2025
Impact of Age and Sex on Coronary Flow Reserve and Microvascular Function in Patients with ANOCA
Kostantinis S, Castro G, Latif N, Cigarroa N, Kunnirickal S, Odanovic N, Shah S. Impact of Age and Sex on Coronary Flow Reserve and Microvascular Function in Patients with ANOCA. Journal Of The Society For Cardiovascular Angiography & Interventions 2025, 103989. DOI: 10.1016/j.jscai.2025.103989.Peer-Reviewed Original ResearchCoronary flow reserveCoronary microvascular functionMicrovascular functionImpact of ageMicrocirculatory resistanceInvasive coronary function testingFlow reserveCoronary function testingAssessment of coronary flow reserveNonobstructive coronary arteriesAssociated with progressive decreasesHyperemic mean transit timeHyperemic TmnAssociation of ageCoronary physiology indicesAcetylcholine provocationMean transit timeVasoreactivity testingConsecutive patientsBolus thermodilutionSex-stratified analysesMultivariate regression modelSubgroup analysisAge-related impairmentANOCA
2024
T7. COVID-19 RELATED STRESSORS ARE ASSOCIATED WITH PSYCHIATRIC DISORDERS AND ACCELERATED EPIGENETIC AGING IN AN ISLAND-BASED PUERTO RICAN POPULATION
Garayua A, Nunez D, Nagamatsu S, Giusti-Rodriguez P, Martinez-Gonzalez K, Montalvo-Ortiz J. T7. COVID-19 RELATED STRESSORS ARE ASSOCIATED WITH PSYCHIATRIC DISORDERS AND ACCELERATED EPIGENETIC AGING IN AN ISLAND-BASED PUERTO RICAN POPULATION. European Neuropsychopharmacology 2024, 87: 159. DOI: 10.1016/j.euroneuro.2024.08.317.Peer-Reviewed Original ResearchPost-traumatic stress disorderMajor depressive disorderCOVID-19 related stressorsCOVID-19 stressorsMajor depressive disorder symptomsPost-traumatic stress disorder symptomsAccelerated Epigenetic AgingRelated stressorsCombined sex analysesSymptoms of major depressive disorderPsychiatric disorder symptomsCOVID-19-related stressorsSex-stratified analysesSelf-report measuresCOVID-related stressorsAdverse mental health outcomesTargeted mental health interventionsSignificant stressorsAt-risk populationsMental health interventionsMental health outcomesConsequences of stressorsAccelerated biological agingEpigenetic ageAt-riskMaladaptive health factors as potential mediators for the association between posttraumatic stress disorder and cardiovascular disease: A sex-stratified analysis in the U.S. adult population
Pierce S, Reynolds K, Sommer J, El-Gabalawy R, Pietrzak R, Sumner J, Mota N. Maladaptive health factors as potential mediators for the association between posttraumatic stress disorder and cardiovascular disease: A sex-stratified analysis in the U.S. adult population. Journal Of Psychiatric Research 2024, 177: 102-108. PMID: 39002531, DOI: 10.1016/j.jpsychires.2024.06.028.Peer-Reviewed Original ResearchHealth risk factorsPosttraumatic stress disorderRisk factorsPotential mediatorsCardiovascular diseaseLow physical activityCross-sectional surveyNatural effect modelsSex-stratified analysesU.S. adult populationCardiovascular disease riskStress disorderPhysical activityNational Epidemiologic SurveyLogistic regression analysisHealth factorsEvaluate health risk factorsU.S. adultsHigher BMICausal pathwaysPrevention strategiesEffects of posttraumatic stress disorderWave 3Adult populationSubstance useA Genome-wide Association Study of Susceptibility to Upper Urinary Tract Infections
Flatby H, Ravi A, Liyanarachi K, Afset J, Rasheed H, Brumpton B, Hveem K, Åsvold B, DeWan A, Solligård E, Damås J, Rogne T. A Genome-wide Association Study of Susceptibility to Upper Urinary Tract Infections. The Journal Of Infectious Diseases 2024, 230: e1334-e1343. PMID: 38713594, PMCID: PMC11646603, DOI: 10.1093/infdis/jiae231.Peer-Reviewed Original ResearchGenome-wide association studiesMichigan Genomics InitiativeAssociation studiesUpper UTIMendelian randomizationMR analysisUpper urinary tract infectionRisk factorsPotential causal risk factorsCardiometabolic risk factorsModifiable risk factorsSex-stratified analysesCausal risk factorUrinary tract infectionGenome-wideFemale-only analysisGenetic lociPotential causal relationshipGenome InitiativeHealth StudyUK BiobankHLA-DQA2LociTract infectionsSmoking scoreSex-specific associations of environmental exposures with prevalent diabetes and obesity – Results from the KORA Fit study
Niedermayer F, Wolf K, Zhang S, Dallavalle M, Nikolaou N, Schwettmann L, Selsam P, Hoffmann B, Schneider A, Peters A. Sex-specific associations of environmental exposures with prevalent diabetes and obesity – Results from the KORA Fit study. Environmental Research 2024, 252: 118965. PMID: 38642640, DOI: 10.1016/j.envres.2024.118965.Peer-Reviewed Original ResearchConceptsAssociations of environmental exposuresAssociated with higher body-mass indexBody-mass indexHigh body-mass indexSex-specific associationsPrevalent diabetesEnvironmental exposuresAssociated with lower obesity prevalenceUrban menRural womenAssociated with diabetes prevalenceEvaluated sex-specific associationsLower obesity prevalenceAir pollutionAnalyzed cross-sectional dataGerman population-based cohortPopulation-based cohortSusceptibility to air pollutionSex-stratified analysesLack of greennessEffects of environmental exposuresFitness studiesSusceptibility to environmental exposuresSurrounding greennessCross-sectional data
2023
Sex differences in the polygenic architecture of hearing problems in adults
De Angelis F, Zeleznik O, Wendt F, Pathak G, Tylee D, De Lillo A, Koller D, Cabrera-Mendoza B, Clifford R, Maihofer A, Nievergelt C, Curhan G, Curhan S, Polimanti R. Sex differences in the polygenic architecture of hearing problems in adults. Genome Medicine 2023, 15: 36. PMID: 37165447, PMCID: PMC10173489, DOI: 10.1186/s13073-023-01186-3.Peer-Reviewed Original ResearchConceptsPolygenic architectureRisk lociGenome-wide investigationLarge-scale genetic studiesTranscriptomic regulationGWAS findingsTranscriptomic associationsGene interactionsPotential roleRegulation analysisGenetic studiesInference analysisMillion Veteran ProgramHealth Professionals FollowMolecular pathwaysPolygenic riskPreventive screening programsMultivariate interaction analysisNovel insightsCentral nervous systemEnvironmental risk factorsSex-stratified analysesSex-specific analysesSex differencesMental health outcomesTemporal variation in the association between temperature and cause-specific mortality in 15 German cities
Rai M, Breitner S, Huber V, Zhang S, Peters A, Schneider A. Temporal variation in the association between temperature and cause-specific mortality in 15 German cities. Environmental Research 2023, 229: 115668. PMID: 36958378, DOI: 10.1016/j.envres.2023.115668.Peer-Reviewed Original ResearchConceptsCVD mortalityNon-accidentalRelative riskMortality riskAge- and sex-stratified analysesMultivariate meta-analytic modelsCause-specific mortalitySex-stratified analysesAge groupsTemperature-mortality associationsRD mortalityYounger age groupsOlder age groupsMeta-analytic modelCold-relatedStudy periodRD deathsMortalityAssociationRiskTemperature percentileHeat-related risksCVDGerman citiesTime series analysisThe genetic contribution of the X chromosome in age-related hearing loss
Naderi E, Cornejo-Sanchez D, Li G, Schrauwen I, Wang G, Dewan A, Leal S. The genetic contribution of the X chromosome in age-related hearing loss. Frontiers In Genetics 2023, 14: 1106328. PMID: 36896235, PMCID: PMC9988903, DOI: 10.3389/fgene.2023.1106328.Peer-Reviewed Original ResearchX chromosomeChromosome XGenome-wide significance levelMRNA expression analysisExpression analysisChromosomesAssociation analysisGenetic variantsCommon sensory impairmentGenetic contributionAnalysis of malesAge-related hearing lossHair cellsInner ear tissuesInner hair cellsUK BiobankARHLVariantsHuman inner ear tissueEar tissueGenesLociHeritabilitySex-stratified analysesCells
2022
Iron status and the risk of sepsis and severe COVID-19: a two-sample Mendelian randomization study
Mohus RM, Flatby H, Liyanarachi KV, DeWan AT, Solligård E, Damås JK, Åsvold BO, Gustad LT, Rogne T. Iron status and the risk of sepsis and severe COVID-19: a two-sample Mendelian randomization study. Scientific Reports 2022, 12: 16157. PMID: 36171422, PMCID: PMC9516524, DOI: 10.1038/s41598-022-20679-6.Peer-Reviewed Original ResearchConceptsRisk of sepsisTwo-sample Mendelian randomization studyIron statusMendelian randomization studySerum ironOdds ratioCOVID-19Randomization studyTotal iron binding capacitySevere COVID-19Risk of hospitalizationHigh iron statusIron binding capacitySex-stratified analysesTransferrin saturationSevere infectionsIron biomarkersObservational studyHigh riskSepsisStandard deviation increaseHospitalizationFurther studiesRiskStatusInterventions Targeted to Address Social Determinants of Health in Ischemic Heart Disease: A Sex- and Gender-Oriented Scoping Review
Raparelli V, Wright CX, Corica B, Sharma G, Lindley K, Brackett A, Pilote L, Wood MJ, Dreyer RP. Interventions Targeted to Address Social Determinants of Health in Ischemic Heart Disease: A Sex- and Gender-Oriented Scoping Review. Canadian Journal Of Cardiology 2022, 38: 1881-1892. PMID: 35809812, DOI: 10.1016/j.cjca.2022.06.025.Peer-Reviewed Original ResearchConceptsIschemic heart diseaseHealth care systemHeart diseaseCare systemPatient education interventionsMajor health problemSex-stratified analysesSocial supportSDOH interventionsIHD patientsMale patientsSDOH domainsMinority patientsCare implementationHealth literacyPatientsHealth problemsRCTsSocial determinantsReporting of findingsInterventionSuch interventionsSDOHScoping ReviewSocioeconomic determinants
2020
Sex differences in the associations of physical activity and macronutrient intake with child body composition: A cross‐sectional study of 3‐ to 7‐year‐olds in Samoa
Thompson AA, Duckham RL, Desai MM, Choy CC, Sherar LB, Naseri T, Soti‐Ulberg C, Reupena MS, Wetzel AI, Hawley NL. Sex differences in the associations of physical activity and macronutrient intake with child body composition: A cross‐sectional study of 3‐ to 7‐year‐olds in Samoa. Pediatric Obesity 2020, 15: e12603. PMID: 31925928, PMCID: PMC7060109, DOI: 10.1111/ijpo.12603.Peer-Reviewed Original ResearchConceptsOverweight/obesityPhysical activityBody compositionNutritional intakeDual-energy X-ray absorptiometryPeripheral fat ratioFood frequency questionnaireChildren's nutritional intakeCross-sectional studyChildren's body compositionSamoan childrenX-ray absorptiometrySex-specific associationsSex-stratified analysesFrequency questionnaireObjective physical activity monitoringCarbohydrate intakeIndependent associationDietary intakeMacronutrient intakePhysical activity monitoringIntakeLower trunkFat ratioObesity
2010
The Role of Social Support in Health Status and Depressive Symptoms After Acute Myocardial Infarction
Leifheit-Limson EC, Reid KJ, Kasl SV, Lin H, Jones PG, Buchanan DM, Parashar S, Peterson PN, Spertus JA, Lichtman JH. The Role of Social Support in Health Status and Depressive Symptoms After Acute Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2010, 3: 143-150. PMID: 20160162, PMCID: PMC3016989, DOI: 10.1161/circoutcomes.109.899815.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngina PectorisChi-Square DistributionDepressionEvidence-Based MedicineFemaleHealth StatusHealth Status IndicatorsHumansLinear ModelsMaleMiddle AgedMyocardial InfarctionPoisson DistributionProspective StudiesQuality of LifeRegistriesRisk AssessmentRisk FactorsSex FactorsSocial SupportTime FactorsUnited StatesWomen's HealthWomen's Health ServicesConceptsAcute myocardial infarctionLow social supportDisease-specific qualityDepressive symptomsMyocardial infarctionHealth statusPhysical functioningLower disease-specific qualitySocial supportBaseline health statusBaseline depressive symptomsWorse health statusRisk of anginaLower physical functioningMyocardial infarction recoverySex-stratified associationsLower mental functioningSex-stratified analysesMore depressive symptomsFirst yearClinical factorsProspective studyNonsignificant trendSymptomsInfarction
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