2024
Ventral hippocampal parvalbumin interneurons gate the acute anxiolytic action of the serotonergic psychedelic DOI
Tiwari P, Davoudian P, Kapri D, Vuruputuri R, Karaba L, Sharma M, Zanni G, Balakrishnan A, Chaudhari P, Pradhan A, Suryavanshi S, Bath K, Ansorge M, Fernandez-Ruiz A, Kwan A, Vaidya V. Ventral hippocampal parvalbumin interneurons gate the acute anxiolytic action of the serotonergic psychedelic DOI. Neuron 2024, 112: 3697-3714.e6. PMID: 39321791, PMCID: PMC11581910, DOI: 10.1016/j.neuron.2024.08.016.Peer-Reviewed Original ResearchAnxiolytic actionVentral hippocampusParvalbumin (PV)-positive interneuronsAnxiety-like behaviorAction of DOIPV-positive interneuronsPsychedelic DOIAnxiolytic responseAnxiolytic effectsSerotonergic psychedelicsFast-spiking cellsParvalbumin interneuronsGABAergic interneuronsVHPCFiring rateDOIHippocampusInterneuronsTherapeutic potentialReceptorsPsychedelicsCellular triggersGenetic approachesElectrophysiologyDynamic effects of ventral hippocampal NRG3/ERBB4 signaling on nicotine withdrawal-induced responses
Fisher M, Prantzalos E, O'Donovan B, Anderson T, Sahoo P, Twiss J, Ortinski P, Turner J. Dynamic effects of ventral hippocampal NRG3/ERBB4 signaling on nicotine withdrawal-induced responses. Neuropharmacology 2024, 247: 109846. PMID: 38211698, PMCID: PMC10923109, DOI: 10.1016/j.neuropharm.2024.109846.Peer-Reviewed Original ResearchConceptsAnxiety-like behaviorNeuregulin 3Ventral hippocampusAnxiety-related behaviorDrugs of abuseSmoking cessation therapySingle nucleotide polymorphismsNicotine withdrawalAnxiety-relatedErbB-4Nicotine addictionKnock-down miceGABAergic transmissionNeuronal mechanismsCA1 areaCessation therapyNicotineSynaptic expressionWithdrawalRelapse rateFemale miceNetwork activityGenetic factorsNucleotide polymorphismsGenetic disruption
2023
Longitudinal magnetic resonance evaluation of the schizophrenia model of neonatal lesion in the ventral hippocampus
Genis-Mendoza A, Elizalde-Martínez C, Martínez-Magaña J, Cabrera-Mendoza B, Morales-Guadarrama A, Sacristán E, Beltrán-Villalobos I, Tovilla-Zarate C, Nicolini H. Longitudinal magnetic resonance evaluation of the schizophrenia model of neonatal lesion in the ventral hippocampus. Cirugía Y Cirujanos (English Edition) 2023, 89 DOI: 10.24875/cirue.m23000257.Peer-Reviewed Original Research
2021
Vulnerability of cholecystokinin-expressing GABAergic interneurons in the unilateral intrahippocampal kainate mouse model of temporal lobe epilepsy
Kang YJ, Clement EM, Park IH, Greenfield LJ, Smith BN, Lee SH. Vulnerability of cholecystokinin-expressing GABAergic interneurons in the unilateral intrahippocampal kainate mouse model of temporal lobe epilepsy. Experimental Neurology 2021, 342: 113724. PMID: 33915166, PMCID: PMC8192495, DOI: 10.1016/j.expneurol.2021.113724.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyIntrahippocampal kainate mouse modelVentral CA1 regionEpileptic miceCA1 pyramidal cellsSclerotic hippocampusPyramidal cellsSham controlsSpontaneous seizuresLobe epilepsyCA1 regionMouse modelFrequency of IPSCsNetwork oscillationsRecurrent spontaneous seizuresNumber of boutonsHippocampal theta oscillationsIpsilateral hippocampusElectrical recordingsVentral hippocampusCA1 layerGABAergic interneuronsStratum pyramidaleDorsal hippocampusBehavioral comorbiditiesDeficits in hippocampal-dependent memory across different rodent models of early life stress: systematic review and meta-analysis
Rocha M, Wang D, Avila-Quintero V, Bloch MH, Kaffman A. Deficits in hippocampal-dependent memory across different rodent models of early life stress: systematic review and meta-analysis. Translational Psychiatry 2021, 11: 231. PMID: 33879774, PMCID: PMC8058062, DOI: 10.1038/s41398-021-01352-4.Peer-Reviewed Original ResearchConceptsEarly life stressNovel object recognitionMorris water mazeDifferent rodent modelsContextual fear conditioningMaternal separationHippocampal-dependent memoryVentral hippocampusDorsal hippocampusRodent modelsLife stressAbnormal hippocampal developmentStandardized mean differenceSimilar cognitive deficitsWeb of ScienceModerate effect sizeCFC taskFunctional deficitsFear conditioningInclusion criteriaPreclinical studiesReduced freezingHippocampal developmentLimited beddingWater mazeUcp2-dependent microglia-neuronal coupling controls ventral hippocampal circuit function and anxiety-like behavior
Yasumoto Y, Stoiljkovic M, Kim JD, Sestan-Pesa M, Gao XB, Diano S, Horvath TL. Ucp2-dependent microglia-neuronal coupling controls ventral hippocampal circuit function and anxiety-like behavior. Molecular Psychiatry 2021, 26: 2740-2752. PMID: 33879866, PMCID: PMC8056795, DOI: 10.1038/s41380-021-01105-1.Peer-Reviewed Original ResearchConceptsAnxiety-like behaviorReactive oxygen speciesMicroglia-synapse contactsSpine synapse numberHippocampal circuit functionNeuronal circuit dysfunctionMicroglial productionVentral hippocampusCircuit dysfunctionSpine synapsesSynapse numberAdult brainTransient riseMitochondrial ROS generationMicrogliaBrain functionConditional ablationPhagocytic inclusionsSynaptic elementsProtein 2ROS generationSignificant reductionCircuit functionConsequent accumulationOxygen speciesChanges in Representation of Thalamic Projection Neurons within Prefrontal-Thalamic-Hippocampal Circuitry in a Rat Model of Third Trimester Binge Drinking
Gursky ZH, Klintsova AY. Changes in Representation of Thalamic Projection Neurons within Prefrontal-Thalamic-Hippocampal Circuitry in a Rat Model of Third Trimester Binge Drinking. Brain Sciences 2021, 11: 323. PMID: 33806485, PMCID: PMC8001051, DOI: 10.3390/brainsci11030323.Peer-Reviewed Original ResearchFetal alcohol spectrum disordersAlcohol exposureMedial prefrontal cortexVentral hippocampusProjection neuronsShort-term alcohol exposureLong-Evans rat pupsPrefrontal cortexBrain growth spurtThalamic projection neuronsDevelopmental alcohol exposureAlcohol spectrum disordersThalamic nucleus reuniensExecutive functioningRE neuronsNeuron lossThird trimesterThalamic connectivityRat modelRat pupsHippocampal circuitryRodent modelsBinge drinkingNucleus reuniensNeuron number
2019
Ventral hippocampus interacts with prelimbic cortex during inhibition of threat response via learned safety in both mice and humans
Meyer HC, Odriozola P, Cohodes EM, Mandell JD, Li A, Yang R, Hall BS, Haberman JT, Zacharek SJ, Liston C, Lee FS, Gee DG. Ventral hippocampus interacts with prelimbic cortex during inhibition of threat response via learned safety in both mice and humans. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 26970-26979. PMID: 31822612, PMCID: PMC6936350, DOI: 10.1073/pnas.1910481116.Peer-Reviewed Original ResearchCompound cueAnxiety disordersPrelimbic cortexSafety signal learningCurrent evidence-based treatmentsVentromedial prefrontal cortexCognitive behavioral therapyAlternative neural mechanismVentral hippocampal neuronsPresence of threatNeural activity patternsEvidence-based treatmentsAnxious individualsThreat cuesEvidence-based interventionsSafety learningFear extinctionVentral hippocampusThreat responsesSignal learningNeural mechanismsBehavioral therapyInhibition paradigmPrefrontal cortexHippocampal responses
2016
Differential expression of cytoskeletal regulatory factors in the adolescent prefrontal cortex: Implications for cortical development
Shapiro LP, Parsons RG, Koleske AJ, Gourley SL. Differential expression of cytoskeletal regulatory factors in the adolescent prefrontal cortex: Implications for cortical development. Journal Of Neuroscience Research 2016, 95: 1123-1143. PMID: 27735056, PMCID: PMC5352542, DOI: 10.1002/jnr.23960.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsAnalysis of VarianceAnimalsBrain-Derived Neurotrophic FactorCytoskeletonDendritic SpinesFemaleGene Expression Regulation, DevelopmentalHumansIntegrin beta1MaleMembrane GlycoproteinsMiceMice, TransgenicNeural PathwaysNeuronsPrefrontal CortexReceptor, trkBSignal TransductionSynapsesSynaptophysinConceptsPrefrontal cortexDendritic spinesTropomyosin-related kinase receptor BDifferent adolescent agesKinase receptor BPrevalence of depressionMental health disordersDeep-layer excitatory neuronsRho kinase 2TrkB levelsVentral hippocampusOrbital prefrontal cortexAge-related differencesPsychiatric illnessReceptor BExcitatory neuronsPostnatal brainHealth disordersAnatomical connectionsNeuronal structuresWestern blottingAdolescent ageEarly adulthoodDramatic structural reorganizationPFC subregions
2014
Optogenetic insights on the relationship between anxiety-related behaviors and social deficits
Allsop S, Vander Weele C, Wichmann R, Tye K. Optogenetic insights on the relationship between anxiety-related behaviors and social deficits. Frontiers In Behavioral Neuroscience 2014, 8: 241. PMID: 25076878, PMCID: PMC4099964, DOI: 10.3389/fnbeh.2014.00241.Peer-Reviewed Original ResearchAnxiety-related behaviorAutism spectrum disorderAnxiety disordersSocial deficitsSocial behaviorBasolateral amygdalaVentral hippocampusSpectrum disorderPathogenesis of social anxiety disorderModulating anxiety-related behaviorsRates of co-morbiditySocial anxiety disorderModulate social behaviorPsychiatric disease statesNeural circuit mechanismsComplex emotional statesPsychiatric illnessPsychiatric diseasesInvestigation of neural circuitsCircuit mechanismsAnxietyNeural circuitsEmotional statesSocial domainsDeficitsRapid Eye Movement Sleep and Hippocampal Theta Oscillations Precede Seizure Onset in the Tetanus Toxin Model of Temporal Lobe Epilepsy
Sedigh-Sarvestani M, Thuku G, Sunderam S, Parkar A, Weinstein S, Schiff S, Gluckman B. Rapid Eye Movement Sleep and Hippocampal Theta Oscillations Precede Seizure Onset in the Tetanus Toxin Model of Temporal Lobe Epilepsy. Journal Of Neuroscience 2014, 34: 1105-1114. PMID: 24453303, PMCID: PMC3898281, DOI: 10.1523/jneurosci.3103-13.2014.Peer-Reviewed Original ResearchConceptsRapid eye movement (REM) sleepNonrapid eye movement sleepEye movement sleepHippocampal theta rhythmState of vigilanceTemporal lobe epilepsyMovement sleepSeizure onsetLobe epilepsySeizure susceptibilityTheta rhythmChronic spontaneous seizuresNatural behavioral statesTetanus toxin modelHalf of baselineSpontaneous seizuresSeizure rateVentral hippocampusToxin modelSeizuresSurvival analysisTetanus toxinTherapeutic potentialREM boutsProminent theta
2009
Seizure entrainment with polarizing low-frequency electric fields in a chronic animal epilepsy model
Sunderam S, Chernyy N, Peixoto N, Mason J, Weinstein S, Schiff S, Gluckman B. Seizure entrainment with polarizing low-frequency electric fields in a chronic animal epilepsy model. Journal Of Neural Engineering 2009, 6: 046009. PMID: 19602730, PMCID: PMC3057918, DOI: 10.1088/1741-2560/6/4/046009.Peer-Reviewed Original ResearchConceptsField postsynaptic potentialsAnimal epilepsy modelsNeural activitySimultaneous recordingSpontaneous seizuresHippocampal epilepsyVentral hippocampusEpilepsy modelLocal field potentialsPostsynaptic potentialsNeuronal excitabilityNeuronal activityModulatory effectsAnimal modelsSeizuresStatistical significanceStimulationField potentialsMultiple presentationsAnimalsCharacteristic patternEpilepsyHippocampusRecordingsExcitability
2002
Hippocampal α7 and α4β2 nicotinic receptors and working memory
Levin E, Bradley A, Addy N, Sigurani N. Hippocampal α7 and α4β2 nicotinic receptors and working memory. Neuroscience 2002, 109: 757-765. PMID: 11927157, DOI: 10.1016/s0306-4522(01)00538-3.Peer-Reviewed Original ResearchConceptsDH beta EAlpha 7 nicotinic receptorAlpha 4 beta 2Ventral hippocampusNicotinic receptorsLow dosesBeta EReference memory errorsCounter-balanced orderRadial mazeHigh dosesAdult female Sprague-Dawley ratsFemale Sprague-Dawley ratsNicotine-induced memory improvementAcute intrahippocampal infusionsVentral hippocampal infusionsBeta 2Nicotinic receptor blockadeNicotinic receptor agonistsSprague-Dawley ratsΑ4β2 nicotinic receptorsSignificant increaseChronic guide cannulaeHippocampal α7Nicotinic involvement
1995
Preferential neuronal loss in layer III of the medial entorhinal cortex in rat models of temporal lobe epilepsy
Du F, Eid T, Lothman E, Kohler C, Schwarcz R. Preferential neuronal loss in layer III of the medial entorhinal cortex in rat models of temporal lobe epilepsy. Journal Of Neuroscience 1995, 15: 6301-6313. PMID: 7472396, PMCID: PMC6577998, DOI: 10.1523/jneurosci.15-10-06301.1995.Peer-Reviewed Original ResearchConceptsPreferential neuronal lossTemporal lobe epilepsyNeuronal lossMedial entorhinal cortexEntorhinal cortexLayer IIILobe epilepsyRat modelIntractable temporal lobe epilepsyAcute status epilepticusLithium/pilocarpineParvalbumin-positive neuronsIntracellular calcium ion concentrationKainic acid administrationNerve cell lossAdult male ratsInjection of diazepamSurviving neuronsProlonged seizuresStatus epilepticusAcid administrationNissl stainingVentral hippocampusKainic acidPathological elevation
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