2024
Acute pancreatitis: pathogenesis and emerging therapies
Zaman S, Gorelick F. Acute pancreatitis: pathogenesis and emerging therapies. Journal Of Pancreatology 2024, 7: 10-20. PMID: 38524855, PMCID: PMC10959536, DOI: 10.1097/jp9.0000000000000168.Peer-Reviewed Original ResearchAcute pancreatitisSevere inflammatory disordersLimited treatment optionsLong-term outcomesPotential treatment benefitsPromising new therapyDisease mechanismsPotential therapeutic targetEmerging TherapiesAcute injuryInflammatory disordersPharmacologic interventionsTreatment optionsTreatment benefitPotential therapyNew therapiesSpecific treatmentTherapeutic targetNew treatmentsTherapyPancreatitisTreatmentComplicationsPathogenesisInjury
2023
A discrete ‘early-responder’ stromal-cell subtype orchestrates immunocyte recruitment to injured tissue
Yaghi O, Hanna B, Langston P, Michelson D, Jayewickreme T, Marin-Rodero M, Benoist C, Mathis D. A discrete ‘early-responder’ stromal-cell subtype orchestrates immunocyte recruitment to injured tissue. Nature Immunology 2023, 24: 2053-2067. PMID: 37932455, PMCID: PMC10792729, DOI: 10.1038/s41590-023-01669-w.Peer-Reviewed Original ResearchConceptsMesenchymal stromal cellsStromal cellsMouse modelMouse model of muscular dystrophyModels of muscular dystrophyAcute injuryUnique surface markersRecruitment of neutrophilsResponse to injuryStromal cell subtypesImmunomodulatory programsImmunocyte recruitmentCell collaborationTissue regenerationStroma-specificTNF-aSurface markersDay 1IL-1BCell subtypesInflammatory programMuscular dystrophyInduce inflammationSubtypesOncostatin MMicroRNA-1 protects the endothelium in acute lung injury
Korde A, Haslip M, Pednekar P, Khan A, Chioccioli M, Mehta S, Lopez-Giraldez F, Bermejo S, Rojas M, Dela Cruz C, Matthay M, Pober J, Pierce R, Takyar S. MicroRNA-1 protects the endothelium in acute lung injury. JCI Insight 2023, 8: e164816. PMID: 37737266, PMCID: PMC10561733, DOI: 10.1172/jci.insight.164816.Peer-Reviewed Original ResearchConceptsAcute respiratory distress syndromeAcute lung injuryVascular endothelial growth factorAngiopoietin-2Lung injuryAcute injuryMiR-1MicroRNA-1Endothelial cell-specific overexpressionSevere endothelial dysfunctionRespiratory distress syndromeSurvival of miceIntrinsic protective effectContext of injuryCell-specific overexpressionEndothelial growth factorFamily member 3Pneumonia cohortMiR-1 targetsEndothelial dysfunctionDistress syndromeBarrier dysfunctionCapillary leakProtective effectSevere formAntimicrobial Wound Dressings: A Concise Review for Clinicians
Yousefian F, Hesari R, Jensen T, Obagi S, Rgeai A, Damiani G, Bunick C, Grada A. Antimicrobial Wound Dressings: A Concise Review for Clinicians. Antibiotics 2023, 12: 1434. PMID: 37760730, PMCID: PMC10526066, DOI: 10.3390/antibiotics12091434.Peer-Reviewed Original ResearchAntimicrobial dressingsWound managementSubstantial clinical challengeRisk of infectionChronic skin woundsVenous insufficiencyAcute injurySurgical woundsClinical challengeWound careWound typesMicrobial burdenSkin woundsMode of actionWoundsCliniciansHealingConcise reviewDressingMorbidityObesityDiabetesReviewInjuryInsufficiencyNLRX1 knockdown attenuates pro-apoptotic signaling and cell death in pulmonary hyperoxic acute injury
Kim H, Kim M, Kim E, Leem J, Baek S, Lee Y, Kim K, Kang M, Song T, Sohn M. NLRX1 knockdown attenuates pro-apoptotic signaling and cell death in pulmonary hyperoxic acute injury. Scientific Reports 2023, 13: 3441. PMID: 36859435, PMCID: PMC9975446, DOI: 10.1038/s41598-023-28206-x.Peer-Reviewed Original ResearchConceptsHyperoxic acute lung injuryAcute lung injuryLung injuryWT miceAcute respiratory failurePro-inflammatory cytokinesCell deathRespiratory failureAcute injuryInflammatory cellsReduced mortalityRole of NLRX1Murine modelNLRX1 expressionPro-apoptotic signalingCell cytotoxicityHyperoxiaInjuryMiceProtein leakageHyperoxic conditionsNLRX1Apoptotic cell deathERK 1/2Reactive oxygen species
2022
Cellular Heterogeneity and Molecular Reprogramming of the Host Response during Influenza Acute Lung Injury
Guo K, Yombo D, Schmit T, Wang Z, Navaeiseddighi Z, Sathish V, Mathur R, Wu M, De Kumar B, Hur J, Khan N. Cellular Heterogeneity and Molecular Reprogramming of the Host Response during Influenza Acute Lung Injury. Journal Of Virology 2022, 96: e01246-22. PMID: 36286482, PMCID: PMC9645213, DOI: 10.1128/jvi.01246-22.Peer-Reviewed Original ResearchConceptsAcute lung injuryLung injuryIAV infectionHost responseDysregulated host responseExuberant host responseOutcome of interferonTotal immune cellsMonocyte-derived macrophagesSingle-cell RNA sequencing analysisChemokine responsesAcute injuryCellular levelImmune cellsNonimmune cellsBarrier integrityMyeloid cellsTherapeutic interventionsCellular heterogeneityInjuryChemokine signalingNonhematopoietic cellsInfectionRNA sequencing analysisMechanistic associationRENALASE: DISCOVERY, BIOLOGY, AND THERAPEUTIC APPLICATIONS.
Desir GV. RENALASE: DISCOVERY, BIOLOGY, AND THERAPEUTIC APPLICATIONS. Transactions Of The American Clinical And Climatological Association 2022, 132: 117-125. PMID: 36196172, PMCID: PMC9480547.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseStage renal diseaseCardiovascular complicationsOrgan survivalRenal diseaseAcute injuryKidney diseaseChronic injurySignificant burdenRenalaseStressful stimuliPeptide agonistsNicotinamide adenine dinucleotideMitochondrial functionInjuryEnergy metabolismDiseaseTherapeutic applicationsAdenine dinucleotideCellsComplicationsPathophysiologyAgonistsKidneyPancreas
2021
Renalase: A Multi-Functional Signaling Molecule with Roles in Gastrointestinal Disease
Pointer TC, Gorelick FS, Desir GV. Renalase: A Multi-Functional Signaling Molecule with Roles in Gastrointestinal Disease. Cells 2021, 10: 2006. PMID: 34440775, PMCID: PMC8391834, DOI: 10.3390/cells10082006.Peer-Reviewed Original ResearchConceptsProsurvival effectAcute cerulein pancreatitisRole of renalaseAnti-inflammatory effectsDisease modelsAcute organ injuryRelevant clinical settingsShortens life expectancyPreclinical disease modelsCell survivalHuman cancer tissuesCancer cell survivalOrgan injuryAcute injuryPancreatic cancerIntestinal diseaseGastrointestinal diseasesRodent modelsCerulein pancreatitisSelect cancersCancer tissuesRenalaseClinical settingTherapeutic agentsExport transportersVector Appropriate Distraction and Reduction of a Neglected Trimalleolar Fracture‐Dislocation Performed with a Temporary Intraoperative External Fixator
Brand J, Moran J, Yoo B. Vector Appropriate Distraction and Reduction of a Neglected Trimalleolar Fracture‐Dislocation Performed with a Temporary Intraoperative External Fixator. Case Reports In Orthopedics 2021, 2021: 5577626. PMID: 34336330, PMCID: PMC8286194, DOI: 10.1155/2021/5577626.Peer-Reviewed Original ResearchExternal fixatorPostoperative complicationsSoft tissue contracturesSoft tissue releaseMultiplanar external fixatorOne-stage procedureHigh rateTibiotalar dislocationAnkle fracturesFracture dislocationOpen injuriesAcute injuryAnatomic reductionInternal fixationPatient noncomplianceTraumatic fracturesMalunited fracturesTissue contracturesTissue releaseWorse outcomesWorse patientCare plansStable fixationLoose bodiesComplex treatmentOvariectomy Affects Acute Pancreatitis in Mice
Wang M, Gorelick F. Ovariectomy Affects Acute Pancreatitis in Mice. Digestive Diseases And Sciences 2021, 67: 2971-2980. PMID: 34169436, PMCID: PMC8702581, DOI: 10.1007/s10620-021-07116-w.Peer-Reviewed Original ResearchConceptsOvariectomized mouse modelEffects of estradiolOvariectomized miceAcute pancreatitisEstradiol levelsPancreatitis severityMouse modelPancreatic studiesSevere acute injurySerum estradiol levelsMild acute pancreatitisAcute pancreatitis severityEstradiol conditionsHospital mortalityHourly injectionsAcute injuryOvariectomized modelFemale hormonesEstradiol injectionPancreatitisEstradiol depletionCausative roleDisease severityConclusionsThese findingsMiceLeukocyte dynamics after intracerebral hemorrhage in a living patient reveal rapid adaptations to tissue milieu
Goods BA, Askenase MH, Markarian E, Beatty HE, Drake RS, Fleming I, DeLong JH, Philip NH, Matouk CC, Awad IA, Zuccarello M, Hanley DF, Love JC, Shalek AK, Sansing LH, Investigators T. Leukocyte dynamics after intracerebral hemorrhage in a living patient reveal rapid adaptations to tissue milieu. JCI Insight 2021, 6: e145857. PMID: 33749664, PMCID: PMC8026179, DOI: 10.1172/jci.insight.145857.Peer-Reviewed Original ResearchConceptsIntracerebral hemorrhageAcute brain injurySystemic immune responsesBrain tissue injuryHigh mortality rateLocal cellular responseAcute injuryTreatment optionsIntracerebral eventsBrain injuryCerebral hematomaLeukocyte responseTissue injuryT cellsImmune responseCT scanMortality rateDevastating formImmune dynamicsTherapeutic interventionsLeukocyte dynamicsBrain tissuePatientsInvasive surgeryInjury
2019
Alcohol-related trauma reinjury prevention with hospital-based screening in adult populations: An Eastern Association for the Surgery of Trauma evidence-based systematic review.
Kodadek LM, Freeman JJ, Tiwary D, Drake MD, Schroeder ME, Dultz L, White C, Abdel Aziz H, Crandall M, Como JJ, Rattan R. Alcohol-related trauma reinjury prevention with hospital-based screening in adult populations: An Eastern Association for the Surgery of Trauma evidence-based systematic review. Journal Of Trauma And Acute Care Surgery 2019, 88: 106-112. PMID: 31490336, DOI: 10.1097/ta.0000000000002501.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsEvidence-based systematic reviewHospital-based alcoholTrauma centerBrief interventionSystematic reviewAppropriate patientsEmergency departmentAlcohol screeningQuery of PubMedAdult trauma patientsHospital-based screeningAlcohol use disorderOutcomes of interestRecommendations AssessmentUsual careAdult patientsHospital readmissionRecurrent injuryTrauma patientsAcute injuryCochrane LibraryUse disordersPatientsAlcohol consumptionEastern Association
2017
The serum protein renalase reduces injury in experimental pancreatitis
Kolodecik TR, Reed AM, Date K, Shugrue C, Patel V, Chung SL, Desir GV, Gorelick FS. The serum protein renalase reduces injury in experimental pancreatitis. Journal Of Biological Chemistry 2017, 292: 21047-21059. PMID: 29042438, PMCID: PMC5743078, DOI: 10.1074/jbc.m117.789776.Peer-Reviewed Original ResearchMeSH KeywordsAcinar CellsAnimalsAnti-Inflammatory Agents, Non-SteroidalBiomarkersCalcium SignalingCarbacholCell LineCeruletideEnzyme ActivationFluorescent Antibody Technique, IndirectGene Expression Regulation, EnzymologicHumansHypertensionLigandsMembrane Transport ModulatorsMiceMice, KnockoutMonoamine OxidasePancreasPancreatitisPlasma Membrane Calcium-Transporting ATPasesRecombinant Fusion ProteinsTaurolithocholic AcidConceptsRecombinant human renalaseAcute pancreatitisAcute injuryCell injuryAcinar cell injuryHuman acinar cellsCytosolic calcium levelsPlasma membrane calcium ATPasePancreatitis onsetIschemic injuryWT micePathological increaseHistological changesProtective effectSevere diseaseMurine modelMembrane calcium ATPasePancreatitisCalcium levelsExperimental pancreatitisBile acidsTissue damageRenalaseInjuryCerulein model
2015
Clinical Correlates and Prognostic Significance of Lateralized Periodic Discharges in Patients Without Acute or Progressive Brain Injury
Sainju RK, Manganas LN, Gilmore EJ, Petroff OA, Rampal N, Hirsch LJ, Gaspard N. Clinical Correlates and Prognostic Significance of Lateralized Periodic Discharges in Patients Without Acute or Progressive Brain Injury. Journal Of Clinical Neurophysiology 2015, 32: 495-500. PMID: 26200591, DOI: 10.1097/wnp.0000000000000206.Peer-Reviewed Original ResearchConceptsProgressive brain injuryAcute brain injuryBrain injuryAbnormal consciousnessPeriodic dischargesClinical correlatesFunctional declineLateralized periodic dischargesRemote brain injuryOutcomes of patientsCase-control studyContinuous EEG monitoringHistory of epilepsyRadiologic evidenceHospital dischargeStatus epilepticusWorse prognosisAcute injuryPrognostic significanceWorse outcomesEEG monitoringMultivariate analysisInjuryPatientsLower likelihood
2014
Lower extremity overuse injuries in the skeletally immature athlete
Williams A, Valasek A, Wilckens J. Lower extremity overuse injuries in the skeletally immature athlete. Current Orthopaedic Practice 2014, 25: 375-382. DOI: 10.1097/bco.0000000000000117.Peer-Reviewed Original ResearchOveruse injuriesLower extremity overuse injuriesCombination of repetitive microtraumaTreatment of overuse injuriesMuscle-tendon imbalancesAthlete’s sports participationSports participationPromote preventionSports activitiesRepetitive microtraumaEarly recognitionHealing timeImproper techniqueAcute injuryOveruseInjuryImmature skeletonTalking pointsParticipantsChildrenAdolescentsMultiple teamsPhysiciansSportsCoachingWound healing in acutely injured fascia
Lau F, Pomahac B. Wound healing in acutely injured fascia. Wound Repair And Regeneration 2014, 22: 14-17. PMID: 24813359, DOI: 10.1111/wrr.12165.Peer-Reviewed Original ResearchConceptsFascial healingIncisional herniaApparent functional deficitsSpecific surgical methodsFascial wound healingPaucity of dataHealing failureAcute injuryFunctional deficitsSurgical methodsSurgical proceduresSuch herniasMedical costsClinical settingHerniaClinical methodsFasciaWound healingHealingUnexpected findingRecent studiesSuch healingFailureCeliotomyPatients
2012
IL-22 Promotes Fibroblast-Mediated Wound Repair in the Skin
McGee HM, Schmidt BA, Booth CJ, Yancopoulos GD, Valenzuela DM, Murphy AJ, Stevens S, Flavell RA, Horsley V. IL-22 Promotes Fibroblast-Mediated Wound Repair in the Skin. Journal Of Investigative Dermatology 2012, 133: 1321-1329. PMID: 23223145, PMCID: PMC3610794, DOI: 10.1038/jid.2012.463.Peer-Reviewed Original ResearchConceptsIL-22Immune cellsCytokine IL-22Epithelial cellsWound repairIL-22 signalingDermal compartmentFull-thickness woundingAcute injuryPeripheral tissuesSkin wound repairEpithelial regenerationMyofibroblast differentiationSkin woundingEpidermal barrierExtracellular matrix gene expressionMatrix gene expressionInjuryVivo roleSkin repairMiceUnidentified roleFibroblastsRepairUnidirectional signaling
2008
Apoptosis of the Thick Ascending Limb Results in Acute Kidney Injury
Srichai MB, Hao C, Davis L, Golovin A, Zhao M, Moeckel G, Dunn S, Bulus N, Harris RC, Zent R, Breyer MD. Apoptosis of the Thick Ascending Limb Results in Acute Kidney Injury. Journal Of The American Society Of Nephrology 2008, 19: 1538-1546. PMID: 18495962, PMCID: PMC2488270, DOI: 10.1681/asn.2007101101.Peer-Reviewed Original ResearchConceptsAcute kidney injuryKidney injuryToxin-induced acute kidney injurySevere acute kidney injuryNovel transgenic mouse modelAdministration of gancyclovirIschemia/reperfusionBlood urea nitrogenTransgenic mouse modelToxin-induced injuryThick ascending limbHerpes simplex virus 1 thymidine kinase geneCreatinine levelsNeutrophil infiltrationAcute injuryControl miceInjury resultsMouse modelTransgenic miceUrea nitrogenProximal tubulesTAL cellsAscending limbInjuryTubular segmentsTraumatic Spinal Cord Injury Without CT or Radiographic Abnormality—An Under‐Recognized Entity
Yu L, Poon C, Sze G. Traumatic Spinal Cord Injury Without CT or Radiographic Abnormality—An Under‐Recognized Entity. Contemporary Diagnostic Radiology 2008, 31: 1-5. DOI: 10.1097/01.cdr.0000314875.43025.ae.Peer-Reviewed Original ResearchSpinal cord injuryTraumatic spine injuryCord injuryLigamentous injuriesSpine injuriesTraumatic spinal cord injuryFirst-line imaging examinationMechanism of injuryUnder-Recognized EntityAcute fracturesPotential devastating consequencesRadiographic evidenceClinical presentationAcute injuryRadiographic abnormalitiesImaging examinationsMRI studiesInjuryCTDevastating consequencesRadiographyExcellent evaluationFracturesMyelomalaciaPatients
2003
Importance of Functional EGF Receptors in Recovery from Acute Nephrotoxic Injury
Wang Z, Chen JK, Wang SW, Moeckel G, Harris RC. Importance of Functional EGF Receptors in Recovery from Acute Nephrotoxic Injury. Journal Of The American Society Of Nephrology 2003, 14: 3147-3154. PMID: 14638913, DOI: 10.1097/01.asn.0000098681.56240.1a.Peer-Reviewed Original ResearchConceptsAcute nephrotoxic injuryTubular injuryNephrotoxic injurySerum blood urea nitrogenEGF receptorDUTP nick end labeling stainingNick end labeling stainingRenal tubular injuryBlood urea nitrogenWild-type miceReceptor tyrosine kinase activityTubule injuryRenal compromiseCreatinine levelsRenal expressionAcute injuryHistologic evidenceExogenous administrationSuch injuriesLabeling stainingKidney's abilityUrea nitrogenRate of recoveryInjuryMice
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