2024
Modeling Endothelial Cell-Targeted Polymeric Nanoparticle Delivery in Renal Glomeruli
Richfield O, Tolbert-Schwartz E, Saltzman W. Modeling Endothelial Cell-Targeted Polymeric Nanoparticle Delivery in Renal Glomeruli. 2024 DOI: 10.70534/zjdh1719.Peer-Reviewed Original ResearchGlomerular diseaseNanoparticle deliveryGlomerular capillariesGlomerular endotheliumRenal autoregulationDesign of novel therapiesReduced renal massCell-targeting antibodiesChronic kidney diseaseDelivery of nanoparticlesCapillary networkNormothermic machine perfusionFiltration of plasmaRenal massesEffective therapeutic delivery systemsNovel therapiesGlomerular capillary wallGlomerular hemodynamicsRat glomeruliKidney diseaseTherapeutic delivery systemsGlomerular capillary networkShear stressHematocrit changesEndotheliumStudying the Pulmonary Endothelium in Health and Disease: An Official American Thoracic Society Workshop Report
Hough R, Alvira C, Bastarache J, Erzurum S, Kuebler W, Schmidt E, Shimoda L, Abman S, Alvarez D, Belvitch P, Bhattacharya J, Birukov K, Chan S, Cornfield D, Dudek S, Garcia J, Harrington E, Hsia C, Islam M, Jonigk D, Kalinichenko V, Kolb T, Lee J, Mammoto A, Mehta D, Rounds S, Schupp J, Shaver C, Suresh K, Tambe D, Ventetuolo C, Yoder M, Stevens T, Damarla M. Studying the Pulmonary Endothelium in Health and Disease: An Official American Thoracic Society Workshop Report. American Journal Of Respiratory Cell And Molecular Biology 2024, 71: 388-406. PMID: 39189891, PMCID: PMC11450313, DOI: 10.1165/rcmb.2024-0330st.Peer-Reviewed Original ResearchVascular diseaseEndothelial cell injuryAmerican Thoracic SocietyEndothelial cell functionPulmonary endotheliumMechanical propertiesLung endotheliumChronic vascular diseaseEndothelial functionPathophysiological mechanismsHealth and DiseaseVascular locationThoracic SocietyCell injuryEndotheliumCell functionTissue compartmentsDiseaseVascular circuitBidirectional signalingTranslation of discoveriesBloodEndothelial γ-protocadherins inhibit KLF2 and KLF4 to promote atherosclerosis
Joshi D, Coon B, Chakraborty R, Deng H, Yang Z, Babar M, Fernandez-Tussy P, Meredith E, Attanasio J, Joshi N, Traylor J, Orr A, Fernandez-Hernando C, Libreros S, Schwartz M. Endothelial γ-protocadherins inhibit KLF2 and KLF4 to promote atherosclerosis. Nature Cardiovascular Research 2024, 3: 1035-1048. PMID: 39232138, PMCID: PMC11399086, DOI: 10.1038/s44161-024-00522-z.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAtherosclerosisCadherin Related ProteinsCadherinsDisease Models, AnimalEndothelial CellsHuman Umbilical Vein Endothelial CellsHumansKruppel-Like Factor 4Kruppel-Like Transcription FactorsMaleMiceMice, Inbred C57BLMice, KnockoutPlaque, AtheroscleroticReceptors, NotchSignal TransductionConceptsAtherosclerotic cardiovascular diseaseIntracellular domainNotch intracellular domainTranscription factor KLF2Mechanisms of vascular inflammationAnti-inflammatory programVascular endothelial cellsHost defenseCleavage resultsAntibody blockadeGenetic deletionVascular inflammationViral infectionImmune systemEndothelial cellsCardiovascular diseasePromote atherosclerosisBlood flowKLF2KLF4Suppressive signalsEndotheliumMechanistic studiesACVR1/ALK2-p21 signaling axis modulates proliferation of the venous endothelium in the retinal vasculature
Pak B, Kim M, Han O, Lee H, Dubrac A, Choi W, Yang J, Boyé K, Cho H, Citrin K, Kim I, Eichmann A, Bautch V, Jin S. ACVR1/ALK2-p21 signaling axis modulates proliferation of the venous endothelium in the retinal vasculature. Angiogenesis 2024, 27: 765-777. PMID: 38955953, DOI: 10.1007/s10456-024-09936-6.Peer-Reviewed Original ResearchBone morphogenetic proteinVenous endotheliumProliferation of endotheliumBone morphogenetic protein signalingRetinal vesselsActivin A type I receptorExpression of CDKN1A/p21Bone morphogenetic protein receptorProliferation of endothelial cellsCell cycle progressionRetinal vasculatureEndothelial proliferationACVR1/ALK2I receptorEndotheliumEndothelial cellsCycle progressionModulate angiogenesisActive proliferationMorphogenetic proteinsProliferationContext of angiogenesisAngiogenesisVasculatureCDKN1A/p21
2023
Lung endothelium, tau, and amyloids in health and disease
Balczon R, Lin M, Voth S, Nelson A, Schupp J, Wagener B, Pittet J, Stevens T. Lung endothelium, tau, and amyloids in health and disease. Physiological Reviews 2023, 104: 533-587. PMID: 37561137, PMCID: PMC11281824, DOI: 10.1152/physrev.00006.2023.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsEnd-organ dysfunctionLung endotheliumLower respiratory tract infectionsRespiratory tract infectionsAlveolar-capillary barrierLung capillary endotheliumTract infectionsImmune responseNeurocognitive dysfunctionBarrier integrityProtein tauLung capillariesInfectionCapillary endotheliumDysfunctionEpithelial cellsEndotheliumTau variantsVascular nicheTauHost-pathogen interactionsType ICytotoxic activityCytotoxicAmyloid variantsInsights from immunoproteomic profiling of a rejected full-face transplant
Lee C, Wang D, Kauke-Navarro M, Russell-Goldman E, Xu S, Mucciarone K, Sohrabi S, Lian C, Pomahac B, Murphy G. Insights from immunoproteomic profiling of a rejected full-face transplant. American Journal Of Transplantation 2023, 23: 1058-1061. PMID: 37037378, DOI: 10.1016/j.ajt.2023.04.008.Peer-Reviewed Original ResearchConceptsVascularized Composite AllograftsT cellsChronic rejectionCD8-positive T cellsEffector T cellsFull face transplantArteriosclerotic alterationsIntragraft arteriesVCA rejectionGraft arteryAccelerated arteriosclerosisRecipient originPunch biopsyAtherogenic responseComposite allograftsImmunoproteomic profilingDioxygenase 1Target endotheliumArteryEndotheliumProteomic profilingPathway componentsCellsRejectionAllografts
2022
Nucleic Acid Delivery to the Vascular Endothelium
Reschke M, Piotrowski-Daspit AS, Pober JS, Saltzman WM. Nucleic Acid Delivery to the Vascular Endothelium. Molecular Pharmaceutics 2022, 19: 4466-4486. PMID: 36251765, PMCID: PMC10673694, DOI: 10.1021/acs.molpharmaceut.2c00653.Peer-Reviewed Original Research
2021
A Pulmonary Vascular Model From Endothelialized Whole Organ Scaffolds
Yuan Y, Leiby KL, Greaney AM, Raredon MSB, Qian H, Schupp JC, Engler AJ, Baevova P, Adams TS, Kural MH, Wang J, Obata T, Yoder MC, Kaminski N, Niklason LE. A Pulmonary Vascular Model From Endothelialized Whole Organ Scaffolds. Frontiers In Bioengineering And Biotechnology 2021, 9: 760309. PMID: 34869270, PMCID: PMC8640093, DOI: 10.3389/fbioe.2021.760309.Peer-Reviewed Original ResearchVascular diseaseEndothelial phenotypeLung vascular diseaseAcute lung injuryPulmonary microvascular functionWhole lung scaffoldsVascular barrier functionLung injuryMicrovascular functionEndothelial cell coverageSingle-cell RNA-sequencing analysisLPS treatmentProinflammatory signalsWhole lungLung endotheliumLung systemVascular barrierOrgan engineering approachesBarrier functionLungWhole-organ scaffoldsVascular structuresDrug mechanismsEndotheliumDiseaseMitofusin‐2 regulates leukocyte adhesion through the maturation of β2 integrin activation in differentiation
Fan Z, Liu W, Wang Y, Hsu A, Lin T, Sun H, Pachter J, Groisman A, Imperioli M, Yungher F, Hu L, Wang P, Deng Q. Mitofusin‐2 regulates leukocyte adhesion through the maturation of β2 integrin activation in differentiation. The FASEB Journal 2021, 35 DOI: 10.1096/fasebj.2021.35.s1.00211.Peer-Reviewed Original ResearchΒ2 integrin activationNeutrophil adhesionLeukocyte adhesionMitofusin 2HL60 cellsIntegrin activationNeutrophil recruitmentNeutrophil-like HL60 cellsVascular endotheliumFMLP receptorInnate immunityReduced expressionΒ2 integrinsConformational specific antibodiesMitofusin 2 deficiencyActivationCellsMaturationCD35InflammationNeutrophilsEndotheliumDiseaseΒ2Immunity
2020
The Role of Tricellular Junctions in the Transport of Macromolecules Across Endothelium
Ghim M, Mohamied Y, Weinberg P. The Role of Tricellular Junctions in the Transport of Macromolecules Across Endothelium. Cardiovascular Engineering And Technology 2020, 12: 101-113. PMID: 32820467, PMCID: PMC7904563, DOI: 10.1007/s13239-020-00483-x.Peer-Reviewed Original ResearchConceptsDensity lipoproteinHigh-density lipoproteinLow-density lipoproteinNew therapeutic strategiesEffects of agonistsEndothelial barrier functionConclusionThese dataInfluence of agonistsTherapeutic strategiesVascular endotheliumEndotheliumBarrier functionEndothelial monolayersNormal physiologyTransendothelial transportAgonistsLipoproteinDiseaseFurther investigation
2019
Engineering of human brain organoids with a functional vascular-like system
Cakir B, Xiang Y, Tanaka Y, Kural MH, Parent M, Kang YJ, Chapeton K, Patterson B, Yuan Y, He CS, Raredon MSB, Dengelegi J, Kim KY, Sun P, Zhong M, Lee S, Patra P, Hyder F, Niklason LE, Lee SH, Yoon YS, Park IH. Engineering of human brain organoids with a functional vascular-like system. Nature Methods 2019, 16: 1169-1175. PMID: 31591580, PMCID: PMC6918722, DOI: 10.1038/s41592-019-0586-5.Peer-Reviewed Original ResearchConceptsHuman cortical organoidsBlood-brain barrier characteristicsTrans-endothelial electrical resistanceVasculature-like structuresHuman brain organoidsHuman brain developmentCortical organoidsFunctional maturationPrenatal brainBrain diseasesBrain developmentHuman embryonic stem cellsBlood vesselsBrain organoidsTight junctionsDiseaseStem cellsOrganoidsVariant 2Nutrient transportersNutrient deliveryCellsEndotheliumMicrovasculature
2018
Investigation of Nanodroplet Adhesion to Endothelial Cells Under Atheroprone Flow Conditions
Zhang G, Pang K, Ghim M, Weinberg P, Tang M. Investigation of Nanodroplet Adhesion to Endothelial Cells Under Atheroprone Flow Conditions. 2018, 00: 1-4. DOI: 10.1109/ultsym.2018.8579749.Peer-Reviewed Original ResearchA novel method for segmenting growth of cells in sheared endothelial culture reveals the secretion of an anti-inflammatory mediator
Ghim M, Pang K, Arshad M, Wang X, Weinberg P. A novel method for segmenting growth of cells in sheared endothelial culture reveals the secretion of an anti-inflammatory mediator. Journal Of Biological Engineering 2018, 12: 15. PMID: 30127849, PMCID: PMC6092814, DOI: 10.1186/s13036-018-0107-6.Peer-Reviewed Original ResearchVascular cell adhesion molecule-1Intercellular adhesion molecule-1Adhesion molecule-1Molecule-1Cell adhesion molecule-1Anti-inflammatory mediatorsAnti-inflammatory effectsPathogenesis of atherosclerosisEndothelial cellsBlood vesselsNormal physiologyEndothelial culturesGrowth of cellsMediatorsConclusionsThe resultsEndotheliumEndothelial Dysfunction and Vascular Remodeling in Hypertension
Goodwin J. Endothelial Dysfunction and Vascular Remodeling in Hypertension. 2018, 205-219. DOI: 10.1007/978-3-319-31107-4_41.Peer-Reviewed Original ResearchEndothelial dysfunctionVascular remodelingAcute kidney injuryChronic kidney diseaseSystemic blood pressureBlood pressure homeostasisKidney injuryBlood pressurePediatric populationResistance vesselsKidney diseaseChildhood obesityAdipokine adiponectinPressure homeostasisVasoactive compoundsCardiovascular diseaseNitric oxideDysfunctionCritical mediatorReactive oxygen speciesRemodelingHemodynamic forcesEndotheliumDiseaseOxygen species
2017
Endothelial Dysfunction and Vascular Remodeling in Hypertension
Goodwin J. Endothelial Dysfunction and Vascular Remodeling in Hypertension. 2017, 1-16. DOI: 10.1007/978-3-319-31420-4_41-1.Peer-Reviewed Original ResearchEndothelial dysfunctionVascular remodelingAcute kidney injuryChronic kidney diseaseSystemic blood pressureBlood pressure homeostasisKidney injuryBlood pressurePediatric populationResistance vesselsKidney diseaseChildhood obesityAdipokine adiponectinPressure homeostasisVasoactive compoundsCardiovascular diseaseNitric oxideDysfunctionCritical mediatorReactive oxygen speciesRemodelingHemodynamic forcesEndotheliumDiseaseOxygen species
2014
Polarized Granzyme Release Is Required for Antigen-Driven Transendothelial Migration of Human Effector Memory CD4 T Cells
Manes TD, Pober JS. Polarized Granzyme Release Is Required for Antigen-Driven Transendothelial Migration of Human Effector Memory CD4 T Cells. The Journal Of Immunology 2014, 193: 5809-5815. PMID: 25367116, PMCID: PMC4258477, DOI: 10.4049/jimmunol.1401665.Peer-Reviewed Original ResearchConceptsEffector memory CD4 T cellsMemory CD4 T cellsCD4 T cellsT cellsTransendothelial migrationImmune synapse formationEndothelial cell monolayersInflammatory chemokinesMorphologic manifestationsGranzyme releaseSynapse formationTCR recognitionGranule dischargeDynein-driven transportChemokinesCell monolayersEarly eventsEndotheliumCytosolic granulesCellsMTOC reorientationProteolytic activityMicrotubule organizing centerMolecular requirementsGranule functionNeutrophils scan for activated platelets to initiate inflammation
Sreeramkumar V, Adrover JM, Ballesteros I, Cuartero MI, Rossaint J, Bilbao I, Nácher M, Pitaval C, Radovanovic I, Fukui Y, McEver RP, Filippi MD, Lizasoain I, Ruiz-Cabello J, Zarbock A, Moro MA, Hidalgo A. Neutrophils scan for activated platelets to initiate inflammation. Science 2014, 346: 1234-1238. PMID: 25477463, PMCID: PMC4280847, DOI: 10.1126/science.1256478.Peer-Reviewed Original ResearchEffects of Sex and Gender on Adaptation to Space: Cardiovascular Alterations
Platts SH, Merz C, Barr Y, Fu Q, Gulati M, Hughson R, Levine BD, Mehran R, Stachenfeld N, Wenger NK. Effects of Sex and Gender on Adaptation to Space: Cardiovascular Alterations. Journal Of Women's Health 2014, 23: 950-955. PMID: 25401939, PMCID: PMC4236093, DOI: 10.1089/jwh.2014.4912.Peer-Reviewed Original ResearchConceptsIntracranial pressure syndromeFemale astronautsSex-specific effectsBasic science researchCardiovascular alterationsOrthostatic intoleranceCardiovascular adaptationVascular agingClinical studiesVascular endotheliumOverall populationEffects of sexCurrent cohortWarrants examinationWomenSexGender differencesPotential benefitsAstronaut ageSyndromeCohortEndotheliumIntoleranceEndothelial PINK1 Mediates the Protective Effects of NLRP3 Deficiency during Lethal Oxidant Injury
Zhang Y, Sauler M, Shinn AS, Gong H, Haslip M, Shan P, Mannam P, Lee PJ. Endothelial PINK1 Mediates the Protective Effects of NLRP3 Deficiency during Lethal Oxidant Injury. The Journal Of Immunology 2014, 192: 5296-5304. PMID: 24778451, PMCID: PMC4047670, DOI: 10.4049/jimmunol.1400653.Peer-Reviewed Original ResearchConceptsAcute respiratory failurePTEN-induced putative kinase 1Respiratory failureWild-type miceNLRP3 deficiencyAutophagy/mitophagySpecific therapyProtective effectProtein NLRP3Oxidant injuryLung endotheliumHigh mortalityHyperoxiaGenetic deletionHigher basalIntermediate susceptibilityMiceOxidant generationPutative kinase 1PINK1 expressionProteasome activationNovel roleDouble knockoutEndotheliumKinase 1Angiophagy Prevents Early Embolus Washout But Recanalizes Microvessels Through Embolus Extravasation
Grutzendler J, Murikinati S, Hiner B, Ji L, Lam CK, Yoo T, Gupta S, Hafler BP, Adelman RA, Yuan P, Rodriguez G. Angiophagy Prevents Early Embolus Washout But Recanalizes Microvessels Through Embolus Extravasation. Science Translational Medicine 2014, 6: 226ra31. PMID: 24598589, DOI: 10.1126/scitranslmed.3006585.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCerebrovascular CirculationCoronary CirculationEmbolismFibrinFibrinolysisFundus OculiGreen Fluorescent ProteinsHemodynamicsHumansKidney TubulesLungMacrophagesMiceMice, TransgenicMicrocirculationMicrogliaMicroscopy, Electron, TransmissionMicrovesselsMonocytesPhagocytosisRetinaRetinal VesselsThrombosisConceptsBlood flow reestablishmentHours of occlusionVascular occlusive disordersDifferent therapeutic strategiesEmbolic occlusionOcclusive disordersVessel recanalizationAlveolar spaceTherapeutic strategiesTherapeutic targetHemodynamic pressureFibrinolytic systemPerivascular spacesEmboliRenal tubulesBlood clotsMicrovascular wallMost human organsOcclusionLungExtravasationKidneyEndotheliumMicrovasculatureWashout
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