2022
An exploratory study of anxiety-motivated gambling in adolescents: Associations with minority status and gambling, health and functioning measures
Cardwell E, Hoff RA, Garakani A, Krishnan-Sarin S, Potenza MN, Zhai ZW. An exploratory study of anxiety-motivated gambling in adolescents: Associations with minority status and gambling, health and functioning measures. Journal Of Psychiatric Research 2022, 151: 445-453. PMID: 35598502, PMCID: PMC9204846, DOI: 10.1016/j.jpsychires.2022.03.052.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdolescent BehaviorAnxietyBehavior, AddictiveGamblingHumansMinority GroupsStudentsConceptsProblem gamblingGambling-related measuresRisk/problem gamblingNon-strategic gamblingEmotion dysregulationEmotional dysregulationHealth/functioningHigh school studentsBehavioral correlatesGroup differencesConnecticut high school studentsGamblingRisky behaviorsAnxietyAdolescentsPermissive attitudesFeeling pressureGambling perceptionsMinority statusMotivationExploratory studyDrug useSpecific factorsMinority groupsMeasures
2021
Selective Serotonin Reuptake Inhibitors: How Long Is Long Enough?
Thom RP, Alexander JL, Baron D, Garakani A, Gross L, Pine JH, Radhakrishnan R, Slaby A, Sumner CR. Selective Serotonin Reuptake Inhibitors: How Long Is Long Enough? Journal Of Psychiatric Practice 2021, 27: 361-371. PMID: 34529602, DOI: 10.1097/pra.0000000000000578.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAdolescentAgedAnxiety DisordersDepressive Disorder, MajorHumansSelective Serotonin Reuptake InhibitorsConceptsSelective serotonin reuptake inhibitorsLong-term SSRI useSSRI useEase of titrationFirst-line medicationSerotonin reuptake inhibitorsRisk-benefit ratioMajor depressive disorderGeneral health risksShort-term useClinical practice considerationsDiscontinuation syndromeReuptake inhibitorsSafety profileDepressive disorderPatientsPsychiatric conditionsRelapse preventionMedicationsPossible adverse consequencesSpecial populationsAnxiety disordersTolerabilityPrescribersAdverse consequencesClinical and imaging outcomes after intrathecal injection of umbilical cord tissue mesenchymal stem cells in cerebral palsy: a randomized double-blind sham-controlled clinical trial
Amanat M, Majmaa A, Zarrabi M, Nouri M, Akbari MG, Moaiedi AR, Ghaemi O, Zamani F, Najafi S, Badv RS, Vosough M, Hamidieh AA, Salehi M, Montazerlotfelahi H, Tavasoli AR, Heidari M, Mohebi H, Fatemi A, Garakani A, Ashrafi MR. Clinical and imaging outcomes after intrathecal injection of umbilical cord tissue mesenchymal stem cells in cerebral palsy: a randomized double-blind sham-controlled clinical trial. Stem Cell Research & Therapy 2021, 12: 439. PMID: 34362453, PMCID: PMC8343813, DOI: 10.1186/s13287-021-02513-4.Peer-Reviewed Original ResearchConceptsModified Ashworth ScaleCerebral palsyMean changeTissue mesenchymal stem cellsPosterior thalamic radiationDiffusion tensor imagingIntrathecal injectionFractional anisotropyCorticospinal tractDouble-blind sham-controlled clinical trialControl groupMesenchymal stem cellsMean GMFM-66 scoresGross Motor Function MeasureSham-controlled clinical trialSham control armSpastic cerebral palsyMotor Function MeasureGMFM-66 scoresTrial registrationThe studyMonths of interventionExperimental groupWhite matter integrityStem cellsCP-QOLGaming to relieve tension or anxiety and associations with health functioning, substance use and physical violence in high school students
Garakani A, Zhai ZW, Hoff RA, Krishnan-Sarin S, Potenza MN. Gaming to relieve tension or anxiety and associations with health functioning, substance use and physical violence in high school students. Journal Of Psychiatric Research 2021, 140: 461-467. PMID: 34147933, DOI: 10.1016/j.jpsychires.2021.05.055.Peer-Reviewed Original ResearchConceptsHigh school studentsAcademic performanceSubstance useNegative emotional statesMeasures of demographicsPoor academic performanceProblematic Internet useEmotional statesGaming disorderExtracurricular involvementHealth functioningConnecticut high school studentsDepression symptomsAsian adolescentsAnxietyAdolescentsIntervention strategiesSchool studentsExtracurricular activitiesViolent behaviorGamingPhysical violenceDrug usePhysical fightsAdditional researchCommentary: Diagnostic Challenges in Evaluating Adolescents
Garakani A. Commentary: Diagnostic Challenges in Evaluating Adolescents. Journal Of Psychiatric Practice 2021, 27: 239-240. PMID: 33939380, DOI: 10.1097/pra.0000000000000553.Commentaries, Editorials and LettersMeSH KeywordsAdolescentAdultAntipsychotic AgentsDelusionsFemaleHallucinationsHumansPsychotic DisordersSchizophreniaConceptsDiagnostic challengeConstellation of symptomsProminent mood symptomsPosttraumatic stress disorderFemale patientsTrauma-related symptomsMedication treatmentAntipsychotic medicationAdolescent patientsUnnecessary treatmentVisual hallucinationsDifferential diagnosisPatient reportsTerms of stigmaMood symptomsDepressive symptomsPsychotic symptomsSide effectsPatientsPsychotic disordersSuicidal ideasFull differential diagnosisAuditory hallucinationsCotard's syndromeIncorrect diagnosis
2019
Patient Requests for Discharge from Voluntary Psychiatric Hospitalization: a Chart Review
Garakani A, Appel JM, Aloysi AS, Martinez JM, Larkin K, Buono FD. Patient Requests for Discharge from Voluntary Psychiatric Hospitalization: a Chart Review. Psychiatric Quarterly 2019, 90: 849-859. PMID: 31468251, DOI: 10.1007/s11126-019-09671-y.Peer-Reviewed Original ResearchConceptsPsychiatric hospitalizationAdmission dayUrine toxicologyVoluntary Psychiatric HospitalizationSuicidal ideationNew York City hospitalsPositive urine toxicologyPrevious psychiatric hospitalizationInpatient psychiatric admissionStepwise linear regression analysisCalendar year 2007Chart reviewEarly dischargePsychiatric admissionsPatient outcomesInpatient careTobacco useCity HospitalPatient's requestInpatient servicesLinear regression analysisCigarette usePsychiatric inpatientsVoluntary admissionHospitalization
2012
Clinician-rated versus self-rated screening for bipolar disorder among inpatients with mood symptoms and substance misuse.
Goldberg JF, Garakani A, Ackerman SH. Clinician-rated versus self-rated screening for bipolar disorder among inpatients with mood symptoms and substance misuse. The Journal Of Clinical Psychiatry 2012, 73: 1525-30. PMID: 23290325, DOI: 10.4088/jcp.12m07926.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAlcoholismBipolar DisorderCross-Sectional StudiesDiagnosis, Dual (Psychiatry)Diagnostic Self EvaluationFemaleHospitalizationHumansInterview, PsychologicalMaleMass ScreeningMiddle AgedObserver VariationPsychometricsReproducibility of ResultsSubstance-Related DisordersYoung AdultConceptsMood Disorder QuestionnaireBipolar disorderSubstance misusePredictive valueHigh negative predictive valuePatient-clinician concordanceLow positive predictive valueDSM-IV-TR criteriaMood disorder patientsHigh prevalence ratesCross-sectional assessmentCurrent substance misuseSubstance use disordersNegative predictive valuePositive predictive valueSubstance use symptomsPsychiatrist's reviewClinician interviewsPositive statusMood disordersPrevalence ratesMood symptomsLifetime substanceUse disordersBipolar diagnosisMental Health Approaches to Child Victims of Acts of Terrorism
Saraiya A, Garakani A, Billick SB. Mental Health Approaches to Child Victims of Acts of Terrorism. Psychiatric Quarterly 2012, 84: 115-124. PMID: 22736303, DOI: 10.1007/s11126-012-9232-4.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2010
Heart Rate and Blood Pressure Changes During Autonomic Nervous System Challenge in Panic Disorder Patients
Martinez JM, Garakani A, Kaufmann H, Aaronson CJ, Gorman JM. Heart Rate and Blood Pressure Changes During Autonomic Nervous System Challenge in Panic Disorder Patients. Psychosomatic Medicine 2010, 72: 442-449. PMID: 20368476, DOI: 10.1097/psy.0b013e3181d972c2.Peer-Reviewed Original ResearchConceptsLower heart rate variabilityMean diastolic blood pressureHigher heart rateHeart rate variabilityDiastolic blood pressureBlood pressureHealthy controlsHeart ratePanic disorder patientsPD patientsLF/HFOrthostatic challengeSympathovagal balanceDisorder patientsHigher mean diastolic blood pressureGreater cardiac riskIllness severity ratingsLess ill patientsSystolic blood pressureBlood pressure changesSeverity of illnessHigher low-frequency componentsAutonomic nervous systemIll patientsCardiac risk
2008
Effect of medication and psychotherapy on heart rate variability in panic disorder
Garakani A, Martinez JM, Aaronson CJ, Voustianiouk A, Kaufmann H, Gorman JM. Effect of medication and psychotherapy on heart rate variability in panic disorder. Depression And Anxiety 2008, 26: 251-258. PMID: 18839407, DOI: 10.1002/da.20533.Peer-Reviewed Original ResearchConceptsHeart rate variabilityHeart rateRate variabilityLower heart rate variabilitySignificant clinical improvementWeeks of treatmentWeeks of CBTEffects of medicationPanic disorder patientsEffect of treatmentClinical improvementCardiac riskPD patientsCardiovascular diseaseTreatment respondersClinical measuresElevated riskDisorder patientsTreatment phasePatientsSymptom reductionPanic disorderHyperventilation challengeStatistical ManualSignificant decreaseA randomized, double-blind, and placebo-controlled trial of quetiapine augmentation of fluoxetine in major depressive disorder
Garakani A, Martinez JM, Marcus S, Weaver J, Rickels K, Fava M, Hirschowitz J. A randomized, double-blind, and placebo-controlled trial of quetiapine augmentation of fluoxetine in major depressive disorder. International Clinical Psychopharmacology 2008, 23: 269-275. PMID: 18703936, DOI: 10.1097/yic.0b013e328301a74c.Peer-Reviewed Original ResearchConceptsMontgomery-Asberg Depression Rating Scale scoreMajor depressive disorderDepression Rating Scale scoresHamilton Anxiety ScaleRating Scale scoresPlacebo groupDepressive disorderScale scoreCGI improvement scoreCombination of quetiapinePlacebo-controlled trialClinical global improvementWeeks of treatmentOnset of actionMixed effects linear regressionQuetiapine augmentationAnxiety ScaleFluoxetine groupFluoxetine treatmentCGI scoresImproved sleepMixed effects regressionInsomnia scoresQuetiapineFluoxetineShort-term tolerability of a nonazapirone selective serotonin 1A agonist in adults with generalized anxiety disorder: A 28-day, open-label study
Mathew SJ, Garakani A, Reinhard JF, Oshana S, Donahue S. Short-term tolerability of a nonazapirone selective serotonin 1A agonist in adults with generalized anxiety disorder: A 28-day, open-label study. Clinical Therapeutics 2008, 30: 1658-1666. PMID: 18840371, DOI: 10.1016/j.clinthera.2008.09.006.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAnti-Anxiety AgentsAnxiety DisordersDiagnostic and Statistical Manual of Mental DisordersDrug Administration ScheduleFemaleHumansMaleMiddle AgedPiperazinesPsychiatric Status Rating ScalesSerotonin 5-HT1 Receptor AgonistsSerotonin Receptor AgonistsSingle-Blind MethodSulfonamidesSurveys and QuestionnairesTreatment OutcomeConceptsGeneralized anxiety disorderShort-term tolerabilityAdverse eventsPRX-00023Hamilton Anxiety Rating Scale scoresVital signsResponse criteriaAnxiety disordersTotal scoreOpen-label studySerotonin 1A agonistSingle-blind placeboAnxiety Rating Scale scoresSerious adverse eventsStudy end pointInfluenza-like symptomsOpen-label treatmentPrimary outcome measureDiagnosis of GADRating Scale scoresEnd point changeSample of patientsSerotonin 1A receptorPremature ventricular contractionsSelective partial agonist