Edward J Miller, MD, PhD
Cards
Research
About
Contact/Administration
Research
About
Contact/Administration
Research
Publications Overview
- 208 Publications
- 3,495 Citations
- 81 Yale Co-Authors
Titles
Associate Professor of Medicine (Cardiovascular Medicine)
Vice Chief of Cardiovascular Medicine (Education), Cardiovascular Medicine
Associate Professor of Medicine and Radiology
Director, Nuclear Cardiology, Cardiovascular Medicine
Director, Cardiology Fellowship Program, Cardiovascular Medicine
Affiliated Faculty, Yale Institute for Global Health
Appointments
Contact Info
Cardiovascular Medicine
Yale University School of Medicine, Section of Cardiovascular Medicine, PO Box 208017
New Haven, CT 06520-8017
United States
Publications Overview
- 208 Publications
- 3,495 Citations
- 81 Yale Co-Authors
Titles
Associate Professor of Medicine (Cardiovascular Medicine)
Vice Chief of Cardiovascular Medicine (Education), Cardiovascular Medicine
Associate Professor of Medicine and Radiology
Director, Nuclear Cardiology, Cardiovascular Medicine
Director, Cardiology Fellowship Program, Cardiovascular Medicine
Affiliated Faculty, Yale Institute for Global Health
Appointments
Contact Info
Cardiovascular Medicine
Yale University School of Medicine, Section of Cardiovascular Medicine, PO Box 208017
New Haven, CT 06520-8017
United States
Publications Overview
- 208 Publications
- 3,495 Citations
- 81 Yale Co-Authors
About
Titles
Associate Professor of Medicine (Cardiovascular Medicine)
Vice Chief of Cardiovascular Medicine (Education), Cardiovascular Medicine; Associate Professor of Medicine and Radiology; Director, Nuclear Cardiology, Cardiovascular Medicine; Director, Cardiology Fellowship Program, Cardiovascular Medicine; Affiliated Faculty, Yale Institute for Global Health
Biography
Dr. Edward J. Miller, MD, PhD is the Vice Chief of Cardiovascular Medicine (Education) and an Associate Professor of Medicine and Radiology in the Section of Cardiovascular Medicine. Dr. Miller directs the clinical nuclear cardiology laboratory at Yale-New Haven Hospital as well as the Cardiology Fellowship Program for the Yale School of Medicine. His clinical and research interests center on the evaluation and treatment of infiltrative cardiomyopathies, particularly cardiac sarcoidosis and amyloidosis, and are focused on the role of nuclear cardiac imaging in diagnosing and defining treatment response in these disorders.
Dr. Miller received his undergraduate degree from the University of Notre Dame, majoring in Preprofessional Studies with a concentration in Science, Technology and Values. He completed medical school at the Loyola-Stritch School of Medicine in Chicago where he was awarded an American Heart Association Student Research Fellowship. Dr. Miller completed his internal medicine residency at Yale-New Haven Hospital, as well as research and clinical cardiology fellowships at Yale. He also completed a PhD in Investigative Medicine from the Yale School of Medicine, working in the laboratory of Dr. Lawrence Young focused on "The Cardioprotective Effects of AMP-Activated Protein Kinase." Dr. Miller is a recipient of an NIH/NLHBI K08 award, mentored by Dr. Wilson Colucci at Boston University School of Medicine on "The Role and Regulation of the LKB1-AMPK Axis in Diabetic Cardiomyopathy."
Dr. Miller was recruited back to Yale in 2015 to direct the nuclear cardiology lab and the cardiology fellowship program. He was named Vice Chief (Education) for Yale Cardiovascular Medicine in 2021.
Appointments
Cardiovascular Medicine
ProfessorPrimaryRadiology & Biomedical Imaging
Associate Professor on TermSecondary
Other Departments & Organizations
- Cardiac Amyloidosis Program
- Cardiomyopathy & Inherited Cardiovascular Disease Program
- Cardiovascular Imaging Program
- Cardiovascular Medicine
- Internal Medicine
- Nuclear Cardiology
- Radiology & Biomedical Imaging
- Scleroderma Program
- Yale Biomedical Imaging Institute
- Yale Medicine
Education & Training
- Clinical Fellow
- Yale School of Medicine (2008)
- PhD
- Yale University School of Medicine, Investigative Medicine (2008)
- Research Fellow
- Yale School of Medicine (2005)
- Resident
- Yale-New Haven Hospital (2003)
- Intern
- Yale-New Haven Hospital (2000)
- MD
- Loyola-Stritch School of Medicine, Medicine (1999)
- BS
- University of Notre Dame, Preprofessional Studies (1994)
Research
Overview
Medical Research Interests
Public Health Interests
ORCID
0000-0002-2156-5962
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Albert Sinusas, MD
Attila Feher, MD, PhD
Yi-Hwa Liu, PhD
Chi Liu, PhD
Lawrence Young, MD
Daniel Jacoby, MD
Sarcoidosis
Amyloidosis
Radionuclide Imaging
Single Photon Emission Computed Tomography Computed Tomography
Positron Emission Tomography Computed Tomography
Cardiology
Publications
2025
The Relationship Between Quantitative Ischemia, Early Revascularization, and Major Adverse Cardiovascular Events A Multicenter Study
Miller R, Bednarski B, Cui Y, Calsavara V, Patel K, Rozanski A, Liang J, Builoff V, Acampa W, Bateman T, Di Carli M, Dorbala S, Einstein A, Fish M, Hauser M, Kaufmann P, Miller E, Ruddy T, Sharir T, Sinusas A, Dey D, Berman D, Slomka P. The Relationship Between Quantitative Ischemia, Early Revascularization, and Major Adverse Cardiovascular Events A Multicenter Study. JACC Advances 2025, 4: 101440. DOI: 10.1016/j.jacadv.2024.101440.Peer-Reviewed Original ResearchConceptsMyocardial perfusion imagingEarly revascularizationMyocardial infarctionPerfusion imagingAssociated with reduced riskMedian follow-upImprove patient selectionAssociated with reduced deathSeverity of ischemiaMulticenter registryMale patientsPatient selectionRetrospective analysisFollow-upRandomized trialsRegistry sitesMyocardial ischemiaRevascularizationPatientsIschemiaSurvival analysisAuthors evaluated differencesPropensity scoreRegistryDeath
2024
Parametric FDG PET K i images using dual-time-point imaging data for cardiac sarcoidosis: a proof of concept study
Wu J, Young B, Liu H, Sadeghi M, Miller E, Liu C. Parametric FDG PET K i images using dual-time-point imaging data for cardiac sarcoidosis: a proof of concept study. Journal Of Nuclear Cardiology 2024, 102121. PMID: 39653168, DOI: 10.1016/j.nuclcard.2024.102121.Peer-Reviewed Original ResearchConceptsThe Impact of Active Ascertainment on Sex-Specific Differences in the Prevalence and Phenotype of Transthyretin Cardiac Amyloidosis: The SCAN-MP Study
Chan N, Einstein A, Teruya S, Rodriguez C, Helmke S, Cuomo M, Santana D, Castillo M, Smiley D, Sabogal N, Lamour S, Winburn M, Fine D, de Freitas C, Kattan C, Miller E, Maurer M, Ruberg F. The Impact of Active Ascertainment on Sex-Specific Differences in the Prevalence and Phenotype of Transthyretin Cardiac Amyloidosis: The SCAN-MP Study. The American Journal Of Cardiology 2024, 237: 60-64. PMID: 39581521, DOI: 10.1016/j.amjcard.2024.11.019.Peer-Reviewed Original ResearchConceptsATTR-CATransthyretin cardiac amyloidosisProportion of womenCardiac amyloidosisReferral cohortLower left ventricular mass indexHigher left ventricular ejection fractionPrevalence of ATTR-CAATTR-CA patientsWild-type diseaseVentricular ejection fractionVentricular mass indexPosterior wall thicknessAscertainment cohortLeft ventricular hypertrophyReduce sex disparitiesHigher proportion of womenATTRwt-CAEjection fractionEchocardiographic evidenceHeart failureMass indexSex-specific differencesSevere phenotypeSex distributionIntegrating genome-wide information and wearable device data to explore the link of anxiety and antidepressants with pulse rate variability
Friligkou E, Koller D, Pathak G, Miller E, Lampert R, Stein M, Polimanti R. Integrating genome-wide information and wearable device data to explore the link of anxiety and antidepressants with pulse rate variability. Molecular Psychiatry 2024, 1-7. PMID: 39558002, DOI: 10.1038/s41380-024-02836-7.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresMendelian randomizationReuptake inhibitorsOne-sample Mendelian randomizationElectronic health record dataOne-sample MRHealth record dataMillion Veteran ProgramPotential causal effectSerotonin reuptake inhibitorsNorepinephrine reuptake inhibitorsGenome-wide association studiesEffects of anxietyImpact of anxietyWearable device dataUK BiobankVeteran ProgramAntidepressant prescriptionsAnxiety disordersAntidepressant medicationAntidepressant useAntidepressant exposureTricyclic antidepressantsPRS-CSRecord dataThe Updated Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT 2.0).
Miller R, Lemley M, Shanbhag A, Ramirez G, Liang J, Builoff V, Kavanagh P, Sharir T, Hauser M, Ruddy T, Fish M, Bateman T, Acampa W, Einstein A, Dorbala S, Di Carli M, Feher A, Miller E, Sinusas A, Halcox J, Martins M, Kaufmann P, Dey D, Berman D, Slomka P. The Updated Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT 2.0). Journal Of Nuclear Medicine 2024, 65: 1795-1801. PMID: 39362762, PMCID: PMC11533915, DOI: 10.2967/jnumed.124.268292.Peer-Reviewed Original ResearchConceptsCoronary artery calciumCT attenuation correction imagesStress total perfusion deficitMyocardial perfusion imagingTotal perfusion deficitAttenuation correction imagesPerfusion imagingREFINE SPECTImprove prediction of adverse outcomesPerfusion deficitsSPECT myocardial perfusion imagingIncreased risk of MACEPredictive of adverse outcomesMedian follow-upInvasive coronary angiographyRisk of MACEAdverse cardiovascular eventsCAC scoreExperience MACECoronary angiographyArtery calciumInternational registryCardiovascular eventsFollow-upClinical dataMYOCARDIAL ISCHEMIC BURDEN IN PATIENTS WITH PERIPHERAL ARTERY DISEASE UNDERGOING MYOCARDIAL PERFUSION IMAGING
Wang K, Shanbhag A, Sharir T, Hauser M, Dorbala S, Di Carli M, Fish M, Ruddy T, Bateman T, Einstein A, Kaufmann P, Miller E, Sinusas A, Acampa W, Halcox J, Dey D, Berman D, Miller R, Slomka P. MYOCARDIAL ISCHEMIC BURDEN IN PATIENTS WITH PERIPHERAL ARTERY DISEASE UNDERGOING MYOCARDIAL PERFUSION IMAGING. Canadian Journal Of Cardiology 2024, 40: s120-s121. DOI: 10.1016/j.cjca.2024.08.182.Peer-Reviewed Original ResearchRISK STRATIFICATION WITH PRE-OPERATIVE MYOCARDIAL PERFUSION IMAGING
Kim D, Builoff V, Sharir T, Hauser M, Dorbala S, Ruddy T, Bateman T, Einstein A, Kaufmann P, Miller E, Sinusas A, Acampa W, Dey D, Berman D, Miller R, Slomka P, Fish M. RISK STRATIFICATION WITH PRE-OPERATIVE MYOCARDIAL PERFUSION IMAGING. Canadian Journal Of Cardiology 2024, 40: s122. DOI: 10.1016/j.cjca.2024.08.185.Peer-Reviewed Original ResearchAmerican Society of Nuclear Cardiology quality metrics for cardiac amyloid radionuclide imaging
Hage F, Bourque J, Pandey S, Shah N, Soman P, Abbott B, Abidov A, Aggarwal N, AlJaroudi W, Bhambhvani P, Bokhari S, Dorbala S, Doukky R, Duran J, Einstein A, Gallagher D, Hendel R, Jaber W, Kattan C, Malhotra S, Masri A, Miller E, Murthy V, Sperry B. American Society of Nuclear Cardiology quality metrics for cardiac amyloid radionuclide imaging. Journal Of Nuclear Cardiology 2024, 40: 102041. DOI: 10.1016/j.nuclcard.2024.102041.Peer-Reviewed Original ResearchAssociation between 82Rb positron emission tomography-derived regional myocardial blood flow, severity of angiographic coronary artery stenosis, and mortality in patients with chest pain
Gallegos C, Paredes C, Hu J, Posada E, Saito Y, Lansky A, Shah S, Liu Y, Smolderen K, Mena-Hurtado C, Sinusas A, Miller E. Association between 82Rb positron emission tomography-derived regional myocardial blood flow, severity of angiographic coronary artery stenosis, and mortality in patients with chest pain. Advances In Radiotherapy & Nuclear Medicine 2024, 2: 3786. DOI: 10.36922/arnm.3786.Peer-Reviewed Original ResearchConceptsMyocardial flow reserveGlobal myocardial flow reserveQuantitative coronary angiographyAssociated with increased all-cause mortalityPositron emission tomographyCoronary artery stenosis severityMyocardial blood flowAll-cause mortalityCoronary angiographyChest painStenosis severityAngiographic coronary artery stenosisResting myocardial blood flowAcute chest painBlood flowInvasive coronary angiographyLeft circumflex arteryLeft descending arteryRight coronary arteryCoronary artery stenosisStress testCoronary stenosis severityCardiovascular eventsDescending arteryWeak correlationAutomating Revascularization Decision Support: Clinical Application of Artificial Intelligence
Zhang W, Miller R, Patel K, Shanbhag A, Liang J, DiCarli M, Dorbala S, Einstein A, Fish M, Hauser M, Kaufmann P, Miller E, Ruddy T, Bateman T, Martins M, Sharir T, Halcox J, Acampa W, Dey D, Berman D, Slomka P. Automating Revascularization Decision Support: Clinical Application of Artificial Intelligence. Journal Of Nuclear Cardiology 2024, 38: 102001. DOI: 10.1016/j.nuclcard.2024.102001.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
activity Certification Board of Nuclear Cardiology
Professional OrganizationsMemberDetailsBoard of Directors2013 - Presentactivity Society of Nuclear Medicine and Molecular Imaging - Cardiovascular Council
Professional OrganizationsMemberDetailsBoard of Directors2015 - Presenthonor Fellow, American College of Cardiology
National AwardAmerican College of CardiologyDetails03/29/2017United Stateshonor Fellow, American Society of Nuclear Cardiology
National AwardAmerican Society of Nuclear CardiologyDetails01/01/2014United Statesactivity American Society of Nuclear Cardiology
CommitteesMemberDetailsLeadership Development Program07/01/2009 - 06/30/2010
Clinical Care
Overview
Edward J. Miller, MD, PhD, treats chronic heart including infiltrative cardiomyopathies. “The Yale Medicine Cardiomyopathy Inherited Cardiovascular Disease Program has a wonderful interdisciplinary team of experts in the diagnosis and management of infiltrative cardiomyopathies,” says Dr. Miller, who also directs the clinical nuclear cardiology laboratory at Yale New Haven Hospital.
An expert at using imaging to diagnose and treat heart disease, Dr. Miller is especially interested in the use of new imaging techniques in cardiac sarcoidosis (an inflammatory disorder) and cardiac amyloidosis (a disorder of protein deposits). He is also focused on the role of obesity in certain types of heart disease.
Dr. Miller is an associate professor of medicine, and of radiology and biomedical imaging at Yale School of Medicine.
Clinical Specialties
Fact Sheets
Cardiac Amyloidosis
Learn More on Yale MedicineAmyloidosis
Learn More on Yale MedicineSarcoidosis
Learn More on Yale MedicineHeart Disease in Women
Learn More on Yale Medicine
Board Certifications
Cardiovascular Disease
- Certification Organization
- AB of Internal Medicine
- Latest Certification Date
- 2018
- Original Certification Date
- 2008
Yale Medicine News
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News
- January 03, 2025
Building Clinical Capacity in Cardiovascular Medicine Across the Caribbean
- October 24, 2024
New Analytics Center for Cardiovascular Medicine
- September 18, 2024
Drs. Gallegos and Akintoye Named New Leaders of Yale’s Advanced Cardiac Imaging Fellowship Program
- April 01, 2024
Yale Faculty Present Groundbreaking Clinical Research at the 2024 American College of Cardiology Scientific Sessions
Get In Touch
Contacts
Cardiovascular Medicine
Yale University School of Medicine, Section of Cardiovascular Medicine, PO Box 208017
New Haven, CT 06520-8017
United States
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