2021
Clinical and imaging outcomes after intrathecal injection of umbilical cord tissue mesenchymal stem cells in cerebral palsy: a randomized double-blind sham-controlled clinical trial
Amanat M, Majmaa A, Zarrabi M, Nouri M, Akbari MG, Moaiedi AR, Ghaemi O, Zamani F, Najafi S, Badv RS, Vosough M, Hamidieh AA, Salehi M, Montazerlotfelahi H, Tavasoli AR, Heidari M, Mohebi H, Fatemi A, Garakani A, Ashrafi MR. Clinical and imaging outcomes after intrathecal injection of umbilical cord tissue mesenchymal stem cells in cerebral palsy: a randomized double-blind sham-controlled clinical trial. Stem Cell Research & Therapy 2021, 12: 439. PMID: 34362453, PMCID: PMC8343813, DOI: 10.1186/s13287-021-02513-4.Peer-Reviewed Original ResearchConceptsModified Ashworth ScaleCerebral palsyMean changeTissue mesenchymal stem cellsPosterior thalamic radiationDiffusion tensor imagingIntrathecal injectionFractional anisotropyCorticospinal tractDouble-blind sham-controlled clinical trialControl groupMesenchymal stem cellsMean GMFM-66 scoresGross Motor Function MeasureSham-controlled clinical trialSham control armSpastic cerebral palsyMotor Function MeasureGMFM-66 scoresTrial registrationThe studyMonths of interventionExperimental groupWhite matter integrityStem cellsCP-QOLThe mediating effects of quality of life, depression, and generalized anxiety on perceived barriers to employment success for people diagnosed with Neurofibromatosis Type 1
Buono FD, Sprong ME, Paul E, Martin S, Larkin K, Garakani A. The mediating effects of quality of life, depression, and generalized anxiety on perceived barriers to employment success for people diagnosed with Neurofibromatosis Type 1. Orphanet Journal Of Rare Diseases 2021, 16: 234. PMID: 34020694, PMCID: PMC8138923, DOI: 10.1186/s13023-021-01866-6.Peer-Reviewed Original ResearchMeSH KeywordsAnxietyCross-Sectional StudiesDepressionEmploymentHumansNeurofibromatosis 1Quality of LifeSurveys and Questionnaires
2020
Impact of depressive symptoms on self-perceived severity of autonomic dysfunction in multiple system atrophy: relevance for patient-reported outcomes in clinical trials
Martinez J, Palma JA, Norcliffe-Kaufmann L, Garakani A, Kaufmann H. Impact of depressive symptoms on self-perceived severity of autonomic dysfunction in multiple system atrophy: relevance for patient-reported outcomes in clinical trials. Clinical Autonomic Research 2020, 30: 215-221. PMID: 32246226, PMCID: PMC7341538, DOI: 10.1007/s10286-020-00681-6.Peer-Reviewed Original ResearchConceptsMultiple system atrophyOrthostatic Hypotension QuestionnaireSymptoms of depressionOrthostatic hypotensionAutonomic dysfunctionDepressive symptomsSelf-perceived severityAutonomic symptomsSystem atrophyDepression scoresOHQ scoresOrthostatic blood pressure fallUnified MSA Rating ScaleProbable multiple system atrophyComposite Autonomic Symptom ScoreBlood pressure fallResultsFifty-eight patientsSystolic blood pressureZung depression scorePatient-reported outcomesAutonomic symptom scoreClinical trial designMultivariable regression modelsQuality of lifeConclusionsIn patients