Clinical and imaging outcomes after intrathecal injection of umbilical cord tissue mesenchymal stem cells in cerebral palsy: a randomized double-blind sham-controlled clinical trial
Amanat M, Majmaa A, Zarrabi M, Nouri M, Akbari MG, Moaiedi AR, Ghaemi O, Zamani F, Najafi S, Badv RS, Vosough M, Hamidieh AA, Salehi M, Montazerlotfelahi H, Tavasoli AR, Heidari M, Mohebi H, Fatemi A, Garakani A, Ashrafi MR. Clinical and imaging outcomes after intrathecal injection of umbilical cord tissue mesenchymal stem cells in cerebral palsy: a randomized double-blind sham-controlled clinical trial. Stem Cell Research & Therapy 2021, 12: 439. PMID: 34362453, PMCID: PMC8343813, DOI: 10.1186/s13287-021-02513-4.Peer-Reviewed Original ResearchConceptsModified Ashworth ScaleCerebral palsyMean changeTissue mesenchymal stem cellsPosterior thalamic radiationDiffusion tensor imagingIntrathecal injectionFractional anisotropyCorticospinal tractDouble-blind sham-controlled clinical trialControl groupMesenchymal stem cellsMean GMFM-66 scoresGross Motor Function MeasureSham-controlled clinical trialSham control armSpastic cerebral palsyMotor Function MeasureGMFM-66 scoresTrial registrationThe studyMonths of interventionExperimental groupWhite matter integrityStem cellsCP-QOL