantsValidating Harmful Alcohol Use as a Phenotype for Genetic Discovery Using Phosphatidylethanol and a Polymorphism in ADH1B
Justice AC, McGinnis KA, Tate JP, Xu K, Becker WC, Zhao H, Gelernter J, Kranzler HR. Validating Harmful Alcohol Use as a Phenotype for Genetic Discovery Using Phosphatidylethanol and a Polymorphism in ADH1B. Alcohol Clinical And Experimental Research 2017, 41: 998-1003. PMID: 28295416, PMCID: PMC5501250, DOI: 10.1111/acer.13373.Peer-Reviewed Original ResearchConceptsHarmful alcohol useAlcohol exposureAlcohol useElectronic health record dataEHR dataAUDIT-C scoresHealth record dataLongitudinal electronic health record dataLongitudinal trajectoriesChi-square testEHR-derived phenotypesStudy cohortBlood drawCommon missense polymorphismGenetic risk variantsBlood samplingMissense polymorphismAlcohol riskQuantitative biomarkersRecord dataMedianRisk variantsOverall sampleAfrican AmericansADH1B geneSleep Disturbance Among HIV-Infected and Uninfected Veterans
Womack JA, Murphy TE, Bathulapalli H, Akgün KM, Gibert C, Kunisaki KM, Rimland D, Rodriguez-Barradas M, Yaggi H, Justice AC, Redeker NS. Sleep Disturbance Among HIV-Infected and Uninfected Veterans. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2017, 74: e117-e120. PMID: 27906767, PMCID: PMC5326673, DOI: 10.1097/qai.0000000000001264.Peer-Reviewed Original ResearchTrajectories of Sleep Disturbance Severity in HIV-Infected and Uninfected Veterans
Womack JA, Murphy TE, Bathulapalli H, Akgün KM, Gibert C, Kunisaki KM, Rodriguez-Barradas M, Yaggi HK, Justice AC, Redeker NS. Trajectories of Sleep Disturbance Severity in HIV-Infected and Uninfected Veterans. Journal Of The Association Of Nurses In AIDS Care 2017, 28: 431-437. PMID: 28389058, PMCID: PMC5442598, DOI: 10.1016/j.jana.2017.02.006.Peer-Reviewed Original Research
2016
The impact of prescribed opioids on CD4 cell count recovery among HIV‐infected patients newly initiating antiretroviral therapy
Edelman E, Gordon K, Tate J, Becker W, Bryant K, Crothers K, Gaither, Gibert C, Gordon A, Marshall B, Rodriguez‐Barradas M, Samet J, Skanderson M, Justice A, Fiellin D. The impact of prescribed opioids on CD4 cell count recovery among HIV‐infected patients newly initiating antiretroviral therapy. HIV Medicine 2016, 17: 728-739. PMID: 27186715, PMCID: PMC5053822, DOI: 10.1111/hiv.12377.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalgesics, OpioidAnti-Retroviral AgentsCD4 Lymphocyte CountFemaleHIV InfectionsHumansImmunosuppressive AgentsLongitudinal StudiesMaleMiddle AgedConceptsCD4 cell countBaseline CD4 cell countCell countPrescribed opioidsImmunosuppressive propertiesVeterans Aging Cohort Study (VACS) dataCD4 cell count recoveryAntiretroviral therapy responseCell count recoveryShort-term opioidsViral load suppressionCohort study dataOverall disease severityYear of initiationPrimary independent variableOpioid durationAntiretroviral therapyCount recoveryComorbid conditionsPharmacy dataOpioid propertiesTherapy responseOpioidsPatientsHIVIncarceration History and Uncontrolled Blood Pressure in a Multi-Site Cohort
Howell BA, Long JB, Edelman EJ, McGinnis KA, Rimland D, Fiellin DA, Justice AC, Wang EA. Incarceration History and Uncontrolled Blood Pressure in a Multi-Site Cohort. Journal Of General Internal Medicine 2016, 31: 1496-1502. PMID: 27619934, PMCID: PMC5130961, DOI: 10.1007/s11606-016-3857-1.Peer-Reviewed Original ResearchConceptsVeterans Aging Cohort StudyRecent incarcerationPost-traumatic stress disorderBP controlPast historyUncontrolled blood pressureBlood pressure controlHistory of hypertensionAging Cohort StudyCardiovascular disease mortalityRisk of hypertensionPrimary care engagementHistory of incarcerationLogistic regression modelsConclusionsAmong patientsUncontrolled BPAntihypertensive medicationsCohort studyBlood pressureClinical factorsHypertension outcomesMultivariable analysisCare engagementDisease mortalityInclusion criteriaWhat are the Patterns Between Depression, Smoking, Unhealthy Alcohol Use, and Other Substance Use Among Individuals Receiving Medical Care? A Longitudinal Study of 5479 Participants
Ruggles KV, Fang Y, Tate J, Mentor SM, Bryant KJ, Fiellin DA, Justice AC, Braithwaite RS. What are the Patterns Between Depression, Smoking, Unhealthy Alcohol Use, and Other Substance Use Among Individuals Receiving Medical Care? A Longitudinal Study of 5479 Participants. AIDS And Behavior 2016, 21: 2014-2022. PMID: 27475945, PMCID: PMC5542002, DOI: 10.1007/s10461-016-1492-9.Peer-Reviewed Original ResearchConceptsUnhealthy alcohol useVeterans Aging Cohort StudyAlcohol useSubstance useTreatment strategiesIntegrated screeningCurrent depressionMedical careHIV-negative subgroupsAging Cohort StudyPatterns of depressionCohort studyCurrent smokingOpioid useNegative subgroupSmokingDepressionLongitudinal studyHIVMarijuana useSubgroupsCareCurrent useScreeningStatus