Elizabeth Woo
MD, PhD Student, NeuroscienceAbout
Research
Publications
2024
Key Roles of CACNA1C/Cav1.2 and CALB1/Calbindin in Prefrontal Neurons Altered in Cognitive Disorders
Datta D, Yang S, Joyce M, Woo E, McCarroll S, Gonzalez-Burgos G, Perone I, Uchendu S, Ling E, Goldman M, Berretta S, Murray J, Morozov Y, Arellano J, Duque A, Rakic P, O’Dell R, van Dyck C, Lewis D, Wang M, Krienen F, Arnsten A. Key Roles of CACNA1C/Cav1.2 and CALB1/Calbindin in Prefrontal Neurons Altered in Cognitive Disorders. JAMA Psychiatry 2024, 81: 870-881. PMID: 38776078, PMCID: PMC11112502, DOI: 10.1001/jamapsychiatry.2024.1112.Peer-Reviewed Original ResearchDorsolateral prefrontal cortexPrefrontal cortexLayer III pyramidal cellsWorking memoryCognitive disordersNeuronal firingPrimate dorsolateral prefrontal cortexPyramidal cellsSpatial working memoryWorking memory performanceRisk of mental disordersCalcium-related proteinsReduced neuronal firingL-type calcium channel Cav1.2GluN2B-NMDA receptorsL-type calcium channel activityPrefrontal neuronsL-type calcium channel blockerMemory performanceL-type calcium channelsMental disordersRisk of cognitive disordersCognitive behaviorProtein expressionAssociated with increased risk
2022
Glutamate Metabotropic Receptor Type 3 (mGlu3) Localization in the Rat Prelimbic Medial Prefrontal Cortex
Woo E, Datta D, Arnsten AFT. Glutamate Metabotropic Receptor Type 3 (mGlu3) Localization in the Rat Prelimbic Medial Prefrontal Cortex. Frontiers In Neuroanatomy 2022, 16: 849937. PMID: 35444520, PMCID: PMC9013768, DOI: 10.3389/fnana.2022.849937.Peer-Reviewed Original ResearchPrelimbic medial prefrontal cortexRat prelimbic medial prefrontal cortexMedial prefrontal cortexLayer IIIPrefrontal cortexDendritic spinesReceptor type 3Dorsolateral prefrontal cortexPrimate dlPFCReceptor subtypesAxon terminalsNeuronal firingPL-mPFCIntervaricose segmentsMGlu3Glial membranesRhesus monkeysPredominant locationType 3GliaCognitive functioningDLPFCCortexSpineCurrent studyUnusual Molecular Regulation of Dorsolateral Prefrontal Cortex Layer III Synapses Increases Vulnerability to Genetic and Environmental Insults in Schizophrenia
Arnsten AFT, Woo E, Yang S, Wang M, Datta D. Unusual Molecular Regulation of Dorsolateral Prefrontal Cortex Layer III Synapses Increases Vulnerability to Genetic and Environmental Insults in Schizophrenia. Biological Psychiatry 2022, 92: 480-490. PMID: 35305820, PMCID: PMC9372235, DOI: 10.1016/j.biopsych.2022.02.003.Peer-Reviewed Original ResearchConceptsEnvironmental insultsMore superficial layersDorsolateral prefrontal cortexPrimate dlPFCInflammatory mechanismsInflammatory insultKynurenic acidNMDA receptorsReceptor neurotransmissionDendritic spinesLayer IIICAMP/PKAGlutamatergic synapsePrefrontal cortexInsultPotassium channelsNeurotransmissionCalcium signalingSynapsesGenetic insultsSuperficial layersSchizophreniaSpineCortexNeuromodulation
2021
Glutamate Carboxypeptidase II in Aging Rat Prefrontal Cortex Impairs Working Memory Performance
Datta D, Leslie SN, Woo E, Amancharla N, Elmansy A, Lepe M, Mecca AP, Slusher BS, Nairn AC, Arnsten AFT. Glutamate Carboxypeptidase II in Aging Rat Prefrontal Cortex Impairs Working Memory Performance. Frontiers In Aging Neuroscience 2021, 13: 760270. PMID: 34867287, PMCID: PMC8634091, DOI: 10.3389/fnagi.2021.760270.Peer-Reviewed Original ResearchCognitive disordersRat medial PFCMedial PFCGCPII inhibitorsPFC cognitive deficitsPrefrontal cortical activationGlutamate carboxypeptidase IIGCPII proteinMGluR3 expressionLocal infusionSystemic administrationAged ratsGCPII inhibitionMemory performancePrefrontal cortex impairsCortical activationCognitive impairmentCognitive deficitsInflammationGenetic insultsCarboxypeptidase IIDisordersGCPIICurrent studyInhibitorsDiscovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
Flynn RA, Belk JA, Qi Y, Yasumoto Y, Wei J, Alfajaro MM, Shi Q, Mumbach MR, Limaye A, DeWeirdt PC, Schmitz CO, Parker KR, Woo E, Chang HY, Horvath TL, Carette JE, Bertozzi CR, Wilen CB, Satpathy AT. Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions. Cell 2021, 184: 2394-2411.e16. PMID: 33743211, PMCID: PMC7951565, DOI: 10.1016/j.cell.2021.03.012.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 RNASARS-CoV-2Virus-induced cell deathHost protein interactionsRNA-binding proteinActive infectionRNA virusesHost-virus interfaceGlobal mortalityTherapeutic benefitCRISPR screensAntiviral factorsProtein interactionsAntiviral activityViral specificityHost pathwaysFunctional RNA-binding proteinsFunctional connectionsRNA-centric approachesCell deathHost proteinsVirusFunctional interrogationRNAComprehensive catalogChronic Stress Weakens Connectivity in the Prefrontal Cortex: Architectural and Molecular Changes
Woo E, Sansing LH, Arnsten AFT, Datta D. Chronic Stress Weakens Connectivity in the Prefrontal Cortex: Architectural and Molecular Changes. Chronic Stress 2021, 5: 24705470211029254. PMID: 34485797, PMCID: PMC8408896, DOI: 10.1177/24705470211029254.Peer-Reviewed Original ResearchLoss of spinesPrefrontal cortexSpine lossPersistent firingUncontrollable stressDendritic spine lossChronic stress exposureMarked cognitive impairmentInternal calcium releaseRecurrent excitatory connectionsCatecholamine releaseInflammatory signalingSynaptic connectivityCognitive disordersChronic exposureCalcium homeostasisPFC neuronsCognitive impairmentBrain regionsChronic stressCalcium releaseExcitatory connectionsStress exposurePotassium channelsSpine
2017
BIN1 localization is distinct from Tau tangles in Alzheimer's disease.
De Rossi P, Buggia-Prevot V, Andrew RJ, Krause SV, Woo E, Nelson PT, Pytel P, Thinakaran G. BIN1 localization is distinct from Tau tangles in Alzheimer's disease. Matters 2017, 2017 PMID: 29479533, PMCID: PMC5823513, DOI: 10.19185/matters.201611000018.Peer-Reviewed Original ResearchTangle pathologyHuman ADBIN1 expressionNeurofibrillary tangle pathologyBrains of patientsSubset of neuronsRisk factor genesAD brainNeurofibrillary tanglesTau tanglesPeripheral tissuesSenile plaquesTau propagationPathological lesionsWhite matterAlzheimer's diseaseMature oligodendrocytesGray matterCellular markersBrainCellular expressionComplex cellular mechanismsInverse correlationCellular mechanismsDisease
News
News
- December 15, 2023
Yuen Directs Film Production for Novel Intervention Program
- March 09, 2023
Anna Lynn and Elizabeth Woo are 3-Minute Thesis Divisional Winners
- February 28, 2021
Wednesday Evening Clinic is a Popular/Valuable Elective