2023
Lymphocytic Choriomeningitis Virus in Person Living with HIV, Connecticut, USA, 2021 - Volume 29, Number 9—September 2023 - Emerging Infectious Diseases journal - CDC
Dyal J, Gandhi S, Cossaboom C, Leach A, Patel K, Golden M, Canterino J, Landry M, Cannon D, Choi M, Krapiunaya I, Klena J, Shoemaker T. Lymphocytic Choriomeningitis Virus in Person Living with HIV, Connecticut, USA, 2021 - Volume 29, Number 9—September 2023 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2023, 29: 1886-1889. PMID: 37610188, PMCID: PMC10461659, DOI: 10.3201/eid2909.230087.Peer-Reviewed Original Research
2017
Interleukin-10 from CD4+ follicular regulatory T cells promotes the germinal center response
Laidlaw BJ, Lu Y, Amezquita RA, Weinstein JS, Vander Heiden JA, Gupta NT, Kleinstein SH, Kaech SM, Craft J. Interleukin-10 from CD4+ follicular regulatory T cells promotes the germinal center response. Science Immunology 2017, 2 PMID: 29054998, PMCID: PMC5846620, DOI: 10.1126/sciimmunol.aan4767.Peer-Reviewed Original ResearchConceptsFollicular regulatory T cellsRegulatory T cellsIL-10Lymphocytic choriomeningitis virusT cellsB cellsInterleukin-10GC responseCell-derived IL-10Follicular helper T cellsHelper T cellsB cell responsesGerminal center responseGerminal center developmentActivated B cellsBox protein 1GC B cellsAcute infectionCenter responseCell responsesImportant mediatorNuclear translocationGC reactionProtein 1Forkhead box protein 1
2015
Lassa-Vesicular Stomatitis Chimeric Virus Safely Destroys Brain Tumors
Wollmann G, Drokhlyansky E, Davis JN, Cepko C, van den Pol AN. Lassa-Vesicular Stomatitis Chimeric Virus Safely Destroys Brain Tumors. Journal Of Virology 2015, 89: 6711-6724. PMID: 25878115, PMCID: PMC4468483, DOI: 10.1128/jvi.00709-15.Peer-Reviewed Original ResearchConceptsLymphocytic choriomeningitis virusBrain tumorsVesicular stomatitis virusChimeric virusesBrain cancerLassa virusEbola virusMarburg virusRabies virusAdverse neurologic consequencesExquisite tumor specificityHigh-grade tumorsPromising oncolytic virusLassa virus glycoprotein precursorAdverse side effectsTumor-bearing miceMetastatic cancer modelsStomatitis virusNovel chimeric virusHigh-grade glioblastomaEbola virus glycoproteinMultiple cancer typesNoninjected tumorNeurologic consequencesOncolytic potential
2014
Transcription Factor STAT3 and Type I Interferons Are Corepressive Insulators for Differentiation of Follicular Helper and T Helper 1 Cells
Ray JP, Marshall HD, Laidlaw BJ, Staron MM, Kaech SM, Craft J. Transcription Factor STAT3 and Type I Interferons Are Corepressive Insulators for Differentiation of Follicular Helper and T Helper 1 Cells. Immunity 2014, 40: 367-377. PMID: 24631156, PMCID: PMC3992517, DOI: 10.1016/j.immuni.2014.02.005.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, ViralAntibody SpecificityB-LymphocytesCD4 AntigensCD4-Positive T-LymphocytesCell DifferentiationGene Expression ProfilingGene Expression RegulationGerminal CenterImmunoglobulin Class SwitchingInterferon Type ILymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMiceMice, KnockoutSignal TransductionSTAT1 Transcription FactorSTAT3 Transcription FactorT-Lymphocytes, Helper-InducerTranscriptomeConceptsTfh cellsType I interferonI interferonViral infectionFollicular helper T cellsT helper 1 cellsAntigen-specific antibody productionGC B cell phenotypeHigh affinity antibody-secreting cellsTfh cell differentiationHelper T cellsB cell memoryLymphocytic choriomeningitis virusB-cell phenotypeAntibody-secreting cellsGerminal center B cellsEffector phenotypeReceptor blockadeAcute infectionFollicular helperIFN-inducible genesT cellsTranscription factor STAT3B cellsAntibody production
2013
The risk of hemophagocytic lymphohistiocytosis in Hermansky-Pudlak syndrome type 2
Jessen B, Bode S, Ammann S, Chakravorty S, Davies G, Diestelhorst J, Frei-Jones M, Gahl W, Gochuico B, Griese M, Griffiths G, Janka G, Klein C, Kögl T, Kurnik K, Lehmberg K, Maul-Pavicic A, Mumford A, Pace D, Parvaneh N, Rezaei N, de Saint Basile G, Schmitt-Graeff A, Schwarz K, Karasu G, Zieger B, Stadt U, Aichele P, Ehl S. The risk of hemophagocytic lymphohistiocytosis in Hermansky-Pudlak syndrome type 2. Blood 2013, 121: 2943-2951. PMID: 23403622, PMCID: PMC3624940, DOI: 10.1182/blood-2012-10-463166.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Protein Complex 3Adaptor Protein Complex beta SubunitsAdolescentAdultAnimalsChildChild, PreschoolCytotoxicity, ImmunologicFlow CytometryHermanski-Pudlak SyndromeHumansLymphohistiocytosis, HemophagocyticMiceMice, Inbred C57BLMice, KnockoutMutationrab GTP-Binding Proteinsrab27 GTP-Binding ProteinsRisk FactorsT-Lymphocytes, CytotoxicYoung AdultConceptsHermansky-Pudlak syndrome type 2Hemophagocytic lymphohistiocytosisLymphocyte cytotoxicityHPS2 patientsRAB27A mutationsPatients to hemophagocytic lymphohistiocytosisRisk of hemophagocytic lymphohistiocytosisFeatures of hemophagocytic lymphohistiocytosisHematopoietic stem cell transplantationHermansky-PudlakImpaired virus controlPerforin-deficient miceStem cell transplantationType 2Lymphocytic choriomeningitis virusCytotoxicity in vivoChediak-Higashi syndromeCytotoxicity defectsCell transplantationPatient yearsPearl micePatientsGenetic disordersMilder defectsDisease parameters
2012
Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients with Wiskott-Aldrich syndrome protein deficiency
Lang P, Shaabani N, Borkens S, Honke N, Scheu S, Booth S, Brenner D, Meryk A, Barthuber C, Recher M, Mak T, Ohashi P, Häussinger D, Griffiths G, Thrasher A, Bouma G, Lang K. Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients with Wiskott-Aldrich syndrome protein deficiency. Journal Of Allergy And Clinical Immunology 2012, 131: 815-824.e2. PMID: 23141740, PMCID: PMC3757164, DOI: 10.1016/j.jaci.2012.08.050.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArenaviridae InfectionsCD8-Positive T-LymphocytesDendritic CellsDisease Models, AnimalHumansInterferon Type ILymphocytic choriomeningitis virusMiceMice, Inbred C57BLMice, KnockoutRhabdoviridae InfectionsVesicular stomatitis Indiana virusWiskott-Aldrich SyndromeWiskott-Aldrich Syndrome ProteinConceptsLymphocytic choriomeningitis virusWiskott-Aldrich syndromeDendritic cellsKO miceIFN-IWiskott-Aldrich syndrome protein-deficientViral clearanceWASP deficiencyPriming of CD8(+) T cellsAntigen-specific T-cell numbersCD8(+) T cell immunityCD8(+) T cell responsesEffects of WASP deficiencyLymphocytic choriomeningitis virus infectionCD8(+) T cellsViral infectionX-linked primary immunodeficiencyProduction of IFN-IRecurrent viral infectionsT cell defectsT cell numbersT cell responsesAntiviral immunityT cell immunityRare X-linked primary immunodeficiency
2011
Development of Autoimmune Diabetes in the Absence of Detectable IL-17A in a CD8-Driven Virally Induced Model
Van Belle TL, Esplugues E, Liao J, Juntti T, Flavell RA, von Herrath MG. Development of Autoimmune Diabetes in the Absence of Detectable IL-17A in a CD8-Driven Virally Induced Model. The Journal Of Immunology 2011, 187: 2915-2922. PMID: 21832162, PMCID: PMC3169711, DOI: 10.4049/jimmunol.1000180.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell SeparationDiabetes Mellitus, Type 1Disease Models, AnimalFemaleFlow CytometryGene Knock-In TechniquesGenes, ReporterGreen Fluorescent ProteinsInterleukin-17Lymphocytic choriomeningitis virusMaleMiceMice, Inbred C57BLVirus DiseasesConceptsType 1 diabetesIL-17AIL-17IL-17A.T cellsViral infectionAutoimmune diabetes developmentVirus-induced modelIL-17 levelsIL-17A productionΓδ T cellsLymphocytic choriomeningitis virusAutoimmune diabetesAutoimmune disordersChronic inflammationDiabetes developmentViral eliminationReporter miceDiabetesBacterial infectionsInfectionCD8Recent studiesCellsInflammationMemory T cells from minor histocompatibility antigen–vaccinated and virus-immune donors improve GVL and immune reconstitution
Li N, Matte-Martone C, Zheng H, Cui W, Venkatesan S, Tan HS, McNiff J, Demetris AJ, Roopenian D, Kaech S, Shlomchik WD. Memory T cells from minor histocompatibility antigen–vaccinated and virus-immune donors improve GVL and immune reconstitution. Blood 2011, 118: 5965-5976. PMID: 21917752, PMCID: PMC3228506, DOI: 10.1182/blood-2011-07-367011.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell ProliferationGraft vs Leukemia EffectHematopoiesisImmunologic MemoryLymphocytesLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMiceMice, Inbred C3HMice, Inbred C57BLMice, KnockoutMinor Histocompatibility AntigensT-LymphocytesTissue DonorsTransplantation ImmunologyUp-RegulationVaccinationConceptsDonor T cellsMemory T cellsImmune reconstitutionT cellsAllogeneic hematopoietic stem cell transplantationSingle minor histocompatibility antigenHematopoietic stem cell transplantationVirus-immune donorsLeukemia cellsStem cell transplantationMinor histocompatibility antigensT-cell manipulationChronic myeloid leukemiaLymphocytic choriomeningitis virusGVL effectLeukemia relapseAdoptive immunotherapyMinor histocompatibilityTreatment failureCell transplantationMyeloid leukemiaHistocompatibility antigensGVHDVaccinationInfection
2009
Meningitis in a College Student in Connecticut, 2007
Sosa LE, Gupta S, Juthani-Mehta M, Hadler JL. Meningitis in a College Student in Connecticut, 2007. Journal Of American College Health 2009, 58: 12-14. PMID: 19592348, DOI: 10.3200/jach.58.1.12-14.Peer-Reviewed Original ResearchConceptsLymphocytic choriomeningitis virusCause of meningitisPublic health implicationsAseptic meningitisLCMV infectionRodent exposureMeningitisHealth implicationsInfectionEpidemiology
2008
The Proline-Rich Homeodomain (PRH/HEX) Protein Is Down-Regulated in Liver during Infection with Lymphocytic Choriomeningitis Virus
Djavani M, Topisirovic I, Zapata J, Sadowska M, Yang Y, Rodas J, Lukashevich I, Bogue C, Pauza C, Borden K, Salvato M. The Proline-Rich Homeodomain (PRH/HEX) Protein Is Down-Regulated in Liver during Infection with Lymphocytic Choriomeningitis Virus. Journal Of Virology 2008, 82: 8954-8954. PMCID: PMC2519670, DOI: 10.1128/jvi.01304-08.Peer-Reviewed Original ResearchLymphocytic choriomeningitis virus
2002
Role of Lymphotoxin α in T-Cell Responses during an Acute Viral Infection
Suresh M, Lanier G, Large MK, Whitmire JK, Altman JD, Ruddle NH, Ahmed R. Role of Lymphotoxin α in T-Cell Responses during an Acute Viral Infection. Journal Of Virology 2002, 76: 3943-3951. PMID: 11907234, PMCID: PMC136110, DOI: 10.1128/jvi.76.8.3943-3951.2002.Peer-Reviewed Original ResearchConceptsT cell responsesCD8 T cellsLymphocytic choriomeningitis virusT cellsT cell activationLymphoid architectureMajor histocompatibility complex class I tetramersVirus-specific CD8 T cell responsesLCMV-specific CD8 T cellsLCMV-specific T-cell responsesVirus-specific CD8 T cellsAntigen-specific T cell responsesCD8 T cell responsesLCMV-specific T cellsT cell-mediated immunopathologyLTalpha-deficient miceClass I tetramersAcute viral infectionCD4 T cellsAdoptive transfer experimentsCell transfer experimentsLCMV clearanceNonlymphoid organsAdoptive transferAcute infection
1992
Lymphocytic choriomeningitis virus infection and house mouse (Mus musculus) distribution in urban Baltimore.
Childs J, Glass G, Korch G, Ksiazek T, Leduc J. Lymphocytic choriomeningitis virus infection and house mouse (Mus musculus) distribution in urban Baltimore. American Journal Of Tropical Medicine And Hygiene 1992, 47: 27-34. PMID: 1636880, DOI: 10.4269/ajtmh.1992.47.27.Peer-Reviewed Original Research
1991
Human-rodent contact and infection with lymphocytic choriomeningitis and Seoul viruses in an inner-city population.
Childs J, Glass G, Ksiazek T, Rossi C, Oro J, Leduc J. Human-rodent contact and infection with lymphocytic choriomeningitis and Seoul viruses in an inner-city population. American Journal Of Tropical Medicine And Hygiene 1991, 44: 117-21. PMID: 1672798, DOI: 10.4269/ajtmh.1991.44.117.Peer-Reviewed Original ResearchConceptsLymphocytic choriomeningitis virusSeoul virusRodent-borne virusesHuman-rodent contactHistory of travelInner-city populationDisease clinicRodent exposureLymphocytic choriomeningitisAntibody prevalenceNeutralization testSerological testsAntibodiesVirusHigh rateInfectionRatsMore exposureExposureQuestionnaire responsesChoriomeningitisClinicPrevalenceMicePersons
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