2024
Relating depressive and manic symptomatology to 1H-MRS spectra
Choquette A, Dager A, Marjańska M, Zatony M, Pearlson G, Glahn D, Knowles E. Relating depressive and manic symptomatology to 1H-MRS spectra. Journal Of Affective Disorders Reports 2024, 16: 100774. DOI: 10.1016/j.jadr.2024.100774.Peer-Reviewed Original ResearchAnterior cingulate cortexN-acetylaspartateRight anterior cingulate cortexAssociated with maniaDepressive symptom scalesSymptom Rating ScaleProfiles of associationDisorder symptomatologyManic symptomsReduced N-acetylaspartateCingulate cortexAffective disordersNeurochemical levelsSymptom ScaleManiaCholine-containing compoundsDichotomous diagnosisMagnetic resonance spectroscopyRating ScalePotential in vivo biomarkersHippocampusIllness etiologyMagnetic resonance spectroscopy dataTotal cholineFollow-up
2004
Subtype-Specific Alterations of γ-Aminobutyric Acid and Glutamatein Patients With Major Depression
Sanacora G, Gueorguieva R, Epperson CN, Wu YT, Appel M, Rothman DL, Krystal JH, Mason GF. Subtype-Specific Alterations of γ-Aminobutyric Acid and Glutamatein Patients With Major Depression. JAMA Psychiatry 2004, 61: 705-713. PMID: 15237082, DOI: 10.1001/archpsyc.61.7.705.Peer-Reviewed Original ResearchConceptsMajor depressive disorderGamma-aminobutyric acidOccipital cortex GABA concentrationsProton magnetic resonance spectroscopyDepressed subjectsGABA concentrationHealthy controlsSubtypes of MDDCortical gamma-aminobutyric acidHealthy control subjectsMetabolite levelsCholine-containing compoundsHealthy comparison subjectsClinical research programSubtype-specific alterationsΓ-aminobutyric acidClinical correlatesMDD patientsControl subjectsDepressive disorderNeurotransmitter levelsGlutamate levelsMajor depressionMDD subtypesOccipital cortex
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