Extravasation of pathogenic human type 17 Th cells requires both endothelial cell-bound and non-cell bound chemokines
Parween F, Singh S, Zhang H, Kathuria N, Farber J. Extravasation of pathogenic human type 17 Th cells requires both endothelial cell-bound and non-cell bound chemokines. The Journal Of Immunology 2023, 210: 79.07-79.07. DOI: 10.4049/jimmunol.210.supp.79.07.Peer-Reviewed Original ResearchEndothelial cellsTransendothelial migrationPro-inflammatory T cellsCCR2+ cellsMultiple chemokine receptorsHuman Th17 cellsImmune-mediated diseasesTransduced endothelial cellsBinding to endothelial cellsActivated endothelial cellsSites of inflammationActivity of receptorsTh17 signatureEndothelial cell surfaceTh17 cellsT cellsTh cellsChemokine receptorsGM-CSFCCR6Chemokine systemActivation of individual receptorsInhibition of transendothelial migrationApical sideTherapeutic benefit