2025
Integration of Metabolomic and Brain Imaging Data Highlights Pleiotropy Among Posttraumatic Stress Disorder, Glycoprotein Acetyls, and Pallidum Structure
Løkhammer S, Tesfaye M, Cabrera-Mendoza B, Sandås K, Pathak G, Friligkou E, Le Hellard S, Polimanti R. Integration of Metabolomic and Brain Imaging Data Highlights Pleiotropy Among Posttraumatic Stress Disorder, Glycoprotein Acetyls, and Pallidum Structure. Biological Psychiatry Global Open Science 2025, 5: 100482. PMID: 40270839, PMCID: PMC12013147, DOI: 10.1016/j.bpsgos.2025.100482.Peer-Reviewed Original ResearchPosttraumatic stress disorderLocal genetic correlationImaging-derived phenotypesBrain imaging-derived phenotypesStress disorderAssociated with posttraumatic stress disorderDevelopment of posttraumatic stress disorderExposure to severe traumatic eventsGenetic correlationsGenome-wide dataSevere traumatic eventsBrain frontal cortexBrain imaging markersFrontal cortexLeft pallidumMap genesGenetic regionsGlycoprotein acetylsTraumatic eventsMetabolic biomarkersGenetic relationshipsTranscriptome regulationGenetic overlapStress responseMetabolic processes
2024
Association of a dietary inflammatory index with cardiometabolic, endocrine, liver, renal and bones biomarkers: cross-sectional analysis of the UK Biobank study
Carrasco-Marín F, Zhao L, Hébert J, Wirth M, Petermann-Rocha F, Phillips N, Malcomson F, Mathers J, Ferguson L, Ho F, Pell J, Celis-Morales C, Molina-Recio G, Molina-Luque R. Association of a dietary inflammatory index with cardiometabolic, endocrine, liver, renal and bones biomarkers: cross-sectional analysis of the UK Biobank study. Nutrition Metabolism And Cardiovascular Diseases 2024, 34: 1731-1740. PMID: 38664123, DOI: 10.1016/j.numecd.2024.03.010.Peer-Reviewed Original ResearchConceptsPro-inflammatory dietLiver functionUK Biobank participantsUK Biobank studyHealthy individualsDiet Inflammatory IndexDietary inflammatory indexCross-sectional studyCross-sectional analysisAnti-inflammatory dietBiobank participantsBiobank studyCardiometabolic healthChronic diseasesInflammatory indexRenal functionBone biomarkersProfiles of biomarkersBone healthMetabolic biomarkersCardiometabolicRenal markersIGF-1Metabolic healthTotal cholesterol
2023
THU605 Impact Of Abnormal Circadian Cortisol Secretion On Bone Metabolism In Patients With Mild Autonomous Cortisol Secretion
Saini J, Nathani R, Singh S, Fell V, Atkinson E, Achenbach S, Khosla S, Bancos I. THU605 Impact Of Abnormal Circadian Cortisol Secretion On Bone Metabolism In Patients With Mild Autonomous Cortisol Secretion. Journal Of The Endocrine Society 2023, 7: bvad114.135. PMCID: PMC10554199, DOI: 10.1210/jendso/bvad114.135.Peer-Reviewed Original ResearchArea under the curveAutonomous cortisol secretionParathyroid hormoneBone metabolism biomarkersCortisol secretionFree cortisolType 1 collagenBone metabolismReference subjectsCircadian cortisol secretionCarboxy-terminal telopeptide of type 1 collagenMetabolic biomarkersMild autonomous cortisol secretionIncreased risk of fractureCross-sectional study of patientsCortisol productionParathyroid hormone productionDexamethasone suppression testRisk of fractureCarboxy-terminal telopeptideImpaired bone metabolismStudy of patientsCircadian secretory patternClinical research unitIncreased cortisol productionGenetic variants of glucose metabolism and exposure to smoking in African American breast cancer.
Jung S, Papp J, Sobel E, Pellegrini M, Yu H. Genetic variants of glucose metabolism and exposure to smoking in African American breast cancer. Endocrine Related Cancer 2023, 30 PMID: 36705562, PMCID: PMC10095926, DOI: 10.1530/erc-22-0184.Peer-Reviewed Original ResearchConceptsInsulin resistanceBC riskLifestyle factorsSingle nucleotide polymorphismsAA womenRisk genotypesAfrican American postmenopausal womenAfrican-American breast cancerRisk of BCBreast cancer developmentDose-dependent mannerPostmenopausal womenPositive BCPredictive markerRisk factorsFemale hormonesBreast cancerGlucose metabolismMetabolic biomarkersGene-environment interaction analysisSmokingPreventive interventionsCancer developmentWhite womenIndividual single nucleotide polymorphisms
2019
Randomized phase II trial of exercise, metformin, or both on metabolic biomarkers in colorectal and breast cancer survivors
Meyerhardt JA, Irwin ML, Jones LW, Zhang S, Campbell N, Brown JC, Pollak M, Sorrentino A, Cartmel B, Harrigan M, Tolaney SM, Winer E, Ng K, Abrams T, Fuchs CS, Sanft T, Douglas PS, Hu F, Ligibel JA. Randomized phase II trial of exercise, metformin, or both on metabolic biomarkers in colorectal and breast cancer survivors. JNCI Cancer Spectrum 2019, 4: pkz096. PMID: 32090192, PMCID: PMC7025659, DOI: 10.1093/jncics/pkz096.Peer-Reviewed Original ResearchBreast cancer survivorsPhase II trialCancer survivorsControl armII trialInsulin levelsRandomized phase II trialInsulin-like growth factor-1Insulin-like growth factorHomeostatic model assessmentCombination of exerciseSignificant weight lossGrowth factor-1Combination armMetformin useSecondary outcomesStandard therapyPrimary outcomeIntervention armInsulin resistanceDisease outcomeModality interventionsAnthropometric measurementsMetabolic markersMetabolic biomarkers
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