Tyrone Cannon
Clark L. Hull Professor of Psychology and Professor of PsychiatryCards
About
Research
Publications
2025
Delineating Empirically Plausible Causal Pathways to Suicidality Among People at Clinical High Risk for Psychosis
Bronstein M, Kummerfeld E, Bearden C, Cornblatt B, Walker E, Woods S, Mathalon D, Perkins D, Cadenhead K, Addington J, Cannon T, Vinogradov S. Delineating Empirically Plausible Causal Pathways to Suicidality Among People at Clinical High Risk for Psychosis. Journal Of Psychopathology And Clinical Science 2025, 134: 239-250. PMID: 39913476, DOI: 10.1037/abn0000969.Peer-Reviewed Original ResearchConceptsClinical high riskNorth American Prodrome Longitudinal StudyClinical high-risk samplesAttenuated psychosis symptomsPathways to suicideSuicide risk reductionPsychosis symptomsCausal pathwaysDepressed moodPsychosisIntervention effortsSelf-deprecationSuicideLongitudinal studyMeasurement time pointsStudy timepointsHigh riskSymptomsInterventionHopelessnessMoodTime pointsDepressionIndividualsDirect causesResponse to Psychotherapy by Clients With Varying Levels of Distress Treated in a Graduate Student Outpatient Clinic
O’Brien M, O’Leary C, Cannon T, Lympus C, Salinger J, Prelli F, Gale M. Response to Psychotherapy by Clients With Varying Levels of Distress Treated in a Graduate Student Outpatient Clinic. Training And Education In Professional Psychology 2025 DOI: 10.1037/tep0000508.Peer-Reviewed Original ResearchOutcome Questionnaire-45Levels of distressResponse to psychotherapyPositive therapeutic allianceIndividual psychotherapyCognitive reappraisalPerseverative thinkingTherapeutic allianceSelf-compassionTraining clinicTherapeutic relationshipPsychological processesPsychological skillsPsychotherapyCourse of treatmentEnd treatmentRepeated-measures analysisRepeated-measures analysis of varianceDistressContext variablesRepeated-measuresClientsAnalysis of varianceDoctoral studentsOutpatient clinicEmergence and dynamics of delusions and hallucinations across stages in early psychosis
Mourgues-Codern C, Benrimoh D, Gandhi J, Farina E, Vin R, Zamorano T, Parekh D, Malla A, Joober R, Lepage M, Iyer S, Addington J, Bearden C, Cadenhead K, Cornblatt B, Keshavan M, Stone W, Mathalon D, Perkins D, Walker E, Cannon T, Woods S, Shah J, Powers A. Emergence and dynamics of delusions and hallucinations across stages in early psychosis. Biological Psychiatry 2025 PMID: 40020853, DOI: 10.1016/j.biopsych.2025.02.891.Peer-Reviewed Original ResearchFirst-episode psychosis patientsSymptom patternsNorth American Prodrome Longitudinal StudyPositive symptoms of psychosisSymptoms of psychosisCHR-P samplesEarly intervention programsPositive symptomsDelusional ideationPsychosis patientsEarly psychosisCHR-PNeural mechanismsDelusionsHallucination onsetHallucinationsPsychosisBaseline assessmentLongitudinal studyIntervention programsSymptomsTime courseParticipantsIdeationOnsetPredicting conversion to psychosis using machine learning: response to Cannon
Smucny J, Cannon T, Bearden C, Addington J, Cadenhead K, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Walker E, Woods S, Davidson I, Carter C. Predicting conversion to psychosis using machine learning: response to Cannon. Frontiers In Psychiatry 2025, 15: 1520173. PMID: 39882161, PMCID: PMC11775650, DOI: 10.3389/fpsyt.2024.1520173.Peer-Reviewed Original ResearchMachine learning algorithmsMachine learning modelsLearning algorithmsConversion to psychosisMachine learningLearning modelsStandard machine learning algorithmsClinical high riskNAPLS-2Overall performanceNaive BayesModel generalizationClinical high-risk individualsPredicting conversion to psychosisTest setIndependent datasetsRandom forest methodDataset
2024
Polygenic Risk Scores and Twin Concordance for Schizophrenia and Bipolar Disorder
Song J, Pasman J, Johansson V, Kuja-Halkola R, Harder A, Karlsson R, Lu Y, Kowalec K, Pedersen N, Cannon T, Hultman C, Sullivan P. Polygenic Risk Scores and Twin Concordance for Schizophrenia and Bipolar Disorder. JAMA Psychiatry 2024, 81: 1246-1252. PMID: 39196586, PMCID: PMC11359115, DOI: 10.1001/jamapsychiatry.2024.2406.Peer-Reviewed Original ResearchPolygenic risk scoresGenome-wide association studiesSwedish Twin RegistryBipolar disorderCase-control studyTwin concordanceTwin heritabilityLevels of polygenic risk scoreTwin RegistrySwedish national register dataCompare polygenic risk scoresRisk scoreNational register dataHeritable psychiatric disorderAffected co-twinsPairs of twinsPsychosis phenotypeIllness vulnerabilityClinical interviewPsychiatric disordersGenetic liabilityMain OutcomesStructural equation modelingPsychosisSchizophreniaMismatch Negativity as an Index of Auditory Short-Term Plasticity: Associations with Cortisol, Inflammation, and Gray Matter Volume in Youth at Clinical High Risk for Psychosis
Hamilton H, Roach B, Bachman P, Belger A, Carrión R, Duncan E, Johannesen J, Light G, Niznikiewicz M, Addington J, Bearden C, Cadenhead K, Cornblatt B, Perkins D, Tsuang M, Walker E, Woods S, Cannon T, Mathalon D. Mismatch Negativity as an Index of Auditory Short-Term Plasticity: Associations with Cortisol, Inflammation, and Gray Matter Volume in Youth at Clinical High Risk for Psychosis. Clinical EEG And Neuroscience 2024, 56: 46-59. PMID: 39552576, DOI: 10.1177/15500594241294035.Peer-Reviewed Original ResearchNMDAR-dependent plasticityClinical high riskGray matter volumeMismatch negativityMagnetic resonance imagingGray matter lossShort-term plasticityMMN amplitudeMatter volumeN-methyl-D-aspartateHigh riskCHR-PPro-inflammatory cytokine levelsPathogenesis of schizophreniaModel of schizophreniaBiomarkers of schizophreniaMismatch negativity amplitudeCHR-P individualsNorth American Prodrome Longitudinal StudyEvent-related potentialsAberrant neurodevelopmental processesInfluence of psychosisSubcortical gray matter volumesTotal gray matter volumeNMDAR hypofunctionConvergent Validity of Experimental Cognitive Tests in a Large Community Sample.
Dean A, Pochon J, Bilder R, Sabb F, Congdon E, Ghahremani D, Karlsgodt K, van Erp T, Schwarzlose R, Cannon T, Freimer N, London E. Convergent Validity of Experimental Cognitive Tests in a Large Community Sample. Assessment 2024, 10731911241283410. PMID: 39523501, DOI: 10.1177/10731911241283410.Peer-Reviewed Original ResearchExperimental cognitive testsConvergent validityInhibitory controlFactor analysisCognitive testsBalloon Analogue Risk TaskTests of working memoryMultigroup confirmatory factor analysisDelay-discounting taskReversal learning taskStop-signal taskExperimental cognitive measuresTraditional neuropsychological testsAttention Network TestThree-factor structureConfirmatory factor analysisExploratory factor analysisDiscounting taskRemember-knowRisk TaskTask switchingCognitive measuresNeuropsychological testsCognitive domainsPsychiatric diagnosisProtective Factors Predict Resilient Outcomes in Clinical High-Risk Youth with the Highest Individualized Psychosis Risk Scores
Cadenhead K, Addington J, Bearden C, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Walker E, Woods S. Protective Factors Predict Resilient Outcomes in Clinical High-Risk Youth with the Highest Individualized Psychosis Risk Scores. Schizophrenia Bulletin 2024, sbae182. PMID: 39488001, DOI: 10.1093/schbul/sbae182.Peer-Reviewed Original ResearchClinical high riskClinical high-risk participantsClinical high-risk researchPremorbid functioningResilient outcomesProtective factorsClinical high-risk youthClinical high-risk populationsReduced startle reactivityPrediction of psychosisAssociated with greater resilienceHigh-risk youthStudy of protective factorsStartle reactivityPsychotic conversionBrain areasPsychosisChildhood environmentBrain developmentGreater resilienceExploratory analysisLife experiencesPreventive interventionsSocial engagementHispanic heritageNeighborhood ethnoracial diversity and positive psychotic symptoms among youth at high-risk and healthy comparisons
Ku B, Yuan Q, Haardörfer R, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Woods S, Druss B, Walker E, Anglin D. Neighborhood ethnoracial diversity and positive psychotic symptoms among youth at high-risk and healthy comparisons. Psychiatry Research 2024, 342: 116222. PMID: 39378539, PMCID: PMC11617269, DOI: 10.1016/j.psychres.2024.116222.Peer-Reviewed Original ResearchHealthy comparisonPositive symptomsCHR-PPeer victimizationNorth American Prodrome Longitudinal StudyScale of Prodromal SymptomsAttenuated positive symptomsPositive psychotic symptomsClinical high riskFewer life eventsAssociated with schizophreniaEthnoracial diversityPsychotic symptomsHigh riskPrevent psychosisDepressive symptomsStructural equation modelingLife eventsProdromal symptomsPsychosisDiscriminatory experiencesEthnoracial minoritiesSocial determinantsNeighborhood povertyEthnoracial groupsImpact of adverse childhood experiences on risk for internalizing psychiatric disorders in youth at clinical high-risk for psychosis
Giampetruzzi E, Walker E, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Woods S, LoPilato A. Impact of adverse childhood experiences on risk for internalizing psychiatric disorders in youth at clinical high-risk for psychosis. Psychiatry Research 2024, 342: 116214. PMID: 39368239, PMCID: PMC11617268, DOI: 10.1016/j.psychres.2024.116214.Peer-Reviewed Original ResearchAdverse childhood experiencesClinical high riskEffects of protective factorsInternalizing disordersDepressive disorderCHR-PEmotional neglectSelf-harm/suicideProtective factorsChildhood experiencesHigher levels of adverse childhood experiencesHistory of depressive disorderSexual abuseLevels of adverse childhood experiencesInternalizing psychiatric disordersChildhood sexual abusePresence of protective factorsImpact of adverse childhood experiencesAnxiety disordersAdministered measuresPsychiatric diagnosisPsychiatric disordersPsychiatric outcomesChild adversitySubstance use
News
News
- September 16, 2020
Yale Researchers to Lead $52M Investigation Into Cause, Effect of Schizophrenia in Some High-risk Adolescents
- July 05, 2020
Brain Imaging Reveals Patterns That Foreshadow Schizophrenia’s Onset
- February 19, 2019
Cannon appointed Chair of Department of Psychology at Yale University
- July 01, 2016
Yale study: Calculator can predict psychosis risk