2017
NOD2 deficiency exacerbates imiquimod-induced, psoriasis-like dermatitis
Singh T, Cipolla E, Singh S, Farber J. NOD2 deficiency exacerbates imiquimod-induced, psoriasis-like dermatitis. The Journal Of Immunology 2017, 198: 75.17-75.17. DOI: 10.4049/jimmunol.198.supp.75.17.Peer-Reviewed Original ResearchNucleotide-binding oligomerization domainNod2-/- micePsoriasis-like dermatitisToll-like receptorsIL-22Levels of mRNAPattern recognition proteinsIL-17AUp-regulation of NOD2Inhibition of Toll-like receptorImiquimod-treated skinRecognition proteinsDecreased levels of mRNAOligomerization domainAutoimmune skin diseaseIncreased levels of mRNAWild-type controlsExpression of mRNAInactivating mutationsAntibacterial defenseImiquimod-inducedNod2 deficiencyNOD2 functionT cellsIL-1ra
2010
Exaggerated IL-23-induced psoriasis-like inflammation in mice lacking CCR4 (135.32)
Hedrick M, Zhang H, Farber J. Exaggerated IL-23-induced psoriasis-like inflammation in mice lacking CCR4 (135.32). The Journal Of Immunology 2010, 184: 135.32-135.32. DOI: 10.4049/jimmunol.184.supp.135.32.Peer-Reviewed Original ResearchCCR4-deficient micePsoriasis-like inflammationT cellsIL-23Deficient miceIL-22Intradermal injection of IL-23Foxp3+ cellsExaggerated inflammatory responseWild-type miceIL-10 family cytokinesPro-inflammatory cytokinesIntramural Research ProgramIL-10 familyTh17 cellsTh2 cellsDendritic cellsIL-17AIL-17FMicroabscess formationChemokine receptorsInjected skinInfiltrating neutrophilsEffector functionsIntradermal injection