2024
Memory-related brain potentials for visual objects in early AD show impairment and compensatory mechanisms
Xia J, Kutas M, Salmon D, Stoermann A, Rigatuso S, Farias S, Edland S, Brewer J, Olichney J. Memory-related brain potentials for visual objects in early AD show impairment and compensatory mechanisms. Cerebral Cortex 2024, 34: bhae398. PMID: 39390709, PMCID: PMC12098003, DOI: 10.1093/cercor/bhae398.Peer-Reviewed Original ResearchConceptsEvent-related brain potentialsAmnestic mild cognitive impairmentHippocampal occupancyBrain potentialsMemory abilityNegative ERP effectExecutive function abilitiesVisual memory abilityImpaired episodic memoryVerbal memory abilitiesAlzheimer's diseaseInvestigate neural mechanismsObject recognition taskVisual object recognitionVisual object recognition taskCognitively unimpaired participantsMild cognitive impairmentERP effectsNeuropsychological measuresExecutive functionEpisodic memoryHippocampal functionCompensatory mechanismsVisual memoryNeural mechanismsTransient impairment in microglial function causes sex-specific deficits in synaptic maturity and hippocampal function in mice exposed to early adversity
Ahmed S, Polis B, Jamwal S, Sanganahalli B, MacDowell Kaswan Z, Islam R, Kim D, Bowers C, Giuliano L, Biederer T, Hyder F, Kaffman A. Transient impairment in microglial function causes sex-specific deficits in synaptic maturity and hippocampal function in mice exposed to early adversity. Brain Behavior And Immunity 2024, 122: 95-109. PMID: 39134183, PMCID: PMC11402597, DOI: 10.1016/j.bbi.2024.08.010.Peer-Reviewed Original ResearchEarly-life adversityModel of early-life adversityContextual fear conditioningLimited beddingFear conditioningSynaptic engulfmentLB miceSynaptic pruningSex-specific deficitsHippocampus of maleSex-specific effectsHippocampal deficitsAdolescent miceHippocampal functionEarly adversityChemogenetic activationSynaptic connectionsBehavioral aberrationsPotential compensatory mechanismsSynaptic abnormalitiesHippocampusAblation of microgliaRodent hippocampusDeficitsWeeks of lifeAcute Stress Effects on Statistical Learning and Episodic Memory
Sherman B, Huang I, Wijaya E, Turk-Browne N, Goldfarb E. Acute Stress Effects on Statistical Learning and Episodic Memory. Journal Of Cognitive Neuroscience 2024, 36: 1741-1759. PMID: 38713878, PMCID: PMC11223726, DOI: 10.1162/jocn_a_02178.Peer-Reviewed Original ResearchEpisodic memoryAcute stressStatistical learningEffects of acute stressStress-induced cortisol levelsImpaired episodic memoryModulate learning processesAcute stress effectsImpact hippocampal functionEpisodic encodingRodent workEvidence of learningHippocampal functionStress effectsHippocampal pathwaysLearning tasksBehavioral experimentsPreliminary evidenceCortisol levelsNo stressMemoryMultiple measuresHippocampusScene categoriesParticipantsModelling adult neurogenesis in the aging rodent hippocampus: a midlife crisis
Arellano J, Rakic P. Modelling adult neurogenesis in the aging rodent hippocampus: a midlife crisis. Frontiers In Neuroscience 2024, 18: 1416460. PMID: 38887368, PMCID: PMC11181911, DOI: 10.3389/fnins.2024.1416460.Peer-Reviewed Original ResearchAdult neurogenesisHippocampal functionAdult hippocampal neurogenesisAged animalsMiddle aged animalsHippocampal neurogenesisGranule cellsDentate gyrusMature granule cellsRodent hippocampusMidlife crisisNeurogenesisFunctional relevanceRodentsDramatically with ageNeuronsYoung animalsOlder animalsGyrusHippocampusRatsRobust neurogenesisHippocampalMeta-analysisDentateEarly adversity causes sex-specific deficits in perforant pathway connectivity and contextual memory in adolescent mice
Islam R, White J, Arefin T, Mehta S, Liu X, Polis B, Giuliano L, Ahmed S, Bowers C, Zhang J, Kaffman A. Early adversity causes sex-specific deficits in perforant pathway connectivity and contextual memory in adolescent mice. Biology Of Sex Differences 2024, 15: 39. PMID: 38715106, PMCID: PMC11075329, DOI: 10.1186/s13293-024-00616-0.Peer-Reviewed Original ResearchConceptsLateral entorhinal cortexContextual fear conditioningDorsal hippocampusHippocampal developmentSex differencesFear conditioningEarly adversityLimited beddingSevere deficitsModel of early adversitySex-specific deficitsReelin-positive neuronsPerforant pathwayReelin-positive cellsDiffusion magnetic resonance imagingEx vivo diffusion magnetic resonance imagingContextual freezingContextual memoryAdolescent miceHippocampal functionLife adversityEntorhinal cortexHippocampusDeficitsAdolescent males
2023
Hippocampal Mechanisms Support Cortisol-Induced Memory Enhancements
Sherman B, Harris B, Turk-Browne N, Sinha R, Goldfarb E. Hippocampal Mechanisms Support Cortisol-Induced Memory Enhancements. Journal Of Neuroscience 2023, 43: 7198-7212. PMID: 37813570, PMCID: PMC10601369, DOI: 10.1523/jneurosci.0916-23.2023.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingMemory enhancementEpisodic memoryAssociative memoryEpisodic memory encodingBrain regionsHigh-resolution functional magnetic resonance imagingHuman hippocampusHigh-resolution fMRIStress-related hormone cortisolHormone cortisolMemory benefitsEmotional memoryMemory encodingEmotional eventsEmotional associationsHippocampal representationsHippocampal signaturesFunctional neuroimagingHippocampal mechanismsStressful eventsFunctional connectivityHippocampal functionMemory formationSalient information
2022
Neural correlates linking trauma and physical symptoms
Choi J, Martins J, Hwang S, Sinha R, Seo D. Neural correlates linking trauma and physical symptoms. Psychiatry Research Neuroimaging 2022, 327: 111560. PMID: 36327865, PMCID: PMC9757618, DOI: 10.1016/j.pscychresns.2022.111560.Peer-Reviewed Original ResearchConceptsPhysical symptomsFunctional magnetic resonance imagingTrauma patientsLateral prefrontal cortexPrefrontal cortexPhysical symptom frequencyPain-related disordersMagnetic resonance imagingNeural correlatesPhysical health symptomsChronic painHealthy controlsTrauma groupSymptom frequencyDorsal striatumGreater physical symptomsSensorimotor areasCurrent studyHippocampal responsesVentromedial prefrontal cortexHealth symptomsHippocampal functionResonance imagingSymptomsUnderlying neurological mechanismsEarly life stress impairs synaptic pruning in the developing hippocampus
Dayananda KK, Ahmed S, Wang D, Polis B, Islam R, Kaffman A. Early life stress impairs synaptic pruning in the developing hippocampus. Brain Behavior And Immunity 2022, 107: 16-31. PMID: 36174883, PMCID: PMC10497209, DOI: 10.1016/j.bbi.2022.09.014.Peer-Reviewed Original ResearchConceptsSynaptic pruningMicroglial ramificationHippocampal functionAbnormal hippocampal functionCA1 pyramidal neuronsExpression of TREM2Increased spine densityRamification of microgliaEarly life adversityNormal hippocampal functionSynaptic engulfmentClinical outcomesPyramidal neuronsSpine densityFemale miceHippocampal stimulationSevere formHippocampal developmentPhagocytic activitySevere impairmentEx vivoLife adversityThird weekEarly adversityMice
2021
Association of CSF Biomarkers With Hippocampal-Dependent Memory in Preclinical Alzheimer Disease.
Trelle AN, Carr VA, Wilson EN, Swarovski MS, Hunt MP, Toueg TN, Tran TT, Channappa D, Corso NK, Thieu MK, Jayakumar M, Nadiadwala A, Guo W, Tanner NJ, Bernstein JD, Litovsky CP, Guerin SA, Khazenzon AM, Harrison MB, Rutt BK, Deutsch GK, Chin FT, Davidzon GA, Hall JN, Sha SJ, Fredericks CA, Andreasson KI, Kerchner GA, Wagner AD, Mormino EC. Association of CSF Biomarkers With Hippocampal-Dependent Memory in Preclinical Alzheimer Disease. Neurology 2021, 96: e1470-e1481. PMID: 33408146, PMCID: PMC8055319, DOI: 10.1212/wnl.0000000000011477.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAgingAlzheimer DiseaseAmyloid beta-PeptidesAssociation LearningBiomarkersCross-Sectional StudiesCuesDiscrimination, PsychologicalFemaleHippocampusHumansMaleMemoryMemory DisordersMemory, EpisodicMental RecallMiddle AgedNeuropsychological TestsPeptide FragmentsPsychomotor Performancetau ProteinsConceptsMemory taskHippocampal functionMnemonic discrimination taskMnemonic discrimination performanceUnimpaired older adultsHippocampal-dependent memoryPreclinical Alzheimer's diseaseEpisodic memoryPreclinical AD pathologyIndividual differencesMemory assessmentMemory performanceDiscrimination taskTask difficultyAssociative memoryDiscrimination performanceSingle batch analysisCross-sectional relationshipMemory studiesOlder adultsMemoryAlzheimer's disease biomarkersCSF β-amyloidElevated p-tauRecall
2020
Preliminary in vivo evidence of lower hippocampal synaptic density in cannabis use disorder
D’Souza D, Radhakrishnan R, Naganawa M, Ganesh S, Nabulsi N, Najafzadeh S, Ropchan J, Ranganathan M, Cortes-Briones J, Huang Y, Carson RE, Skosnik P. Preliminary in vivo evidence of lower hippocampal synaptic density in cannabis use disorder. Molecular Psychiatry 2020, 26: 3192-3200. PMID: 32973170, DOI: 10.1038/s41380-020-00891-4.Peer-Reviewed Original ResearchConceptsHippocampal synaptic densityCannabis use disorderHealthy controlsSynaptic densityPositron emission tomographyUse disordersDSM-5 cannabis use disorderVivo evidenceAdministration of cannabinoidsHippocampal synaptic integrityVerbal memory taskSynaptic vesicle glycoprotein 2AHuman cannabis usersEffects of cannabisWarrants further studyPlasma input functionMemory taskCentrum semiovaleAdult rodentsOne-tissue compartment modelSynaptic integrityHippocampal functionCannabis misuseArterial samplingEmission tomographyContent-based Dissociation of Hippocampal Involvement in Prediction
Kok P, Rait LI, Turk-Browne NB. Content-based Dissociation of Hippocampal Involvement in Prediction. Journal Of Cognitive Neuroscience 2020, 32: 527-545. PMID: 31820676, PMCID: PMC6996939, DOI: 10.1162/jocn_a_01509.Peer-Reviewed Original ResearchConceptsPredictive processingAbstract shapesDomain-general processesFemale human participantsComplexity of stimuliComplex visual objectsModality of stimuliTypes of stimuliHigh-resolution fMRIDomain-specific rolesAuditory cuesPartial cuesVisual objectsHippocampal involvementBrain activityHuman participantsDistinct representationsHippocampal responsesComputational roleHippocampal functionPrevious researchStimuliCuesUnexpected orientationSuch accounts
2019
Relationships between drinking quantity and frequency and behavioral and hippocampal BOLD responses during working memory performance involving allocentric spatial navigation in college students
Banz BC, Worhunsky PD, Pittman BP, Astur RS, Tennen HA, Raskin SA, Austad CS, Wood RM, Fallahi CR, Potenza MN, Pearlson GD. Relationships between drinking quantity and frequency and behavioral and hippocampal BOLD responses during working memory performance involving allocentric spatial navigation in college students. Drug And Alcohol Dependence 2019, 201: 236-243. PMID: 31254750, PMCID: PMC7370814, DOI: 10.1016/j.drugalcdep.2019.03.030.Peer-Reviewed Original ResearchConceptsSpatial working memorySix monthsYoung adult healthDorsolateral prefrontal cortexFrequency of drinkingVirtual Morris water taskVisible trialsNeurocognitive impairmentMorris water taskHippocampal functionCognitive deficitsPrefrontal cortexAlcohol useAdult HealthYoung adultsBOLD responseDrinking weekTrialsAllocentric spatial navigationGreater frequencyWater taskFuture studiesH periodDrinkingCurrent study
2017
Flexible weighting of diverse inputs makes hippocampal function malleable
Aly M, Turk-Browne NB. Flexible weighting of diverse inputs makes hippocampal function malleable. Neuroscience Letters 2017, 680: 13-22. PMID: 28587901, PMCID: PMC5712489, DOI: 10.1016/j.neulet.2017.05.063.Peer-Reviewed Original ResearchConceptsHippocampal functionAspects of cognitionDiverse cognitive functionsDedicated memory systemGeneral neural mechanismHippocampal computationsHippocampal representationsNeural mechanismsBehavioral goalsCognitive functionFlexible weightingMemory systemAnatomical inputsCognitionRecent researchPerceptionClassic theoryHippocampal modulationHippocampusDiverse inputsAttentionMemoryMalleabilityBroader roleRepresentation
2015
Early-Life Stress Perturbs Key Cellular Programs in the Developing Mouse Hippocampus
Wei L, Hao J, Lacher RK, Abbott T, Chung L, Colangelo CM, Kaffman A. Early-Life Stress Perturbs Key Cellular Programs in the Developing Mouse Hippocampus. Developmental Neuroscience 2015, 37: 476-488. PMID: 26068561, PMCID: PMC4644446, DOI: 10.1159/000430861.Peer-Reviewed Original ResearchConceptsEarly life stressEffects of ELSHippocampal developmentSynaptic maturationAxonal growthExpression of proteinsJuvenile hippocampusJuvenile miceHippocampal functionAbnormal hippocampal developmentNormal axonal growthHippocampal-dependent memoryNormal synaptic developmentHuman imaging studiesTotal protein contentCA1 neuronsSynaptic markersFemale miceMouse modelMouse hippocampusSynaptic pruningAnimal modeMature spinesHippocampusSynaptic proteins
2014
Early Life Stress Inhibits Expression of Ribosomal RNA in the Developing Hippocampus
Wei L, Hao J, Kaffman A. Early Life Stress Inhibits Expression of Ribosomal RNA in the Developing Hippocampus. PLOS ONE 2014, 9: e115283. PMID: 25517398, PMCID: PMC4269428, DOI: 10.1371/journal.pone.0115283.Peer-Reviewed Original ResearchConceptsEarly life stressSecond weekHippocampal growthAbnormal hippocampal functionNormal hippocampal developmentNormal mouse hippocampusLife stressMaternal separationMouse hippocampusMouse modelHippocampal developmentHippocampal functionHippocampus developmentNovel molecular mechanismDaily separationHippocampusWeeksDNA methylationInhibits expressionAdulthoodExposureMolecular mechanismsRNA contentGradual declineNormal growth
2013
Integrin α3 Is Required for Late Postnatal Stability of Dendrite Arbors, Dendritic Spines and Synapses, and Mouse Behavior
Kerrisk ME, Greer CA, Koleske AJ. Integrin α3 Is Required for Late Postnatal Stability of Dendrite Arbors, Dendritic Spines and Synapses, and Mouse Behavior. Journal Of Neuroscience 2013, 33: 6742-6752. PMID: 23595732, PMCID: PMC3711182, DOI: 10.1523/jneurosci.0528-13.2013.Peer-Reviewed Original ResearchMeSH KeywordsAge Factorsalpha-FetoproteinsAnalysis of VarianceAnimalsAnimals, NewbornBasic Helix-Loop-Helix Transcription FactorsCell MembraneDendritesDendritic SpinesDisks Large Homolog 4 ProteinFemaleGene Expression Regulation, DevelopmentalGreen Fluorescent ProteinsGuanylate KinasesHippocampusImmunoprecipitationIntegrin alpha3LysineMaleMembrane ProteinsMemory DisordersMiceMice, Inbred C57BLMice, TransgenicModels, BiologicalNerve Tissue ProteinsNeuronsPhosphopyruvate HydrataseRecognition, PsychologyrhoA GTP-Binding ProteinSynapsesConceptsDendritic spinesIntegrin α3Adult rodent forebrainHippocampal-dependent behaviorsPostnatal day 21Excitatory forebrain neuronsMouse behaviorProper hippocampal functionLong-term potentiationArbor stabilityArg nonreceptor tyrosine kinaseRodent forebrainForebrain neuronsSynapse densitySynapse stabilityDendrite arborsDay 21Arbor sizeHippocampal dendritesHippocampal functionMutant miceSynapse maintenanceBrain functionNeurodegenerative diseasesKey mediator
2012
Modulation of hippocampal rhythms by subthreshold electric fields and network topology
Berzhanskaya J, Chernyy N, Gluckman B, Schiff S, Ascoli G. Modulation of hippocampal rhythms by subthreshold electric fields and network topology. Journal Of Computational Neuroscience 2012, 34: 369-389. PMID: 23053863, PMCID: PMC3549326, DOI: 10.1007/s10827-012-0426-4.Peer-Reviewed Original ResearchConceptsPyramidal cellsGamma rhythmsHippocampal rhythmsSubthreshold electric fieldsSpecific synaptic connectivityExact cellular mechanismsExcitatory contactsSynaptic circuitryBasket cellsLines of resultsArea CA1Inhibitory connectivityInterneuron typesSynaptic connectivityInterneuron classesHippocampal functionNeuron typesNeuronal morphologyTheta/gamma ratioCognitive functionTheta frequencyCellular mechanismsNeural activityElectrophysiological dataNovel role
2011
P4‐197: A selective ORL1 antagonist enhances hippocampal function and reverses pharmacologically induced cognitive deficits in rodents
Roof R, Siok C, Hajos M, Cianfrogna J, Chang C, Leung L, Duplantier A, Brodney M, McDowell L, Prior F, Vanase‐Frawley M, McGinnis D, Kozak R, Seymour P, Leurent C, Iyer R. P4‐197: A selective ORL1 antagonist enhances hippocampal function and reverses pharmacologically induced cognitive deficits in rodents. Alzheimer's & Dementia 2011, 7: s772-s773. DOI: 10.1016/j.jalz.2011.05.2220.Peer-Reviewed Original Research
2006
Muscarine activates the sodium–calcium exchanger via M3 receptors in basal forebrain neurons
Xu C, Wu M, Morozova E, Alreja M. Muscarine activates the sodium–calcium exchanger via M3 receptors in basal forebrain neurons. European Journal Of Neuroscience 2006, 24: 2309-2313. PMID: 17074051, DOI: 10.1111/j.1460-9568.2006.05118.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBasal GangliaBiotransformationDiagonal Band of BrocaDiphenylacetic AcidsElectrophysiologyIn Vitro TechniquesIon ChannelsIonsLithium ChlorideMaleMuscarineMuscarinic AgonistsPatch-Clamp TechniquesPiperidinesProsencephalonRatsRats, Sprague-DawleyReceptor, Muscarinic M3Sodium-Calcium ExchangerThioureaConceptsMuscarinic activationWhole-cell patch-clamp recording techniqueMedial septum/diagonal bandPatch-clamp recording techniquesSeptohippocampal GABAergic neuronsBasal forebrain neuronsMuscarinic cholinergic mechanismsRat brain slicesHippocampus-dependent learningHippocampal theta rhythmSodium-calcium exchangerIntraseptal carbacholMSDB neuronsCholinergic neuronsExcitatory actionGABAergic neuronsCholinergic mechanismsKB-R7943M3 receptorsForebrain neuronsDiagonal bandPrimary involvementBrain slicesHippocampal functionPotent modulatorHippocampus Function Predicts Severity of Post-Traumatic Stress Disorder
Astur RS, St. Germain SA, Tolin D, Ford J, Russell D, Stevens M. Hippocampus Function Predicts Severity of Post-Traumatic Stress Disorder. Cyberpsychology Behavior And Social Networking 2006, 9: 234-240. PMID: 16640486, DOI: 10.1089/cpb.2006.9.234.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderVirtual Morris water taskFunctional magnetic resonance imagingMorris water taskPTSD severityStress disorderHippocampal activityWater taskSevere PTSD symptomsHippocampal-dependent tasksPTSD symptomsTask performanceMemory problemsHippocampal functionBrain structuresTaskAbnormal brain structureHippocampus functionAge-matched controlsMagnetic resonance imagingIQDisordersHippocampusTraumaResonance imaging
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