Tyrone Cannon
Clark L. Hull Professor of Psychology and Professor of PsychiatryCards
About
Research
Publications
2026
Neighborhood social fragmentation and cerebello-thalamo-cortical connectivity in youth at clinical high-risk for psychosis and healthy comparisons
Ku B, Arrant E, Addington J, Bearden C, Cadenhead K, Cannon T, Carrion R, Keshavan M, Mathalon D, Stone W, Woods S, Walker E, Perkins D, Cao H. Neighborhood social fragmentation and cerebello-thalamo-cortical connectivity in youth at clinical high-risk for psychosis and healthy comparisons. Brain And Environment 2026, 5: 100016. PMID: 41907310, PMCID: PMC13030900, DOI: 10.1016/j.braen.2026.100016.Peer-Reviewed Original ResearchNeighbourhood social fragmentationClinical high riskHealthy comparisonCHR-PSocial fragmentationPsychosis riskNorth American Prodrome Longitudinal Study Phase 2Functional connectivity dataPredictive coding frameworkCerebello-thalamo-cortical connectionsHC youthPsychosisIndividual povertyMaladaptive processesBrain's abilitySocial tiesBelief updatingEducational attainmentSocial worldConnectivity dataYouthStudy phase 2Early interventionNeighborhoodSocial environmentThe Utility of Negative Symptoms in Predicting Transition to Psychosis Among Individuals at Clinical High Risk
Arnovitz M, Cornblatt B, Auther A, McLaughlin D, Addington J, Bearden C, Cadenhead K, Cannon T, Keshavan M, Mathalon D, Perkins D, Stone W, Tsuang M, Walker E, Woods S, Kane J, Carrión R. The Utility of Negative Symptoms in Predicting Transition to Psychosis Among Individuals at Clinical High Risk. Schizophrenia Bulletin 2026, 52: sbaf244. PMID: 41863384, PMCID: PMC13005126, DOI: 10.1093/schbul/sbaf244.Peer-Reviewed Original ResearchConceptsNegative symptomsClinical high riskDepressive symptomsCHR-NTCHR-PSymptom modelNorth American Prodrome Longitudinal StudyScale of Prodromal SymptomsHealthy controlsCalgary Depression ScaleExpressive negative symptomsNegative symptom severitySocial anhedoniaCHR-TSymptom severityPsychosisIdeational richnessProdromal symptomsDepression ScaleLongitudinal studyHigh riskData support considerationSymptomsHigh-risk individualsFollow-upVisual P300 and risk for psychosis onset in youth at clinical high-risk
Hamilton H, Roach B, Nicholas S, Dembo R, Bachman P, Belger A, Carrion R, Duncan E, Johannesen J, Light G, Niznikiewicz M, Addington J, Bearden C, Cadenhead K, Perkins D, Walker E, Woods S, Cannon T, Mathalon D. Visual P300 and risk for psychosis onset in youth at clinical high-risk. Biological Psychiatry 2026 PMID: 41771336, DOI: 10.1016/j.biopsych.2026.02.013.Peer-Reviewed Original ResearchClinical high riskHealthy comparisonEvent-related potentialsCHR individualsPsychosis onsetP3b deficitsPsychosis conversionNorth American Prodrome Longitudinal StudyVisual P300 event-related potentialsThree-stimulus visual oddball taskPathogenesis of psychosisPrediction of psychosis onsetP300 event-related potentialVisual oddball taskInfrequent target stimuliAssociated with future outcomesCHR participantsNovelty P3aNovel stimuliNAPLS-2Target stimuliSymptom severityOddball taskP300 amplitudePsychosisContributions of regional cortical thickness and surface area to cognitive functioning in psychosis-risk
Guest R, Addington J, Bearden C, Cadenhead K, Cornblatt B, Mathalon D, Perkins D, Tsuang M, Woods S, Cannon T, Keshavan M, Stone W, Walker E. Contributions of regional cortical thickness and surface area to cognitive functioning in psychosis-risk. Schizophrenia Research 2026, 290: 98-105. PMID: 41671768, DOI: 10.1016/j.schres.2026.02.004.Peer-Reviewed Original ResearchConceptsWechsler Abbreviated ScaleHealthy control participantsCHR-PCognitive functionBetter cognitive functionCortical thicknessControl participantsWechsler Abbreviated Scale of IntelligenceNorth American Prodrome Longitudinal StudyEarly stages of psychosisCHR-P samplesStages of psychosisClinical high riskFull-scale IQAssociated with better cognitive functionStructural MRI scansAberrant neurodevelopmental processesScale of IntelligenceRegional cortical thicknessPsychosis-riskOnset of illnessCognitive deficitsCHR-P.Cortical substratesFrontoparietal regions
2025
Theta Oscillations Assessed From a Passive Auditory Oddball Paradigm in Individuals at Clinical High-Risk for Psychosis and Healthy Control Individuals: Associations with Clinical Outcomes and Mismatch Negativity
Hua J, Roach B, Hamilton H, Bachman P, Belger A, Carrión R, Duncan E, Johannesen J, Light G, Niznikiewicz M, Addington J, Bearden C, Cadenhead K, Perkins D, Stone W, Walker E, Woods S, Cannon T, Mathalon D. Theta Oscillations Assessed From a Passive Auditory Oddball Paradigm in Individuals at Clinical High-Risk for Psychosis and Healthy Control Individuals: Associations with Clinical Outcomes and Mismatch Negativity. Biological Psychiatry Global Open Science 2025, 6: 100664. PMID: 41646831, PMCID: PMC12870832, DOI: 10.1016/j.bpsgos.2025.100664.Peer-Reviewed Original ResearchCHR-CInter-trial phase coherenceAuditory oddball paradigmHealthy controlsClinical high riskCHR-PMismatch negativityCHR-NCNorth American Prodrome Longitudinal Study 2High riskTheta oscillationsClinical outcomesGeneration of theta oscillationsAssociated with clinical outcomesMismatch negativity deficitsOddball paradigmPsychosis conversionMismatch negativity amplitudeCHR-P samplesEvent-related oscillationsCHR-P individualsPassive auditory oddball paradigmFollow-upSchizophrenia biomarkersStandard tonesPsychosis-proneness is associated with reduced cognitive error-monitoring during instrumental learning
Zhao W, McDougle S, Cannon T. Psychosis-proneness is associated with reduced cognitive error-monitoring during instrumental learning. Schizophrenia Research Cognition 2025, 43: 100408. PMID: 41438020, PMCID: PMC12719759, DOI: 10.1016/j.scog.2025.100408.Peer-Reviewed Original ResearchPost-error slowingPsychosis-pronenessError monitoringPositive schizotypyWorking memoryInstrumental learningMultidimensional Schizotypy Scale-BriefLearning tasksExecutive function deficitsInstrumental learning taskImpaired error monitoringReinforcement learning taskCognitive inflexibilityBelief inflexibilityWM loadWM capacityWM limitationsCognitive profilePost-errorSchizotypyFunctional deficitsVisuomotorBriefInflexibilityPerformance monitoringNeighborhood Characteristics and Social Functioning: Exploring Shared and Distinct Psychosocial Pathways Among Individuals at Clinical High-Risk for Psychosis
Yuan Q, Feurer C, Zhou Q, Carrion R, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Woods S, Walker E, Ku B. Neighborhood Characteristics and Social Functioning: Exploring Shared and Distinct Psychosocial Pathways Among Individuals at Clinical High-Risk for Psychosis. Schizophrenia Bulletin 2025, sbaf192. PMID: 41212179, DOI: 10.1093/schbul/sbaf192.Peer-Reviewed Original ResearchNeighborhood socioeconomic deprivationNeighbourhood social fragmentationSocioeconomic deprivationNeighborhood characteristicsAssociated with social functioningContextual risk factorsSocial functioningHigh riskStudy phase 3Impaired social functioningRisk factorsCHR-PSocial fragmentationClinical high riskParticipant's addressGlobal assessmentCHR-P individualsPsychosocial pathwaysGlobal Assessment of FunctioningAssessment of functioningEffective interventionsStructural assessmentStructured Assessment of Violence RiskEnvironmental factorsAssessment of Violence RiskShift in sex and age of individuals at a clinical high risk (CHR) for psychosis: relation to differences in recruitment methods and effect on sample characteristics
Farina E, Mourgues-Codern C, Stimler K, Kenney J, Saxena A, Mukhtar H, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Ellman L, Gold J, Keshavan M, Mathalon D, Mittal V, Perkins D, Schiffman J, Silverstein S, Strauss G, Stone W, Walker E, Waltz J, Corlett P, Powers A, Woods S. Shift in sex and age of individuals at a clinical high risk (CHR) for psychosis: relation to differences in recruitment methods and effect on sample characteristics. Schizophrenia 2025, 11: 123. PMID: 41053030, PMCID: PMC12501016, DOI: 10.1038/s41537-025-00663-5.Peer-Reviewed Original ResearchClinical high riskClinical high-risk samplesNorth American Prodrome Longitudinal StudyOvert psychotic disordersSample characteristicsSample of individualsNegative symptomsPsychotic disordersPsychosis riskSelf-referralRecruitment sourcesBetween-study differencesComputerized assessmentHierarchical regressionPsychosisRecruitment source effectsClinical implicationsLongitudinal studyGeneral symptomsDemographic differencesClinical profileSymptomsParticipantsClinical heterogeneitySex2.67 Long-Term Outcomes of Youth at Clinical High-Risk for Psychosis: Does Lifetime Substance Use Play a Role?
Bianchi S, Addington J, Bearden C, Cannon T, Carrión R, Keshavan M, Mathalon D, Perkins D, Stone W, Walker E, Woods S, Cadenhead K. 2.67 Long-Term Outcomes of Youth at Clinical High-Risk for Psychosis: Does Lifetime Substance Use Play a Role? Journal Of The American Academy Of Child And Adolescent Psychiatry 2025, 64: s214. DOI: 10.1016/j.jaac.2025.08.187.Peer-Reviewed Original ResearchPredictors and Moderators of Long-Term Outcome of Persons at Clinical High Risk for Psychosis: Methods and Preliminary Data
Cadenhead K, Kennedy L, Mirzakhanian H, Addington J, Bearden C, Cannon T, Carrión R, Keshavan M, Mathalon D, Perkins D, Stone W, Walker E, Woods S. Predictors and Moderators of Long-Term Outcome of Persons at Clinical High Risk for Psychosis: Methods and Preliminary Data. Schizophrenia Bulletin 2025, sbaf133. PMID: 40856400, DOI: 10.1093/schbul/sbaf133.Peer-Reviewed Original ResearchClinical high riskClinical high-risk criteriaLong-term outcomesNorth American Prodrome Longitudinal Study sitesClinical high-risk participantsRates of affective disordersHigh riskLife courseNon-converter groupHigh-risk youthAssessment of individualsPsychosis statesAffective disordersPsychosocial functioningPsychosisTrajectory of diagnosisLonger-term outcomesClinical/functional outcomesLong-term assessmentGeneral populationBaseline dataParticipantsPreliminary dataEarly dataPersons