2023
Neonatal Paenibacilliosis: Paenibacillus Infection as a Novel Cause of Sepsis in Term Neonates With High Risk of Sequelae in Uganda
Ericson J, Burgoine K, Kumbakumba E, Ochora M, Hehnly C, Bajunirwe F, Bazira J, Fronterre C, Hagmann C, Kulkarni A, Kumar M, Magombe J, Mbabazi-Kabachelor E, Morton S, Movassagh M, Mugamba J, Mulondo R, Natukwatsa D, Kaaya B, Olupot-Olupot P, Onen J, Sheldon K, Smith J, Ssentongo P, Ssenyonga P, Warf B, Wegoye E, Zhang L, Kiwanuka J, Paulson J, Broach J, Schiff S. Neonatal Paenibacilliosis: Paenibacillus Infection as a Novel Cause of Sepsis in Term Neonates With High Risk of Sequelae in Uganda. Clinical Infectious Diseases 2023, 77: 768-775. PMID: 37279589, PMCID: PMC10495130, DOI: 10.1093/cid/ciad337.Peer-Reviewed Original ResearchConceptsNeonatal sepsisPostinfectious hydrocephalusCerebrospinal fluidSigns of sepsisFull-term neonatesOptimal antibiotic treatmentUgandan referral hospitalQuantitative polymerase chain reactionNeonatal characteristicsClinical sepsisTerm neonatesUnderdiagnosed causeAntibiotic choiceMedian ageReferral hospitalUgandan hospitalNeurodevelopmental impairmentAdverse outcomesSpecimen typesAntibiotic treatmentPolymerase chain reactionClinical signsUnusual pathogensSepsisHigh riskRetinopathy of Prematurity and Glucose-6-Phosphate Dehydrogenase Activity: A Case-Control Study
Paulpandian R, Dutta S, Das R, Katoch D, Kumar P. Retinopathy of Prematurity and Glucose-6-Phosphate Dehydrogenase Activity: A Case-Control Study. Indian Journal Of Pediatrics 2023, 90: 1089-1095. PMID: 37227582, DOI: 10.1007/s12098-023-04604-x.Peer-Reviewed Original ResearchConceptsRetinopathy of prematurityAssociated with retinopathy of prematurityCase-control studyPredicting retinopathy of prematurityG6PD activityMethodsThis case–control studyAssociated with retinopathyDuration of oxygenRecipients of bloodConsecutive unrelated subjectsMultivariate logistic regressionRed blood cell glucose-6-phosphate dehydrogenaseClinical sepsisNeonatal unitConsecutive subjectsBreastmilk feedingExchange transfusionBirth weightUnivariate analysisHb increaseUnrelated subjectsSevere formRisk factorsCase-controlC-statistic
2022
Cytomegalovirus infections in infants in Uganda: Newborn-mother pairs, neonates with sepsis, and infants with hydrocephalus
Hehnly C, Ssentongo P, Bebell L, Burgoine K, Bazira J, Fronterre C, Kumbakumba E, Mulondo R, Mbabazi-Kabachelor E, Morton S, Ngonzi J, Ochora M, Olupot-Olupot P, Mugamba J, Onen J, Roberts D, Sheldon K, Sinnar S, Smith J, Ssenyonga P, Kiwanuka J, Paulson J, Meier F, Ericson J, Broach J, Schiff S. Cytomegalovirus infections in infants in Uganda: Newborn-mother pairs, neonates with sepsis, and infants with hydrocephalus. International Journal Of Infectious Diseases 2022, 118: 24-33. PMID: 35150915, PMCID: PMC9058984, DOI: 10.1016/j.ijid.2022.02.005.Peer-Reviewed Original ResearchConceptsNewborn-mother pairsCMV prevalenceClinical sepsisCytomegalovirus infectionCerebrospinal fluidPrevalence of CMVQuantitative PCRCMV positivityPostinfectious hydrocephalusVaginal sheddingCMV infectionHIV seropositivityNeonatal ageMaternal ageMaternal vaginalRisk factorsMedical CenterLong-term consequencesMother pairsSepsisNeonatesInfantsPrevalenceHydrocephalusCMV
2016
Clinical implications of Paracoccus yeeii bacteremia in a patient with decompensated cirrhosis
Sack J, Peaper DR, Mistry P, Malinis M. Clinical implications of Paracoccus yeeii bacteremia in a patient with decompensated cirrhosis. IDCases 2016, 7: 9-10. PMID: 27920982, PMCID: PMC5133649, DOI: 10.1016/j.idcr.2016.11.008.Peer-Reviewed Case Reports and Technical NotesThird-generation cephalosporinsDecompensated cirrhosisVariceal hemorrhageGeneration cephalosporinsProphylactic antimicrobial treatmentDrug-resistant organismsAdvanced cirrhosisGastrointestinal hemorrhageClinical sepsisNegative patientsRare infectionUncommon organismsInfectious sourceCirrhosisPatientsResistant organismsAntimicrobial treatmentClinical implicationsHemorrhageNegative organismsBacteremiaFirst caseInfectionCephalosporins
2013
Neutrophil CD64 with Hematologic Criteria for Diagnosis of Neonatal Sepsis
Streimish I, Bizzarro M, Northrup V, Wang C, Renna S, Koval N, Li FY, Ehrenkranz RA, Rinder HM, Bhandari V. Neutrophil CD64 with Hematologic Criteria for Diagnosis of Neonatal Sepsis. American Journal Of Perinatology 2013, 31: 021-030. PMID: 23456906, DOI: 10.1055/s-0033-1334453.Peer-Reviewed Original ResearchConceptsCulture-proven sepsisClinical sepsisNeutrophil CD64CD64 indexNeonatal sepsisHematologic criteriaSingle-centre neonatal intensive care unitEarly-onset clinical sepsisNeonatal intensive care unitNeutrophil CD64 indexProspective observational cohortAbsolute neutrophil countNormal birth weightIntensive care unitAbsolute band countNegative predictive valueAdditional markersSepsis evaluationNeutrophil countObservational cohortCare unitBirth weightHematologic parametersSepsisCD64
1993
Calcitonin gene-related peptide mediates hypotension and tachycardia in endotoxic rats
Huttemeier P, Ritter E, Benveniste H. Calcitonin gene-related peptide mediates hypotension and tachycardia in endotoxic rats. American Journal Of Physiology 1993, 265: h767-h769. PMID: 8368378, DOI: 10.1152/ajpheart.1993.265.2.h767.Peer-Reviewed Original ResearchConceptsAcute circulatory changesCirculatory changesSurvival rateCalcitonin gene-related peptide concentrationsCalcitonin gene-related peptideMean blood pressureOverall survival rateGene-related peptideRegional blood flowEscherichia coli endotoxinClinical sepsisSevere hypotensionBlood pressureEndotoxic ratsCardiac functionCGRP antagonismColi endotoxinBlood flowUntreated animalsHypotensionTachycardiaSepsisRatsCGRPHCGRP
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