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Frederick Lewis Altice, MD, MA

Professor of Medicine (Infectious Diseases) and of Epidemiology (Microbial Diseases); Affiliated Faculty, Yale Institute for Global Health; Director, Yale Center for Clinical and Community Research, Department of Medicine; Director, HIV in Prisons Program, Infectious Diseases; Director, Community Health Care Van, Intersection of Infectious Diseases and Substance Use Disorders/Addiction Medicine; Academic Icon Professor of Medicine, University of Malaya-Centre of Excellence for Research in AIDS (CERiA), Faculty of Medicine

Contact Information

Frederick Lewis Altice, MD, MA

Patient Care Locations

Lab Location

Office Location

Mailing Address

  • Infectious Diseases

    135 College Street

    New Haven, CT 06510-2283

    United States



Frederick (Rick) L. Altice is a professor of Medicine, Epidemiology and Public Health and is a clinician, clinical epidemiologist, intervention and implementation science researcher at Yale University School of Medicine and School of Public Health. Dr. Altice’s primary research focuses on interventions and implementation science at the interface between infectious diseases and addiction and he has conducted research in several global health settings. He also has a number of projects working in the criminal justice system, including transitional programs addressing infectious diseases, medications for opioid use disorder (methadone, buprenorphine, extended release naltrexone), mental illness, homelessness and social instability. Specific topics include alcohol, opioid, stimulant and nicotine use disorders on HIV treatment outcomes, HIV and addiction treatment, interface with the criminal justice system, and pharmacokinetic drug interactions between treatment for substance use disorders and antiretroviral and tuberculosis therapy. At a basic level, his research focuses on clinical epidemiology, especially in key populations at risk for HIV (e.g., MSM, TGW, PWID, prisoners, sex workers) and development, adaptation and evaluation of of biomedical and behavioral interventions to improve treatment outcomes. His research, however, has evolved and included development and testing of mobile technologies (mHealth) to intervene with key populations to promote health outcomes. His research is especially concentrated in health services research techniques with a focus on implementation science, seeking to introduce and scale-up evidence-based interventions in numerous contexts. A number of implementation science strategies are underway to examine scale-up of medication-assisted therapies to treat opioid use disorder in community, criminal justice and in primary care settings. Most recently, his work has been augmented through use of decision science techniques to understand and promote patient preferences, including the development of informed and shared decision-making aids. His work has emerged primarily with a global health focus with funded research projects internationally in Malaysia, Ukraine, Moldova, Armenia, Kyrgyzstan, Peru, and Indonesia. He has participated in projects through the National Institute on Alcohol Abuse and Alcoholism, the National Institute on Drug Abuse, Centers for Disease Control and Prevention, Substance Abuse and Mental Health Services Agency, Special Projects of National Significance with HRSA, and the Center for Substance Abuse Treatment. He is currently also collaborating on projects with the WHO, UNAIDS, USAID, PEPFAR and UNODC. Current internationally funded projects in dedicated research sites that are being conducted in Malaysia, Ukraine, Moldova, Azerbaijan, Armenia, Kyrgyzstan and Peru. His research and training sites in Malaysia (2005), Peru (2010) and Ukraine (2005) are dedicated training and research sites for the Global Health Equity Scholars Fogarty Training Program and the Doris Duke International Fellowship program. He is currently the director for two International Implementation Science Research and Training Centers with collaborations between Yale University and the University of Malaya and Sichuan University.

Education & Training

  • MA
    Yale University, Honorary (2008)
  • Fellow
    Yale University School of Medicine (1992)
  • Resident
    Yale University School of Medicine (1989)
  • MD
    Emory University (1986)
  • MA
    Universidad de Santiago de Compostela, Spanish Literature (1982)


  • Bending the HIV Curve in MSM Who Use Amphetamines
    Sydney, NSW, Australia 2019
  • IMPACT (Integrating Treatment for Addiction, HIV and Tuberculosis in Primary Care Settings)
    Kyiv, Ukraine 2017
    A 45 site, cluster randomized controlled trial comparing standard of care (addiction treatment in specialty care settings) versus integrating care into primary care settings, including the assessment of pay-for-performance incentives (P4P). The research uses a facilitation strategy using an ECHO-like platform to teach addiction, HIV and TB care to primary care physicians and uses a Type II Hybrid Implementation Science Trial.
  • Studies of Alcohol and Drug Use Among MSM in Peru
    Lima, Provincia de Lima, Peru (2011-2016)
    Biobehavioral Surveys, RCTs of XR-NTX among HIV+ MSM with alcohol use disorders and RCTs of early vs late initiation of ART among newly seroconverted MSM. This is a Fogarty International Global Health Equity Scholars site.
  • HIV, Opioid, Substance abuse, Malaysia
    Kuala Lumpur, Federal Territory of Kuala Lumpur, Malaysia 2010
    Intervention of HIV, Drug Use and the Criminal Justice System in Malaysia
  • Opioid Dependence and HIV in Malaysia
    Kuala Lumpur, Federal Territory of Kuala Lumpur, Malaysia 2009
    In 2005, the Malaysian government changed its policies toward substance abuse by implementing syringe exchange programs and methadone maintenance programs. Professor Altice has been a consultant in developing and evaluating the new policies and have since begun several different studies in Malaysia at the interface of substance abuse and infectious diseases, including involvement with the Prison Ministry. Collaboration through the University of Malaysia.
  • Infectious Diseases and Addiction
    Kuala Lumpur, Kuala Lumpur, Malaysia 2005
    Funded Research Activities with Centre of Excellence in Research on AIDS (CERiA). Projects are extensive and include epidemiological studies with vulnerable populations including prisoners, female sex workers, men who have sex with men and people who inject drugs. Current studies also include those involving HIV, TB, substance abuse and intervention research. This is a Fogarty International Global Health Equity Scholars site.
  • HIV/AIDS, Tuberculosis and Addiction
    Ukraine 2005
    Technical Assistance and Research, Developed integrated health care delivery system, Rolled out buprenorphine and methadone
  • Opioid Dependence and HIV in Ukraine
    Ukraine 2005
    Since 2005, Professor Altice have trained the physicians on treatment of opioid dependence, HIV and tuberculosis. Specifically, in collaboration with his Ukrainian colleagues, They introduced the first pilot buprenorphine treatment programs in the country. They are now participating in the establishment and expansion of methadone maintenance treatment and how integrated health services can be developed that target substance abuse, HIV and tuberculosis. Currently, there are two NIH funded resea
  • HIV, Tuberculosis and Drug Dependence In Iran
    Tehran, Tehran Province, Iran (2001-2009)
    This involves three projects: 1. HIV and TB Coinfection Among Drug Users in Iran 2. Treatment for Opioid Dependence Among Individuals with HIV or TB 3. Prisoners and Methadone Maintenance.

Honors & Recognition

AwardAwarding OrganizationDate
Most Influential Paper on Addictions - 2016 (Lancet)European Monitoring Centre for Drugs and Drug Addiction2017
Appointed as Academic Icon Professor of Medicine, Centre for Excellence in Research in AIDS (CERiA) at University of MalayaInfectious Diseases Unit, Department of Medicine, Faculty of Medicine, University of Malaya2009
Board of Permanent OfficersYale University School of Medicine2009
National Hope is a Vaccine" Award RecipientGAIA, Global Alliance to Immunize against AIDS2008

Professional Service

Dean's Advisory Committee on LGBTQI Issues, Yale University School of MedicineAdvisor2017 - Present
World Health Organization Guidelines Committee for Treatment of HIV and Tuberculosis Among Drug Users.2009 - Present
Symposium Chair, International AIDS Society Conference, 2009, Cape Town, South Africa2009 - Present
American Board of Correctional MedicineMember2009 - Present
Correctional Academic Liaison Meeting (CALM), CT. Department of Corrections.2008 - Present
The Open Public Health Journal, Open Infectious Diseases Journal, International Journal of Prisoner Health2008 - Present
Addiction, Journal of General Internal Medicine, International Journal of Prison Health Care2008 - Present
Executive Board, Liberty Community Services, Inc. New Haven CT.2008 - Present
Research Director, AIDS Project Hartford2007 - Present
Clinical Infectious Diseases, Drug and Alcohol Dependence, Journal of Substance Abuse Treatment 2005 - Present
American Society of Addiction MedicineMember2005 - Present
AAHIVM-American Academy of HIV MedicineMember2004 - Present
AIDS Reader, Annals of Internal Medicine, JAIDS, JAMA2003 - Present
Advisory Committee, Connecticut AIDS Drug Assistance Program (CADAP)2002 - Present
NIDA K Training & Career Development Subcommittee, National Institute on Drug Abuse Initial Review Group2001 - Present
American Correctional AssociationMember2001 - Present
Society for Correctional PhysiciansMember1997 - Present
International AIDS SocietyMember1994 - Present
American College of PhysiciansFellow1993 - Present
Infectious Disease Society of AmericaMember1993 - Present
American Public Health AssociationMember1992 - Present

Departments & Organizations