Barbara Kazmierczak, PhD, MD

Gustavus and Louise Pfeiffer Research Foundation M.D.-Ph.D. Program Director and Professor of Medicine (Infectious Diseases) and of Microbial Pathogenesis; Professor, Microbial Pathogenesis; Director, MD-PhD Program, Yale University

Departments & Organizations

Internal Medicine: CPIRT - Pulmonary Infection Research and Treatment | Infectious Diseases

Microbial Pathogenesis

Discovery to Cure Internship

MD-PhD Program

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Microbiology | Molecular Cell Biology, Genetics and Development | Molecular Medicine, Pharmacology, and Physiology

Yale Medicine

Office of Cooperative Research

Biography

Dr. Kazmierczak received her Ph.D. from Rockefeller University (1993) and her M.D. from Cornell University Medical College (1994), both in New York City. She completed an Internal Medicine residency and Infectious Diseases fellowship training at the University of California, San Francisco, and joined the Yale faculty in 2001.  She is currently a Professor of Medicine and Microbial Pathogenesis, and Director of the MD-PhD program at Yale.

Dr. Kazmierczak's research program is broadly focused on bacterial and host factors that allow opportunistic infections to occur.  Using Pseudomonas aeruginosa as a clinically relevant model, her lab addresses fundamental questions of how cell-envelope spanning bacterial machines - the Type 3 secretion system, Type 4 pili and polar flagellum - are assembled, regulated, and used during infection.  She has also identified host responses directed at components of these virulence associated structures, in particular those mediated by the NLRC4 inflammasome. Inflammatory responses to bacteria are also a focus of her work on microbiome-host interactions in infants with Cystic Fibrosis, where her lab has used longitudinal data acquired over five years from cohorts of patients and controls to understand gut microbiome composition and the inflammatory and metabolic responses at this site. 

Dr. Kazmierczak has been recognized as a Burroughs-Wellcome Fund Investigator in the Pathogenesis of Infectious Diseases (2007), a Donaghue Investigator (2002), and a Hellman Family Fellow (2002).  She is a Fellow of the Infectious Diseases Society of America and an elected member of the American Society for Clinical Investigation and the American Academy for Microbiology.

Education & Training

MD Cornell University Medical College (1994)
PhD Rockefeller University (1993)
BA University of Chicago (1986)
MS University of Chicago (1986)
Assistant Adjunct Professor University of California, San Francisco
Fellow University of California, San Francisco
Resident University of California, San Francisco
Intern University of California, San Francisco
Board Certification AB of Internal Medicine, Infectious Disease (1999, recertified: 2009)

Honors & Recognition

  • Elected Member, AAMAmerican Academy for Microbiology (2019)

  • Distinguished LecturerAmerican Society for Microbiology (2018)

  • Elected Member, ASCIAmerican Society for Clinical Investigation (2014)

  • Visiting Faculty Research GrantDeutscher Akademischer Austausch Dienst (DAAD) (2010)

  • Elected MemberPolish Institute of Arts and Sciences in America (2009)

  • Fellow, IDSAInfectious Diseases Society of America (2008)

  • Investigator in Pathogenesis of Infectious DiseasesBurroughs Wellcome Fund (2007)

  • Investigator AwardPatrick and Catherine Weldon Donaghue Medical Research Foundation (2003)

Professional Service

  • MD-PhD Steering Committee, GREAT Group, AAMC (2017 - Present)

  • Yale University (2010 - 2014) Associate Director for Basic Research, MD-PhD Program

  • IDSA (2009 - 2012) Annual Meeting Planning Committee

  • Director of Admissions, Microbiology Program, Yale University (2004 - 2007)

  • Yale University (2004 - Present) MD/PhD Faculty Committee

Activities

  • Innate immune responses to bacterial infection Berlin, Germany (2010 - 2010)

    Visiting Researcher

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Contact Info

Barbara Kazmierczak, PhD, MD
Patient Care Location
Yale Infectious DiseasesYale New Haven Hospital
20 York Street

New Haven, CT 06510
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Lab Location
The Anlyan Center
300 Cedar Street, Ste S140

New Haven, CT 06519
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Office Location
The Anlyan Center
300 Cedar Street, Ste S169A

New Haven, CT 06519
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Mailing Address
Infectious DiseasesPO Box 208056
333 Cedar Street

New Haven, CT 06520-8056
Heterogeneous expression of virulence in Pseudomonas aeruginosa

A Type 3 secretion system transcriptional reporter driving sfGFP expression reveals variation among genetically identical bacteria exposed to conditions that induce this virulence system.