2024
Prenatal opioid exposure and subsequent risk of neuropsychiatric disorders in children: nationwide birth cohort study in South Korea
Kang J, Kim H, Kim T, Lee H, Kim M, Lee S, Kim M, Koyanagi A, Smith L, Fond G, Boyer L, Rahmati M, Sánchez G, Dragioti E, Cortese S, Shin J, Yon D, Solmi M. Prenatal opioid exposure and subsequent risk of neuropsychiatric disorders in children: nationwide birth cohort study in South Korea. The BMJ 2024, 385: e077664. PMID: 38658035, PMCID: PMC11040462, DOI: 10.1136/bmj-2023-077664.Peer-Reviewed Original ResearchConceptsRisk of neuropsychiatric disordersPrenatal opioid exposureIncreased risk of neuropsychiatric disordersOpioid exposureNeuropsychiatric disordersComparison cohortNational Health Insurance Service of South KoreaOpioid doseNationwide birth cohort studyOpioid useNational Health Insurance ServiceDiagnosis of neuropsychiatric disordersFollow-upBirth cohort dataIncreased riskBirth cohort studyLong-term opioid useDate of deathData of pregnant womenDate of birthSeveral neuropsychiatric disordersMultiple subgroup analysesCohort studyHazard ratioFirst-trimester
2022
Association of inpatient opioid consumption on postoperative outcomes after open posterior spinal fusion for adult spine deformity
Elsamadicy A, Sandhu M, Reeves B, Freedman I, Koo A, Jayaraj C, Hengartner A, Havlik J, Hersh A, Pennington Z, Lo S, Shin J, Mendel E, Sciubba D. Association of inpatient opioid consumption on postoperative outcomes after open posterior spinal fusion for adult spine deformity. Spine Deformity 2022, 11: 439-453. PMID: 36350557, DOI: 10.1007/s43390-022-00609-2.Peer-Reviewed Original ResearchConceptsAdult spinal deformityInpatient opioid useProportion of patientsOpioid useAdverse eventsHigher MMESpinal fusionHospital costsMME consumptionPostoperative outcomesDischarge dispositionHospital admissionRisk factorsMultivariate analysisLong-term opioid useMethodsA retrospective cohort studyHigh opioid useInpatient opioid consumptionOpioid-related disordersPremier Healthcare DatabasePostoperative adverse eventsPostoperative opioid useRetrospective cohort studyHealthcare resource utilizationNon-routine dischargeComplex Persistent Opioid Dependence—an Opioid-induced Chronic Pain Syndrome
Manhapra A. Complex Persistent Opioid Dependence—an Opioid-induced Chronic Pain Syndrome. Current Treatment Options In Oncology 2022, 23: 921-935. PMID: 35435616, DOI: 10.1007/s11864-022-00985-x.Peer-Reviewed Original ResearchConceptsChronic pain syndromeOpioid dependenceOpioid taperingPain syndromeClinical conundrumLong-term opioid useWorse pain controlNon-cancer painOpioid use disorderPoor patient acceptanceSeparate clinical entityAnti-reward systemsOpioid doseOpioid therapyPain providersPain controlOpioid usePain mechanismsClinical entityMore painIatrogenic problemsPatient acceptanceTreatment choiceChronic cancerPain experience
2021
Opioid Prescribing and Use Among Cancer Survivors: A Mapping Review of Observational and Intervention Studies
Check DK, Avecilla R, Mills C, Dinan MA, Kamal AH, Murphy B, Rezk S, Winn A, Oeffinger K. Opioid Prescribing and Use Among Cancer Survivors: A Mapping Review of Observational and Intervention Studies. Journal Of Pain And Symptom Management 2021, 63: e397-e417. PMID: 34748896, DOI: 10.1016/j.jpainsymman.2021.10.015.Peer-Reviewed Original ResearchConceptsOpioid useOpioid prescribingCancer survivorsHigh-risk opioid prescribingLong-term opioid useEvidence synthesisContinued opioid useLate opioid usePersistent opioid useProlonged opioid useChronic opioid useUse of opioidsHigh-risk medicationsOpioid use outcomesFull-text reviewTitles/abstractsOpioid misuseChronic useInclusion criteriaExclusion criteriaIntervention studiesInterventional researchPrescribingProlonged useStudy designEffects of opioid-limiting legislation on postoperative opioid use in shoulder arthroplasty in an epidemic epicenter
Raji Y, Strony J, Trivedi N, Kroneberger E, Yu J, Calcei J, Voos J, Gillespie R. Effects of opioid-limiting legislation on postoperative opioid use in shoulder arthroplasty in an epidemic epicenter. Journal Of Shoulder And Elbow Surgery 2021, 31: 269-275. PMID: 34389494, DOI: 10.1016/j.jse.2021.07.001.Peer-Reviewed Original ResearchConceptsOpioid-naive patientsLong-term opioid usePostoperative periodShoulder arthroplastyOpioid usePostoperative opioidsAcute painOpioid toleranceRisk factorsAcute opioid exposureNarcotic pain medicationOpioid-limiting legislationOpioid-tolerant patientsRx Reporting SystemPostoperative opioid useIndependent risk factorDay of surgeryBinary logistic regression analysisOpioid-related deathsCurrent opioid epidemicLogistic regression analysisRevision shoulder arthroplastyLong-term useCumulative morphineHigher MMEThe protocol of the Application of Economics & Social psychology to improve Opioid Prescribing Safety Trial 1 (AESOPS-1): Electronic health record nudges
Kelley M, Persell S, Linder J, Friedberg M, Meeker D, Fox C, Goldstein N, Knight T, Zein D, Rowe T, Sullivan M, Doctor J. The protocol of the Application of Economics & Social psychology to improve Opioid Prescribing Safety Trial 1 (AESOPS-1): Electronic health record nudges. Contemporary Clinical Trials 2021, 103: 106329. PMID: 33636344, PMCID: PMC8089040, DOI: 10.1016/j.cct.2021.106329.Peer-Reviewed Original ResearchConceptsEHR-based interventionsElectronic health recordsPrimary careLong-term opioid useHigh-risk prescriptionsProportion of patientsPrimary care clinicsTrial 1Mixed-effects regression modelsPersistence of effectsDaily MMEMorphine equivalentsNoncancer painLack of evidenceOpioid prescribingOpioid useSecondary outcomesDaily dosePrimary outcomeCare clinicsIntervention armPrescribing SafetyClinical guidelinesControl armIntervention period
2020
Identifying Multisite Chronic Pain with Electronic Health Records Data
Von Korff M, DeBar LL, Deyo RA, Mayhew M, Kerns RD, Goulet JL, Brandt C. Identifying Multisite Chronic Pain with Electronic Health Records Data. Pain Medicine 2020, 21: 3387-3392. PMID: 32918481, PMCID: PMC7770230, DOI: 10.1093/pm/pnaa295.Peer-Reviewed Original ResearchConceptsMultisite chronic painElectronic health care dataChronic painChronic pain impactElectronic health recordsHealth care dataCare dataPain impactHealth recordsLong-term opioid useCommon chronic pain conditionsPain-related disabilityChronic pain conditionsKaiser Permanente NorthwestElectronic health record dataHealth record dataPositive predictive valueOpioid usePain severityPain conditionsDepressive symptomsPainPredictive valueEpidemiological researchRecord dataBrief educational video plus telecare to enhance recovery for older emergency department patients with acute musculoskeletal pain: study protocol for the BETTER randomized controlled trial
Platts-Mills TF, McLean SA, Weinberger M, Stearns SC, Bush M, Teresi BB, Hurka-Richardson K, Kroenke K, Kerns RD, Weaver MA, Keefe FJ. Brief educational video plus telecare to enhance recovery for older emergency department patients with acute musculoskeletal pain: study protocol for the BETTER randomized controlled trial. Trials 2020, 21: 615. PMID: 32631400, PMCID: PMC7336469, DOI: 10.1186/s13063-020-04552-3.Peer-Reviewed Original ResearchConceptsChronic musculoskeletal painMusculoskeletal painEmergency departmentUsual careOpioid useChronic painOlder adultsAnalgesic-related side effectsLong-term opioid useOlder emergency department (ED) patientsAcute musculoskeletal painEmergency department patientsCause of disabilityPublic health priorityBrief educational videoDiscussionThis trialPain severitySecondary outcomesSixty patientsDepartment patientsPrimary outcomeHealthcare utilizationStudy enrollmentPhysical functionStudy protocol
2019
Rates of Physician Coprescribing of Opioids and Benzodiazepines After the Release of the Centers for Disease Control and Prevention Guidelines in 2016
Jeffery MM, Hooten WM, Jena AB, Ross JS, Shah ND, Karaca-Mandic P. Rates of Physician Coprescribing of Opioids and Benzodiazepines After the Release of the Centers for Disease Control and Prevention Guidelines in 2016. JAMA Network Open 2019, 2: e198325. PMID: 31373650, PMCID: PMC6681551, DOI: 10.1001/jamanetworkopen.2019.8325.Peer-Reviewed Original ResearchConceptsLong-term opioid useOpioid usePrevention guidelinesMA groupDisease controlCoprescription of opioidsRetrospective cohort studyUS national databaseInsurance groupsMedicare AdvantageSickle cell diseaseGuideline releasePrescription daysPrescribed opioidsBenzodiazepine prescriptionsCohort studyMedian agePharmacy claimsChronic painCell diseaseCoprescriptionMAIN OUTCOMESame clinicianClaims dataHospice carePain management in trauma patients affected by the opioid epidemic: A narrative review.
Karamchandani K, Klick JC, Linskey Dougherty M, Bonavia A, Allen SR, Carr ZJ. Pain management in trauma patients affected by the opioid epidemic: A narrative review. Journal Of Trauma And Acute Care Surgery 2019, 87: 430-439. PMID: 30939572, DOI: 10.1097/ta.0000000000002292.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsOpioid useTrauma patientsNarrative reviewPain managementChronic painOpioid epidemicTraumatic injuryLong-term opioid useAcute opioid withdrawalPersistent opioid useChronic opioid useOpioid use disorderAnalgesic regimensOpioid withdrawalAcute painHospital admissionOpioid dependencePatient populationUse disordersPatientsInadequate treatmentPainAverage riskMultimodal approachInjury
2018
Dual Use of Department of Veterans Affairs and Medicare Benefits on High‐Risk Opioid Prescriptions in Veterans Aged 65 Years and Older: Insights from the VA Musculoskeletal Disorders Cohort
Chui PW, Bastian LA, DeRycke E, Brandt CA, Becker WC, Goulet JL. Dual Use of Department of Veterans Affairs and Medicare Benefits on High‐Risk Opioid Prescriptions in Veterans Aged 65 Years and Older: Insights from the VA Musculoskeletal Disorders Cohort. Health Services Research 2018, 53: 5402-5418. PMID: 30298672, PMCID: PMC6235820, DOI: 10.1111/1475-6773.13060.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationOpioid prescriptionsHigh-risk opioid prescriptionsLong-term opioid therapyLong-term opioid useMultivariable logistic regressionMusculoskeletal disorder diagnosisMSD cohortOpioid therapyClinical characteristicsOpioid useVHA dataRetrospective analysisHealth AdministrationNational MedicareDisorder cohortDual useLogistic regressionDisorder diagnosisMedicareMedicare benefitsVeteransPrescriptionCohortAssociationPain Management in Patients with Chronic Wounds
Mervis J, Federman D. Pain Management in Patients with Chronic Wounds. Current Dermatology Reports 2018, 7: 136-146. DOI: 10.1007/s13671-018-0220-2.Peer-Reviewed Original ResearchNon-pharmacologic therapiesPain managementChronic painNon-pharmacologic pain managementLong-term opioid useChronic woundsNew CDC guidelinesEffective pain managementOngoing opioid crisisQuality of lifeExperience of painNon-healing woundsComplex biopsychosocial processAdjuvant therapyOpioid useSignificant painCDC guidelinesRecent FindingsAsPainOpioid crisisEvidence-based frameworkTherapyWoundsMultimodal approachPatients
2017
Opioid Prescribing for Opioid-Naive Patients in Emergency Departments and Other Settings: Characteristics of Prescriptions and Association With Long-Term Use
Jeffery MM, Hooten WM, Hess EP, Meara ER, Ross JS, Henk HJ, Borgundvaag B, Shah ND, Bellolio MF. Opioid Prescribing for Opioid-Naive Patients in Emergency Departments and Other Settings: Characteristics of Prescriptions and Association With Long-Term Use. Annals Of Emergency Medicine 2017, 71: 326-336.e19. PMID: 28967517, PMCID: PMC6295192, DOI: 10.1016/j.annemergmed.2017.08.042.Peer-Reviewed Original ResearchConceptsLong-term opioid useNon-ED settingsOpioid-naive patientsLong-term useOpioid prescriptionsOpioid useCharacteristics of prescriptionsPrescription opioid useLow daily dosesAdministrative claims dataRate of progressionDisabled Medicare beneficiariesMedicare Advantage beneficiariesED prescriptionGuideline concordancePatients 56Patients 58Opioid prescribingCDC guidelinesPrevention guidelinesDaily dosesEmergency departmentCDC recommendationsDays' supplyInclusion criteria
2015
Prevalence and correlates of co-prescribing psychotropic medications with long-term opioid use nationally in the Veterans Health Administration
Barry DT, Sofuoglu M, Kerns RD, Wiechers IR, Rosenheck RA. Prevalence and correlates of co-prescribing psychotropic medications with long-term opioid use nationally in the Veterans Health Administration. Psychiatry Research 2015, 227: 324-332. PMID: 25863822, DOI: 10.1016/j.psychres.2015.03.006.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Anxiety AgentsAntidepressive AgentsDrug PrescriptionsFemaleHumansHypnotics and SedativesMaleMental DisordersOpioid-Related DisordersPrevalencePsychotropic DrugsSleep Initiation and Maintenance DisordersUnited StatesUnited States Department of Veterans AffairsVeteransVeterans HealthConceptsMental health clinicsPsychotropic medicationsOpioid prescriptionsHealth clinicsMedical indicationsAnxiolytics/sedatives/hypnoticsLong-term opioid useSpecialty mental health clinicsService use correlatesRelated adverse eventsSedative/hypnoticsVeterans Health AdministrationMental health treatmentAdverse eventsOpioid useHarmful side effectsFiscal year 2012More psychotropicsSide effectsPsychiatric diagnosisHealth treatmentMedicationsHealth AdministrationPsychotropicsAnxiety disorders
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