2025
Long-term, bidirectional associations between depressive symptom severity and opioid use among people with HIV: A prospective cohort study
Macmadu A, Li Y, Bhondoekhan F, Chang C, Bahji A, Crystal S, Gordon K, Kerns R, Vickers-Smith R, Edelman E, Marshall B. Long-term, bidirectional associations between depressive symptom severity and opioid use among people with HIV: A prospective cohort study. Addictive Behaviors Reports 2025, 22: 100619. PMID: 40547483, PMCID: PMC12182372, DOI: 10.1016/j.abrep.2025.100619.Peer-Reviewed Original ResearchDepressive symptom severityVeterans Aging Cohort StudySymptom severityOpioid useCohort studySubstance use disordersPrescription opioid useProspective cohort studyOpioid use disorderAging Cohort StudyMental health servicesDose-response patternGeneralized Estimating Equation modelsVeterans Health Administration sitesUse disorderClinical characteristicsProspective cohortBidirectional associationsFollow-upStudy entryOpioidHarm reduction servicesBidirectional relationshipPLHIVAdministration site
2024
Patient Characteristics and Practice Variation Associated With New Community Prescription of Benzodiazepine and z‐Drug Hypnotics After Critical Illness: A Retrospective Cohort Study Using the UK Clinical Practice Research Datalink
Mansi E, Rentsch C, Bourne R, Guthrie B, Lone N. Patient Characteristics and Practice Variation Associated With New Community Prescription of Benzodiazepine and z‐Drug Hypnotics After Critical Illness: A Retrospective Cohort Study Using the UK Clinical Practice Research Datalink. Pharmacoepidemiology And Drug Safety 2024, 33: e70056. PMID: 39603606, PMCID: PMC11602247, DOI: 10.1002/pds.70056.Peer-Reviewed Original ResearchConceptsCommunity prescriptionsZ-drugsIllness survivorsRetrospective cohort studyClinical Practice Research Datalink dataPractice variationUK Clinical Practice Research DatalinkClinical Practice Research DatalinkWorsening mental health conditionsCohort studyMultilevel multivariable logistic regressionSurvivors of critical illnessZ-drug prescribingCritical care survivorsPrimary care practicesCritical illnessMental health conditionsZ-drug prescriptionsCritical illness survivorsMultivariate logistic regressionPrescription opioid useCare practicesRisk of adverse eventsHealth conditionsHistory of insomniaThe impact of chiropractic care on prescription opioid use for non-cancer spine pain: protocol for a systematic review and meta-analysis
Emary P, Corcoran K, Coleman B, Brown A, Ciraco C, DiDonato J, Wang L, Couban R, Sud A, Busse J. The impact of chiropractic care on prescription opioid use for non-cancer spine pain: protocol for a systematic review and meta-analysis. Systematic Reviews 2024, 13: 232. PMID: 39267131, PMCID: PMC11394937, DOI: 10.1186/s13643-024-02654-6.Peer-Reviewed Original ResearchConceptsChiropractic careSpine painRandomized Controlled TrialsPrescription opioid useOdds ratioConfidence intervalsHazard ratioSystematic reviewAssociated with lower oddsHealth care providersObservational studyPairs of reviewersPrescription opioidsRisk-of-bias assessmentOpioid useCertainty of evidencePeer-reviewed publicationsChiropractic LiteratureChiropractic servicesRandom-effects modelCare providersWeb of ScienceMusculoskeletal painSources of heterogeneityDiscussionOur review
2022
Trends in Prescription Opioid Use in Motor Vehicle Crash Injuries in the United States: 2014–2018
Jin L, Vermund S, Zhang Y. Trends in Prescription Opioid Use in Motor Vehicle Crash Injuries in the United States: 2014–2018. International Journal Of Environmental Research And Public Health 2022, 19: 14445. PMID: 36361324, PMCID: PMC9657604, DOI: 10.3390/ijerph192114445.Peer-Reviewed Original ResearchConceptsMotor vehicle crashesPrescription opioidsMVC injuriesLog-binomial regression modelsPrescription opioid usageMotor vehicle crash injuriesPrescription opioid usePrescribing opioidsOpioid usageOpioid useCDC guidelinesChronic painEmergency departmentStudy populationOpioidsEnrollee characteristicsPrevalenceInjuryCrash injuriesDistrict of ColumbiaVehicle crashesDispensing rateEmployment statusRegression modelsTemporal trendsPredicting at-risk opioid use three months after ed visit for trauma: Results from the AURORA study
Punches BE, Stolz U, Freiermuth CE, Ancona RM, McLean SA, House SL, Beaudoin FL, An X, Stevens JS, Zeng D, Neylan TC, Clifford GD, Jovanovic T, Linnstaedt SD, Germine LT, Bollen KA, Rauch SL, Haran JP, Storrow AB, Lewandowski C, Musey PI, Hendry PL, Sheikh S, Jones CW, Kurz MC, Gentile NT, McGrath ME, Hudak LA, Pascual JL, Seamon MJ, Harris E, Chang AM, Pearson C, Peak DA, Merchant RC, Domeier RM, Rathlev NK, O’Neil B, Sanchez LD, Bruce SE, Pietrzak RH, Joormann J, Barch DM, Pizzagalli DA, Smoller JW, Luna B, Harte SE, Elliott JM, Kessler RC, Ressler KJ, Koenen KC, Lyons MS. Predicting at-risk opioid use three months after ed visit for trauma: Results from the AURORA study. PLOS ONE 2022, 17: e0273378. PMID: 36149896, PMCID: PMC9506640, DOI: 10.1371/journal.pone.0273378.Peer-Reviewed Original ResearchConceptsOpioid analgesic exposuresNon-medical opioid useOpioid useAnalgesic exposureOpioid exposureOpioid prescriptionsED opioid administrationED opioid prescriptionInitial ED encounterSubsequent opioid useAdult trauma patientsProspective cohort studyPrescription opioid useMultivariable logistic regressionED administrationED opioidsED prescriptionPain leadOpioid administrationAdult patientsCohort studyED visitsClinical factorsED encountersHospital admission
2021
Association of prescription opioid use on mortality and hospital length of stay in the intensive care unit
Hardy N, Zeba F, Ovalle A, Yanac A, Nzugang-Noutonsi C, Abadier M, Ovalle A, Chahin A. Association of prescription opioid use on mortality and hospital length of stay in the intensive care unit. PLOS ONE 2021, 16: e0250320. PMID: 33886667, PMCID: PMC8061930, DOI: 10.1371/journal.pone.0250320.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAnalgesics, OpioidCase-Control StudiesCritical CareElectronic Health RecordsFemaleHospital MortalityHumansIntensive Care UnitsLength of StayLongitudinal StudiesMaleMiddle AgedOpioid-Related DisordersPatient ReadmissionRetrospective StudiesRisk FactorsUnited StatesConceptsPrescription opioid useIntensive care unitIntensive care unit admissionAssociation of prescription opioid useOpioid usePrescribed opioidsPatients prescribed chronic opioidsAccurate medication reconciliationRisk of hospital readmissionIncreased risk of hospital readmissionLongitudinal retrospective cohort studyAcademic medical centerCare unitCritical care settingHospital lengthAssociated with increased hospital lengthMedication reconciliationHospital stayTertiary-care academic medical centerCare settingsHospital length of stayRetrospective cohort studyAssociated with increased mortalityLength of stayNon-prescription opioid useSafe Pain Management with Opioids in Posttransplant Patients
Weimer M. Safe Pain Management with Opioids in Posttransplant Patients. 2021, 723-745. DOI: 10.1007/978-3-030-53626-8_45.ChaptersPrescription opioid useOpioid usePain managementLong-term prescription opioid useSevere opioid use disorderHematopoietic cell transplantation patientsSafe pain managementEffective pain managementCell transplantation patientsOpioid use disorderPalliative care providersAnti-inflammatory drugsOpioid prescribingPosttransplant patientsTransplantation patientsMore patientsHCT treatmentPrescription opioidsSafer opioidsTreatment optionsMost oncologistsTransplant providersConcerns of toxicityPotent opioidsCare providers
2020
Serious Falls in Middle‐Aged Veterans: Development and Validation of a Predictive Risk Model
Womack JA, Murphy TE, Bathulapalli H, Smith A, Bates J, Jarad S, Redeker NS, Luther SL, Gill TM, Brandt CA, Justice AC. Serious Falls in Middle‐Aged Veterans: Development and Validation of a Predictive Risk Model. Journal Of The American Geriatrics Society 2020, 68: 2847-2854. PMID: 32860222, PMCID: PMC7744431, DOI: 10.1111/jgs.16773.Peer-Reviewed Original ResearchConceptsMiddle-aged veteransVeterans Health AdministrationOpioid useSerious fallsAlcohol Use Disorders Identification Test-Consumption scoresCategory-free net reclassification improvementIllicit substance use disordersMental health comorbiditiesPrescription opioid useMultivariable logistic regressionNet reclassification improvementSubstance use disordersQuality of lifeHazardous alcohol usePredictive risk modelChronic medicationsCohort studyHealth comorbiditiesNinth RevisionReclassification improvementGeriatric healthInjury codesHazardous alcoholInternational ClassificationUse disordersNational Patterns in Prescription Opioid Use and Misuse Among Cancer Survivors in the United States
Jairam V, Yang DX, Verma V, Yu JB, Park HS. National Patterns in Prescription Opioid Use and Misuse Among Cancer Survivors in the United States. JAMA Network Open 2020, 3: e2013605. PMID: 32804217, PMCID: PMC7431994, DOI: 10.1001/jamanetworkopen.2020.13605.Peer-Reviewed Original ResearchConceptsPrescription opioid usePrescription opioid misuseRecent cancer survivorsOpioid useCancer survivorsAdult cancer survivorsOpioid misuseUse disordersHigher prescription opioid useRecent cancer historyCancer-related painHistory of cancerPopulation-based studyNonmelanoma skin cancerDrug use disordersCross-sectional studyAlcohol use disorderLong-term misusePrescription opioidsCancer historyMAIN OUTCOMESkin cancerDrug useYounger ageCancer
2019
Patterns of Prescription Opioid Use in Women With Endometriosis: Evaluating Prolonged Use, Daily Dose, and Concomitant Use With Benzodiazepines
Lamvu G, Soliman A, Manthena S, Gordon K, Knight J, Taylor H. Patterns of Prescription Opioid Use in Women With Endometriosis: Evaluating Prolonged Use, Daily Dose, and Concomitant Use With Benzodiazepines. Obstetrical & Gynecological Survey 2019, 74: 526-528. DOI: 10.1097/01.ogx.0000579680.37770.00.Peer-Reviewed Original ResearchPrescribing, Prescription Monitoring, and Health Policy
Gordon A, Cochran G, Smid M, Manhapra A, Kertesz S. Prescribing, Prescription Monitoring, and Health Policy. Current Clinical Psychiatry 2019, 223-238. DOI: 10.1007/978-3-030-16257-3_11.Peer-Reviewed Original ResearchOpioid use disorderPrescription drug monitoring programsUse disordersOpioid prescribingOpioid prescriptionsOpioid useOpioid misuseClinical interventionsOpioid-related harmsPrescription opioid useDrug monitoring programsOpioid-related morbidityOpioid addiction epidemicUnited States CentersTreatment of personsPrescribing opioidsChronic painIllicit opioidsCDC guidelinesMedication treatmentPrescription monitoringOpioid epidemicHealth of communitiesAddiction epidemicDisease controlMarijuana Use Is Not Associated With Changes in Opioid Prescriptions or Pain Severity Among People Living With HIV and Chronic Pain.
Merlin JS, Long D, Becker WC, Cachay ER, Christopolous KA, Claborn KR, Crane HM, Edelman E, Lovejoy TI, Mathews WC, Morasco BJ, Napravnik S, OʼCleirigh C, Saag MS, Starrels JL, Gross R, Liebschutz JM. Marijuana Use Is Not Associated With Changes in Opioid Prescriptions or Pain Severity Among People Living With HIV and Chronic Pain. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2019, 81: 231-237. PMID: 30865181, PMCID: PMC6522289, DOI: 10.1097/qai.0000000000001998.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidChronic PainFemaleFollow-Up StudiesHIV InfectionsHumansLogistic ModelsMaleMarijuana SmokingMarijuana UseMedical MarijuanaMiddle AgedMultivariate AnalysisOpioid-Related DisordersPrescription DrugsProspective StudiesSelf ReportSurveys and QuestionnairesTreatment OutcomeUnited StatesConceptsChronic painPain severityIndex visitOpioid useMultivariable binary logistic regression modelMarijuana useDiscontinuation of opioidsImproved pain outcomesMedian pain severityAIDS Research NetworkPrescription opioid usePrescribed opioid useIntegrated Clinical SystemsLogistic regression modelsBinary logistic regression modelOpioid discontinuationOpioid initiationOpioid prescribingOpioid prescriptionsPain outcomesClinical systemsHigher oddsLower oddsPainPLWHPatterns of Prescription Opioid Use in Women With Endometriosis
Lamvu G, Soliman AM, Manthena SR, Gordon K, Knight J, Taylor HS. Patterns of Prescription Opioid Use in Women With Endometriosis. Obstetrics And Gynecology 2019, 133: 1120-1130. PMID: 31135725, PMCID: PMC6553518, DOI: 10.1097/aog.0000000000003267.Peer-Reviewed Original ResearchConceptsOpioid prescriptionsControl groupBenzodiazepine prescriptionsOpioid useEndometriosis patientsCase groupClinformatics DataMart databaseFirst opioid prescriptionMultiple opioid prescriptionsOpioid Prescribing PatternsPrescription opioid useMultivariable regression analysisRelative risk ratiosConcomitant opioidsPrescribing patternsDaily doseMean ageRisk ratioConcomitant useDays' supplyRetrospective analysisInsurance payerΧ statisticEndometriosisPatients
2017
Past‐year Prescription Drug Monitoring Program Opioid Prescriptions and Self‐reported Opioid Use in an Emergency Department Population With Opioid Use Disorder
Hawk K, D'Onofrio G, Fiellin DA, Chawarski MC, O'Connor PG, Owens PH, Pantalon MV, Bernstein SL. Past‐year Prescription Drug Monitoring Program Opioid Prescriptions and Self‐reported Opioid Use in an Emergency Department Population With Opioid Use Disorder. Academic Emergency Medicine 2017, 25: 508-516. PMID: 29165853, PMCID: PMC5963969, DOI: 10.1111/acem.13352.Peer-Reviewed Original ResearchConceptsPrescription drug monitoring programsOpioid use disorderNonmedical prescription opioid usePrescription opioid useAberrant drug-related behaviorsOpioid useOpioid prescriptionsUse disordersED patientsDrug-related behaviorsPrescription recordsState prescription drug monitoring programStatistical Manual IV criteriaNonmedical opioid useRandomized clinical trialsEmergency department assessmentEmergency department populationDrug monitoring programsCharacteristics of participantsUrban EDOpioid dependencePrescription opioidsPDMP dataTreatment trialsClinical historyOpioid Prescribing for Opioid-Naive Patients in Emergency Departments and Other Settings: Characteristics of Prescriptions and Association With Long-Term Use
Jeffery MM, Hooten WM, Hess EP, Meara ER, Ross JS, Henk HJ, Borgundvaag B, Shah ND, Bellolio MF. Opioid Prescribing for Opioid-Naive Patients in Emergency Departments and Other Settings: Characteristics of Prescriptions and Association With Long-Term Use. Annals Of Emergency Medicine 2017, 71: 326-336.e19. PMID: 28967517, PMCID: PMC6295192, DOI: 10.1016/j.annemergmed.2017.08.042.Peer-Reviewed Original ResearchConceptsLong-term opioid useNon-ED settingsOpioid-naive patientsLong-term useOpioid prescriptionsOpioid useCharacteristics of prescriptionsPrescription opioid useLow daily dosesAdministrative claims dataRate of progressionDisabled Medicare beneficiariesMedicare Advantage beneficiariesED prescriptionGuideline concordancePatients 56Patients 58Opioid prescribingCDC guidelinesPrevention guidelinesDaily dosesEmergency departmentCDC recommendationsDays' supplyInclusion criteria
2016
Prevalence and correlates of coprescribing anxiolytic medications with extensive prescription opioid use in Veterans Health Administration patients with metastatic cancer.
Barry DT, Sofuoglu M, Kerns RD, Wiechers IR, Rosenheck RA. Prevalence and correlates of coprescribing anxiolytic medications with extensive prescription opioid use in Veterans Health Administration patients with metastatic cancer. Journal Of Opioid Management 2016, 12: 259-68. PMID: 27575827, DOI: 10.5055/jom.2016.0341.Peer-Reviewed Original ResearchConceptsPrescription opioid useVeterans Health Administration patientsOpioid useMetastatic cancerAnxiolytic medicationMedical indicationsMultivariate analysisMore emergency department visitsNational VHA dataEmergency department visitsPrescription of antidepressantsAnxiolytic prescriptionsOpioid prescriptionsDepartment visitsVHA patientsPsychotropic medicationsFiscal year 2012VHA dataDrug AdministrationMedicationsBipolar disorderCareful monitoringYounger ageAnxiolyticsCancer
2015
VA Patients With High Numbers of Opioid Prescriptions
Petrakis I, Sofuoglu M, Rosenheck R. VA Patients With High Numbers of Opioid Prescriptions. Addictive Disorders & Their Treatment 2015, 14: 167-175. DOI: 10.1097/adt.0000000000000058.Peer-Reviewed Original ResearchHigh opioid useOpioid usePrescription opioid useOpioid prescriptionsOpioid groupOutpatient visitsHigher prescription opioid useVeterans Health Administration usersVeterans Health Administration patientsLogistic regressionDrug abuseMajor public health concernAntidepressant medication prescriptionMedical outpatient visitsOpioid prescription useEmergency room visitsComorbid drug useDrug use disordersForm of painPsychotropic medication usagePublic health concernConcomitant antidepressantsAntidepressant prescriptionsPsychotropic prescriptionsMedical illnessReceipt of Prescription Opioids in a National Sample of Pregnant Veterans Receiving Veterans Health Administration Care
Kroll-Desrosiers AR, Skanderson M, Bastian LA, Brandt CA, Haskell S, Kerns RD, Mattocks KM. Receipt of Prescription Opioids in a National Sample of Pregnant Veterans Receiving Veterans Health Administration Care. Women's Health Issues 2015, 26: 240-246. PMID: 26549242, DOI: 10.1016/j.whi.2015.09.010.Peer-Reviewed Original ResearchConceptsPrescription opioid usePregnancy windowsOpioid prescriptionsPsychiatric diagnosisWomen veteransPregnant veteransOpioid usePrescription opioidsVeterans Health Administration (VHA) careMultivariable logistic regression modelVeterans Health Administration (VHA) servicesNontraumatic joint disordersPain management strategiesHealth-related variablesLogistic regression modelsPhysical health variablesPotential undertreatmentVHA servicesJoint disordersVHA systemOperation Enduring FreedomBack problemsOpioidsHealth variablesNational databaseNon-Medical Prescription Opioid Use and Prescription Opioid Use Disorder: A Review.
Tetrault JM, Butner JL. Non-Medical Prescription Opioid Use and Prescription Opioid Use Disorder: A Review. The Yale Journal Of Biology And Medicine 2015, 88: 227-33. PMID: 26339205, PMCID: PMC4553642.Peer-Reviewed Original ResearchConceptsPrescription opioid use disorderOpioid use disorderNon-medical useUse disordersPrescription opioidsMedical prescription opioid usePrescription opioid useOpioid useTreatment optionsHeroin useEpidemic proportionsPotential progressionDrug useRelated stigmaMedical communityDisordersDevastating consequencesOpioidsUnited StatesReview articleUnanswered questionsNational effortsEpidemiologyProgression
2007
Non-medical use, abuse and dependence on prescription opioids among U.S. adults: Psychiatric, medical and substance use correlates
Becker WC, Sullivan LE, Tetrault JM, Desai RA, Fiellin DA. Non-medical use, abuse and dependence on prescription opioids among U.S. adults: Psychiatric, medical and substance use correlates. Drug And Alcohol Dependence 2007, 94: 38-47. PMID: 18063321, DOI: 10.1016/j.drugalcdep.2007.09.018.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgoraphobiaAlcohol DrinkingChildChronic DiseaseCross-Sectional StudiesDiagnostic and Statistical Manual of Mental DisordersDrug PrescriptionsFactor Analysis, StatisticalFemaleHealth StatusHumansMaleOpioid-Related DisordersPainPanic DisorderPhobic DisordersPrevalenceSurveys and QuestionnairesUnited StatesConceptsAbuse/dependenceNon-medical usePast-year non-medical usePrescription opioidsLower self-rated health statusNon-medical prescription opioid useAgoraphobic symptomsSelf-rated health statusPrescription opioid useSubstance use correlatesCross-sectional surveyRespondents 18 yearsOpioid useMultivariable analysisPrescription medicationsMultivariable associationsOpioidsHealth statusSubstance misuseDrug useMeet criteriaU.S. adultsPoor healthSubstance useUse correlates
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