2024
ADLM Guidance Document on the Measurement and Reporting of Lipids and Lipoproteins
Cao J, Donato L, El-Khoury J, Goldberg A, Meeusen J, Remaley A. ADLM Guidance Document on the Measurement and Reporting of Lipids and Lipoproteins. The Journal Of Applied Laboratory Medicine 2024, 9: 1040-1056. PMID: 39225455, DOI: 10.1093/jalm/jfae057.Peer-Reviewed Original ResearchConceptsNon-HDL-CLDL-C calculationLDL-CLipid panelLipoprotein cholesterolMeasurement of blood lipidsNon-high-density lipoprotein cholesterolElevated concentration of triglyceridesLow-density lipoprotein cholesterolMeasured LDL-CAtherosclerotic disease riskLipid testingConcentrations of triglyceridesClinical managementDisease riskReporting of resultsBlood lipidsPre-analytical requirementsApolipoprotein BFasting requirementsImprove standardsGuidance documentsLipidCholesterolLipoproteinLipids, Lipoproteins, and Cardiovascular Outcomes
Sakers A, Mszar R, Soffer D. Lipids, Lipoproteins, and Cardiovascular Outcomes. Contemporary Cardiology 2024, 201-236. DOI: 10.1007/978-3-031-54960-1_9.Peer-Reviewed Original ResearchCardiovascular disease riskDisease riskGuideline-recommended screeningAtherosclerotic cardiovascular diseaseDevelopment of atherosclerotic cardiovascular diseasePatient riskCardiovascular diseaseClinical settingMolecular roleLipid concentrationsLipid derangementsAdverse eventsLipid disordersRiskPhysiological roleLipid loweringFrequent causeMeasured lipid concentrationsLipoprotein metabolismDecision-makingEnvironmental factorsDerangementsLipoproteinLifestyleLipidPla2g12b drives expansion of triglyceride-rich lipoproteins
Thierer J, Foresti O, Yadav P, Wilson M, Moll T, Shen M, Busch-Nentwich E, Morash M, Mohlke K, Rawls J, Malhotra V, Hussain M, Farber S. Pla2g12b drives expansion of triglyceride-rich lipoproteins. Nature Communications 2024, 15: 2095. PMID: 38453914, PMCID: PMC10920679, DOI: 10.1038/s41467-024-46102-4.Peer-Reviewed Original ResearchConceptsEndoplasmic reticulumAccumulation of intracellular lipidsSubcellular localizationTriglyceride-rich lipoproteinsEvolutionary tradeoffsInteraction partnersNascent lipoproteinsFunctional domainsLipoprotein homeostasisPLA2G12BIntracellular lipidsResistant to atherosclerosisMutant miceVertebratesReticulumTriglyceride incorporationLipid secretionCardiovascular disease riskCalcium-dependentExcessive accumulationDisease riskTriglyceride transportLipoproteinTriglyceridesLipid
2020
The Role of Tricellular Junctions in the Transport of Macromolecules Across Endothelium
Ghim M, Mohamied Y, Weinberg P. The Role of Tricellular Junctions in the Transport of Macromolecules Across Endothelium. Cardiovascular Engineering And Technology 2020, 12: 101-113. PMID: 32820467, PMCID: PMC7904563, DOI: 10.1007/s13239-020-00483-x.Peer-Reviewed Original ResearchConceptsDensity lipoproteinHigh-density lipoproteinLow-density lipoproteinNew therapeutic strategiesEffects of agonistsEndothelial barrier functionConclusionThese dataInfluence of agonistsTherapeutic strategiesVascular endotheliumEndotheliumBarrier functionEndothelial monolayersNormal physiologyTransendothelial transportAgonistsLipoproteinDiseaseFurther investigation
2019
ANGPTL4 in Metabolic and Cardiovascular Disease
Aryal B, Price NL, Suarez Y, Fernández-Hernando C. ANGPTL4 in Metabolic and Cardiovascular Disease. Trends In Molecular Medicine 2019, 25: 723-734. PMID: 31235370, PMCID: PMC6779329, DOI: 10.1016/j.molmed.2019.05.010.Peer-Reviewed Original ResearchConceptsCardiovascular diseaseLipoprotein lipaseRisk of atherosclerosisRole of ANGPTL4Type 2 diabetesLow-density lipoproteinFatty acidsMurine studiesPeripheral tissuesRich lipoproteinsLPL activityANGPTL4 functionsDensity lipoproteinMetabolic diseasesPossible autocrineParacrine formsDiseaseANGPTL4Disease developmentLipoproteinRecent findingsRiskTissueDifferent tissuesAtherosclerosis
2018
Bacterial Lipoproteins Constitute the TLR2-Stimulating Activity of Serum Amyloid A
Burgess EJ, Hoyt LR, Randall MJ, Mank MM, Bivona JJ, Eisenhauer PL, Botten JW, Ballif BA, Lam YW, Wargo MJ, Boyson JE, Ather JL, Poynter ME. Bacterial Lipoproteins Constitute the TLR2-Stimulating Activity of Serum Amyloid A. The Journal Of Immunology 2018, 201: 2377-2384. PMID: 30158125, PMCID: PMC6179936, DOI: 10.4049/jimmunol.1800503.Peer-Reviewed Original ResearchConceptsEukaryotic cellsBacterial proteinsSerum amyloid ANumerous bacterial proteinsProteomic analysisMouse cellsRecombinant proteinsBacterial lipoproteinsProteinRecombinant serum amyloid ASAA1 proteinProinflammatory cytokine productionProduction of TNFCytokine productionProinflammatory functionsAmyloid ASerum amyloidCellsLipoprotein lipaseLipoproteinFuture studiesDifferentiationEscherichiaBindingLipopeptides
2013
Haplotype structure and positive selection at TLR1
Heffelfinger C, Pakstis AJ, Speed WC, Clark AP, Haigh E, Fang R, Furtado MR, Kidd KK, Snyder MP. Haplotype structure and positive selection at TLR1. European Journal Of Human Genetics 2013, 22: 551-557. PMID: 24002163, PMCID: PMC3953919, DOI: 10.1038/ejhg.2013.194.Peer-Reviewed Original ResearchConceptsToll-like receptor 2Toll-like receptor 1Missense variantsInnate immune systemReduced riskMedical conditionsReceptor 2Immune systemReceptor 1Cell surface receptorsSepsisSubsequent activationTLR1Surface receptorsBacterial lipoproteinsLeprosySurface traffickingDiseaseHuman healthRiskHealthMultiple functional allelesRs5743618TuberculosisLipoprotein
2011
Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents
Santoro N, Zhang CK, Zhao H, Pakstis AJ, Kim G, Kursawe R, Dykas DJ, Bale AE, Giannini C, Pierpont B, Shaw MM, Groop L, Caprio S. Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents. Hepatology 2011, 55: 781-789. PMID: 22105854, PMCID: PMC3288435, DOI: 10.1002/hep.24806.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdolescentApolipoprotein C-IIIBlack or African AmericanChildFatty LiverFemaleGene FrequencyGenetic Predisposition to DiseaseHaplotypesHispanic or LatinoHumansLipaseLipoproteins, VLDLMaleMembrane ProteinsObesityPolymorphism, Single NucleotideRisk FactorsTriglyceridesWhite PeopleConceptsFatty liverObese childrenSingle nucleotide polymorphismsTriglyceride levelsOral glucose tolerance testGlucokinase regulatory proteinGlucose tolerance testHepatic fat accumulationAccumulation of triglyceridesLow-density lipoproteinElevated triglyceridesLarge VLDLTolerance testFat accumulationObese youthGlucokinase regulatory protein geneMagnetic resonancePNPLA3LiverRs1260326African AmericansTriglyceridesLipoproteinChildrenNucleotide polymorphismsEvaluation of high density lipoprotein as a circulating biomarker of Gaucher disease activity
Stein P, Yang R, Liu J, Pastores GM, Mistry PK. Evaluation of high density lipoprotein as a circulating biomarker of Gaucher disease activity. Journal Of Inherited Metabolic Disease 2011, 34: 429-437. PMID: 21290183, PMCID: PMC3186206, DOI: 10.1007/s10545-010-9271-7.Peer-Reviewed Original ResearchConceptsEnzyme replacement therapyHigh-density lipoproteinHDL cholesterolDisease severityDisease activitySpleen volumeIndividual patientsLow high-density lipoproteinLow HDL cholesterolSeverity Score IndexMonitoring of patientsGD1 patientsSerum levelsReplacement therapyLiver volumeScore indexDensity lipoproteinPatientsCholesterolSeverityChitotriosidaseBiomarkersStriking increaseImportant surrogateLipoprotein
2007
Longitudinal Study of Serum Lipids and Liver Enzymes in Workers With Occupational Exposure to Ammonium Perfluorooctanoate
Sakr CJ, Leonard RC, Kreckmann KH, Slade MD, Cullen MR. Longitudinal Study of Serum Lipids and Liver Enzymes in Workers With Occupational Exposure to Ammonium Perfluorooctanoate. Journal Of Occupational And Environmental Medicine 2007, 49: 872-879. PMID: 17693785, DOI: 10.1097/jom.0b013e318124a93f.Peer-Reviewed Original ResearchConceptsSerum perfluorooctanoateLiver enzymesPerfluorooctanoate exposureSerum aspartate aminotransferaseMedical surveillance dataLongitudinal studySerum lipidsDL increaseTotal cholesterolPotential confoundersTotal bilirubinOccupational exposureAspartate aminotransferaseSurveillance dataHuman liverLiverExposureAmmonium perfluorooctanoateMixed modelsLipidsConfoundersTriglyceridesBilirubinLipoproteinCholesterol
2005
Knowledge of Cholesterol Levels and Targets in Patients With Coronary Artery Disease
Cheng S, Lichtman JH, Amatruda JM, Smith GL, Mattera JA, Roumanis SA, Krumholz HM. Knowledge of Cholesterol Levels and Targets in Patients With Coronary Artery Disease. Preventive Cardiology 2005, 8: 11-17. PMID: 15722689, DOI: 10.1111/j.1520-037x.2005.3939.x.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseHigh-density lipoproteinLow-density lipoproteinCholesterol targetsArtery diseaseCholesterol levelsMultiple cardiac risk factorsCardiac risk factorsTotal cholesterol levelsTotal cholesterol valuesRisk factorsCardiovascular diseaseCholesterol valuesPrevious historyPatientsLipoproteinDiseaseCollege educationWomenNonwhitesEducation effortsNational targetsTargetCholesterol
2004
Sorting of H,K‐ATPase β‐Subunit in MDCK and LLC‐PK1 Cells is Independent of μ1B Adaptin Expression
Duffield A, Fölsch H, Mellman I, Caplan MJ. Sorting of H,K‐ATPase β‐Subunit in MDCK and LLC‐PK1 Cells is Independent of μ1B Adaptin Expression. Traffic 2004, 5: 449-461. PMID: 15117319, DOI: 10.1111/j.1398-9219.2004.00192.x.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Protein Complex mu SubunitsAdaptor Proteins, Vesicular TransportAmino Acid MotifsAnimalsCell LineCytoplasmDogsEpithelial CellsGlutathione TransferaseH(+)-K(+)-Exchanging ATPaseLLC-PK1 CellsMembrane ProteinsProtein SubunitsProtein TransportReceptors, LDLReceptors, TransferrinRecombinant Fusion ProteinsSwineTransfectionTyrosineConceptsLow-density lipoproteinTransferrin receptorBasolateral localizationTyrosine-based motifMDCK cellsB expressionLLC-PK1 cellsEpithelial cellsLipoproteinMadin-Darby canine kidney cellsCertain epithelial cellsReceptorsKidney cellsCanine kidney cellsK-ATPase beta subunitCellsDifferential expressionK-ATPaseBasolateral expressionExpressionApical membrane
1999
Innate immunity: Lipoproteins take their Toll on the host
Janeway C, Medzhitov R. Innate immunity: Lipoproteins take their Toll on the host. Current Biology 1999, 9: r879-r882. PMID: 10607553, DOI: 10.1016/s0960-9822(00)80073-1.Peer-Reviewed Original Research
1998
Intraaortic hemopoietic cells are derived from endothelial cells during ontogeny
Jaffredo T, Gautier R, Eichmann A, Dieterlen-Lièvre F. Intraaortic hemopoietic cells are derived from endothelial cells during ontogeny. Development 1998, 125: 4575-4583. PMID: 9778515, DOI: 10.1242/dev.125.22.4575.Peer-Reviewed Original ResearchHuman CD36 is a high affinity receptor for the native lipoproteins HDL, LDL, and VLDL
Calvo D, Gómez-Coronado D, Suárez Y, Lasunción M, Vega M. Human CD36 is a high affinity receptor for the native lipoproteins HDL, LDL, and VLDL. Journal Of Lipid Research 1998, 39: 777-788. PMID: 9555943, DOI: 10.1016/s0022-2275(20)32566-9.Peer-Reviewed Original ResearchConceptsHigh-affinity receptorHuman CD36Lipoprotein HDLAffinity receptorPathogenesis of atherosclerosisLow-density lipoproteinFoam cell formationBinding of lipoproteinsFatty acid metabolismSR-BIActive fatty acid metabolismDensity lipoproteinModified lipoproteinsScavenger receptorsLipid metabolismCD36CLA-1Monoclonal antibodiesLDLLipoproteinHDLAcid metabolismReceptorsVLDLNative lipoproteins
1997
Lipoprotein Modification by Advanced Glycosylation Endproducts (AGEs): Role in Atherosclerosis
Bucala R. Lipoprotein Modification by Advanced Glycosylation Endproducts (AGEs): Role in Atherosclerosis. Trends In Cardiovascular Medicine 1997, 7: 39-47. PMID: 21235862, DOI: 10.1016/s1050-1738(96)00137-5.Peer-Reviewed Original ResearchLow-density lipoproteinDiabetic patientsLDL levelsElevated LDL levelsEnzyme-linked immunosorbent assay (ELISA) techniqueRecent clinical observationsAdvanced glycosylation reactionsImmunosorbent assay (ELISA) techniqueVascular diseaseVascular pathologyVascular permeabilityNormal controlsClinical observationsAdvanced glycosylationLipoprotein depositionVascular wallClearance mechanismsNitric oxidePatientsRadical generating systemELISA analysisAgeLipoproteinOxidative modification
1996
Increased macrophage uptake of irreversibly glycated albumin modified-low density lipoproteins of normal and diabetic subjects is mediated by non-saturable mechanisms
Dobrian A, Lazar V, Tirziu D, Simionescu M. Increased macrophage uptake of irreversibly glycated albumin modified-low density lipoproteins of normal and diabetic subjects is mediated by non-saturable mechanisms. Biochimica Et Biophysica Acta 1996, 1317: 5-14. PMID: 8876621, DOI: 10.1016/0925-4439(96)00017-8.Peer-Reviewed Original ResearchConceptsAGE-AlbAdvanced glycosylation end productsDiabetic subjectsDensity lipoproteinAGE-albuminModified-low density lipoproteinsMacrophage uptakeOxidative-antioxidative balanceIndependent risk factorNon-saturable pathwayLow-density lipoproteinNon-saturable mechanismReceptor-mediated uptakeGlycosylation end productsLevel of glycationDiabetes mellitusDiabetic stateRisk factorsAtherosclerotic plaquesLipid peroxidesAcetylated LDLPeritoneal macrophagesReceptor pathwayLipoproteinDLDLWhat is the effect of hyperglycemia on atherogenesis and can it be reversed by aminoguanidine?
Bucala R. What is the effect of hyperglycemia on atherogenesis and can it be reversed by aminoguanidine? Diabetes Research And Clinical Practice 1996, 30: s123-s130. PMID: 8964186, DOI: 10.1016/s0168-8227(96)80048-9.Peer-Reviewed Original ResearchConceptsDiabetic patientsLDL levelsEndothelium-derived relaxing factorsElevated LDL levelsEffects of hyperglycemiaLow-density lipoproteinRelaxing factorsVascular diseaseVascular pathologyVascular permeabilityNormal controlsClinical observationsAdvanced glycosylationLipoprotein depositionVascular wallELISA techniqueClearance mechanismsNitric oxideClearance kineticsPatientsELISA analysisLDLAgeAminoguanidineLipoprotein
1994
Advanced glycosylation endproducts: Role in diabetic and non‐diabetic vascular disease
Bucala R, Vlassara H, Cerami A. Advanced glycosylation endproducts: Role in diabetic and non‐diabetic vascular disease. Drug Development Research 1994, 32: 77-89. DOI: 10.1002/ddr.430320204.Peer-Reviewed Original ResearchAdvanced glycosylationVascular diseasePhase II clinical trialOxidized low-density lipoproteinSpecific therapeutic modalitiesLow-density lipoproteinDirect toxic effectReversible Schiff base adductsClinical trialsAdvanced glycosylation endproductsTherapeutic modalitiesVascular permeabilityDensity lipoproteinLipoprotein depositionVascular wallELISA techniqueHeterogenous groupPathological effectsEndothelial cellsPharmacological inhibitorsPathological conditionsAgeToxic effectsLipoproteinDiseaseA chromosomal Borrelia burgdorferi gene encodes a 22-kilodalton lipoprotein, P22, that is serologically recognized in Lyme disease
Lam TT, Nguyen TP, Fikrig E, Flavell RA. A chromosomal Borrelia burgdorferi gene encodes a 22-kilodalton lipoprotein, P22, that is serologically recognized in Lyme disease. Journal Of Clinical Microbiology 1994, 32: 876-883. PMID: 8027338, PMCID: PMC263156, DOI: 10.1128/jcm.32.4.876-883.1994.Peer-Reviewed Original ResearchConceptsLate-stage diseaseLyme diseaseOuter surface proteinsEarly-stage diseaseExamination of seraErythema migransSurface proteinsPulsed-field gel electrophoresisPatientsEtiologic agentDiseaseBorrelia burgdorferiB. burgdorferiAntibodiesLipoproteinBorrelia burgdorferi genesSerumBurgdorferiShort amino terminus
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