2025
Patient-Reported Outcomes From Males Regarding Germline Testing for Prostate Cancer: Results From the PROGRESS Registry
Loeb S, Keith S, Gross L, Hartman R, Beer T, Brierley K, Cheng H, Couvillon A, Dicker A, Friedman S, Gomella L, Karsh L, Kelly W, Lallas C, Leader A, Mann M, Mark J, Mille P, Paller C, Rana H, Sokolova A, Trabulsi E, Whang Y, Giri V. Patient-Reported Outcomes From Males Regarding Germline Testing for Prostate Cancer: Results From the PROGRESS Registry. JCO Precision Oncology 2025, 9: e2500571. PMID: 40971753, PMCID: PMC12462908, DOI: 10.1200/po-25-00571.Peer-Reviewed Original ResearchConceptsPatient-reported outcomesGermline testingDecisional conflictPretest counselingPROGRESS registryCancer genetics knowledgeHereditary cancer riskFamily cancer historyDecisional conflict scoresHigher decisional conflictCovariate-adjusted modelsProstate cancerGenetic careCare deliveryCancer screeningPatient experienceCancer historyNon-HispanicCancer riskParticipant characteristicsBenefit scoreProstate cancer historyLinear regression modelsMultiple linear regression modelEnglish speaking malesEvaluating survivorship-related communication gaps to develop a community health worker-led intervention for Hispanic/Latino young adult childhood cancer survivors and their families.
Smith S, Martin-Villa B, Pu K, Lewinsohn R, Smith M, Boynton H, Schapira L. Evaluating survivorship-related communication gaps to develop a community health worker-led intervention for Hispanic/Latino young adult childhood cancer survivors and their families. Journal Of Clinical Oncology 2025, 43: 10072-10072. DOI: 10.1200/jco.2025.43.16_suppl.10072.Peer-Reviewed Original ResearchYoung adult childhood cancer survivorsAdult childhood cancer survivorsCommunity-based organizationsFamily-centered communicationChildhood cancer survivorsCancer survivorsCommunity health worker-led interventionCommunity-based organization staffCommunication barriersCommunity-clinical partnershipsSurvivorship clinic visitCancer survivorship careCommunity health workersSurvivorship care needsIntervention design processPediatric oncology clinicYears post-diagnosisSurvivorship careCare needsDedoose softwareHealth workersCancer historyEmotional burdenClinical encountersOncology clinicGermline testing for prostate cancer: current state and opportunities for enhanced access
Loeb S, Vadaparampil S, Giri V. Germline testing for prostate cancer: current state and opportunities for enhanced access. EBioMedicine 2025, 116: 105705. PMID: 40398351, PMCID: PMC12148599, DOI: 10.1016/j.ebiom.2025.105705.Peer-Reviewed Original ResearchConceptsGermline testingProstate cancerHereditary cancer assessmentFamily cancer historyHereditary cancer syndromesGenetic counseling programsCancer-related outcomesProstate cancer careCancer historyCancer syndromesDelivery modelsAdvanced prostate cancerMetastatic prostate cancerHigh-risk featuresImplementation strategiesBenefits of GTCounseling programCancer assessmentEnhanced accessTested patientsDisparitiesPCA-relatedPatientsGuidelinesProstate
2024
Brief Report: Should a prior cancer history be reevaluated as an exclusion for clinical trial participation?
Ayoade O, Canavan M, Caturegli G, Boffa D. Brief Report: Should a prior cancer history be reevaluated as an exclusion for clinical trial participation? Lung Cancer 2024, 198: 108032. PMID: 39561624, DOI: 10.1016/j.lungcan.2024.108032.Peer-Reviewed Original ResearchNon-small cell lung cancerAssociated with superior survivalSuperior survivalStage III NSCLC patientsCancer historyIII NSCLC patientsReceipt of immunotherapyNational Cancer DatabaseRegimens of chemotherapyStage IV patientsAnalyze overall survivalCell lung cancerKaplan Meier analysisStage III andCox proportional hazards modelsProportional hazards modelInnovative treatment approachesInfluence patient outcomesNSCLC patientsIV patientsOverall survivalImmunotherapy trialsCancer DatabaseMeier analysisNon-smallEvaluating differences in receipt of survivorship care plan among cancer survivors with and without disabilities
Sarkar S, Zaidi M, Raziani Y, Poghosyan H. Evaluating differences in receipt of survivorship care plan among cancer survivors with and without disabilities. Supportive Care In Cancer 2024, 32: 637. PMID: 39235704, DOI: 10.1007/s00520-024-08796-6.Peer-Reviewed Original ResearchConceptsSurvivorship care plan receiptSurvivorship care plansDisability countCancer survivorsCare planningReceipt of survivorship care plansMethodsWe analyzed cross-sectional dataBehavioral Risk Factor Surveillance SystemFollow-up care instructionsRisk Factor Surveillance SystemSelf-reported cancer historyTreatment adherenceSelf-care difficultiesMultinomial multivariable logistic regressionIndependent living difficultiesPromote treatment adherenceMultivariate logistic regressionCancer survivorshipCross-sectional dataTreatment summarySelf-CareCancer historyNo disabilityLiving difficultiesResultsThe sample
2023
The role of financial security in loneliness or sadness among Medicare-enrolled cancer survivors during the COVID-19 pandemic
Sarkar S, Arakelyan S, Choa E, Poghosyan H. The role of financial security in loneliness or sadness among Medicare-enrolled cancer survivors during the COVID-19 pandemic. Journal Of Geriatric Oncology 2023, 14: 101507. PMID: 37216846, PMCID: PMC10123351, DOI: 10.1016/j.jgo.2023.101507.Peer-Reviewed Original ResearchConceptsFeelings of lonelinessCancer survivorsSurge of COVID-19Increased feelings of lonelinessCancer historyMedicare beneficiariesSelf-reported cancer historyIncreasing rates of lonelinessWinter surgeIncreased feelingsRates of lonelinessCOVID-19 pandemicCross-sectional dataMultivariate logistic regression analysisLogistic regression analysisPopulation-basedFinancial securityCOVID-19MedicareSocioeconomic vulnerabilityLonelinessStudy cohortSurvivorsRegression analysisCross-tabulation analysisPancoronary plaque characteristics and clinical outcomes in acute coronary syndrome patients with cancer history
Wang C, Tian X, Feng X, Demuyakor A, Hu S, Wang Y, Li L, Cui L, Dong F, Dai J, Lei F, Xu Y, Du Z, Shi M, Liu J, Xing L, E M. Pancoronary plaque characteristics and clinical outcomes in acute coronary syndrome patients with cancer history. Atherosclerosis 2023, 378: 117118. PMID: 37127496, DOI: 10.1016/j.atherosclerosis.2023.03.023.Peer-Reviewed Original ResearchConceptsAcute coronary syndrome patientsAcute coronary syndromeMaximum lipid arcOptical coherence tomographyThin-cap fibroatheromaCancer historyFibrous cap thicknessPercutaneous coronary interventionNonculprit lesionsLipid arcPrevalence of high-risk plaqueIncidence of thin-cap fibroatheromaCulprit lesionPrevalence of acute coronary syndromeHigh-risk plaque featuresHigher incidencePlaque characteristicsTime of percutaneous coronary interventionAssociated with high mortalityCharacteristics of coronary plaquesLipid indicesAbsence of cancer historyCoronary syndrome patientsNon-culprit lesionsIncidence of calcification
2022
COVID-19 Vaccine Hesitancy Among Medicare Beneficiaries with and Without Cancer History: A US Population-based Study
Poghosyan H, Ni Z, Vlahov D, Nelson L, Nam S. COVID-19 Vaccine Hesitancy Among Medicare Beneficiaries with and Without Cancer History: A US Population-based Study. Journal Of Community Health 2022, 48: 315-324. PMID: 36427111, PMCID: PMC9702715, DOI: 10.1007/s10900-022-01174-5.Peer-Reviewed Original ResearchConceptsCOVID-19 vaccineCOVID-19 vaccine hesitancyCancer historyVaccine hesitancyMedicare beneficiariesVaccine uptakeMultivariable logistic regression modelCOVID-19 vaccine uptakeVaccine hesitancy ratesOngoing health conditionsCOVID-19 vaccinationLogistic regression modelsComplex survey designLack of recommendationsHesitancy ratesVaccine benefitsCommon reasonHesitant individualsSide effectsUS populationVaccineHealth conditionsCross-sectional dataHesitancyRegression modelsAttitudes, Perceptions, and Use of Cancer-based Genetic Testing Among Healthy U.S. Adults and Those With Prostate or Breast/Ovarian Cancer
Thakker S, Loeb S, Giri V, Bjurlin M, Matulewicz R. Attitudes, Perceptions, and Use of Cancer-based Genetic Testing Among Healthy U.S. Adults and Those With Prostate or Breast/Ovarian Cancer. Urology Practice 2022, 10: 26-32. PMID: 37103438, DOI: 10.1097/upj.0000000000000352.Peer-Reviewed Original ResearchConceptsBreast/ovarian cancerHealth Information National Trends Survey 5Ovarian cancerProstate cancerGenetic testingCancer historyGenetic testing informationHistory of cancerHealthy U.S. adultsExposure of interestHealth care professionalsSelf-reported ratesEvidence-based informationPatient populationRepresentative sampleCare professionalsPatientsSecondary objectiveU.S. adultsCancerCommon sourceCategorical variablesSurvey 5Lack of awarenessCycle 4Racial and Ethnic Variation in COVID-19 Vaccination Uptake Among Medicare Beneficiaries with Cancer History
Poghosyan H, Dinan MA, Tamamyan G, Nelson L, Jeon S. Racial and Ethnic Variation in COVID-19 Vaccination Uptake Among Medicare Beneficiaries with Cancer History. Journal Of Racial And Ethnic Health Disparities 2022, 10: 2354-2362. PMID: 36149576, PMCID: PMC9510246, DOI: 10.1007/s40615-022-01415-2.Peer-Reviewed Original ResearchConceptsNon-Hispanic white beneficiariesCancer historyVaccine doseMedicare beneficiariesWhite beneficiariesVaccine uptakeHispanic beneficiariesMultivariable logistic regression analysisCOVID-19 vaccination uptakeSelf-reported cancer historyCOVID-19 vaccine uptakeSelf-reported receiptCOVID-19 vaccination ratesLogistic regression analysisNon-Hispanic blacksSelf-reported raceUnvaccinated beneficiariesVaccination uptakeVaccine dosesVaccination ratesVaccine confidenceVaccine availabilitySupplement surveyCross-sectional dataEthnic variationEvaluation of social connectedness, loneliness, and anxiety among cancer survivors during the 2020-2021 winter surge of COVID-19 pandemic.
Poghosyan H, Yu J. Evaluation of social connectedness, loneliness, and anxiety among cancer survivors during the 2020-2021 winter surge of COVID-19 pandemic. Journal Of Clinical Oncology 2022, 40: 12061-12061. DOI: 10.1200/jco.2022.40.16_suppl.12061.Peer-Reviewed Original ResearchDecreased social connectednessCancer survivorsSocial connectednessIncreased feelingsSelf-reported socio-demographicSelf-reported cancer historySelf-ReportWinter surgeComplex survey designSelf-reported raceCross-sectional studyMultivariate logistic regressionSurge of COVID-19Levels of stressCancer historyHealth careMental healthMedicare beneficiariesHigher oddsSocio-DemographicMetropolitan residentsLogistic regressionPhone surveyLimited researchSurvey design
2021
Emergency department visits for radiation cystitis among patients with a prostate cancer history
Lee V, An Y, Park HS, Yu JB, Kim SP, Jairam V. Emergency department visits for radiation cystitis among patients with a prostate cancer history. BJU International 2021, 130: 208-216. PMID: 34806813, DOI: 10.1111/bju.15650.Peer-Reviewed Original ResearchConceptsProstate cancer historyRadiation cystitisED visitsInvasive proceduresCancer historyProstate cancerRadiation therapyHigher median total chargesNationwide Emergency Department SampleEmergency department visitsEmergency Department SampleMedian total chargesPrior prostatectomyUrinary retentionBlood transfusionDepartment visitsMedian lengthEmergency departmentNational burdenSecondary diagnosisPrimary diagnosisHospital characteristicsPotential complicationsEffective modalityInvasive measuresAnxiety and depression associate with heightened risk of deep venous thrombosis: mediation through neural pathways
Mezue K, Osborne M, Abohashem S, Zureigat H, Abbasi T, Gharios C, Cardeiro A, Akuffo E, Pitman R, Shin L, Jaffer F, Rosovsky R, Tawakol A. Anxiety and depression associate with heightened risk of deep venous thrombosis: mediation through neural pathways. European Heart Journal 2021, 42: ehab724.2045. DOI: 10.1093/eurheartj/ehab724.2045.Peer-Reviewed Original ResearchAnxiety disordersInternational Classification of DiseasesRisk of deep venous thrombosisDeep venous thrombosisNeural activityNeural pathwaysFollow-up periodMass General Brigham BiobankIncreased riskClassification of diseasesBiobank enrollmentVenous thrombosisIncreased risk of DVTCancer historyIncreased risk of deep venous thrombosisHealth informationMediation analysisDeep venous thrombosis riskInternational ClassificationMedian follow-up periodPotential confoundersAnxietyLower extremity deep venous thrombosisExtremity deep venous thrombosisDepressionImpact of Cancer History on Outcomes Among Hospitalized Patients with COVID-19
Klein IA, Rosenberg SM, Reynolds KL, Zubiri L, Rosovsky R, Piper-Vallillo A, Gao X, Boland G, Bardia A, Gaither R, Freeman H, Kirkner GJ, Rhee C, Klompas M, Baker MA, Wadleigh M, Winer EP, Kotton CN, Partridge AH. Impact of Cancer History on Outcomes Among Hospitalized Patients with COVID-19. The Oncologist 2021, 26: 685-693. PMID: 33856099, PMCID: PMC8251362, DOI: 10.1002/onco.13794.Peer-Reviewed Original ResearchConceptsHistory of cancerIndependent risk factorDeath/hospiceSevere COVID-19Survivors of cancerHospitalized patientsCancer historyActive cancerRisk factorsCurrent cancer diagnosisCancer diagnosisCOVID-19Laboratory-confirmed COVID-19Intensive care unit admissionCare unit admissionOdds of intubationCancer-directed therapySystemic cancer therapyStandard anticancer therapiesRecent cancer treatmentUnit admissionHospice admissionMedian ageMedian timeMultivariable analysisPhenotypic Differences in Juvenile Polyposis Syndrome With or Without a Disease-causing SMAD4/BMPR1A Variant
MacFarland SP, Ebrahimzadeh JE, Zelley K, Begum L, Bass LM, Brand RE, Dudley B, Fishman DS, Ganzak A, Karloski E, Latham A, Llor X, Plon S, Riordan MK, Scollon SR, Stadler ZK, Syngal S, Ukaegbu C, Weiss JM, Yurgelun MB, Brodeur GM, Mamula P, Katona BW. Phenotypic Differences in Juvenile Polyposis Syndrome With or Without a Disease-causing SMAD4/BMPR1A Variant. Cancer Prevention Research 2021, 14: 215-222. PMID: 33097490, PMCID: PMC8557953, DOI: 10.1158/1940-6207.capr-20-0348.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedBone Morphogenetic Protein Receptors, Type IChildChild, PreschoolColectomyColonoscopyFemaleFollow-Up StudiesGerm-Line MutationHumansIntestinal PolyposisMaleMedical History TakingMiddle AgedNeoplastic Syndromes, HereditaryPractice Guidelines as TopicPrecision MedicineSmad4 ProteinWatchful WaitingYoung AdultConceptsJuvenile polyposis syndromePolyposis syndromeFamily historyDisease-causing variantsCancer riskGermline disease-causing variantsGastrointestinal cancer predisposition syndromesUpper gastrointestinal polypsHamartomatous polyposis syndromesCancer predisposition syndromeLifelong surveillanceAdult centersDuodenal polypsGastrointestinal cancerCancer historySubgroup analysisIndividualized managementLower riskGastrointestinal polypsPredisposition syndromeSyndromeYounger ageDistinct phenotypic differencesLower likelihoodGastrectomyDifferences in Uptake of Low-Dose CT Scan for Lung Cancer among White and Black Adult Smokers in the United States-2017.
Poghosyan H, Fortin D, Moen E, Quigley K, Young G. Differences in Uptake of Low-Dose CT Scan for Lung Cancer among White and Black Adult Smokers in the United States-2017. Journal Of Health Care For The Poor And Underserved 2021, 32: 165-178. PMID: 33678689, DOI: 10.1353/hpu.2021.0016.Peer-Reviewed Original ResearchConceptsLow-dose computerized tomographyLDCT scansLung Cancer Screening ModuleBehavioral Risk Factor Surveillance SystemAdult smokersRisk Factor Surveillance SystemStudy racial/ethnic differencesPack-year smoking historyMultivariate logistic regressionCross-sectional dataHigh blood pressureLung cancerCancer historyRacial/Ethnic DifferencesLow-dose CT scansPack-yearsHealth insuranceLogistic regressionRacial differencesSurveillance systemScreening moduleSmoking historyCT scanOddsLung disease
2020
Cardiovascular Care of the Oncology Patient During COVID-19: An Expert Consensus Document From the ACC Cardio-Oncology and Imaging Councils
Baldassarre LA, Yang EH, Cheng RK, DeCara JM, Dent S, Liu JE, Rudski LG, Strom JB, Thavendiranathan P, Barac A, Zaha VG, Bucciarelli-Ducci C, Ellahham S, Deswal A, Lenneman C, Villarraga HR, Blaes AH, Ismail-Khan R, Ky B, Leja MJ, Scherrer-Crosbie M. Cardiovascular Care of the Oncology Patient During COVID-19: An Expert Consensus Document From the ACC Cardio-Oncology and Imaging Councils. Journal Of The National Cancer Institute 2020, 113: 513-522. PMID: 33179744, PMCID: PMC7717327, DOI: 10.1093/jnci/djaa177.Peer-Reviewed Original ResearchConceptsCardio-OncologyCardiovascular careCOVID-19Cardio-oncology patientsPrior cancer historyExpert consensus statementCoronavirus disease 2019 (COVID-19) pandemicExpert consensus documentRisk of infectionDisease 2019 pandemicCardiotoxicity surveillanceCardiovascular complicationsPericardial involvementLethal complicationCardiac dysfunctionOncology patientsRisk of exposureCancer historyCancer patientsCardiovascular diseaseConsensus statementAmerican CollegeCardiovascular treatmentConsensus documentPatientsNational Patterns in Prescription Opioid Use and Misuse Among Cancer Survivors in the United States
Jairam V, Yang DX, Verma V, Yu JB, Park HS. National Patterns in Prescription Opioid Use and Misuse Among Cancer Survivors in the United States. JAMA Network Open 2020, 3: e2013605. PMID: 32804217, PMCID: PMC7431994, DOI: 10.1001/jamanetworkopen.2020.13605.Peer-Reviewed Original ResearchConceptsPrescription opioid usePrescription opioid misuseRecent cancer survivorsOpioid useCancer survivorsAdult cancer survivorsOpioid misuseUse disordersHigher prescription opioid useRecent cancer historyCancer-related painHistory of cancerPopulation-based studyNonmelanoma skin cancerDrug use disordersCross-sectional studyAlcohol use disorderLong-term misusePrescription opioidsCancer historyMAIN OUTCOMESkin cancerDrug useYounger ageCancerThe association of health status and cancer history of young adult survivors of childhood cancer with parental accompaniment to survivorship clinic visits
Janardan SK, Balsamo LM, Ross WL, Rotatori J, Auerbach C, Kadan-Lottick NS. The association of health status and cancer history of young adult survivors of childhood cancer with parental accompaniment to survivorship clinic visits. Supportive Care In Cancer 2020, 29: 1565-1573. PMID: 32734393, PMCID: PMC8105083, DOI: 10.1007/s00520-020-05653-0.Peer-Reviewed Original ResearchConceptsYoung adult survivorsChildhood cancerLate effectsSurveillance testsHealth complexityHealth statusAdult survivorsCentral nervous system tumour diagnosisSurvivors' health statusChildhood cancer survivorsCancer survivorship clinicMedical late effectsCross-sectional studyClinic visitsSurvivorship clinicMultivariable analysisCancer survivorsParental accompanimentCancer historyClinical evaluationFirst visitNeurocognitive impairmentPatientsClinicSurvivors
2019
Patterns of pain medication use associated with reported pain interference in older adults with and without cancer
Davidoff AJ, Canavan ME, Feder S, Wang S, Sheinfeld E, Kent EE, Kapo J, Presley CJ. Patterns of pain medication use associated with reported pain interference in older adults with and without cancer. Supportive Care In Cancer 2019, 28: 3061-3072. PMID: 31637515, PMCID: PMC7338979, DOI: 10.1007/s00520-019-05074-8.Peer-Reviewed Original ResearchConceptsSevere pain interferencePrescription pain medicationPain interferencePain medicationOlder adultsMedication receiptMedicare Part D prescription claimsNon-steroidal anti-inflammatory drugsModerate pain interferenceReceipt of opioidsPain medication useManagement of painHalf of adultsAnti-inflammatory drugsPart D low-income subsidyLow-income subsidyOpioid prescribingOpioid prescriptionsSevere painMedication usePain managementSurveillance EpidemiologyPrescription claimsCancer historyChronic conditions
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