2025
ANGINA RELATED HEALTH STATUS IN PATIENTS WITH ISCHEMIA AND NONOBSTRUCTIVE CORONARY ARTERIES: INSIGHTS FROM THE DISCOVER INOCA REGISTRY
Shah S, Toleva O, Tremmel J, Henry T, Samuels B, Smilowitz N, Prasad M, Kobayashi Y, Henry G, Lerman A, Moses J, Pietras C, Latif N, Parise H, Cristea E, Chamie D, Cigarroa N, Lansky A. ANGINA RELATED HEALTH STATUS IN PATIENTS WITH ISCHEMIA AND NONOBSTRUCTIVE CORONARY ARTERIES: INSIGHTS FROM THE DISCOVER INOCA REGISTRY. Journal Of The American College Of Cardiology 2025, 85: 1922. DOI: 10.1016/s0735-1097(25)02406-4.Peer-Reviewed Original Research
2024
Diagnostic Yield and Clinical Utility of Coronary Angiography Versus Coronary Function Testing in Women With Angina and Nonobstructive Coronary Arteries
Cigarroa N, Latif N, Maayah M, Khokhar A, Kunnirickal S, Schwann A, Maciejewski K, Odanovic N, Mazure C, Spatz E, Pfau S, Lansky A, Shah S. Diagnostic Yield and Clinical Utility of Coronary Angiography Versus Coronary Function Testing in Women With Angina and Nonobstructive Coronary Arteries. Journal Of The American Heart Association 2024, 13: e035852. PMID: 39291500, PMCID: PMC11681466, DOI: 10.1161/jaha.124.035852.Peer-Reviewed Original ResearchCoronary function testingNonobstructive coronary arteriesInvasive coronary angiographyCoronary microvascular dysfunctionCoronary angiographyVasomotor disordersFunction testsCoronary arteryAntianginal therapyDiagnostic yieldVasospastic anginaMicrovascular dysfunctionDiagnostic yield of invasive coronary angiographyNonobstructive coronary artery diseaseSuspected ischemic heart diseaseCalcium channel blockersCoronary vasomotor disordersSymptomatic myocardial bridgingCoronary artery diseaseIschemic heart diseaseChannel blockersAnatomic diagnosisEndothelial dysfunctionArtery diseaseMyocardial bridgingMyocardial infarction with nonobstructive coronary arteries: a single-center retrospective study by sex and race
Hsueh C, Esin G, Breen T, Gitto M, Katz M, Gulati M, Capers Q, Reynolds H, Volgman A, Wenger N, Altin S. Myocardial infarction with nonobstructive coronary arteries: a single-center retrospective study by sex and race. Coronary Artery Disease 2024, 35: 684-691. PMID: 38989611, DOI: 10.1097/mca.0000000000001402.Peer-Reviewed Original ResearchRate of nonfatal MINonobstructive coronary arteriesMyocardial infarctionCerebrovascular accidentBlack patientsNonfatal MISecondary outcomesSingle-center retrospective studyCoronary arteryRate of cerebrovascular accidentsIncreased risk of readmissionAssociated with decreased oddsNonfatal cerebrovascular accidentAssociated with increased oddsAcute myocardial infarctionMINOCA patientsPatient-level dataRepeat angiographyCoronary angiographyRisk of readmissionBaseline demographicsRetrospective studyMINOCAFemale sexAngiographic reviewEvaluating Ischemic Heart Disease in Women: Focus on Angina With Nonobstructive Coronary Arteries (ANOCA)
Maayah M, Latif N, Vijay A, Gallegos C, Cigarroa N, Martinez E, Mazure C, Miller E, Spatz E, Shah S. Evaluating Ischemic Heart Disease in Women: Focus on Angina With Nonobstructive Coronary Arteries (ANOCA). Journal Of The Society For Cardiovascular Angiography & Interventions 2024, 3: 102195. PMID: 39166160, PMCID: PMC11330936, DOI: 10.1016/j.jscai.2024.102195.Peer-Reviewed Original ResearchIschemic heart diseaseNonobstructive coronary arteriesCoronary artery diseaseArtery diseaseObstructive coronary artery diseaseCoronary arteryLong-term cardiovascular prognosisHeart diseaseSuspected ischemic heart diseaseAtherosclerotic coronary artery diseaseCoronary vasomotor disordersPretest probability of diseasePragmatic diagnostic algorithmExpert consensus documentEvaluating ischemic heart diseaseImpact quality of lifeQuality of lifeSymptomatic patientsPretest probabilityANOCACardiovascular prognosisVasomotor disordersDiagnostic evaluationPersistent symptomsDiagnostic strategiesDetermining the Cause of Coronary Vasomotor Disorders in Patients With Ischemia and Nonobstructive Coronary Arteries: Design and Rationale of the DISCOVER INOCA Prospective, Multicenter Registry
Shah S, Tremmel J, Henry T, Smilowitz N, Prasad M, Kobayashi Y, Henry G, Samady H, Samuels B, Lerman A, Moses J, Pietras C, Zhang Z, Tirziu D, Parise H, Cristea E, Chamié D, Grubman D, Henrici K, Matmusaeva E, Latif N, Cigarroa N, Lansky A. Determining the Cause of Coronary Vasomotor Disorders in Patients With Ischemia and Nonobstructive Coronary Arteries: Design and Rationale of the DISCOVER INOCA Prospective, Multicenter Registry. Journal Of The Society For Cardiovascular Angiography & Interventions 2024, 3: 102046. PMID: 39132594, PMCID: PMC11308755, DOI: 10.1016/j.jscai.2024.102046.Peer-Reviewed Original ResearchCoronary function testingObstructive coronary artery diseaseCoronary artery diseaseNonobstructive coronary arteriesLong-term outcomesFollow-upVasomotor disordersEnd pointsComposite of cardiovascular deathCoronary arteryLong-term follow-upCoronary microvascular dysfunctionDiagnostic coronary angiographyCardiovascular adverse eventsAdverse cardiovascular eventsCoronary vasomotor disordersOptical coherence tomographySymptomatic myocardial bridgingShort-term end pointsAtherosclerotic plaque burdenIschemic heart diseaseLong-term end pointsINOCA patientsAcetylcholine provocationPatient-reported outcome measures
2023
Comprehensive Management of ANOCA, Part 1—Definition, Patient Population, and Diagnosis JACC State-of-the-Art Review
Samuels B, Shah S, Widmer R, Kobayashi Y, Miner S, Taqueti V, Jeremias A, Albadri A, Blair J, Kearney K, Wei J, Park K, El-Farra A, Holoshitz N, Janaszek K, Kesarwani M, Lerman A, Prasad M, Quesada O, Reynolds H, Savage M, Smilowitz N, Sutton N, Sweeny J, Toleva O, Henry T, Moses J, Fearon W, Tremmel J, Network M. Comprehensive Management of ANOCA, Part 1—Definition, Patient Population, and Diagnosis JACC State-of-the-Art Review. Journal Of The American College Of Cardiology 2023, 82: 1245-1263. PMID: 37704315, DOI: 10.1016/j.jacc.2023.06.043.Peer-Reviewed Original ResearchConceptsCoronary function testingMyocardial bridgingCoronary angiographyMultiple medical providersNonobstructive coronary arteriesCoronary microvascular dysfunctionDiagnostic coronary angiographyIschemic heart diseaseInvasive coronary angiographyCoronary flow reserveCardiac catheterization laboratoryCoronary abnormalitiesCoronary vasospasmEpicardial spasmMicrocirculatory resistanceEndothelial dysfunctionMicrovascular dysfunctionHemodynamic assessmentProvocative testingCoronary arteryFunction testingPatient populationHeart diseaseJACC StateFlow reserveComprehensive Management of ANOCA, Part 2—Program Development, Treatment, and Research Initiatives JACC State-of-the-Art Review
Smilowitz N, Prasad M, Widmer R, Toleva O, Quesada O, Sutton N, Lerman A, Reynolds H, Kesarwani M, Savage M, Sweeny J, Janaszek K, El-Farra A, Holoshitz N, Park K, Albadri A, Blair J, Jeremias A, Kearney K, Kobayashi Y, Miner S, Samuels B, Shah S, Taqueti V, Wei J, Fearon W, Moses J, Henry T, Tremmel J, Network M. Comprehensive Management of ANOCA, Part 2—Program Development, Treatment, and Research Initiatives JACC State-of-the-Art Review. Journal Of The American College Of Cardiology 2023, 82: 1264-1279. PMID: 37704316, DOI: 10.1016/j.jacc.2023.06.044.Peer-Reviewed Original ResearchConceptsCoronary function testingFunction testingFuture large-scale clinical trialsLarge-scale clinical trialsNonobstructive coronary arteriesStandardized symptom assessmentMultidisciplinary care teamTreatment of anginaIndividual patient needsQuality of lifeAngina burdenTherapeutic optionsCoronary arterySymptom assessmentClinical trialsCare teamTitrate therapyPatient needsANOCAComprehensive managementTreatmentComprehensive programAnginaPatientsArtery
2022
Clinical Characteristics and Prognosis of MINOCA Caused by Atherosclerotic and Nonatherosclerotic Mechanisms Assessed by OCT
Zeng M, Zhao C, Bao X, Liu M, He L, Xu Y, Meng W, Qin Y, Weng Z, Yi B, Zhang D, Wang S, Luo X, Lv Y, Chen X, Sun Q, Feng X, Gao Z, Sun Y, Demuyakor A, Li J, Hu S, Guagliumi G, Mintz G, Jia H, Yu B. Clinical Characteristics and Prognosis of MINOCA Caused by Atherosclerotic and Nonatherosclerotic Mechanisms Assessed by OCT. JACC Cardiovascular Imaging 2022, 16: 521-532. PMID: 36648054, DOI: 10.1016/j.jcmg.2022.10.023.Peer-Reviewed Original ResearchConceptsMajor adverse cardiac eventsOptical coherence tomographyTarget lesion revascularizationCardiac deathLesion revascularizationPredictors of Major Adverse Cardiac EventsAssociated with worse outcomesSpontaneous coronary artery dissectionClinical diagnosis of MIPrognosis of MINOCAMechanisms of MINOCAAdverse cardiac eventsNonobstructive coronary arteriesPrognosis of patientsCoronary artery dissectionDiagnosis of MIOCT findingsAtherosclerotic causeCardiac eventsClinical characteristicsClinical outcomesArtery dissectionComposite endpointMINOCACoronary spasm
2018
Presentation, Clinical Profile, and Prognosis of Young Patients With Myocardial Infarction With Nonobstructive Coronary Arteries (MINOCA): Results From the VIRGO Study
Safdar B, Spatz ES, Dreyer RP, Beltrame JF, Lichtman JH, Spertus JA, Reynolds HR, Geda M, Bueno H, Dziura JD, Krumholz HM, D'Onofrio G. Presentation, Clinical Profile, and Prognosis of Young Patients With Myocardial Infarction With Nonobstructive Coronary Arteries (MINOCA): Results From the VIRGO Study. Journal Of The American Heart Association 2018, 7: e009174. PMID: 29954744, PMCID: PMC6064896, DOI: 10.1161/jaha.118.009174.Peer-Reviewed Original ResearchConceptsMI-CAD patientsNonobstructive coronary arteriesMI-CADYounger patientsClinical profileCoronary arteryMyocardial infarctionTraditional cardiac risk factorsAcute myocardial infarction patientsCardiac risk factorsGestational diabetes mellitusMyocardial infarction patientsTimes higher oddsMINOCA patientsSAQ qualityVIRGO StudyClinical characteristicsHypercoaguable stateDiabetes mellitusObstructive diseaseClinical outcomesInfarction patientsRisk factorsMINOCAPsychosocial status
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