Rachel Perry, PhD

Assistant Professor

Departments & Organizations

Endocrinology

Yale Cancer Center: Signal Transduction

Biography

Dr. Rachel Perry is an Assistant Professor in Medicine/Endocrinology and Cellular & Molecular Physiology at the Yale University School of Medicine. Rachel's background is in the use of hyperinsulinemic-euglycemic clamps and stable isotope infusions to assess insulin sensitivity, having earned her B.S. in Biomedical Engineering, Ph.D. (with Distinction) in Cellular & Molecular Physiology, and performed her postdoctoral training in Medicine/Endocrinology, all in the laboratory of Dr. Gerald Shulman. Rachel's CV includes first-author papers in Nature, Cell (2), Science, JCI, Nature Medicine (2), Nature Communications (2), JBC, Cell Metabolism (2), and AJP-Endocrinology. 

Dr. Perry's laboratory focuses on applying stable isotope tracer methods to understand obesity-associated alterations in metabolic flux pathways that occur with obesity. She and her colleagues have recently identified hyperinsulinemia-induced increases in tumor glucose uptake and oxidation as a critical driver of colon cancer in two mouse models of the disease, and mitochondrial uncoupling as a potential therapeutic strategy against the disease (Wang et al. Cell Reports 2018). Future work from the Perry lab will seek to elucidate potential alterations in tumor immunometabolism that may contribute to tumor progression, and the impact of cancer therapy on substrate preference in immune cells.

Education & Training

PhD Yale University Graduate School, Cellular & Molecular Physiology (2013)
BS Yale University, Biomedical Engineering (2008)
Postdoctoral Fellow Yale University

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Rachel Perry, PhD