Francis Lee, MD, PhD, FAAOS, MBA
Wayne O. Southwick Professor of Orthopaedics and RehabilitationCards
About
Research
Overview
Clinical Research
Bone Defect Reconstruction & Regeneration
Metastatic Cancers to Bone, Pathological Fractures, Minimally Invasive Reconstruction of Pathological Fractures, AORIF (Ablation - Osteoplasty - Reinforcement - Internal Fixation)
Translational Research
Tissue Engineering, Bone Regeneration, Fracture Healing (Diabetes, Chronic Smoking, Infection), Bone Inflammation, Bone Infection, Cancer-Induced Bone Loss
Please refer to NIH RePorter on Descriptions of NIH-funded Research Programs.
My research group is committed to engaging undergraduate students, Yale medical students for Thesis, M.D.-Ph.D. Students, other graduate students, and visiting fellows for research opportunities and career advancement. For inquires, please contact francis.lee@yale.edu. I am an Orthopaedic Surgeon in active clinical practice and a Scientist fostering research experience for future clinician scholars and clinically relevant translational research scientists. I focus on high impact orthopaedic research that is directly relevant to pathogenesis, diagnosis, and treatment of Orthopaedic disorders.
Medical Research Interests
Academic Achievements & Community Involvement
Clinical Care
Overview
Francis Y. Lee, MD, PhD, is an orthopaedic surgeon with extensive expertise treating both adults and children. Committed to providing care of the highest quality, Dr. Lee works with a range of musculoskeletal problems, from fractures and limb deformities to musculoskeletal tumors and infections. He is an expert in complex musculoskeletal reconstruction.
A professor in the Department of Orthopaedics & Rehabilitation at Yale School of Medicine, Dr. Lee has a secondary appointment in the Department of Pathology. He holds the rare distinction of being both an orthopaedic surgeon and a musculoskeletal scientist scholar working with National Institutes of Health (NIH) research programs. Dr. Lee conducts extensive research into such areas as fracture healing and bone metastasis. Dr. Lee has been a pioneer in developing minimally invasive Ablation-Osteoplasty-Reinforcement-Internal Fixation (AORIF) that is specially designed for patients with cancer that has spread to bone. This paradigm-shifting ambulatory procedure provides local cancer control, decreases pain, and improves ambulatory function.
Dr. Lee says he especially enjoys interacting with patients and their families. He draws upon his research background to approach each case with a sense of discovery and innovation. “I will provide care for you and your family as if I were treating my own family members and friends,” he says.
Dr. Lee also serves as a Presidential Line Officer (2022-2023: Treasurer; 2023-2034: Secretary; 2024-2025: President-Elect; 2025-2026: President) for the Musculoskeletal Tumor Society, a premier professional organization for musculoskeletal tumor surgeons.
Clinical Specialties
Fact Sheets
Bone Cancer
Learn More on Yale MedicineRunning Injuries
Learn More on Yale MedicineNeoplasm (Tumor)
Learn More on Yale MedicineGeriatric Hip Fractures
Learn More on Yale Medicine
Board Certifications
Orthopaedic Surgery
- Certification Organization
- AB of Orthopaedic Surgery
- Latest Certification Date
- 2022
- Original Certification Date
- 2001
Yale Medicine News
News & Links
Media
- Minimally Invasive Ambulatory Procedure for Bone Destruction Secondary to Cancers (Impending Pathological Fractures): Percutaneous Ambulatory Procedure
News
- April 10, 2024
Six Faculty Selected as Research All Stars by Avant Garde Health
- November 29, 2023Source: Yale Medicine
When Metastatic Cancer Weakens Bone, the AORIF Procedure Can Help
- July 13, 2023Source: Orthopaedics Today
Minimally invasive procedure enhances care for periacetabular osteolytic metastasis
- July 01, 2020
Yale Orthopaedics & Rehabilitation Appoints Four New Vice Chairs