2024
Patterns of Cytogenomic Findings from a Case Series of Recurrent Pregnancy Loss Provide Insight into the Extent of Genetic Defects Causing Miscarriages
DiAdamo A, Chai H, Chong M, Wang G, Wen J, Jiang Y, Li P. Patterns of Cytogenomic Findings from a Case Series of Recurrent Pregnancy Loss Provide Insight into the Extent of Genetic Defects Causing Miscarriages. Global Medical Genetics 2024, 11: 123-131. PMID: 38560483, PMCID: PMC10980555, DOI: 10.1055/s-0044-1785227.Peer-Reviewed Original ResearchRecurrent pregnancy lossProducts of conceptionAbnormal karyotypeConsecutive miscarriagesCase seriesCytogenomic abnormalitiesCA groupCytogenomic findingsRoutine cytogenetic analysisCopy number variantsMonosomy XNormal karyotypeRetrospective studyPregnancy lossCytogenetic analysisPathogenic variantsMiscarriageSA groupAneuploidyKaryotypeLethal variantWomenAbnormalitiesGenome sequenceAbstract Background
2023
Placental Pathology Findings in Unexplained Pregnancy Losses
Thompson B, Holzer P, Kliman H. Placental Pathology Findings in Unexplained Pregnancy Losses. Reproductive Sciences 2023, 31: 488-504. PMID: 37725247, PMCID: PMC10827979, DOI: 10.1007/s43032-023-01344-3.Peer-Reviewed Original ResearchWeeks of gestationCommon pathologic featureSmall placentaPathologic featuresPregnancy lossChorionic villiPlacental pathology findingsUnexplained lossUnexplained pregnancy lossAntepartum stillbirthPlacental examinationUnexplained stillbirthPathology findingsUnexplained miscarriagePrevalent abnormalityPathologic diagnosisClinical databaseStillbirthMiscarriagePathology slidesDiagnostic categoriesGenetic abnormalitiesClassification systemPlacentaPotential mechanismsLymphocytic Choriomeningitis Virus in Person Living with HIV, Connecticut, USA, 2021 - Volume 29, Number 9—September 2023 - Emerging Infectious Diseases journal - CDC
Dyal J, Gandhi S, Cossaboom C, Leach A, Patel K, Golden M, Canterino J, Landry M, Cannon D, Choi M, Krapiunaya I, Klena J, Shoemaker T. Lymphocytic Choriomeningitis Virus in Person Living with HIV, Connecticut, USA, 2021 - Volume 29, Number 9—September 2023 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2023, 29: 1886-1889. PMID: 37610188, PMCID: PMC10461659, DOI: 10.3201/eid2909.230087.Peer-Reviewed Original Research
2022
A Bedside Test to Detect the Presence of Embryonic or Fetal Tissue in Vaginal Blood
Volovsky M, Ayala M, Narayanamoorthy S, Chiware T, Kotlyar A, Taylor H, Seifer D, Mor A. A Bedside Test to Detect the Presence of Embryonic or Fetal Tissue in Vaginal Blood. Obstetrics And Gynecology 2022, 140: 983-988. PMID: 36357961, DOI: 10.1097/aog.0000000000004975.Peer-Reviewed Original ResearchConceptsVaginal bloodEctopic pregnancyPositive control groupAlpha-fetoproteinControl groupFetal tissuesNegative control groupComplete miscarriageIGFBP-1Bedside testStudy groupInsulin-like growth factor-binding protein-1Growth factor-binding protein-1First-trimester bleedingProspective cohort studyRapid bedside testIntrauterine pregnancyVaginal bleedingCohort studyNonpregnant individualsReproductive-aged individualsPregnant individualsRapid test stripPregnancyMiscarriage
2021
Diagnosis of dengue fever in a patient with early pregnancy loss
Adjei NN, Lynn AY, Topran E, Adeyemo OO. Diagnosis of dengue fever in a patient with early pregnancy loss. BMJ Case Reports 2021, 14: e243968. PMID: 34404662, PMCID: PMC8375744, DOI: 10.1136/bcr-2021-243968.Peer-Reviewed Original ResearchConceptsInfluenza-like illnessEarly pregnancy lossConsistent clinical evidenceHistory of travelMosquito-borne virusDengue-endemic areasAbdominal crampingDengue serologyOrbital painVaginal bleedingMultiparous womenPreterm birthWeeks' gestationNeonatal deathClinical evidenceIntravenous fluidsPregnant womenAdverse outcomesPregnancy lossDengue feverDengueFeverGestationMiscarriageWomenIndividual culture leads to decreased blastocyst formation but does not affect pregnancy outcomes in the setting of a single, vitrified-warmed euploid blastocyst transfer
Glatthorn HN, Hanson BM, Kim JG, Herlihy NS, Klimczak AM, Hong KH, Seli E, Scott RT. Individual culture leads to decreased blastocyst formation but does not affect pregnancy outcomes in the setting of a single, vitrified-warmed euploid blastocyst transfer. Journal Of Assisted Reproduction And Genetics 2021, 38: 2157-2164. PMID: 34086147, PMCID: PMC8417170, DOI: 10.1007/s10815-021-02252-8.Peer-Reviewed Original ResearchConceptsEuploid blastocyst transferIntracytoplasmic sperm injectionPregnancy outcomesBlastocyst transferSignificant differencesBlastocyst formationSingle embryo transferMann-Whitney U testPreimplantation genetic testingLogistic regression modelsOvarian stimulationClinical miscarriageEuploid blastocystsSperm injectionEuploid embryosEmbryo transferTrophectoderm biopsyGenetic testingGroup embryo cultureU testSame time frameDecreased rateOutcomesMiscarriageFertilization rateCausal Genetic Variants in Stillbirth
Stanley K, Giordano J, Thorsten V, Buchovecky C, Thomas A, Ganapathi M, Liao J, Dharmadhikari A, Revah‐Politi A, Ernst M, Lippa N, Holmes H, Povysil G, Hostyk J, Parker C, Goldenberg R, Saade G, Dudley D, Pinar H, Hogue C, Reddy U, Silver R, Aggarwal V, Allen A, Wapner R, Goldstein D. Causal Genetic Variants in Stillbirth. Obstetric Anesthesia Digest 2021, 41: 42-42. DOI: 10.1097/01.aoa.0000732532.96202.8a.Peer-Reviewed Original ResearchMiscarriage determination in first trimester based on alpha-fetoprotein extracted from sanitary pads
Mor A, Gardezi M, Jubanyik K, Simsek B, Seifer DB, Patrizio P, Esencan E, Imamoglu G, Zhang M, Nichols-Burns SM, Taylor HS. Miscarriage determination in first trimester based on alpha-fetoprotein extracted from sanitary pads. Fertility And Sterility 2021, 116: 462-469. PMID: 33461753, DOI: 10.1016/j.fertnstert.2020.10.006.Peer-Reviewed Original ResearchConceptsExtrauterine pregnancyVaginal bloodAlpha-fetoproteinOngoing pregnancyAFP levelsSanitary padsHigh alpha-fetoprotein levelsOngoing pregnancy groupProspective cohort studyAlpha-fetoprotein levelsAcademic medical centerPregnancy groupCohort studyMiscarriage casesFirst trimesterOffice visitsMedical CenterMAIN OUTCOMEPregnancyMedian levelsMiscarriageBloodAnxiety levelsAFPCharacteristic analysis
2018
Same-day confirmation of intrauterine pregnancy failure in women with first- and early second-trimester bleeding
Mor A, Tal R, Haberman S, Kalgi B, Nasab SH, Minkoff H. Same-day confirmation of intrauterine pregnancy failure in women with first- and early second-trimester bleeding. Fertility And Sterility 2018, 109: 1060-1064. PMID: 29935643, DOI: 10.1016/j.fertnstert.2018.02.006.Peer-Reviewed Original ResearchMeSH KeywordsAbortion, IncompleteAbortion, LegalAbortion, SpontaneousAbortion, ThreatenedAdultalpha-FetoproteinsBlood Chemical AnalysisCerclage, CervicalDilatation and CurettageFemaleHumansMaternal Serum Screening TestsPregnancyPregnancy Trimester, FirstPregnancy Trimester, SecondReproducibility of ResultsSensitivity and SpecificityTime FactorsUterine HemorrhageVaginaConceptsMaternal serumVaginal bloodVaginal bleedingFetal tissuesSecond trimester bleedingProspective cohort studyAlpha-fetoprotein concentrationAFP concentrationProducts of conceptionGroup of womenCerclage groupCerclage placementCohort studyIncomplete miscarriagePregnancy failureMedical CenterMAIN OUTCOMEBleedingMiscarriageBloodSerumAFPTissueWomenCharacteristic analysisDiethylstilbestrol (DES)
Bjorkman S, Taylor H. Diethylstilbestrol (DES). 2018, 760-766. DOI: 10.1016/b978-0-12-801238-3.64417-3.Peer-Reviewed Original Research
2017
Listeria Placental Infection
Vázquez-Boland J, Krypotou E, Scortti M. Listeria Placental Infection. MBio 2017, 8: 10.1128/mbio.00949-17. PMID: 28655824, PMCID: PMC5487735, DOI: 10.1128/mbio.00949-17.Peer-Reviewed Original ResearchConceptsCongenital neonatal infectionsAdverse pregnancy outcomesAbsence of overt illnessSystemic bacterial infectionNonhuman primate modelFetal complicationsCausative agent of listeriosisNeonatal infectionPreterm birthPregnancy outcomesPregnant womenFood-borne infectionsBacterial infectionsPrimate modelTransplacental infectionInfectionOvert illnessMedical interventionsCausative agentListeriosisComplicationsMiscarriageStillbirthPathophysiologyBirth
2014
GSTO1 uncommon genetic variants are associated with recurrent miscarriage risk
Polimanti R, Graziano ME, Lazzarin N, Vaquero E, Manfellotto D, Fuciarelli M. GSTO1 uncommon genetic variants are associated with recurrent miscarriage risk. Fertility And Sterility 2014, 101: 735-739. PMID: 24417908, DOI: 10.1016/j.fertnstert.2013.12.010.Peer-Reviewed Original ResearchConceptsRecurrent miscarriageUncommon genetic variantsGSTO1 geneRecurrent miscarriage riskGenetic variantsPhysiologic pregnancyPregnancy complicationsRisk factorsMiscarriage riskMAIN OUTCOMERM riskSignificant associationSingle nucleotide polymorphismsWomenK variantGenetic association studiesGSTO1Nucleotide polymorphismsRiskAssociation studiesDetoxification metabolismComplicationsPregnancyMiscarriagePathogenesis
2012
Glutathione S-transferase genes and the risk of recurrent miscarriage in Italian women
Polimanti R, Piacentini S, Lazzarin N, Vaquero E, Re MA, Manfellotto D, Fuciarelli M. Glutathione S-transferase genes and the risk of recurrent miscarriage in Italian women. Fertility And Sterility 2012, 98: 396-400. PMID: 22633257, DOI: 10.1016/j.fertnstert.2012.05.003.Peer-Reviewed Original ResearchConceptsRecurrent miscarriageT alleleRisk of RMGSTA1 geneGlutathione S-transferaseGSTM1 variantsPregnancy complicationsRM riskMAIN OUTCOMEGST polymorphismsRM groupNull genotypeControl groupGSTT1 genesSignificant associationGSTP1 geneBuccal cellsItalian womenDifferent genetic modelsSingle nucleotide polymorphismsWomenGSTA1MiscarriageRiskGenetic association studies
2010
Reproductive Outcomes Among Male and Female Workers at an Aluminum Smelter
Sakr CJ, Taiwo OA, Galusha DH, Slade MD, Fiellin MG, Bayer F, Savitz DA, Cullen MR. Reproductive Outcomes Among Male and Female Workers at an Aluminum Smelter. Journal Of Occupational And Environmental Medicine 2010, 52: 137-143. PMID: 20134342, PMCID: PMC2830270, DOI: 10.1097/jom.0b013e3181cb59bc.Peer-Reviewed Original ResearchMeSH KeywordsAbortion, SpontaneousAdultAluminumChi-Square DistributionCongenital AbnormalitiesCross-Sectional StudiesFemaleHumansLogistic ModelsMaleMedical Laboratory PersonnelMetallurgyMultivariate AnalysisOccupational ExposureOdds RatioPregnancyPregnancy OutcomePremature BirthSex FactorsTime FactorsWorkforceConceptsFemale laboratory workersCongenital anomaliesOccupational exposureLaboratory workersAdverse pregnancy outcomesRate of miscarriageMajor congenital anomaliesCross-sectional surveyPregnancy outcomesSingleton birthsReproductive outcomesDiverse anomaliesFemale workersReference groupPotential exposureOutcomesExposureSpecific patternsPregnancyMiscarriageWorkersDevelopment and maturation of the normal female reproductive system
Kondapalli L, Woodruff T, Doherty L, Taylor H, Maffini M, Sonnenschein C, Soto A. Development and maturation of the normal female reproductive system. 2010 DOI: 10.1017/cbo9780511674686.004.Peer-Reviewed Original ResearchEnvironmental reproductive healthPoor pregnancy outcomesAbnormal fetal developmentReproductive health outcomesFemale reproductive systemPregnancy outcomesClinical careFetal developmentHealth outcomesHealth problemsReproductive healthEarly pubertyPublic health fieldReproductive systemEnvironmental contaminantsCritical periodReproductive organsOutcomesHealth fieldHealthExposurePotential effectsEndometriosisInfertilityMiscarriage
2002
Detection and Therapeutic Approaches to Age-Related Infertility
Sharara F, Scott R, Seifer D. Detection and Therapeutic Approaches to Age-Related Infertility. 2002, 24-38. DOI: 10.1007/978-3-642-87690-5_3.Peer-Reviewed Original Research
1996
Recurrent Pregnancy Loss
Arici A, Bukulmez O. Recurrent Pregnancy Loss. 1996, 119-133. DOI: 10.1007/978-3-642-60961-9_12.Peer-Reviewed Original Research
1986
Risk of Late First and Second Trimester Miscarriage After Induced Abortion
Bracken M, Bryce-Buchanan C, Srisuphan W, Holford T, Silten R. Risk of Late First and Second Trimester Miscarriage After Induced Abortion. American Journal Of Perinatology 1986, 3: 84-91. PMID: 3964388, DOI: 10.1055/s-2007-999839.Peer-Reviewed Original ResearchConceptsFirst prenatal visitSecond trimester miscarriagePrivate obstetric practicesLate miscarriagePrenatal visitFirst pregnancySecond pregnancySecond trimesterSubsequent miscarriageTrimester miscarriagePregnancy historyObstetric practiceInduced abortionMiscarriagePregnancyWomenAbortionRiskLate FirstTrimesterCohortVisits
1985
Menarcheal age and habitual miscarriage: evidence for an association
Bracken M, Bryce-Buchanan C, Stilten R, Holford T. Menarcheal age and habitual miscarriage: evidence for an association. Annals Of Human Biology 1985, 12: 525-531. PMID: 4091507, DOI: 10.1080/03014468500008101.Peer-Reviewed Original Research
1983
EVENTS OF REPRODUCTIVE LIFE AND THE INCIDENCE OF EPITHELIAL OVARIAN CANCER
RISCH H, WEISS N, LYON J, DALING J, LIFF J. EVENTS OF REPRODUCTIVE LIFE AND THE INCIDENCE OF EPITHELIAL OVARIAN CANCER. American Journal Of Epidemiology 1983, 117: 128-139. PMID: 6681935, DOI: 10.1093/oxfordjournals.aje.a113523.Peer-Reviewed Original ResearchConceptsEpithelial ovarian cancerOvarian cancerOral contraceptionInhibition of ovulationPituitary gonadotrophin secretionLack of associationThyroid medicationOral contraceptivesNoncontraceptive estrogensGonadotrophin secretionMedical historyRelative riskDiminished riskTotal doseYears of lactationCancerLogistic regression methodReproductive lifePregnancyMiscarriageRiskContraceptionRandom sampleWomenLactation
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