Halogenated aromatic amino acid 3,5-dibromo-d-tyrosine produces beneficial effects in experimental stroke and seizures
Cao W, Glushakov A, Shah HP, Mecca AP, Sumners C, Shi P, Seubert CN, Martynyuk AE. Halogenated aromatic amino acid 3,5-dibromo-d-tyrosine produces beneficial effects in experimental stroke and seizures. Amino Acids 2010, 40: 1151-1158. PMID: 20839013, PMCID: PMC8396070, DOI: 10.1007/s00726-010-0739-4.Peer-Reviewed Original ResearchConceptsMiddle cerebral artery occlusionET-1 administrationInfarct volumePTZ administrationEndothelin-1Cardiovascular parametersOnset of MCAOCerebral artery occlusionArterial blood pressureCaspase-3-positive cellsSpontaneous locomotor activityNovel therapeutic directionArtery occlusionExperimental strokeNeurological deficitsBlood pressureSeizure scoreNeurological functionIntracerebral injectionIntraperitoneal injectionBolus injectionRat modelHeart rateControl animalsPositive cells