2025
Exposotypes in psychotic disorders
Yassin W, Kromenacker B, Green J, Tamminga C, del Re E, Seif P, Xia C, Alliey-Rodriguez N, Gershon E, Clementz B, Pearlson G, Keedy S, Ivleva E, Hill S, McDowell J, Keshavan M. Exposotypes in psychotic disorders. Scientific Reports 2025, 15: 29003. PMID: 40781464, PMCID: PMC12334662, DOI: 10.1038/s41598-025-14438-6.Peer-Reviewed Original ResearchConceptsChildhood traumaSubstance usePsychotic disordersSchizophrenia polygenic risk scoresHigh childhood traumaNo group differencesNegative symptomsDisorder symptomsPolygenic risk scoresSocioeconomic statusHigher anxietyGroup differencesIntracranial volumeUnique effectsGenetic riskAnxietyDepressionSymptomsGeneral symptomsDisordersFunctional outcomesImpulseSchizophreniaManiaApproach to diagnosis
2024
F35. INVESTIGATING GENETIC RISK FOR PSYCHOSIS IN BIPOLAR DISORDER IN INDIA USING POLYGENIC SCORES
Jeevan Y, Mahadevan J, Viswanath B, Jain S, Ganesh S, Holla B, Purushottam M, Shankarappa B, consortium A, India S. F35. INVESTIGATING GENETIC RISK FOR PSYCHOSIS IN BIPOLAR DISORDER IN INDIA USING POLYGENIC SCORES. European Neuropsychopharmacology 2024, 87: 224. DOI: 10.1016/j.euroneuro.2024.08.446.Peer-Reviewed Original ResearchPsychotic symptomsBipolar disorderPolygenic scoresGenetic susceptibility to bipolar disorderAbsence of psychotic symptomsHistory of psychotic symptomsPresence of psychotic symptomsClinical heterogeneity of BDCourse of maniaSchizophrenia polygenic scoreRisk of psychosisChronic mental disordersHeterogeneity of BDSusceptibility to bipolar disorderOdds of psychosisRisk of BDEpisodic courseBD-PRSMental disordersPsychosisIndependent dimensionsBD-1Investigate genetic riskGenetic riskManiaRelating depressive and manic symptomatology to 1H-MRS spectra
Choquette A, Dager A, Marjańska M, Zatony M, Pearlson G, Glahn D, Knowles E. Relating depressive and manic symptomatology to 1H-MRS spectra. Journal Of Affective Disorders Reports 2024, 16: 100774. DOI: 10.1016/j.jadr.2024.100774.Peer-Reviewed Original ResearchAnterior cingulate cortexN-acetylaspartateRight anterior cingulate cortexAssociated with maniaDepressive symptom scalesSymptom Rating ScaleProfiles of associationDisorder symptomatologyManic symptomsReduced N-acetylaspartateCingulate cortexAffective disordersNeurochemical levelsSymptom ScaleManiaCholine-containing compoundsDichotomous diagnosisMagnetic resonance spectroscopyRating ScalePotential in vivo biomarkersHippocampusIllness etiologyMagnetic resonance spectroscopy dataTotal cholineFollow-upChapter 21 Gamma Knife for psychiatric indications
Lopes A, de Arruda I, Batistuzzo M, Gorgulho A, de Salles A, Miguel E. Chapter 21 Gamma Knife for psychiatric indications. 2024, 495-517. DOI: 10.1016/b978-0-443-18496-3.00021-5.Peer-Reviewed Original ResearchAnorexia nervosaObsessive-compulsive disorder patientsTreatment of psychiatric disordersAnterior limb of internal capsuleObsessive-compulsive disorderVentral anterior limbGamma KnifeGK radiosurgeryMajor depressionDisorder patientsPsychiatric disordersPsychiatric indicationsNervosaDepressionInternal capsuleSurgical modalitiesAdverse eventsDisordersAnorexiaRadiosurgeryWeight gainManiaPsychiatryBrain cystsComplications
2019
Increased Anterior Cingulate and Caudate Activity in Bipolar Mania
Blumberg H, Stem E, Martinez D, Ricketts S, de Asis J, White T, Epstein J, McBride P, Eidelberg D, Kocsis J, Silbersweig D. Increased Anterior Cingulate and Caudate Activity in Bipolar Mania. 2019, 177-184. DOI: 10.4324/9781315054308-17.Peer-Reviewed Original ResearchManic stateBipolar disorderAnterior cingulateHead of caudatePositron emission tomography techniquesDorsal anterior cingulateEmission tomography techniquesSuch dysfunctionFunctional brainDisordersBrain activityCaudateCingulateNeural systemsPrincipal findingsDysfunctionEuthymiaExecutive controlFindingsManiaActivityBrain
2015
Low-Dose Quetiapine Induced or Worsened Mania in the Context of Possible Undertreatment
Millard HY, Wilson BA, Noordsy DL. Low-Dose Quetiapine Induced or Worsened Mania in the Context of Possible Undertreatment. The Journal Of The American Board Of Family Medicine 2015, 28: 154-158. PMID: 25567837, DOI: 10.3122/jabfm.2015.01.140105.Peer-Reviewed Educational MaterialsConceptsLow-dose quetiapineCase reportManic symptomsLow dosesDrug-naïve patientsD2 receptor antagonismQuality of lifePossible undertreatmentAcute maniaReceptor blockadeAtypical antipsychoticsBipolar depressionReceptor antagonismPsychotic featuresLifetime prevalenceIrritable moodBipolar disorderMental illnessQuetiapineDopamine concentrationsManiaPotential inductionSymptomsWorseningDoses
2009
Aripiprazole monotherapy in acute mania: 12-week randomised placebo- and haloperidol-controlled study
Young A, Oren D, Lowy A, McQuade R, Marcus R, Carson W, Spiller N, Torbeyns A, Sanchez R. Aripiprazole monotherapy in acute mania: 12-week randomised placebo- and haloperidol-controlled study. The British Journal Of Psychiatry 2009, 194: 40-48. PMID: 19118324, DOI: 10.1192/bjp.bp.108.049965.Peer-Reviewed Original ResearchConceptsWeek 12Young Mania Rating Scale (YMRS) total scoreDouble-blind aripiprazoleHaloperidol-treated patientsTolerability of aripiprazoleExtrapyramidal adverse eventsScale total scoreMasked treatmentAdverse eventsClinical improvementAcute maniaAripiprazole monotherapyBipolar maniaMixed episodesEffective therapyEffect therapyAripiprazoleAdditional weeksHaloperidolWeek 3PlaceboPatientsTotal scoreTherapyMania
2003
GABA and mood disorders
TAYLOR M, BHAGWAGAR Z, COWEN P, SHARP T. GABA and mood disorders. Psychological Medicine 2003, 33: 387-393. PMID: 12701660, DOI: 10.1017/s0033291702006876.Peer-Reviewed Original Research
2002
Plasma catecholamine metabolites in antidepressant-exacerbated mania and psychosis
Fortunati F, Mazure C, Preda A, Wahl R, Bowers M. Plasma catecholamine metabolites in antidepressant-exacerbated mania and psychosis. Journal Of Affective Disorders 2002, 68: 331-334. PMID: 12063160, DOI: 10.1016/s0165-0327(00)00327-x.Peer-Reviewed Original Research
2001
Antidepressant-associated mania and psychosis resulting in psychiatric admissions.
Preda A, MacLean RW, Mazure CM, Bowers MB. Antidepressant-associated mania and psychosis resulting in psychiatric admissions. The Journal Of Clinical Psychiatry 2001, 62: 30-3. PMID: 11235925, DOI: 10.4088/jcp.v62n0107.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsGeneral hospital psychiatric unitAntidepressant-associated maniaNewer atypical agentsSide effect profileSerotonin reuptake inhibitorsHospital psychiatric unitRate of admissionAdverse behavioral effectsAntidepressant useReuptake inhibitorsEffect profileAtypical agentsPsychiatric admissionsAntidepressant drugsPsychiatric unitBehavioral effectsAdverse behavioral reactionsAdmissionSignificant increasePsychosisManiaDrugsTolerabilityAntidepressants
2000
Increased anterior cingulate and caudate activity in bipolar mania
Blumberg H, Stern E, Martinez D, Ricketts S, de Asis J, White T, Epstein J, McBride P, Eidelberg D, Kocsis J, Silbersweig D. Increased anterior cingulate and caudate activity in bipolar mania. Biological Psychiatry 2000, 48: 1045-1052. PMID: 11094137, DOI: 10.1016/s0006-3223(00)00962-8.Peer-Reviewed Original ResearchConceptsManic stateAnterior cingulateBipolar disorderHead of caudateFunctional brain abnormalitiesPositron emission tomography techniquesDorsal anterior cingulateEmission tomography techniquesBipolar maniaBrain abnormalitiesSuch dysfunctionCingulateDisordersBrain activityCaudate activityCaudateManiaNeural systemsPrincipal findingsDysfunctionActivityAbnormalitiesEuthymiaExecutive controlFindings
1994
Neuroleptic exposure following inpatient treatment of acute mania with lithium and neuroleptic
Sernyak M, Griffin R, Johnson R, Pearsall H, Wexler B, Woods S. Neuroleptic exposure following inpatient treatment of acute mania with lithium and neuroleptic. American Journal Of Psychiatry 1994, 151: 133-135. PMID: 7903511, DOI: 10.1176/ajp.151.1.133.Peer-Reviewed Original Research
1993
Psychiatric manifestations of Lyme borreliosis.
Fallon B, Nields J, Parsons B, Liebowitz M, Klein D. Psychiatric manifestations of Lyme borreliosis. The Journal Of Clinical Psychiatry 1993, 54: 263-8. PMID: 8335653.Peer-Reviewed Original ResearchConceptsPanic disorderOrganic mood syndromeMental health professionalsAntibiotic treatmentMood syndromesPsychiatric disordersPsychiatric symptomsPsychiatric presentationsAdequate antibiotic treatmentPanicManifestations of Lyme borreliosisDepressionSevere neurological damageDisordersManiaStructured interviewsHealth professionalsLyme borreliosisCardiac symptomsClinical pictureNeurological damagePatientsBorrelial infectionSymptomsInfection
1988
Manic Syndrome Associated With Zidovudine
Schaerf F, Miller R, Pearlson G, Kaminsky M, Weaver D. Manic Syndrome Associated With Zidovudine. JAMA 1988, 260: 3587-3588. DOI: 10.1001/jama.1988.03410240045016.Peer-Reviewed Original ResearchCases of maniaZidovudine therapySyndrome AssociatedHuman immunodeficiency virus-seropositive individualsAffective disordersImmunodeficiency syndrome dementia complexZidovudine dosageZidovudine treatmentSuch patientsDementia complexManic episodesMajor depressionFamily historyDepressive symptomsCognitive declinePsychiatric syndromesPatientsPersonal historyZidovudineTherapyEt al1ManiaDisordersAssociatedSyndrome
1987
Mania After Brain Injury: A Controlled Study of Causative Factors
Starkstein S, Pearlson G, Boston J, Robinson R. Mania After Brain Injury: A Controlled Study of Causative Factors. JAMA Neurology 1987, 44: 1069-1073. PMID: 3632381, DOI: 10.1001/archneur.1987.00520220065019.Peer-Reviewed Original ResearchConceptsBrain injuryVentricle/brain ratiosPossible family historyFocal brain injurySecondary maniaRight hemisphere lesionsSubcortical atrophyBrain ratioDepressive episodeLimbic areasManic patientsFamily historyManic syndromeFocal lesionsAffective disordersPatientsInjuryLesionsCausative factorsRare occurrenceHemisphere lesionsGenetic loadingRight hemisphereManiaRight hemisphere involvement
1986
AIDS presenting as mania
Gabel R, Barnard N, Norko M, O'Connell R. AIDS presenting as mania. Comprehensive Psychiatry 1986, 27: 251-254. PMID: 3709140, DOI: 10.1016/0010-440x(86)90050-7.Peer-Reviewed Original Research
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