2019
Epigenetic Associations With Estimated Glomerular Filtration Rate Among Men With Human Immunodeficiency Virus Infection
Chen J, Huang Y, Hui Q, Mathur R, Gwinn M, So-Armah K, Freiberg MS, Justice AC, Xu K, Marconi VC, Sun YV. Epigenetic Associations With Estimated Glomerular Filtration Rate Among Men With Human Immunodeficiency Virus Infection. Clinical Infectious Diseases 2019, 70: 667-673. PMID: 30893429, PMCID: PMC7319269, DOI: 10.1093/cid/ciz240.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionGlomerular filtration rateKidney functionFiltration rateVirus infectionVeterans Aging Cohort StudyPeripheral blood mononuclear cellsAging Cohort StudyHIV-positive participantsBlood mononuclear cellsMechanisms of HIVCKD riskCohort studyKidney diseaseMononuclear cellsHigh riskHIVPooled populationEGFREpigenetic associationsSignificant CpG sitesGuanine dinucleotide sitesPotential epigenetic mechanisms
2018
Recent Abacavir Use Increases Risk of Type 1 and Type 2 Myocardial Infarctions Among Adults With HIV
Elion RA, Althoff KN, Zhang J, Moore RD, Gange SJ, Kitahata MM, Crane HM, Drozd DR, Stein JH, Klein MB, Eron JJ, Silverberg MJ, Mathews WC, Justice AC, Sterling TR, Rabkin CS, Mayor AM, Klein DB, Horberg MA, Bosch RJ, Eyawo O, Palella FJ. Recent Abacavir Use Increases Risk of Type 1 and Type 2 Myocardial Infarctions Among Adults With HIV. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2018, 78: 62-72. PMID: 29419568, PMCID: PMC5889316, DOI: 10.1097/qai.0000000000001642.Peer-Reviewed Original ResearchConceptsFramingham risk scoreEffect of abacavirMyocardial infarctionHazard ratioHepatitis C virus infectionType 1Type 2 myocardial infarctionCrude hazard ratioC virus infectionIncident myocardial infarctionInjection drug useHistory of AIDSUse increases riskMarginal structural modelsCohort CollaborationLow CD4Antiretroviral therapyKidney functionMI outcomesTime-dependent confoundingRisk factorsMI occurrenceVirus infectionIncrease riskRisk score