2012
Altered Response to Neuroendocrine Challenge Linked to Indices of the Metabolic Syndrome in Healthy Adults
Tyrka A, Walters O, Price L, Anderson G, Carpenter L. Altered Response to Neuroendocrine Challenge Linked to Indices of the Metabolic Syndrome in Healthy Adults. Hormone And Metabolic Research 2012, 44: 543-549. PMID: 22549400, PMCID: PMC3580172, DOI: 10.1055/s-0032-1306342.Peer-Reviewed Original ResearchConceptsDEX/CRH testBody mass indexHealthy adultsCRH testBlood pressureACTH responseMetabolic syndromeAdrenocorticotropic hormoneDexamethasone/corticotropin-releasing hormone testCorticotropin-releasing hormone testIndices of MetSHPA axis functionNeuroendocrine challenge testsAdrenal axis activityPathogenesis of MetS.Significant medical problemEarly life stressHealthy community sampleCommunity sampleCentral obesityChronic medicationsMetS componentsHDL cholesterolCentral adiposityDevelopment of disease
2011
Adrenocorticotropic hormone and cortisol response to corticotropin releasing hormone in the critically ill—a novel assessment of the hypothalamic-pituitary-adrenal axis
Schuster KM, Macleod JB, Fernandez JB, Kumar M, Barquist ES. Adrenocorticotropic hormone and cortisol response to corticotropin releasing hormone in the critically ill—a novel assessment of the hypothalamic-pituitary-adrenal axis. The American Journal Of Surgery 2011, 203: 205-210. PMID: 21679920, DOI: 10.1016/j.amjsurg.2010.11.015.Peer-Reviewed Original ResearchMeSH KeywordsAdrenal InsufficiencyAdrenocorticotropic HormoneAgedAged, 80 and overArea Under CurveCorticotropin-Releasing HormoneCosyntropinCritical IllnessFemaleHumansHydrocortisoneHypothalamo-Hypophyseal SystemIntensive Care UnitsLinear ModelsMaleMiddle AgedPituitary-Adrenal SystemPostoperative ComplicationsPrognosisConceptsCorticotropin-releasing hormoneAdrenocorticotropic hormoneSurgical intensive care unitCosyntropin stimulation testIntensive care unitAdrenal insufficiencyCRH administrationACTH responseAdrenal functionCare unitStimulation testingAdrenal axisStimulation testACTH peakACTH responsivenessCortisol peakCortisol responseNormal responsePatientsChi-squareHormoneCortisolNonsurvivorsT-testP-value
2007
Hypothalamic-Pituitary-Adrenal Axis Activity in Obese Men with and without Sleep Apnea: Effects of Continuous Positive Airway Pressure Therapy
Vgontzas A, Pejovic S, Zoumakis E, Lin H, Bentley C, Bixler E, Sarrigiannidis A, Basta M, Chrousos G. Hypothalamic-Pituitary-Adrenal Axis Activity in Obese Men with and without Sleep Apnea: Effects of Continuous Positive Airway Pressure Therapy. The Journal Of Clinical Endocrinology & Metabolism 2007, 92: 4199-4207. PMID: 17785363, DOI: 10.1210/jc.2007-0774.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressureSleep apneaHypothalamic-pituitary-adrenal axis activityNonobese controlsApneic patientsObese menCRH administrationCortisol secretionLow cortisol secretionImpact of continuous positive airway pressureContinuous positive airway pressure therapyContinuous positive airway pressure useMonths of CPAP usePositive airway pressure therapyAxis activityOvine CRH administrationAirway pressure therapyPositive airway pressureEffects of continuous positive airway pressure therapyHypothalamic-pituitary-adrenal axisSleep apneic patientsCortisol levelsCPAP useACTH responseAirway pressure
2001
Effects of Estrogen Antagonists and Agonists on the ACTH Response to Restraint Stress in Female Rats
Young E, Altemus M, Parkison V, Shastry S. Effects of Estrogen Antagonists and Agonists on the ACTH Response to Restraint Stress in Female Rats. Neuropsychopharmacology 2001, 25: 881-891. PMID: 11750181, DOI: 10.1016/s0893-133x(01)00301-3.Peer-Reviewed Original ResearchMeSH KeywordsAdrenocorticotropic HormoneAnimalsAnti-Inflammatory AgentsCorticosteroneDrug ImplantsEstradiolEstrogen AntagonistsEstrogensFeedbackFemaleGlucocorticoidsHypothalamo-Hypophyseal SystemMaleNitromifeneOvariectomyProgesteroneRatsRats, Sprague-DawleyRestraint, PhysicalStress, PsychologicalTamoxifenConceptsRestraint stressACTH responseCorticosterone responseFemale ratsDays of estradiolLow-dose estradiolExogenous glucocorticoid administrationEstrogen antagonist tamoxifenCombination of estradiolAdrenal stress responseImportant inhibitory factorProgesterone replacementDose estradiolGlucocorticoid administrationEstrogen contributesAntagonist tamoxifenEstrogen antagonistEstradiol treatmentACTHInhibitory factorEstradiolRatsTamoxifenProgesteroneSex differencesAbnormalities in response to vasopressin infusion in chronic fatigue syndrome
Altemus M, Dale J, Michelson D, Demitrack M, Gold P, Straus S. Abnormalities in response to vasopressin infusion in chronic fatigue syndrome. Psychoneuroendocrinology 2001, 26: 175-188. PMID: 11087963, DOI: 10.1016/s0306-4530(00)00044-5.Peer-Reviewed Original ResearchConceptsChronic fatigue syndromeCorticotropin-releasing hormoneHypothalamic CRH secretionFatigue syndromeCRH secretionACTH responseVasopressin infusionCortisol responsePeripheral infusionHour infusionACTH secretionNeuroendocrine abnormalitiesAdrenal axisHypothalamic secretionHypothalamus actsHealthy volunteersPrimary symptomsNeuroendocrine studiesArginine vasopressinInfusionSyndromePatientsSecretionVasopressinAbnormalities
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