2025
Acquired angio-oedema as a mimicker of drug allergy
Liao J, Mathew M, Elmansy L, Hsu F, Belmont A. Acquired angio-oedema as a mimicker of drug allergy. BMJ Case Reports 2025, 18: e265525. PMID: 40389294, DOI: 10.1136/bcr-2025-265525.Peer-Reviewed Original ResearchConceptsAcquired angio-oedemaAngio-oedemaSplenic marginal zone lymphomaBradykinin-mediated diseaseSevere angio-oedemaMarginal zone lymphomaLocal anaesthetic allergyDrug allergy testingDental proceduresAcute therapyCase reportClinical historyDrug allergyAllergy centresAllergy testingClinical pearlsClinical diagnosisEmergency departmentMultiple physiciansDiagnosisAllergyLymphomaTherapyPatientsAetiologyVariability of the posteromedial meniscocapsular junction of the knee on MRI: Pitfall to imaging diagnosis of ramp lesions
Porrino J, Marten E, Richardson M, Moran J, Shreve C, Lee H, Haims A. Variability of the posteromedial meniscocapsular junction of the knee on MRI: Pitfall to imaging diagnosis of ramp lesions. European Journal Of Radiology Open 2025, 14: 100647. PMID: 40585065, PMCID: PMC12206330, DOI: 10.1016/j.ejro.2025.100647.Peer-Reviewed Original ResearchRamp lesionsMeniscocapsular junctionMedial meniscusAnterior cruciate ligament deficiencyPatient ageRoutine MRIMRI findingsCruciate ligament deficiencyClinical historyClinical indicationsACL insufficiencyFemale sexAncillary findingsKnee MRILesionsNormal appearancePosteromedial joint capsuleMRIImaging diagnosisKnee studiesLigament deficiencyGeneral populationPosteromedial capsuleKneeJoint capsuleAn international perspective on the future of systemic sclerosis research
Abraham D, Black C, Denton C, Distler J, Domsic R, Feghali-Bostwick C, Gourh P, Hinchcliff M, Kolling F, Kuwana M, Lafyatis R, Landegren U, Mahoney J, Martin J, Matucci-Cerinic M, McMahan Z, Mora A, Mouthon L, Rabinovitch M, Rojas M, Rubin K, Trojanowska M, Varga J, Whitfield M, Gabrielli A, Krieg T. An international perspective on the future of systemic sclerosis research. Nature Reviews Rheumatology 2025, 21: 174-187. PMID: 39953141, DOI: 10.1038/s41584-024-01217-2.Peer-Reviewed Original ResearchConceptsSystemic sclerosisSystemic sclerosis researchHistory of systemic sclerosisInnovative clinical trial designsSystemic autoimmune diseaseEarly pathogenetic eventClinical trial designCollaborative global effortAutoimmune phenomenaImprove patient outcomesDisease activityMicrovascular dysfunctionClinical historyEmergency therapyAutoimmune diseasesDisease-modifying treatmentsTissue fibrosisSingle-cell RNA sequencingClinical heterogeneityEffective disease-modifying treatmentsPersonalized therapyAnimal modelsComplex pathogenesisEffective treatmentNext-generation sequencing
2024
Skin Thickening and Vascular Lesions
Andrejeva L, Lanjewar S, Woolf G, Killelea B, Brownson K, Podany P, Harigopal M. Skin Thickening and Vascular Lesions. 2024, 297-323. DOI: 10.1007/978-3-031-65711-5_11.Peer-Reviewed Original ResearchRare group of neoplasmsInflammatory breast carcinomaInvasive lobular carcinomaMalignant vascular tumorsGroup of neoplasmsIll-defined marginsLobular carcinomaBreast carcinomaBenign tumorsClinical presentationBenign lesionsVascular tumorsBreast parenchymaClinical historyWell-circumscribedSkin thickeningMalignant processVascular lesionsRare groupImaging appearanceSubcutaneous tissueContrast enhancementBreastCarcinomaTumorExpanding the spectrum of progressive familial intrahepatic cholestasis: A report of 3 cases
Jiao J, Morotti R, Shafizadeh N, Jain D. Expanding the spectrum of progressive familial intrahepatic cholestasis: A report of 3 cases. American Journal Of Clinical Pathology 2024, 163: 332-339. PMID: 39333837, DOI: 10.1093/ajcp/aqae123.Peer-Reviewed Original ResearchProgressive familial intrahepatic cholestasisATP-binding cassette subfamily B member 4Whole-exome sequencingFamilial intrahepatic cholestasisIntrahepatic cholestasisDiagnostic challengeGroup of autosomal recessive disordersAbnormal liver function testsHomozygous splice site variantDrug-induced liver injuryHeterozygous frameshift mutationHeterozygous missense mutationLiver function testsAged 2 monthsAutosomal recessive disorderSplice site variantHistory of alcoholismABCB4 mutationsPediatric ageLiver biopsyClinical historyRecessive disorderLiver injuryMolecular testingHeterogeneous presentationHigher sensitivity of pericardial fluid cytology than biopsy in malignant effusions with potential explanation of false‐negative cytology: A multi‐institutional analysis
Takeda K, Gereg C, Liu X, Ma W, Bearse M, Tang H, Delfino I, Huang E, Lin X, Chandler J, Wang H. Higher sensitivity of pericardial fluid cytology than biopsy in malignant effusions with potential explanation of false‐negative cytology: A multi‐institutional analysis. Cytopathology 2024, 36: 31-40. PMID: 39301772, DOI: 10.1111/cyt.13447.Peer-Reviewed Original ResearchPericardial fluid cytologySensitivity of cytologyMalignant pericardial effusionMulti-institutional analysisFluid cytologyCytology casesPericardial effusionDiagnostic sensitivity of cytologyFalse-negative cytologyFalse-negative resultsSite of originConcurrent biopsyPericardial biopsyHistological subtypesMalignant effusionsHistologic reviewPericardial involvementRetrospective reviewMalignant casesPoor prognosisImmunohistochemistry studiesClinical historyDiagnostic superiorityBiopsyCytologyElevated antibody binding to striatal cholinergic interneurons in patients with pediatric acute-onset neuropsychiatric syndrome
Xu J, Frankovich J, Liu R, Thienemann M, Silverman M, Farhadian B, Willett T, Manko C, Columbo L, Leibold C, Vaccarino F, Che A, Pittenger C. Elevated antibody binding to striatal cholinergic interneurons in patients with pediatric acute-onset neuropsychiatric syndrome. Brain Behavior And Immunity 2024, 122: 241-255. PMID: 39084540, PMCID: PMC11569416, DOI: 10.1016/j.bbi.2024.07.044.Peer-Reviewed Original ResearchPediatric Autoimmune Neuropsychiatric Disorders Associated with StreptococcusPediatric acute-onset neuropsychiatric syndromeStriatal cholinergic interneuronsCholinergic interneuronsObsessive-compulsive symptomsModulate basal ganglia functionNeuropsychiatric syndromeSignificant obsessive-compulsive symptomsBasal ganglia functionEx vivo brain slicesSevere food restrictionElevated antibodiesClinical historyPatient plasmaNeuropsychiatric manifestationsStreptococcus infectionBrain slicesSymptom flaresControl plasmaFood restrictionSerum antibodiesHuman brainInfectionAbrupt onsetClinical contextHistologic Features of Mycobacterial Spindle Cell Pseudotumors
Szczepanski J, Lieberman J, Lamps L, Gonzalez R, Xue Y, Zhang X, Yilmaz O, Hart J, Krausz T, Mantilla J, McHugh J, Westerhoff M. Histologic Features of Mycobacterial Spindle Cell Pseudotumors. The American Journal Of Surgical Pathology 2024, 48: 890-900. PMID: 38726848, DOI: 10.1097/pas.0000000000002234.Peer-Reviewed Original ResearchConceptsMycobacterial spindle cell pseudotumorSpindle cell pseudotumorImmunocompromised patientsFoamy histiocytesLymph nodesNeutrophilic inflammationNeutrophilic microabscessesEvaluated lymph nodesComposition of inflammatory infiltratesSpindle cell neoplasmSecondary to infectionNon-tuberculous mycobacteriaArchitectural growth patternAcid-fast stainingMultinucleated giant cellsPeripheral granulomaSurgical therapyCell neoplasmsStromal changesHistological factorsSpindle cellsLymphocytic inflammationMicrobiological findingsClinical historyInflammatory infiltrate
2023
Liver and Biliary Tract
Wang X, Cai G. Liver and Biliary Tract. 2023, 247-266. DOI: 10.1007/978-3-031-44289-6_14.Peer-Reviewed Original ResearchBiliary tractPrimary sclerosis cholangitisExtrahepatic biliary tractRelevant clinical historyEchinococcal cystsLiver cystsAmebic abscessClinical historyNonneoplastic lesionsNonneoplastic disordersCytomorphologic featuresBenign lesionsSolid lesionsHepatocyte hyperplasiaMalignant counterpartsInfectious entitiesLesionsCystsLiverTractCholangitisCirrhosisAbscessStentingHyperplasiaHepatocellular Adenoma: Report of 2 Cases That Highlight the Relevance of Phenotype-Genotype Correlation in the Pediatric Population
Jiao J, Finberg K, Jain D, Morotti R. Hepatocellular Adenoma: Report of 2 Cases That Highlight the Relevance of Phenotype-Genotype Correlation in the Pediatric Population. Pediatric And Developmental Pathology 2023, 26: 394-403. PMID: 37334553, DOI: 10.1177/10935266231175426.Peer-Reviewed Case Reports and Technical NotesConceptsHepatocellular adenomaPediatric populationInflammatory HCASonic hedgehog hepatocellular adenomasYoung type 3Maturity-onset diabetesInflammatory hepatocellular adenomaΒ-catenin-activated hepatocellular adenomaAbernethy malformationPhenotype-genotype correlationClinical historyHCA subtypesH-HCACase 2Case 1Type 3Pathological informationB-HCASubtypesFamily surveillanceLimited studiesMalesChapter 7 The role of febrile seizures in directing surgical therapies for temporal lobe epilepsy
McGrath H, Lamsam L, Spencer D. Chapter 7 The role of febrile seizures in directing surgical therapies for temporal lobe epilepsy. 2023, 121-139. DOI: 10.1016/b978-0-323-89932-1.00010-x.ChaptersTemporal lobe epilepsyFebrile seizuresEpilepsy surgeryLobe epilepsyTreatment modalitiesMesial temporal sclerosisSurgical treatment optionsComprehensive preoperative evaluationSurgical treatment modalitiesTemporal sclerosisSurgical therapyPreoperative evaluationPreoperative findingsAppropriate therapyIntractable epilepsySurgical dataTreatment optionsClinical historyDisease processBetter outcomesSurgeryEpilepsySeizuresPatientsTherapy
2022
NEIM-02 DEVELOPMENT OF A DEEP LEARNING MODEL FOR DISCRIMINATING TRUE PROGRESSION FROM PSEUDOPROGRESSION IN GLIOBLASTOMA PATIENTS
Moassefi M, Faghani S, Conte G, Rouzrokh P, Kowalchuk R, Trifiletti D, Erickson B. NEIM-02 DEVELOPMENT OF A DEEP LEARNING MODEL FOR DISCRIMINATING TRUE PROGRESSION FROM PSEUDOPROGRESSION IN GLIOBLASTOMA PATIENTS. Neuro-Oncology Advances 2022, 4: i17-i18. PMCID: PMC9354212, DOI: 10.1093/noajnl/vdac078.069.Peer-Reviewed Original ResearchMagnetic resonance imagingGlioblastoma patientsMedian overall survival rangesTreatment planningOriginal radiation fieldOverall survival rangesStandard treatment regimenConventional magnetic resonance imagingT2-weighted imagesPatient treatment plansDiagnosing PSPAdjuvant temozolomideConcurrent chemoradiotherapySurgical resectionEnhancing lesionsAggressive tumorsMultimodal treatmentTreatment regimenAggressive managementRecurrence locationTrue progressionClinical historyClinical deteriorationMedical historyClinical challengeHistological changes associated with laser interstitial thermal therapy for radiation necrosis: illustrative cases
Fomchenko EI, Leelatian N, Darbinyan A, Huttner AJ, Chiang VL. Histological changes associated with laser interstitial thermal therapy for radiation necrosis: illustrative cases. Journal Of Neurosurgery Case Lessons 2022, 4: case21373. PMID: 35855352, PMCID: PMC9257400, DOI: 10.3171/case21373.Peer-Reviewed Original ResearchLaser interstitial thermal therapyRadiation necrosisInterstitial thermal therapyBrain metastasesAssociated cerebral edemaStage IV diseaseUse of immunotherapyPredictors of responseOngoing immunotherapySurgical decompressionCerebral edemaPerilesional edemaSurgical approachClinical historyLung cancerNeurological compromiseGood patientHistological changesStereotactic radiosurgeryPatientsEarly reductionSized lesionsImmunotherapyTherapyThermal therapyExplainable Deep Learning Improves Physician Interpretation of Myocardial Perfusion Imaging.
Miller RJH, Kuronuma K, Singh A, Otaki Y, Hayes S, Chareonthaitawee P, Kavanagh P, Parekh T, Tamarappoo BK, Sharir T, Einstein AJ, Fish MB, Ruddy TD, Kaufmann PA, Sinusas AJ, Miller EJ, Bateman TM, Dorbala S, Carli MD, Cadet S, Liang JX, Dey D, Berman DS, Slomka PJ. Explainable Deep Learning Improves Physician Interpretation of Myocardial Perfusion Imaging. Journal Of Nuclear Medicine 2022, 63: 1768-1774. PMID: 35512997, PMCID: PMC9635672, DOI: 10.2967/jnumed.121.263686.Peer-Reviewed Original ResearchConceptsMyocardial perfusion imagingCoronary artery diseaseObstructive coronary artery diseasePhysician interpretationDiagnostic accuracyPerfusion imagingLeft main arteryOverall net reclassification improvementInvasive coronary angiographyNet reclassification improvementTotal perfusion deficitArtery diseaseCoronary angiographyMedian agePhysician diagnosisReclassification improvementPerfusion deficitsClinical historyCoronary segmentsRepresentative cohortMeaningful improvementsMain arteryPatientsDL resultsQuantitative perfusionSubstance use screening in transplant populations: Recommendations from a consensus workgroup
Jowsey-Gregoire S, Jannetto PJ, Jesse MT, Fleming J, Winder GS, Balliet W, Kuntz K, Vasquez A, Weinland S, Hussain F, Weinrieb R, Fireman M, Nickels MW, Peipert JD, Thomas C, Zimbrean PC. Substance use screening in transplant populations: Recommendations from a consensus workgroup. Transplantation Reviews 2022, 36: 100694. PMID: 35537285, DOI: 10.1016/j.trre.2022.100694.Peer-Reviewed Original ResearchConceptsSubstance use disordersUse disordersTransplant patientsDrug testingConsultation-liaison psychiatryTransplant populationTransplant teamClinical historyOptimal carePatient practicesPatientsCurrent laboratory testingAmerican SocietyDisordersTransplantationPharmacy communityPossible risksInsurance issuesLaboratory testingOngoing testingRiskCertain substancesGroup discussionsTestingSubstancesProteomic differences in hippocampus and cortex of sudden unexplained death in childhood
Leitner DF, William C, Faustin A, Askenazi M, Kanshin E, Snuderl M, McGuone D, Wisniewski T, Ueberheide B, Gould L, Devinsky O. Proteomic differences in hippocampus and cortex of sudden unexplained death in childhood. Acta Neuropathologica 2022, 143: 585-599. PMID: 35333953, PMCID: PMC8953962, DOI: 10.1007/s00401-022-02414-7.Peer-Reviewed Original ResearchConceptsSudden unexplained deathDentate gyrusFrontal cortexClinical historyCA1-3Unexplained deathBrain regionsSudden unexpected deathHippocampal dentate gyrusFebrile seizure historyAcute phase responseCause of deathYears of ageMechanism of deathCircumstances of deathSUDC casesMolecular signaling pathwaysClinical featuresSeizure historyPathological featuresMultiple etiologiesCornu ammonisUnexpected deathPreventive strategiesAncillary testingPhase 1/2 study of ARV-110, an androgen receptor (AR) PROTAC degrader, in metastatic castration-resistant prostate cancer (mCRPC).
Gao X, Burris H, Vuky J, Dreicer R, Sartor A, Sternberg C, Percent I, Hussain M, Kalebasty A, Shen J, Heath E, Abesada-Terk G, Gandhi S, McKean M, Lu H, Berghorn E, Gedrich R, Chirnomas S, Vogelzang N, Petrylak D. Phase 1/2 study of ARV-110, an androgen receptor (AR) PROTAC degrader, in metastatic castration-resistant prostate cancer (mCRPC). Journal Of Clinical Oncology 2022, 40: 17-17. DOI: 10.1200/jco.2022.40.6_suppl.017.Peer-Reviewed Original ResearchMetastatic castration-resistant prostate cancerNovel hormonal agentsProstate-specific antigenClinical activityBetter prostate-specific antigenOngoing phase 1/2 studyCastration-resistant prostate cancerBiomarker-defined subgroupsPhase 2 dosePhase 1/2 studyWild-type ARFourth subgroupPhase 1AR alterationsRECIST responseSpecific molecular profilePrior therapyAdverse eventsAR-V7Tumor shrinkageHormonal agentsTreatment optionsClinical historyDisease progressionProstate cancer
2021
A Case of Possible Chronic Traumatic Encephalopathy and Alzheimer’s Disease in an Ex-Football Player
Fesharaki-Zadeh A. A Case of Possible Chronic Traumatic Encephalopathy and Alzheimer’s Disease in an Ex-Football Player. The Neurologist 2021, 27: 249-252. PMID: 34879014, PMCID: PMC9439689, DOI: 10.1097/nrl.0000000000000391.Peer-Reviewed Original ResearchConceptsChronic traumatic encephalopathyTraumatic encephalopathyAlzheimer's diseasePrior traumatic brain injuryBehavioral variant frontotemporal dementiaRepetitive head traumaTraumatic brain injuryPrior psychiatric historyPrimary progressive aphasiaVariant frontotemporal dementiaPositron emission tomographyCTE casesClinical presentationHead traumaCase reportClinical historyDefinitive diagnosisClinical algorithmBrain injuryComorbid moodPsychiatric historyCerebrospinal fluidNeuroimaging biomarkersProgressive aphasiaFrontotemporal dementiaAnaplastic Thyroid Carcinoma: Cytomorphologic Features on Fine-Needle Aspiration and Associated Diagnostic Challenges
Podany P, Abi-Raad R, Barbieri A, Garritano J, Prasad ML, Cai G, Adeniran AJ, Gilani SM. Anaplastic Thyroid Carcinoma: Cytomorphologic Features on Fine-Needle Aspiration and Associated Diagnostic Challenges. American Journal Of Clinical Pathology 2021, 157: 608-619. PMID: 34661606, PMCID: PMC8973262, DOI: 10.1093/ajcp/aqab159.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAnaplastic thyroid carcinomaFine-needle aspirationCytologic featuresATC casesTumor cellsThyroid carcinomaControl groupDiagnosis of ATCAcute inflammatory cellsKey cytologic featuresNuclear membrane irregularitySingle tumor cellsAggressive malignancyInflammatory cellsClinical historyDiagnostic challengePatient prognosisInclusion criteriaNeedle aspirationCytomorphologic featuresEarly diagnosisEpithelioid cytomorphologyNuclear pleomorphismAvailable slidesElectronic databasesPancreatic Neuroendocrine Tumors
Muniraj T, Aslanian H. Pancreatic Neuroendocrine Tumors. 2021, 1933-1951. DOI: 10.1007/978-3-030-30192-7_81.Peer-Reviewed Original ResearchNeuroendocrine tumorsProlongs disease-free survivalDiagnosis of NETsNon-functioning neuroendocrine tumoursDisease-free survivalCareful clinical historyTreatment of choicePancreatic neuroendocrine tumorsQuality of lifeHormone hypersecretionMetastatic diseaseNonfunctional tumorsSurgical resectionTreatment modalitiesClinical historyPotential treatmentHeterogeneous groupTumorsMass effectAgeTreatmentLaboratory testsHypersecretionResectionPatients
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