2024
Multiomic Network Analysis Identifies Dysregulated Neurobiological Pathways in Opioid Addiction
Sullivan K, Kainer D, Lane M, Cashman M, Miller J, Garvin M, Townsend A, Quach B, Willis C, Kruse P, Gaddis N, Mathur R, Corradin O, Maher B, Scacheri P, Sanchez-Roige S, Palmer A, Troiani V, Chesler E, Kember R, Kranzler H, Justice A, Xu K, Aouizerat B, Hancock D, Johnson E, Jacobson D, Program V. Multiomic Network Analysis Identifies Dysregulated Neurobiological Pathways in Opioid Addiction. Biological Psychiatry 2024, 98: 11-22. PMID: 39615775, PMCID: PMC12119972, DOI: 10.1016/j.biopsych.2024.11.013.Peer-Reviewed Original ResearchGenome-wide association studiesSubstance use disordersOpioid use disorderAddiction treatmentOpioid addictionDorsolateral prefrontal cortexOpioid addiction treatmentMulti-omics network analysisPrefrontal cortexPrescription opioid misuseSystems biology approachNeurobiological pathwaysOpioid overdose victimsUse disorderOverdose victimsAddictionAssociation studiesEpigenetic dataOpioid misuseOpioidDLPFCERK pathwayBiology approachMulti-OmicsGene targeting
2020
National Patterns in Prescription Opioid Use and Misuse Among Cancer Survivors in the United States
Jairam V, Yang DX, Verma V, Yu JB, Park HS. National Patterns in Prescription Opioid Use and Misuse Among Cancer Survivors in the United States. JAMA Network Open 2020, 3: e2013605. PMID: 32804217, PMCID: PMC7431994, DOI: 10.1001/jamanetworkopen.2020.13605.Peer-Reviewed Original ResearchConceptsPrescription opioid usePrescription opioid misuseRecent cancer survivorsOpioid useCancer survivorsAdult cancer survivorsOpioid misuseUse disordersHigher prescription opioid useRecent cancer historyCancer-related painHistory of cancerPopulation-based studyNonmelanoma skin cancerDrug use disordersCross-sectional studyAlcohol use disorderLong-term misusePrescription opioidsCancer historyMAIN OUTCOMESkin cancerDrug useYounger ageCancer
2019
Prescription opioid misuse among heterosexual versus lesbian, gay, and bisexual military veterans: Evidence from the 2015-2017 national survey of drug use and health
Anderson-Carpenter K, Rutledge J, Mitchell K. Prescription opioid misuse among heterosexual versus lesbian, gay, and bisexual military veterans: Evidence from the 2015-2017 national survey of drug use and health. Drug And Alcohol Dependence 2019, 207: 107794. PMID: 31864165, DOI: 10.1016/j.drugalcdep.2019.107794.Peer-Reviewed Original ResearchConceptsPrescription opioid misuseNational surveyNational survey of drug useMilitary veteransSurvey of drug useDrug Use and HealthLifetime prescription opioid misuseOpioid misuseRisk of prescription opioid misuseBisexual veteransHeterosexual peersImprove health outcomesRisk of opioid misuseWomen veteransSubstance useLifetime oddsNationally representative estimatesU.S. military veteransDrug useHealth outcomesUnited StatesMultivariate logistic regression analysisOlder veteransLogistic regression analysisSociodemographic characteristics
2013
Error and Bias in the Evaluation of Prescription Opioid Misuse: Should the FDA Regulate Clinical Assessment Tools?
Meltzer E, Hall W, Fins J. Error and Bias in the Evaluation of Prescription Opioid Misuse: Should the FDA Regulate Clinical Assessment Tools? Pain Medicine 2013, 14: 982-987. PMID: 23594383, DOI: 10.1111/pme.12099.Peer-Reviewed Original ResearchConceptsFood and Drug AdministrationClinical assessment toolScreening toolAssessment toolOpioid-related aberrant behaviorsAberrant medication-related behaviorsOpioid-related risksChronic opioid therapyPrescription opioid misusePredictive of addictionMedication-related behaviorsOpioid therapyPain medicationStandardized questionnaireOpioid misuseIdentified patientsAt-riskDrug AdministrationDiagnose illnessAddictive disordersPatientsAberrant behaviorScreeningComprehensive planAddiction
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