2000
Chapter 9 Molecular Control of Endothelial Derived Nitric Oxide A New Paradigm for Endothelial NOS Regulation by Posttranslational Modifications
Gratton J, Fontana J, Sessa W. Chapter 9 Molecular Control of Endothelial Derived Nitric Oxide A New Paradigm for Endothelial NOS Regulation by Posttranslational Modifications. 2000, 157-166. DOI: 10.1016/b978-012370420-7/50010-1.Peer-Reviewed Original ResearchNitric oxideEndothelial NOSVascular remodelingEndothelium-derived relaxing factorsEndothelium-derived nitric oxideEndothelial nitric oxide synthase regulationBlood pressure controlNitric oxide synthase regulationRelaxing factorsVasomotor controlCardiovascular homeostasisNOS isoformsVascular endotheliumVascular biologyNOS regulationPhysiological productionPosttranslational control mechanismsFamily membersAngiogenesisProfound perturbationRemodelingPosttranslational modificationsMolecular controlThrombosisInflammation
1996
What is the effect of hyperglycemia on atherogenesis and can it be reversed by aminoguanidine?
Bucala R. What is the effect of hyperglycemia on atherogenesis and can it be reversed by aminoguanidine? Diabetes Research And Clinical Practice 1996, 30: s123-s130. PMID: 8964186, DOI: 10.1016/s0168-8227(96)80048-9.Peer-Reviewed Original ResearchConceptsDiabetic patientsLDL levelsEndothelium-derived relaxing factorsElevated LDL levelsEffects of hyperglycemiaLow-density lipoproteinRelaxing factorsVascular diseaseVascular pathologyVascular permeabilityNormal controlsClinical observationsAdvanced glycosylationLipoprotein depositionVascular wallELISA techniqueClearance mechanismsNitric oxideClearance kineticsPatientsELISA analysisLDLAgeAminoguanidineLipoprotein
1994
Cyclic strain increases endothelial nitric oxide synthase activity.
Awolesi MA, Widmann MD, Sessa WC, Sumpio BE. Cyclic strain increases endothelial nitric oxide synthase activity. Surgery 1994, 116: 439-44; discussion 444-5. PMID: 7519368.Peer-Reviewed Original ResearchConceptsEndothelial nitric oxide synthaseRegulation of eNOSCultured bovine aortic endothelial cellsENOS activityAortic endothelial cellsEndothelial cellsBovine aortic endothelial cellsEndothelial nitric oxide synthase activityNitric oxideNitric oxide synthase activityOxide synthase activityNitric oxide synthaseNitric oxide productionHemodynamic forcesRelaxing factorsGreiss reactionCycles/minOxide synthaseENOS geneMedium of ECOxide productionCycles/minuteFunctional activityStrain regimensSynthase activity
1991
The Biosynthesis of Endothelium-Derived Relaxing Factor by Endothelial Cells as a Means of Removing Excess Nitrogen
Hecker M, Sessa W, Mitchell J, Änggård E, Vane J. The Biosynthesis of Endothelium-Derived Relaxing Factor by Endothelial Cells as a Means of Removing Excess Nitrogen. Journal Of Cardiovascular Pharmacology 1991, 17: s19-s24. DOI: 10.1097/00005344-199117003-00005.Peer-Reviewed Original ResearchCultured endothelial cellsBiosynthesis of EDRFRelease of EDRFEndothelial cellsNitric oxideKrebs solutionComplete urea cycleImportant regulatory factorCellular regulationExcess nitrogenVariety of cellsRegulatory factorsBiosynthesisPhysiologic buffer solutionFlow-induced releaseRelaxing factorsCytotoxic macrophagesIntracellular sourcesBrain synaptosomesEDRF biosynthesisEDRFIntracellular concentrationTransient riseCalcium ionophoreGln
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