2025
The Brain Care Score and its associations with cardiovascular disease and cancer
Senff J, Rivier C, Tack R, Tan B, Kimball T, Brouwers H, Newhouse A, Fricchione G, Tanzi R, Yechoor N, Chemali Z, Anderson C, Rosand J, Falcone G, Singh S. The Brain Care Score and its associations with cardiovascular disease and cancer. Family Practice 2025, 42: cmaf034. PMID: 40464807, DOI: 10.1093/fampra/cmaf034.Peer-Reviewed Original ResearchConceptsLate-life depressionIncidence of cardiovascular diseaseCare scoresCardiovascular diseaseUK Biobank (UKBCases of cardiovascular diseaseRisk of dementiaHealth-related behaviorsIncident cardiovascular diseaseModifiable risk factorsCases of cancerCancer typesUKB participantsCox proportional hazards regression analysisProportional hazards regression analysisHazards regression analysisHealthy agingRisk factorsUKBDementiaRegression analysisFollow-upParticipantsAge-related brain diseasesBaseline
2024
Association of Physician Certification and Outcomes Among Patients Undergoing Left Atrial Appendage Occlusion
Vora A, Pereira L, Du C, Tan Z, Huang C, Friedman D, Wang Y, Faridi K, Lakkireddy D, Zimmerman S, Higgins A, Kapadia S, Curtis J, Freeman J. Association of Physician Certification and Outcomes Among Patients Undergoing Left Atrial Appendage Occlusion. JACC Cardiovascular Interventions 2024, 18: 591-602. PMID: 39474982, DOI: 10.1016/j.jcin.2024.10.020.Peer-Reviewed Original ResearchPhysician certificationAppendage occlusionAdverse eventsPercutaneous left atrial appendage occlusionLong-term oral anticoagulationDischarged patientsMultivariate Cox proportional hazards regression analysisRate of procedural complicationsLeft atrial appendage occlusionCox proportional hazards regression analysisProportional hazards regression analysisRisk of adverse eventsHazards regression analysisIn-Hospital DeathOral anticoagulantsWatchman FLXNo significant differenceLAAO devicesProcedural complicationsStratify patientsIntracardiac echocardiographyAtrial fibrillationEligible patientsIdentified patientsMultivariable adjustmentEarly-onset appendiceal adenocarcinoma (EOAA): 10-year experience from a single center.
Gujarathi R, Belmont E, Rodman C, Bansal V, Setia N, Alpert L, Hart J, Moller M, Eng O, Lee G, Chin J, Amin M, Polite B, Liao C, Turaga K, Shergill A. Early-onset appendiceal adenocarcinoma (EOAA): 10-year experience from a single center. Journal Of Clinical Oncology 2024, 42: 4178-4178. DOI: 10.1200/jco.2024.42.16_suppl.4178.Peer-Reviewed Original ResearchOutcomes of overall survivalAppendiceal adenocarcinomaEarly-onset diseasePerineural invasionCytoreductive surgeryUnivariate Cox proportional hazards regression analysisCox proportional hazards regression analysisIncidence of early-onsetAssociated with poor outcomesGrade 3 diseaseProportional hazards regression analysisTargetable genomic alterationsHigh-volume centersLymph node metastasisRecords of patientsHazards regression analysisGermline mutation testingLate-onset diseaseCHEK2 mutationsMedian OSVulnerable patient populationCancer ptsOverall survivalLocalized diseaseMetastatic/recurrent diseaseAssociation between activating GNAS mutations and outcomes with chemotherapy in metastatic appendiceal adenocarcinoma.
Gujarathi R, Rodman C, Bansal V, Belmont E, Setia N, Alpert L, Hart J, Moller M, Eng O, Lee G, Chin J, Amin M, Polite B, Liao C, Turaga K, Shergill A. Association between activating GNAS mutations and outcomes with chemotherapy in metastatic appendiceal adenocarcinoma. Journal Of Clinical Oncology 2024, 42: 4179-4179. DOI: 10.1200/jco.2024.42.16_suppl.4179.Peer-Reviewed Original ResearchAppendiceal adenocarcinomaGNAS mutationsOverall survivalActivating GNAS mutationsGNAS statusSynchronous metastasesPredictive biomarkersMetastatic disease treated with chemotherapyCox proportional hazards regression analysisGNAS activating mutationsMetastatic appendiceal adenocarcinomaProportional hazards regression analysisEvent free survivalEvent-free survivalMedian Follow-UpHazards regression analysisFree survivalRadiographic recurrenceFavorable diseaseAA patientsSurvival benefitAssociated with differential outcomesClinicopathological characteristicsClinicopathological featuresNo significant differenceDifferential patterns of reproductive and lifestyle risk factors for breast cancer according to birth cohorts among women in China, Japan and Korea
Nabila S, Choi J, Abe S, Islam M, Rahman M, Saito E, Shin A, Merritt M, Katagiri R, Shu X, Sawada N, Tamakoshi A, Sakata R, Hozawa A, Kim J, Nagata C, Park S, Kweon S, Cai H, Tsugane S, Kimura T, Kanemura S, Sugawara Y, Wada K, Shin M, Ahsan H, Boffetta P, Chia K, Matsuo K, Qiao Y, Rothman N, Zheng W, Inoue M, Kang D. Differential patterns of reproductive and lifestyle risk factors for breast cancer according to birth cohorts among women in China, Japan and Korea. Breast Cancer Research 2024, 26: 15. PMID: 38254178, PMCID: PMC10801993, DOI: 10.1186/s13058-024-01766-0.Peer-Reviewed Original ResearchConceptsBreast cancer riskBirth cohortCancer riskCohort studyLifestyle factorsRates of breast cancer incidenceRisk of breast cancerAlcohol consumptionHazard ratioAssociated with breast cancerBreast cancerBreast cancer incidenceLifestyle risk factorsEffect sizeConfidence intervalsBirth cohort effectsYounger birth cohortsBirth cohort groupsCohort groupCancer incidenceCox proportional hazards regression analysisProportional hazards regression analysisParous womenCohort effectsHazards regression analysis
2023
Deep learning of image-derived measures of body composition in pediatric, adolescent, and young adult lymphoma: association with late treatment effects
Tram N, Chou T, Janse S, Bobbey A, Audino A, Onofrey J, Stacy M. Deep learning of image-derived measures of body composition in pediatric, adolescent, and young adult lymphoma: association with late treatment effects. European Radiology 2023, 33: 6599-6607. PMID: 36988714, DOI: 10.1007/s00330-023-09587-z.Peer-Reviewed Original ResearchConceptsProportional hazards regression analysisHazards regression analysisLate effectsBody composition measuresAYA patientsHigh riskBody compositionCox proportional hazards regression analysisTreatment-related late effectsComposition measuresCancer treatmentSerious adverse eventsLate treatment effectsYoung adult patientsSubcutaneous adipose tissueRegression analysisCare CT imagesSingle-site studyMuscle tissueAdult patientsAdverse eventsInitial stagingPediatric patientsAdult lymphomasPrognostic valueIdentifying Sex-Specific Cancer Metabolites and Associations to Prognosis
Shen X, Ma S, Khan S, Johnson C. Identifying Sex-Specific Cancer Metabolites and Associations to Prognosis. Learning Materials In Biosciences 2023, 271-299. DOI: 10.1007/978-3-031-44256-8_11.Peer-Reviewed Original ResearchMetabolomics dataSurvival analysisCancer metabolitesColorectal cancerCox proportional hazards regression analysisProportional hazards regression analysisHazards regression analysisSex-specific associationsClinical dataCancer patientsCancer prognosisCancerMetabolomicsMultiple comparisonsPrognosisAnalytical methodSurvivalOncology studiesPatientsAlternative analytical approachRegression analysisSex-SpecificMetabolitesSex interactionAssociation
2021
Comparing Outcomes between Liposomal Daunorubicin/Cytarabine (CPX-351) and HMA+Venetoclax As Frontline Therapy in Acute Myeloid Leukemia
Grenet J, Jain A, Burkart M, Waksal J, Famulare C, Numan Y, Stahl M, Mckinnell Z, Ball B, Ma X, Christos P, Ritchie E, Samuel M, Kaner J, Lee S, Goldberg A, Dinner S, Sweet K, Roboz G, Desai P. Comparing Outcomes between Liposomal Daunorubicin/Cytarabine (CPX-351) and HMA+Venetoclax As Frontline Therapy in Acute Myeloid Leukemia. Blood 2021, 138: 32. DOI: 10.1182/blood-2021-145947.Peer-Reviewed Original ResearchRelapse free survivalEntity's Board of DirectorsCPX-351Overall survivalFrontline therapyTreated ptsMultivariate analysisRetrospective studySurvival advantageSubgroup analysisMedian relapse free survivalMulti-center retrospective studyMultivariate Cox proportional hazards regression analysisCox proportional hazards regression analysisVariability of treatment responseMultivariate subgroup analysisNewly diagnosed AMLKaplan-Meier survival analysisMultivariate logistic regression analysisProportional hazards regression analysisMulticenter retrospective studyLog-rank testAcute myeloid leukemiaHazards regression analysisPrimary outcome variableThe role of feature-tracking strain analysis in the differentiation of cardiac amyloidosis from hypertrophic cardiomyopathy
Dohy Z, Szabo L, Pozsonyi Z, Csecs I, Toth A, Suhai F, Czimbalmos C, Szucs A, Kiss A, Becker D, Merkely B, Vago H. The role of feature-tracking strain analysis in the differentiation of cardiac amyloidosis from hypertrophic cardiomyopathy. European Heart Journal 2021, 42: ehab724.0240. DOI: 10.1093/eurheartj/ehab724.0240.Peer-Reviewed Original ResearchCardiac involvement of amyloidosisLeft ventricular ejection fractionLate gadolinium enhancementCardiac magnetic resonanceAmount of late gadolinium enhancementHypertrophic cardiomyopathy patientsFeature-tracking strain analysisCA patientsHypertrophic cardiomyopathyBasal LSDiagnostic accuracyPattern of late gadolinium enhancementCardiac magnetic resonance diagnosisCardiac magnetic resonance examinationSignificant independent predictors of mortalityCox proportional hazards regression analysisIndependent predictor of mortalityLV strain parametersRegional strain valuesYears of follow-upProportional hazards regression analysisVentricular ejection fractionOptimal cutoff valueLog-rank testDiagnosis of CAEffects of genetic risk for alcohol dependence and onset of regular drinking on the progression to alcohol dependence: A polygenic risk score approach
Yeung EW, Spychala KM, Miller AP, Otto JM, Deak JD, Kim H, Gilder DA, Ehlers CL, Wilhelmsen KC, Gizer IR. Effects of genetic risk for alcohol dependence and onset of regular drinking on the progression to alcohol dependence: A polygenic risk score approach. Drug And Alcohol Dependence 2021, 230: 109117. PMID: 34844060, PMCID: PMC8714681, DOI: 10.1016/j.drugalcdep.2021.109117.Peer-Reviewed Original ResearchConceptsRate of progressionRegular drinkingAlcohol dependenceCox proportional hazards regression analysisProportional hazards regression analysisEarly onsetGenetic riskHazards regression analysisHazard of progressionMixed-effects logistic regressionEuropean-ancestry adultsHigh clinical relevanceAD risk variantsEffects logistic regressionAD independentPolygenic risk score approachClinical courseRapid progressionAD preventionFaster progressionPolygenic risk scoresRisk scoreClinical relevanceLate onsetAD diagnosisLong-Term Kidney Outcomes Following Dialysis-Treated Childhood Acute Kidney Injury: A Population-Based Cohort Study
Robinson CH, Jeyakumar N, Luo B, Wald R, Garg AX, Nash DM, McArthur E, Greenberg J, Askenazi D, Mammen C, Thabane L, Goldstein S, Parekh RS, Zappitelli M, Chanchlani R. Long-Term Kidney Outcomes Following Dialysis-Treated Childhood Acute Kidney Injury: A Population-Based Cohort Study. Journal Of The American Society Of Nephrology 2021, 32: 2005-2019. PMID: 34039667, PMCID: PMC8455253, DOI: 10.1681/asn.2020111665.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAdolescentCase-Control StudiesChildChild, PreschoolFemaleFollow-Up StudiesHumansHypertensionIncidenceInfantInfant, NewbornKidney Failure, ChronicMaleMortalityOntarioProportional Hazards ModelsRenal DialysisRenal Insufficiency, ChronicRetrospective StudiesRisk FactorsSurvivorsTime FactorsConceptsAKI survivorsKidney failureLong-term riskCohort studyCox proportional hazards regression analysisAdverse short-term outcomesChildhood acute kidney injuryProportional hazards regression analysisHigher long-term riskAcute kidney injuryHealth administrative databasesRetrospective cohort studyHazards regression analysisShort-term outcomesLong-term outcomesBasis of ageAKI episodesPediatric AKISubsequent AKIKidney injuryComposite outcomeCardiac surgeryHospitalized cohortMechanical ventilationPediatric hospitalizationsImpact of Racial Disparities on All-Cause Mortality in Patients With Tumors of the Spinal Cord or Spinal Meninges: A Propensity-Score Analysis
Elsamadicy AA, Freedman I, Koo AB, David WB, Reeves BC, Hengartner A, Pennington Z, Laurans M, Kolb L, Shin JH, Sciubba D. Impact of Racial Disparities on All-Cause Mortality in Patients With Tumors of the Spinal Cord or Spinal Meninges: A Propensity-Score Analysis. Global Spine Journal 2021, 13: 1365-1373. PMID: 34318727, PMCID: PMC10416582, DOI: 10.1177/21925682211033827.Peer-Reviewed Original ResearchSpinal cordCause mortalitySpinal meningesNonmalignant tumorsCox proportional hazards regression analysisProportional hazards regression analysisIntradural spine tumorsReceipt of RTOutcomes of patientsRetrospective cohort studyEnd Results registryKaplan-Meier methodOverall survival estimatesSpinal cord tumorsAssociation of survivalLog-rank testAfrican American patientsPopulation-based estimatesPropensity score analysisPropensity-score matchingCohort studyCord tumorsSpine tumorsWhite patientsAnalysis ageHigh‐Sensitivity Cardiac Troponin T and Recurrent Vascular Events After First Ischemic Stroke
Scheitz J, Lim J, Broersen L, Ganeshan R, Huo S, Sperber P, Piper S, Heuschmann P, Audebert H, Nolte C, Siegerink B, Endres M, Liman T. High‐Sensitivity Cardiac Troponin T and Recurrent Vascular Events After First Ischemic Stroke. Journal Of The American Heart Association 2021, 10: e018326. PMID: 33982599, PMCID: PMC8200699, DOI: 10.1161/jaha.120.018326.Peer-Reviewed Original ResearchConceptsRecurrent vascular eventsModerate ischemic strokeVascular eventsCardiac troponin TIschemic strokePrimary outcomeHs-cTnTCox proportional hazards regression analysisTroponin THigh-sensitivity cardiac troponin TProportional hazards regression analysisSensitivity cardiac troponin TFirst ischemic strokeCardiac troponin levelsHazards regression analysisHs-cTnT levelsIndividualized risk stratificationBackground Recent evidenceUpper reference limitDose-response relationshipCause deathRecurrent strokeTroponin levelsStudy entryVascular riskPatterns of treatment with everolimus exemestane in hormone receptor-positive HER2-negative metastatic breast cancer in the era of targeted therapy
Rozenblit M, Mun S, Soulos P, Adelson K, Pusztai L, Mougalian S. Patterns of treatment with everolimus exemestane in hormone receptor-positive HER2-negative metastatic breast cancer in the era of targeted therapy. Breast Cancer Research 2021, 23: 14. PMID: 33514405, PMCID: PMC7844919, DOI: 10.1186/s13058-021-01394-y.Peer-Reviewed Original ResearchConceptsPrior endocrine therapyEndocrine therapyMetastatic breast cancerEffective treatment optionTreatment optionsBreast cancerMedian treatmentMedian OSEE therapyHormone receptor-positive HER2-negative metastatic breast cancerMultivariable Cox proportional hazards regression analysisHER2-negative metastatic breast cancerPrior treatmentCox proportional hazards regression analysisFirst-line therapy initiationProportional hazards regression analysisPrior treatment optionsLines of therapyProportion of patientsKaplan-Meier methodHazards regression analysisPatterns of treatmentElectronic health record-derived dataClinical trial dataOS benefit
2020
Survival on the Heart Transplant Waiting List
Bakhtiyar SS, Godfrey EL, Ahmed S, Lamba H, Morgan J, Loor G, Civitello A, Cheema FH, Etheridge WB, Goss J, Rana A. Survival on the Heart Transplant Waiting List. JAMA Cardiology 2020, 5: 1227-1235. PMID: 32785619, PMCID: PMC7675100, DOI: 10.1001/jamacardio.2020.2795.Peer-Reviewed Original ResearchConceptsVentricular assist deviceHeart transplant waiting listList survivalTransplant waiting listWaiting listMultivariable Cox proportional hazards regression analysisCox proportional hazards regression analysisProportional hazards regression analysisHeart transplantation waiting listAdjusted survival analysisHazards regression analysisTransplantation waiting listWait-listed candidatesCandidate risk factorsHeart transplantationList mortalityUNOS databaseClinical improvementHeart transplantPrimary outcomeAdjusted analysisSurvival outcomesKaplan-MeierPatient groupUnited Network
2019
Delayed nephrectomy has comparable long-term overall survival to immediate nephrectomy for cT1a renal cell carcinoma: A population-based analysis
Tan W, Trinh Q, Hayn M, Marchese M, Lipsitz S, Nabi J, Kilbridge K, Vale J, Khoubehi B, Kibel A, Sun M, Chang S, Sammon J. Delayed nephrectomy has comparable long-term overall survival to immediate nephrectomy for cT1a renal cell carcinoma: A population-based analysis. Urologic Oncology Seminars And Original Investigations 2019, 38: 74.e13-74.e20. PMID: 31864937, DOI: 10.1016/j.urolonc.2019.11.008.Peer-Reviewed Original ResearchConceptsRenal cell carcinomaCT1a renal cell carcinomaImmediate nephrectomyKaplan-Meier curvesOverall survivalCell carcinomaSurgical resectionRenal massesPatient ageTreatment armsCharlson Comorbidity Index 0Compare OS of patientsLong-term overall survivalInfluence of patient ageCox proportional hazards regression analysisEarly surgical resectionLong-term OSMedian patient ageProportional hazards regression analysisMedian Follow-UpNational Cancer DatabaseOS of patientsSmall renal massesInverse probabilityRecommended treatment optionComparison of Survival After Mohs Micrographic Surgery vs Wide Margin Excision for Early-Stage Invasive Melanoma
Cheraghlou S, Christensen SR, Agogo GO, Girardi M. Comparison of Survival After Mohs Micrographic Surgery vs Wide Margin Excision for Early-Stage Invasive Melanoma. JAMA Dermatology 2019, 155: 1252-1259. PMID: 31553403, PMCID: PMC6764120, DOI: 10.1001/jamadermatol.2019.2890.Peer-Reviewed Original ResearchWide margin excisionMohs micrographic surgeryNational Cancer DatabaseOverall survivalInvasive melanomaStage IMargin excisionCancer DatabaseMicrographic surgeryCox proportional hazards regression survival analysisCox proportional hazards regression analysisCancer (AJCC) Cancer Staging ManualUse of MMSPropensity score-matched analysisProportional hazards regression analysisCancer-accredited facilitiesRetrospective cohort studyAmerican Joint CommitteeCancer Staging ManualHazards regression analysisCommon malignant neoplasmTreatment of melanomaRegression survival analysisComparison of survivalEligible patientsComparing Long-Term Outcomes Following Radical and Partial Nephrectomy for cT1 Renal Cell Carcinoma in Young and Healthy Individuals
Tan W, Berg S, Cole A, Krimphove M, Marchese M, Lipsitz S, Nabi J, Sammon J, Choueiri T, Kibel A, Sun M, Chang S, Trinh Q. Comparing Long-Term Outcomes Following Radical and Partial Nephrectomy for cT1 Renal Cell Carcinoma in Young and Healthy Individuals. JNCI Cancer Spectrum 2019, 3: pkz003. PMID: 31360891, PMCID: PMC6649692, DOI: 10.1093/jncics/pkz003.Peer-Reviewed Original ResearchLow-stage renal cell carcinomaRenal cell carcinomaTreated with radical nephrectomyInverse probability of treatment weighting adjustmentPartial nephrectomyRadical nephrectomyType of surgeryOverall survivalTreatment weighting adjustmentCell carcinomaClinical stageCompare overall survival of patientsPatients treated with partial nephrectomyLong-term overall survivalCT1 renal cell carcinomaOverall survival of patientsCox proportional hazards regression analysisProportional hazards regression analysisCompare overall survivalNational Cancer DatabaseMedian Follow-UpSurvival of patientsKaplan-Meier curvesInverse probabilityLong-term outcomes
2018
Severely impaired terminal erythroid differentiation as an independent prognostic marker in myelodysplastic syndromes
Ali AM, Huang Y, Pinheiro RF, Xue F, Hu J, Iverson N, Hoehn D, Coutinho D, Kayani J, Chernak B, Lane J, Hillyer C, Galili N, Jurcic J, Mohandas N, An X, Raza A. Severely impaired terminal erythroid differentiation as an independent prognostic marker in myelodysplastic syndromes. Blood Advances 2018, 2: 1393-1402. PMID: 29903708, PMCID: PMC6020814, DOI: 10.1182/bloodadvances.2018018440.Peer-Reviewed Original ResearchConceptsIndependent prognostic markerMyelodysplastic syndromeOverall survivalPrognostic markerMultivariable Cox proportional hazards regression analysisCox proportional hazards regression analysisPowerful independent prognostic markerInternational Prognostic Scoring SystemProportional hazards regression analysisMyeloid/erythroid ratioTerminal erythroid differentiationIPSS-R categoryPrognostic scoring systemHazards regression analysisWorse overall survivalPoor overall survivalBone marrow samplesSurface expressionMost patientsProportion of cellsErythroid ratioMarrow samplesErythroid differentiationSRSF2 mutationsMDS samplesPeripheral T cell lymphoma, not otherwise specified (PTCL‐NOS). A new prognostic model developed by the International T cell Project Network
Federico M, Bellei M, Marcheselli L, Schwartz M, Manni M, Tarantino V, Pileri S, Ko Y, Cabrera ME, Horwitz S, Kim WS, Shustov A, Foss FM, Nagler A, Carson K, Pinter‐Brown L, Montoto S, Spina M, Feldman TA, Lechowicz MJ, Smith SM, Lansigan F, Gabus R, Vose JM, Advani RH, Network T. Peripheral T cell lymphoma, not otherwise specified (PTCL‐NOS). A new prognostic model developed by the International T cell Project Network. British Journal Of Haematology 2018, 181: 760-769. PMID: 29672827, PMCID: PMC6033106, DOI: 10.1111/bjh.15258.Peer-Reviewed Original ResearchConceptsT-cell ProjectPeripheral T-cell lymphomaT cell scoreProgression-free survivalT-cell lymphomaOverall survivalCell lymphomaCells projectCox proportional hazards regression analysisMultiple Cox proportional hazards regression analysisProportional hazards regression analysisMedian overall survivalHazards regression analysisNew prognostic modelIntermediate riskPTCL-NOSPrognostic valueUnfavourable outcomeClinical variablesRetrospective analysisHigh riskLower riskPrognostic modelGood discriminant powerNew score
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