2025
Could metabolic imaging and artificial intelligence provide a novel path to non-invasive aneuploidy assessments? A certain clinical need
Horta F, Sakkas D, Ledger W, Goldys E, Gilchrist R. Could metabolic imaging and artificial intelligence provide a novel path to non-invasive aneuploidy assessments? A certain clinical need. Reproduction Fertility And Development 2025, 37 PMID: 39874158, DOI: 10.1071/rd24122.Peer-Reviewed Original ResearchConceptsPGT-AMetabolic imagingAneuploid embryosEmbryo biopsyEmbryo selectionNon-invasive PGT-APre-implantation genetic testingEnhancing embryo selectionNon-invasive metabolic imagingAneuploidy assessmentEmbryo ploidyGenetic testingInvasive natureClinical practicePotential mosaicismClinical needBiopsyFluorescence Lifetime Imaging MicroscopyTreatment costsAneuploidyActivation signatureMeasuring cellular metabolismHuman fibroblastsNon-invasive technologyDiagnostic practice
2024
Non-invasive preimplantation genetic testing for aneuploidy: is the promise real?
Volovsky M, Scott R, Seli E. Non-invasive preimplantation genetic testing for aneuploidy: is the promise real? Human Reproduction 2024, 39: 1899-1908. PMID: 38970367, DOI: 10.1093/humrep/deae151.Peer-Reviewed Original ResearchNon-invasive PGT-APGT-APreimplantation genetic testingIntegration of next-generation sequencingGenetic testingGenetic testing platformsNon-invasive preimplantation genetic testingNext-generation sequencingRisk of pregnancy lossAneuploidy screening methodsEmbryo culture mediumAmplification failureSegmental aneuploidyPregnancy lossCulture mediumClinical reliabilityAneuploidyDiagnostic precisionClinical settingDiagnostic inaccuracyEmbryo viabilityClinical adoptionEmbryosScreening methodDNAP-533 Impact on clinical outcomes of day-6 extended culture and reduced culture media volume applied to non-invasive PGT-A
LLuesa C, Navarro-Sánchez L, Ardestani G, Barroso G, Bisioli C, Boynukalin K, Cimadomo D, Andrade G, Valbuena D, Simon-Valles C, Sakkas D. P-533 Impact on clinical outcomes of day-6 extended culture and reduced culture media volume applied to non-invasive PGT-A. Human Reproduction 2024, 39: deae108.873. DOI: 10.1093/humrep/deae108.873.Peer-Reviewed Original ResearchNon-invasive PGT-ACell-free DNAPGT-ASingle embryo transferClinical outcomesDay 5Pregnancy rateStudy groupNiPGT-AConcordance ratePregnancy outcomesDay 6Control groupCell-free DNA resultsDay 5 blastocystsDay 6 blastocystsClinical pregnancy rateDay of biopsyOverall pregnancy outcomeEmbryo culture protocolsBiopsy stepPGT-A.Euploidy rateBlastocyst viabilityBlastocyst quality
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