2024
Mixed and undifferentiated autoimmune connective tissue diseases
Vesely M. Mixed and undifferentiated autoimmune connective tissue diseases. Clinics In Dermatology 2024, 43: 160-165. PMID: 39681290, DOI: 10.1016/j.clindermatol.2024.12.011.Peer-Reviewed Original ResearchConnective tissue diseaseTissue diseaseCutaneous manifestationsUndifferentiated connective tissue diseaseAutoimmune connective tissue diseaseEra of molecular diagnosticsSigns of systemic diseaseUrticarial vasculitisSystemic complicationsSjogren's syndromeClinical entityDescription of patientsSystemic diseaseClinical observationsDisease characterizationMolecular diagnosticsDiseasePatientsVasculitisPig-to-human kidney xenotransplants using genetically modified minipigs
Wang Y, Chen G, Pan D, Guo H, Jiang H, Wang J, Feng H, He S, Du J, Zhang M, Li T, Wang Y, Yu H, Gan H, Wen Q, Song Z, Li D, Yu Y, Wang H, Li B, You Y, Zhou S, Wang M, Liu L, Xu L, Yang M, Pei H, Zhang K, Chen Z. Pig-to-human kidney xenotransplants using genetically modified minipigs. Cell Reports Medicine 2024, 5: 101744. PMID: 39317190, PMCID: PMC11513830, DOI: 10.1016/j.xcrm.2024.101744.Peer-Reviewed Original ResearchConceptsAntibody-mediated rejectionNatural killer (NK) cellsT cell-mediated rejectionCell-mediated rejectionHuman gene transferKidney function recoveryXenogeneic immune responsesTriple-gene knockoutPig-to-humanAcute rejectionCD40-CD154Pathway blockadeXenograft successMacrophage infiltrationXenograft functionImmunopathological changesKidney xenotransplantationBrain-dead patientsImmune responseDonor pigsFunctional recoveryClinical observationsImmunosuppressionGene transferKidneyPsychological, Behavioral, and Pharmacological Treatments for Binge Eating Disorder
Chao A, Grilo C. Psychological, Behavioral, and Pharmacological Treatments for Binge Eating Disorder. 2024, 378-390. DOI: 10.1093/oso/9780190671051.003.0043.Peer-Reviewed Original ResearchBinge Eating DisorderAddiction perspectiveAddiction modelTreatment of binge eating disorderFeatures of binge eating disorderBinge eating disorder treatmentPharmacological treatmentNon-substance addictionBrain-based diseaseFood addictionEating DisordersAddiction conceptAddictionTreatment approachesDisordersHarm reductionClinical observationsAbstinenceBingeSubstancesBehaviorRelapseTreatmentSuggestionsHarm
2023
A Mouse Model of MHV‐1 Virus Infection for Study of Acute and Long COVID Infection
Masciarella A, Di Gregorio D, Ramamoorthy R, Hussain H, Jayakumar A, Paidas M. A Mouse Model of MHV‐1 Virus Infection for Study of Acute and Long COVID Infection. Current Protocols 2023, 3: e896. PMID: 37867460, PMCID: PMC10606938, DOI: 10.1002/cpz1.896.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Pathological changesMouse modelTransgenic miceLong-term organ dysfunctionSARS-CoV-2 pathophysiologyIrreversible neurological complicationsPotential therapeutic interventionsAvailable human dataBiosafety level 2 laboratoryNon-human primatesBiosafety level 3 laboratoryNeurological complicationsOrgan dysfunctionAcute stageClinical symptomsLong-term effectsSevere casesClinical observationsViral infectionTherapeutic interventionsMHV-1Animal preparationsWeight lossBSL-3 laboratoryMulti-scale convolutional recurrent neural network for psychiatric disorder identification in resting-state EEG
Yan W, Yu L, Liu D, Sui J, Calhoun V, Lin Z. Multi-scale convolutional recurrent neural network for psychiatric disorder identification in resting-state EEG. Frontiers In Psychiatry 2023, 14: 1202049. PMID: 37441141, PMCID: PMC10333510, DOI: 10.3389/fpsyt.2023.1202049.Peer-Reviewed Original ResearchConvolutional recurrent neural networkRecurrent neural networkResting-state EEGNeural networkPsychiatric disordersDeep learning classification modelLow-dimensional subspaceTwo-class classificationDesigning individualized treatmentLearning classification modelsEEG backgroundClassification modelHealthy controlsDepressive disorderSpatiotemporal informationClinical observationsDisease severityAccurate classificationIndividualized treatmentBiomarkersDisorder classificationDisorder identificationDisordersClassificationNeuroimaging biomarkersTranslating energy balance research from the bench to the clinic to the community: Parallel animal‐human studies in cancer
Garcia M, Schadler K, Chandra J, Clinton S, Courneya K, Cruz‐Monserrate Z, Daniel C, Dannenberg A, Demark‐Wahnefried W, Dewhirst M, Fabian C, Hursting S, Irwin M, Iyengar N, McQuade J, Schmitz K, Basen‐Engquist K. Translating energy balance research from the bench to the clinic to the community: Parallel animal‐human studies in cancer. CA A Cancer Journal For Clinicians 2023, 73: 425-442. PMID: 36825928, PMCID: PMC11225601, DOI: 10.3322/caac.21773.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsParallel studyHealthy survivorshipCancer outcomesDietary intakePhysical activityAnimal modelsClinical observationsAnimal studiesBody compositionCancer developmentPractice changeCancerPopulation studiesCancer researchEnergy balance researchEnergy balancePatientsSubstantial benefitsClinicStudyIntake
2022
P11.46.A Whole exome sequencing identifies novel SLIT2 mutations in primary CNS lymphoma
Kaulen L, Erson-Omay E, Henegariu O, Karschnia P, Huttner A, Günel M, Baehring J. P11.46.A Whole exome sequencing identifies novel SLIT2 mutations in primary CNS lymphoma. Neuro-Oncology 2022, 24: ii68-ii68. PMCID: PMC9443199, DOI: 10.1093/neuonc/noac174.235.Peer-Reviewed Original ResearchPrimary CNS lymphomaCNS lymphomaOverall survivalExtension cohortEpstein-Barr virus statusKaplan-Meier methodLog-rank testCBio Cancer Genomics PortalReporter luciferase assaysFree survivalShorter OSTumor DNA samplesPCNSL patientsClinical outcomesShorter PFSSomatic insertions/deletionsVirus statusFavorable outcomeLymphoid malignanciesClinical observationsTumor tissuePersonalized careCDKN2A lossCopy number alterationsCohortNovel pathophysiological insights in autoimmune myasthenia gravis
Masi G, O’Connor K. Novel pathophysiological insights in autoimmune myasthenia gravis. Current Opinion In Neurology 2022, 35: 586-596. PMID: 35942663, PMCID: PMC9458626, DOI: 10.1097/wco.0000000000001088.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAutoimmune myasthenia gravisMyasthenia gravisMG patientsClinical responseMuscle-specific tyrosine kinaseSpecific therapeutic strategiesNovel pathophysiological insightsMG pathologyMG subtypesAutoantibody repertoireTreatment optionsCancer immunotherapyPredictive biomarkersSuch therapyImmunological heterogeneityPathophysiological insightsMG phenotypeTherapeutic strategiesClinical observationsTherapeutic outcomesAcetylcholine receptorsDisease subtypesTherapeutic perspectivesSubtypesDevelopment of assaysThrough the looking glass: Endoscopic management of anastomotic leaks
Leeds I, Sklow B. Through the looking glass: Endoscopic management of anastomotic leaks. Seminars In Colon And Rectal Surgery 2022, 33: 100885. DOI: 10.1016/j.scrs.2022.100885.Peer-Reviewed Original ResearchAnastomotic leakEndoscopic managementVacuum-assisted closureScope endoclipsChronic sinusColorectal resectionChronic abscessEndoscopic approachAnatomic circumstancesEndoscopic techniquesClinical observationsSafe useLeakAbscessResectionComplicationsMarsupializationPatientsEndoclipsSinusManagementMortalityStentsTractClinical observations regarding the use of androgen receptor inhibitors in patients with nonmetastatic castration-resistant prostate cancer.
Oh W. Clinical observations regarding the use of androgen receptor inhibitors in patients with nonmetastatic castration-resistant prostate cancer. Clinical Advances In Hematology And Oncology 2022, 20 Suppl 9: 13-16. PMID: 35579580.Peer-Reviewed Original ResearchNivolumab plus ipilimumab with or without live bacterial supplementation in metastatic renal cell carcinoma: a randomized phase 1 trial
Dizman N, Meza L, Bergerot P, Alcantara M, Dorff T, Lyou Y, Frankel P, Cui Y, Mira V, Llamas M, Hsu J, Zengin Z, Salgia N, Salgia S, Malhotra J, Chawla N, Chehrazi-Raffle A, Muddasani R, Gillece J, Reining L, Trent J, Takahashi M, Oka K, Higashi S, Kortylewski M, Highlander SK, Pal SK. Nivolumab plus ipilimumab with or without live bacterial supplementation in metastatic renal cell carcinoma: a randomized phase 1 trial. Nature Medicine 2022, 28: 704-712. PMID: 35228755, PMCID: PMC9018425, DOI: 10.1038/s41591-022-01694-6.Peer-Reviewed Original ResearchConceptsMetastatic renal cell carcinomaProgression-free survivalRenal cell carcinomaCell carcinomaCheckpoint inhibitorsResponse rateGut microbiomePoor-risk diseaseTreatment-naive patientsSingle-center studyPhase 1 trialRandomized phase 1 trialSignificant differencesBifidobacterium sppMechanism of actionNivolumab-ipilimumabSarcomatoid histologyPrimary endpointSecondary endpointsImmune compartmentStudy armsClinical outcomesClear cellsClinical observationsPatientsAdaptive Immunity in Interstitial Lung Disease
Winkler J, Herzog E. Adaptive Immunity in Interstitial Lung Disease. 2022, 144-157. DOI: 10.1016/b978-0-08-102723-3.00018-4.ChaptersInterstitial lung diseaseIdiopathic pulmonary fibrosisLung diseaseAdaptive immunityBasic science investigationsAutoimmune conditionsPulmonary fibrosisHumoral responseClinical observationsTranslational studiesAberrant remodelingDiseaseUnifying hypothesisImmunityUnanswered questionsImmunopathogenesisSclerodermaFibrosisInjury
2021
Patients with chronic pain exhibit individually unique cortical signatures of pain encoding
Mayr A, Jahn P, Stankewitz A, Deak B, Winkler A, Witkovsky V, Eren O, Straube A, Schulz E. Patients with chronic pain exhibit individually unique cortical signatures of pain encoding. Human Brain Mapping 2021, 43: 1676-1693. PMID: 34921467, PMCID: PMC8886665, DOI: 10.1002/hbm.25750.Peer-Reviewed Original ResearchConceptsChronic back painEndogenous painAnterior insular cortexBack painChronic painInsular cortexCortical signaturesChronic pain exhibitChronic migraine patientsChange of painIntensity of painFunctional MRI sessionsUnique cortical signaturesChronic migrainePain intensityMigraine patientsPainMultifaceted diseaseClinical observationsPatientsLinear mixed effects modelsFrontal operculumMRI sessionsMixed effects modelsCortical processesA-66 Neuropsychological Sequalae of SARS-CoV-2
Rivera R, Carballea D. A-66 Neuropsychological Sequalae of SARS-CoV-2. Archives Of Clinical Neuropsychology 2021, 36: 1108-1108. DOI: 10.1093/arclin/acab062.84.Publications for non-academic audiencesSARS-CoV-2Neuropsychological symptomsCOVID-19 infectionNeuropsychological sequelaeNeuropsychological manifestationsCOVID-19Severe COVID-19Significant risk factorsSevere executive dysfunctionMechanism of actionConclusions PatientsRisk factorsPsychiatric illnessInclusion criteriaExclusion criteriaSevere casesClinical observationsSystematic reviewSymptomsSequelaeEtiological hypothesesSystematic searchExecutive dysfunctionGoogle ScholarInfectionSerum Analyte Profiles Associated With Crohn’s Disease and Disease Location
Boucher G, Paradis A, Chabot-Roy G, Coderre L, Hillhouse E, Bitton A, Rosiers C, Levings M, Schumm L, Lazarev M, Brant S, Duerr R, McGovern D, Silverberg M, Cho J, Lesage S, Rioux J, Bitton A, Boucher G, Charron G, Rosiers C, Forest A, Goyette P, Ivinson S, Joseph L, Kohen R, Lachaine J, Lesage S, Levings M, Rioux J, Thompson-Legault J, Vachon L, Veilleux S, White-Guay B, Bajpai M, Birch S, Bitton A, Borowski K, Botwin G, Boucher G, Brant S, Chen W, Cho J, Cordero R, Côté-Daigneault J, Daly M, Datta L, Duerr R, Filice M, Fleshner P, Gettler K, Giri M, Goyette P, Hao K, Haritunians T, Itan Y, Johnston E, Konnikova L, Landers C, Lazarev M, Li D, McGovern D, Mengesha E, Merad M, Miladinova V, Nayeri S, Proksell S, Raquel M, Rioux J, Rymaszewski K, Sabic K, Sands B, Schumm L, Schwartz M, Silverberg M, Simpson C, Stempak J, Stevens C, Targan S, Xavier R. Serum Analyte Profiles Associated With Crohn’s Disease and Disease Location. Inflammatory Bowel Diseases 2021, 28: 9-20. PMID: 34106269, PMCID: PMC8730700, DOI: 10.1093/ibd/izab123.Peer-Reviewed Original ResearchConceptsCrohn's diseaseDisease locationCD patientsIL-6 beingColonic Crohn's diseaseInterleukin IL-6IL-12p70Chronic inflammationColorectal diseaseIL-6Inflammatory processHealthy controlsColorectal regionIntestinal microbiotaClinical observationsEpithelial barrierImmune systemPatientsSerum analytesEndothelial systemDiseaseSerum samplesGrowth factorMultiple cell typesDigestive tractPeer coaching in an interprofessional academic primary care clinic
Morford K, Milligan T, Brienza R. Peer coaching in an interprofessional academic primary care clinic. Journal Of Interprofessional Education & Practice 2021, 23: 100418. DOI: 10.1016/j.xjep.2021.100418.Peer-Reviewed Original ResearchPrimary care clinicsAcademic primary care clinicCare clinicsMotivational interviewing strategiesDirect clinical observationBrief didactic sessionInternal medicine residentsPeer coachesNurse practitionersClinical observationsChief medical residentsCollaborative communication stylePatient encountersPractice settingsClinic observationsClinicMedicine residentsMedical residentsEvaluation questionnaireInterprofessional learning environmentDidactic sessionsInsight ScaleHealth professionsInterprofessional settingSkill demonstrationThe Reward System and Post-Traumatic Stress Disorder: Does Trauma Affect the Way We Interact With Positive Stimuli?
Seidemann R, Duek O, Jia R, Levy I, Harpaz-Rotem I. The Reward System and Post-Traumatic Stress Disorder: Does Trauma Affect the Way We Interact With Positive Stimuli? Chronic Stress 2021, 5: 2470547021996006. PMID: 33718742, PMCID: PMC7917421, DOI: 10.1177/2470547021996006.Peer-Reviewed Original ResearchPost-traumatic stress disorderStress disorderReward systemSelf-reported dataFear learningPositive stimuliMajority of researchImportant constructDisordersPrevalent disorderCurrent reviewComplex relationshipTraumaAnhedoniaFearFunctioningStimuliEthologyResearchLearningRelationshipConstructsPossible hindranceSufficient insightClinical observations
2020
Development and Validation of a Machine Learning Individualized Treatment Rule in First-Episode Schizophrenia
Wu C, Luedtke A, Sadikova E, Tsai H, Liao S, Liu C, Gau S, VanderWeele T, Kessler R. Development and Validation of a Machine Learning Individualized Treatment Rule in First-Episode Schizophrenia. JAMA Network Open 2020, 3: e1921660. PMID: 32083693, PMCID: PMC7043195, DOI: 10.1001/jamanetworkopen.2019.21660.Peer-Reviewed Original ResearchConceptsFirst-episode schizophreniaAntipsychotic medicationPrescribed antipsychotic medicationTreatment success rateTreatment successSchizophrenic disordersFirst-episodeSuccess rateSchizophreniaProbability of treatment successTaiwan National Health Insurance Research DatabaseNational Health Insurance Research DatabaseHealth Insurance Research DatabaseEstimating treatment successValidation sampleIndividualized treatment rulesMedicationPrognostic studyPatientsInvestigated biomarkersClinical implementationDischarge diagnosisClinical observationsDemographic dataPragmatic trialSubacute Neuropsychiatric Syndrome in Girls With SHANK3 Mutations Responds to Immunomodulation
Bey AL, Gorman MP, Gallentine W, Kohlenberg TM, Frankovich J, Jiang YH, Van Haren K. Subacute Neuropsychiatric Syndrome in Girls With SHANK3 Mutations Responds to Immunomodulation. 2020, 145: e20191490. PMID: 32015180, PMCID: PMC7802010, DOI: 10.1542/peds.2019-1490.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAggressionAntipsychotic AgentsAnxietyAutism Spectrum DisorderCatatoniaChildCompulsive BehaviorCryingDevelopmental DisabilitiesFemaleFrameshift MutationHallucinationsHumansImmunoglobulins, IntravenousImmunosuppressive AgentsImmunotherapyIrritable MoodMethylprednisoloneMutismNerve Tissue ProteinsNeuroprotective AgentsObsessive-Compulsive DisorderRecurrenceSelf CareSleep Initiation and Maintenance DisordersStereotyped BehaviorSyndromeUrinary IncontinenceUrinary RetentionConceptsClinical observationsChronic relapsing coursePeriod of treatmentYears of ageImmunomodulatory treatmentUrinary retentionRelapsing courseNeurologic regressionCase seriesAntipsychotic medicationNeuropsychiatric syndromeMood disordersImmune functionObsessive-compulsive behaviorRare monogenic disordersNeurobehavioral syndromeTranslational investigationsPremorbid levelSHANK3 mutationsPatientsHormonal stimuliMonogenic disordersResponsive phenotypeDevelopmental disabilitiesSyndrome
2019
Analysis of genioglossus-centered tongue muscle function groups from dynamic magnetic resonance imaging
Xing F, Stone M, Goldsmith T, Prince J, Fakhri G, Woo J. Analysis of genioglossus-centered tongue muscle function groups from dynamic magnetic resonance imaging. The Journal Of The Acoustical Society Of America 2019, 146: 3086-3086. DOI: 10.1121/1.5137722.Peer-Reviewed Original ResearchMuscle functional groupsSpeech motor controlMotor controlInternal tongue musclesMuscle motionInternal musclesTongue muscle functionMuscle functionMuscle locationMotion patternsFunctional groupsMuscleDynamic magnetic resonance imagingFunctional lossDynamic magnetic resonanceMagnetic resonance imagingExtract motionCooperation patternsNormal controlsGenioglossusDigastric muscleUnique groupGroupResonance imagingClinical observations
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