2025
Gynecologic Cytology and Pap Smears
Krishnamurti U, Mosunjac M, Deftereos G. Gynecologic Cytology and Pap Smears. 2025, 1751-1803. DOI: 10.1007/978-981-97-4822-8_40.Peer-Reviewed Original ResearchAmerican Cancer SocietyCervical cancerCases of invasive cervical cancerParaffin-embedded histological samplesOncogenic HPV typesInvasive cervical cancerCancer SocietyDetection of HPVDNA in situ hybridizationCervical cancer screeningHPV genotypesHPV DNAHPV statusP16 immunohistochemistryCervical cytologyHPV typesBethesda SystemHPV biologyHPVFormalin-FixedCancer screeningPrognostic reasonsHistological samplesScreening strategiesManagement guidelinesHuman papillomavirus genotype distribution and its correlation with intraepithelial neoplasia, vaccination, and ethnicity
Abi-Raad R, Sun T, Krishnamurti U. Human papillomavirus genotype distribution and its correlation with intraepithelial neoplasia, vaccination, and ethnicity. Journal Of The American Society Of Cytopathology 2025, 14: 273-278. PMID: 40307088, DOI: 10.1016/j.jasc.2025.03.006.Peer-Reviewed Original ResearchConceptsHigh-risk human papillomavirusNon-16/18ASC-HHPV genotypesIntraepithelial neoplasiaCases of high-grade squamous intraepithelial lesionCervical cancerPositive high-risk HPVHigh-risk HPVHigh-risk human papillomavirus genotypesHuman papillomavirus genotype distributionNon-16/18 HPV genotypesPrevalence of HPV genotypesHigh-risk human papillomavirus typesHigh-grade intraepithelial neoplasiaIntroduction of HPV vaccinationIncidence of cervical cancerAtypical squamous cellsSquamous intraepithelial lesionsHigh-grade lesionsHSIL patientsNonvaccinated womenIntraepithelial lesionsVaccinated womenSquamous cellsGynecologic Cytology and Pap Smears
Krishnamurti U, Mosunjac M, Deftereos G. Gynecologic Cytology and Pap Smears. 2025, 1-53. DOI: 10.1007/978-981-19-7696-4_40-1.Peer-Reviewed Original ResearchAmerican Cancer SocietyCervical cancerCases of invasive cervical cancerParaffin-embedded histological samplesOncogenic HPV typesInvasive cervical cancerCancer SocietyDetection of HPVDNA in situ hybridizationCervical cancer screeningHPV genotypesHPV DNAHPV statusP16 immunohistochemistryCervical cytologyHPV typesBethesda SystemHPV biologyHPVFormalin-FixedCancer screeningPrognostic reasonsHistological samplesScreening strategiesManagement guidelinesAssociation between psychological flexibility and self-perceived burden in patients with cervical cancer: A computer-simulated network analysis
Chen F, Xiong Y, Li S, Deng Y, Zhang Q, Xiao Z, Knobf M, Ye Z. Association between psychological flexibility and self-perceived burden in patients with cervical cancer: A computer-simulated network analysis. European Journal Of Oncology Nursing 2025, 74: 102822. PMID: 39893708, DOI: 10.1016/j.ejon.2025.102822.Peer-Reviewed Original Research
2024
A proteogenomic analysis of cervical cancer reveals therapeutic and biological insights
Yu J, Gui X, Zou Y, Liu Q, Yang Z, An J, Guo X, Wang K, Guo J, Huang M, Zhou S, Zuo J, Chen Y, Deng L, Yuan G, Li N, Song Y, Jia J, Zeng J, Zhao Y, Liu X, Du X, Liu Y, Wang P, Zhang B, Ding L, Robles A, Rodriguez H, Zhou H, Shao Z, Wu L, Gao D. A proteogenomic analysis of cervical cancer reveals therapeutic and biological insights. Nature Communications 2024, 15: 10114. PMID: 39578447, PMCID: PMC11584810, DOI: 10.1038/s41467-024-53830-0.Peer-Reviewed Original ResearchMeSH KeywordsAcetylationAdultBiomarkers, TumorCell Line, TumorCell ProliferationE1A-Associated p300 ProteinFemaleGene Expression Regulation, NeoplasticHumansMiddle AgedPapillomaviridaePapillomavirus InfectionsPrognosisProtein Kinase C betaProtein Processing, Post-TranslationalProteogenomicsProto-Oncogene Proteins c-fosUterine Cervical NeoplasmsConceptsCervical cancerIncidence of cervical cancerIntegrative proteogenomic analysisMulti-omic changesHuman papillomavirusImmune infiltrationSignificant public health issueProteogenomic analysisGenetic alterationsCC patientsPatient subgroupsMalignant proliferationAnalysis of cervical cancerCC tumorsChinese womenPost-translational modifications regulationPublic health issuePotential treatmentScreening strategiesClinical practiceProliferation of CC cellsPatientsWomen's healthCancerLow-income countriesUnmet needs in cervical cancer – can biological therapies plug the gap?
Greenman M, Chang Y, McNamara B, Mutlu L, Santin A. Unmet needs in cervical cancer – can biological therapies plug the gap? Expert Opinion On Biological Therapy 2024, 24: 995-1003. PMID: 39311611, DOI: 10.1080/14712598.2024.2408754.Peer-Reviewed Original ResearchBiologic therapyCervical cancerIntroduction of biologic therapiesManagement of cervical cancerImmune checkpoint inhibitorsIncreased overall survivalCurrent treatment recommendationsMultiple tumor typesAntibody-drug conjugatesCheckpoint inhibitorsOverall survivalRecurrent diseaseGynecologic malignanciesTreat malignanciesTumor typesClinical outcomesAngiogenesis inhibitorsBurden of casesTreatment recommendationsTherapyImprove current standardsAntitumor activityInadequate screeningCancerMalignancyPrevalence and risk factors associated with high-risk human papillomavirus infection among women living with HIV (WLWH) at a tertiary health facility in Accra, Ghana
Gyane F, Modey E, Maya E, Bonney E, Abaidoo-Myles A, Paintsil E, Torpey K. Prevalence and risk factors associated with high-risk human papillomavirus infection among women living with HIV (WLWH) at a tertiary health facility in Accra, Ghana. PLOS ONE 2024, 19: e0303535. PMID: 38814956, PMCID: PMC11139324, DOI: 10.1371/journal.pone.0303535.Peer-Reviewed Original ResearchConceptsTertiary health facilityHealth facilitiesInterviewer-administered questionnaireAnalytical cross-sectional studyCervical cancer screeningCervical cancerPrevention of cervical cancerCross-sectional studyRisk factor assessmentHR-HPVAttending HIV clinicsCancer screeningHIV diagnosisLogistic regression analysisDemographic data collectionHigh-risk human papillomavirus infectionPrevalence of HR-HPVHIV clinicHigher oddsWLWHDescriptive statisticsStudy participantsHigh-risk patient groupsMultiple HPV genotypesPrevalence of HPVU.S. Women with Invasive Cervical Cancer: Characteristics and Potential Barriers to Prevention
Rosenblum H, Gargano J, Cleveland A, Dahl R, Park I, Whitney E, Castilho J, Sackey E, Niccolai L, Brackney M, Debess E, Ehlers S, Bennett N, Kurtz R, Unger E, Markowitz L. U.S. Women with Invasive Cervical Cancer: Characteristics and Potential Barriers to Prevention. Journal Of Women's Health 2024, 33: 594-603. PMID: 38608239, PMCID: PMC11995403, DOI: 10.1089/jwh.2023.0462.Peer-Reviewed Original ResearchInvasive cervical cancerEvaluate characteristics of womenPopulation-based descriptive studyInvasive cervical cancer diagnosisCervical cancer screeningReduce cervical cancer ratesPopulation-based surveillance sitesCervical cancer ratesIdentified potential barriersNon-white womenAdvent of screeningPotential barriersCharacteristics of womenIncident invasive cervical cancerCancer screeningPreventive careCancer ratesCervical cancerMental illnessSubstance use disordersChi-square testDescriptive frequenciesDescriptive studyMultiple barriersSurveillance sitesPCDHGB7 hypermethylation-based Cervical cancer Methylation (CerMe) detection for the triage of high-risk human papillomavirus-positive women: a prospective cohort study
Cao D, Yang Z, Dong S, Li Y, Mao Z, Lu Q, Xu P, Shao M, Pan L, Han X, Yuan J, Fan Q, Chen L, Wang Y, Zhu W, Yu W, Wang Y. PCDHGB7 hypermethylation-based Cervical cancer Methylation (CerMe) detection for the triage of high-risk human papillomavirus-positive women: a prospective cohort study. BMC Medicine 2024, 22: 55. PMID: 38317152, PMCID: PMC10845746, DOI: 10.1186/s12916-024-03267-5.Peer-Reviewed Original ResearchConceptsHigh-risk human papillomavirusHrHPV-positive womenHigh-risk human papillomavirus-positive womenCervical intraepithelial neoplasia grade 1Triage of hrHPV-positive womenCervical intraepithelial neoplasia grade 2Triage strategiesHuman papillomavirus-positive womenInternational Peace Maternity and Child Health HospitalMaternal and Child Health HospitalMortality of cervical cancerChild Health HospitalProspective cohort studyASC-USLSIL cytologyColposcopy referralHealth HospitalCytology testHuman papillomavirusOver-referralCervical cancerCohort studyMethodsA totalGrade 2Grade 1
2023
Cervical and Vaginal Cytology
Sun T, Gilani S. Cervical and Vaginal Cytology. 2023, 35-50. DOI: 10.1007/978-3-031-44289-6_3.Peer-Reviewed Original ResearchNCCN Guidelines® Insights: Cervical Cancer, Version 1.2024.
Abu-Rustum N, Yashar C, Arend R, Barber E, Bradley K, Brooks R, Campos S, Chino J, Chon H, Crispens M, Damast S, Fisher C, Frederick P, Gaffney D, Gaillard S, Giuntoli R, Glaser S, Holmes J, Howitt B, Lea J, Mantia-Smaldone G, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Rodabaugh K, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wyse E, McMillian N, Aggarwal S, Espinosa S. NCCN Guidelines® Insights: Cervical Cancer, Version 1.2024. Journal Of The National Comprehensive Cancer Network 2023, 21: 1224-1233. PMID: 38081139, DOI: 10.6004/jnccn.2023.0062.Peer-Reviewed Original ResearchConceptsCervical cancerNCCN guidelinesNCCN Guidelines InsightsSystemic therapy recommendationsAdvanced cervical cancerMetastatic diseaseTreatment landscapeClinical outcomesDiagnostic workupHistopathologic classificationTherapy recommendationsCancerMolecular profileAspects of managementRecent updatesDiagnostic featuresGuidelinesWorkupStagingDiseaseRecurrentPathologyEmerging Prognostic and Predictive Significance of Stress Keratin 17 in HPV-Associated and Non HPV-Associated Human Cancers: A Scoping Review
Lozar T, Wang W, Gavrielatou N, Christensen L, Lambert P, Harari P, Rimm D, Burtness B, Kuhar C, Carchman E. Emerging Prognostic and Predictive Significance of Stress Keratin 17 in HPV-Associated and Non HPV-Associated Human Cancers: A Scoping Review. Viruses 2023, 15: 2320. PMID: 38140561, PMCID: PMC10748233, DOI: 10.3390/v15122320.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaTriple-negative breast cancerCancer typesPredictive significancePrognostic factorsClinical outcomesPrognostic significanceCell carcinomaHuman cancersCervical squamous cell carcinomaNeck squamous cell carcinomaAvailable clinical evidenceCochrane Central RegisterInferior clinical outcomesPositive prognostic factorNegative predictive factorNegative prognostic factorWeb of ScienceCentral RegisterControlled TrialsCervical cancerClinical evidencePredictive factorsPancreatic cancerEligible studiesInvestigating the Relationship between the Dose to the Recto-Vaginal Reference Point and Vaginal Stenosis among Cervical Cancer Patients Treated at a North American Academic Institution
Adefres B, Wallington D, Tien C, Damast S. Investigating the Relationship between the Dose to the Recto-Vaginal Reference Point and Vaginal Stenosis among Cervical Cancer Patients Treated at a North American Academic Institution. International Journal Of Radiation Oncology • Biology • Physics 2023, 117: e501. DOI: 10.1016/j.ijrobp.2023.06.1746.Peer-Reviewed Original ResearchVaginal stenosisDose constraintsMedian doseMultivariable Cox proportional hazards regressionCox proportional hazards regressionCohort median ageAdvanced cervical cancerInterstitial needlesKaplan-Meier methodCervical cancer patientsProportional hazards regressionLog-rank testHR-CTV D90MATERIAL/METHODSImage-guided brachytherapyNorth American academic institutionsLACC patientsPrimary endpointCumulative incidenceOnly patientsPatient demographicsMedian ageCervical cancerCancer patientsSingle institutionCervical Cancer Prevention Among Veterans: What Is the Impact of Military Sexual Trauma, PTSD, and Women’s Health Primary Care Providers on Screening and Prevention?
Domenicano I, Combellick J, Warren A, Kyriakides T, Brandt C, Haskell S, Goulet J. Cervical Cancer Prevention Among Veterans: What Is the Impact of Military Sexual Trauma, PTSD, and Women’s Health Primary Care Providers on Screening and Prevention? Journal Of Military Social Work And Behavioral Health Services 2023, 11: 226-235. DOI: 10.1080/21635781.2023.2246884.Peer-Reviewed Original ResearchMental health conditionsWomen veteransMilitary sexual traumaCervical cancerCancer screeningCervical cancer screening ratesHealth conditionsVHA medical centersCancer screening ratesCervical cancer preventionCervical cancer screeningMultivariable logistic regressionPrimary care providersSexual traumaDiagnosis of PTSDPTSD disordersPatient characteristicsScreening ratesOutpatient careCancer preventionMultivariable modelMedical CenterCare providersWomen's healthCurrent studyHuman papillomavirus vaccine effectiveness by age at vaccination: A systematic review
Ellingson M, Sheikha H, Nyhan K, Oliveira C, Niccolai L. Human papillomavirus vaccine effectiveness by age at vaccination: A systematic review. Human Vaccines & Immunotherapeutics 2023, 19: 2239085. PMID: 37529935, PMCID: PMC10399474, DOI: 10.1080/21645515.2023.2239085.Peer-Reviewed Original ResearchConceptsVaccine effectivenessSystematic reviewHuman Papillomavirus Vaccine EffectivenessVaccine-type HPV infectionYounger ageHigh vaccine effectivenessHuman papillomavirus vaccineVaccine effectiveness studiesYounger age groupsAdolescents ages 15Adolescents ages 9HPV infectionHPV vaccineVaccine initiationPapillomavirus vaccineTime vaccinationAnogenital wartsCervical abnormalitiesCervical cancerDisease outcomeAge groupsOlder ageEffectiveness studiesAge 15AgeUnindicated Cervical Cancer Screening in Adolescent Females Within a Large Healthcare System in the United States
Hosier H, Sheth S, Oliveira C, Perley L, Vash-Margita A. Unindicated Cervical Cancer Screening in Adolescent Females Within a Large Healthcare System in the United States. Obstetrical & Gynecological Survey 2023, 78: 470-472. DOI: 10.1097/ogx.0000000000001179.Commentaries, Editorials and LettersCervical cancer screeningIncidence rateUnindicated testsPatient-specific variablesCervical cancerCancer screeningHPV testingYale New Haven Health SystemCervical cancer screening testsAdolescent femalesEligible young womenRepeated cross-sectional studyWell-woman examinationsAtypical squamous cellsHealth system patientsCancer screening testsWomen ages 21Cross-sectional studyLow incidence rateLarge healthcare systemElectronic medical recordsEvidence-based strategiesSelf-reported raceGuideline adherenceHPV testFactors associated with receiving results and attending colposcopy in patients with positive HPV screens in Mexico City
León-Maldonado L, Hernández-Ramírez R, Torres-Ibarra L, Spiegelman D, Sheth S, Lazcano E, Cadena-Fiscal J, Salmerón J. Factors associated with receiving results and attending colposcopy in patients with positive HPV screens in Mexico City. Preventive Medicine Reports 2023, 35: 102347. PMID: 37593354, PMCID: PMC10428024, DOI: 10.1016/j.pmedr.2023.102347.Peer-Reviewed Original ResearchPercent of participantsColposcopy appointmentHealthcare facilitiesHigh-risk human papillomavirusMultivariable logistic regressionHealthcare system factorsScreening resultsPositive screening resultsColposcopy adherenceColposcopy clinicHPV screenPrevious PapMedian ageCervical cancerPap testHuman papillomavirusHigh school educationPatientsGreater adherenceExperienced nursesGood complianceLogistic regressionScheduling appointmentsLimited staff availabilityAdherenceA comparative study on behavior, awareness and belief about cervical cancer among rural and urban women in Vietnam
Phung M, Le An P, Vinh N, Le H, McLean K, Meza R, Mukherjee B, Lee A, Pearce C. A comparative study on behavior, awareness and belief about cervical cancer among rural and urban women in Vietnam. PLOS Global Public Health 2023, 3: e0001817. PMID: 37279208, PMCID: PMC10243615, DOI: 10.1371/journal.pgph.0001817.Peer-Reviewed Original ResearchCervical cancer screeningCancer screeningUrban womenIncrease uptake of cervical cancer screeningUptake of cervical cancer screeningPerceived susceptibility to cervical cancerCancer screening questionnaireIncrease health literacyBenefits of screeningCervical cancerRural-urban differencesSusceptibility to cervical cancerCervical cancer burdenCross-sectional studySeverity of cervical cancerScreening behaviorEngage doctorsHealth literacyPsychosocial barriersUrban participantsCancer burdenPerceived severity of cervical cancerScreening QuestionnaireImprove screeningWorld Health OrganizationSurvival differences between the USA and an urban population from China for all cancer types and 20 individual cancers: a population-based study
Fu R, Sun K, Wang X, Liu B, Wang T, Morze J, Nawrocki S, An L, Zhang S, Li L, Wang S, Chen R, Sun K, Han B, Lin H, Wang H, Liu D, Wang Y, Li Y, Zhang Q, Mu H, Geng Q, Sun F, Zhao H, Zhang X, Lu L, Mei D, Zeng H, Wei W. Survival differences between the USA and an urban population from China for all cancer types and 20 individual cancers: a population-based study. The Lancet Regional Health - Western Pacific 2023, 37: 100799. PMID: 37693879, PMCID: PMC10485681, DOI: 10.1016/j.lanwpc.2023.100799.Peer-Reviewed Original ResearchExcess hazard ratioStage-specific survivalCancer patientsCancer survivalRelative survivalCancer typesIndividual cancersEnd Results (SEER) databasePopulation-based studyFemale breast cancerLung cancer patientsCancer registry dataCancer early detectionMedical SciencesHazard ratioOverall prognosisSurvival disparitiesResults databaseCancer HospitalCancer RegistryCervical cancerPoor prognosisVital statusColorectal cancerCancer careUptake of Cervical Cancer Screening Among Female Patients Using a Mobile Medical Clinic
Degife E, Oliveira C, Znamierowski E, Meyer J, Sheth S. Uptake of Cervical Cancer Screening Among Female Patients Using a Mobile Medical Clinic. American Journal Of Preventive Medicine 2023, 65: 835-843. PMID: 37220860, PMCID: PMC10592483, DOI: 10.1016/j.amepre.2023.05.013.Peer-Reviewed Original ResearchConceptsCervical cancer screeningMobile medical clinicHealth-related social needsCervical cancerCancer screeningMedical clinicsFemale patientsCervical cancer screening uptakeCancer screening uptakeHuman papillomavirus vaccinationHigh-risk populationMultivariate logistic regressionElectronic health recordsPapillomavirus vaccinationScreening uptakePap testingRetrospective cohortPatient cohortClinic modelLower oddsPatientsUnstable housingClinicLogistic regressionCancer
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