2025
Tissue-based gene expression testing in localized prostate cancer
Sivanesan N, Diaz G, Sprenkle P. Tissue-based gene expression testing in localized prostate cancer. Current Opinion In Urology 2025, 35: 432-438. PMID: 40314067, DOI: 10.1097/mou.0000000000001289.Peer-Reviewed Original ResearchConceptsLocalized prostate cancerTissue-based genomic testingProstate cancerRisk stratificationGenomic testingManagement of localized prostate cancerProstate cancer risk stratificationIdentified high-risk patientsClinically significant cancerProstate cancer outcomesImpact of genomic testingHigh-risk patientsAssess tumor aggressivenessLow-risk casesGenomic assaysGene expression testsTreatment decision-makingPSA levelsGleason scoreSignificant cancerOncotype DXTumor aggressivenessTherapeutic choiceReduce overtreatmentProspective study
2021
A novel signature predicts recurrence risk and therapeutic response in breast cancer patients
Tran QH, Than VT, Luu PL, Clarke D, Lam HN, Nguyen T, Nguyen D, Duy PQ, Phung D, Nguyen MN. A novel signature predicts recurrence risk and therapeutic response in breast cancer patients. International Journal Of Cancer 2021, 148: 2848-2856. PMID: 33586202, DOI: 10.1002/ijc.33512.Peer-Reviewed Original ResearchMeSH KeywordsAcetylserotonin O-MethyltransferaseBreast NeoplasmsDatabases, GeneticFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansNeoplasm GradingOligonucleotide Array Sequence AnalysisRetrospective StudiesSequence Analysis, RNASurvival AnalysisTamoxifenTreatment OutcomeUp-RegulationConceptsBreast cancer patientsAcetylserotonin O-methyltransferaseEndocrine therapyCancer patientsASMT expressionRelapse-free survival outcomesMetastasis-free survival timeLonger metastasis-free survival timesLow-risk casesBreast cancer progressionBreast cancer tumorsAdjuvant chemotherapyOverall survivalTamoxifen treatmentEndocrine resistanceDistance recurrenceMRNA array dataRetrospective studySurvival outcomesTherapeutic responseBreast cancerSurvival timePatientsRecurrence riskSynthesis of melatoninThe relationship between cardiac surgeon experience and average patient risk profile: CA and NY statewide analysis
Weininger G, Einarsson A, Mori M, Brooks C, Shang M, Assi R, Vallabhajosyula P, Geirsson A. The relationship between cardiac surgeon experience and average patient risk profile: CA and NY statewide analysis. Journal Of Cardiac Surgery 2021, 36: 1189-1193. PMID: 33462886, DOI: 10.1111/jocs.15333.Peer-Reviewed Original ResearchConceptsLow-risk casesPatient outcomesCardiac surgeonsLow-risk coronary artery bypassSurgeon yearsMedian annual case volumeCoronary artery bypassPatient risk profileAnnual case volumeCross-sectional studyBetter patient outcomesRegression modelsLinear regression modelsCABG casesMedian surgeonArtery bypassMid-career surgeonsMortality ratioMedian numberSurgeon experienceOutcome dataCase volumeExperienced surgeonsMortality rateOnline registry
2020
BOSTN Bundle Intervention for Perioperative Screening and Management of Patients With Suspected Obstructive Sleep Apnea: A Hospital Registry Study.
Raub D, Santer P, Nabel S, Platzbecker K, Munoz-Acuna R, Xu X, Friedrich S, Ramachandran SK, Eikermann M, Sundar E. BOSTN Bundle Intervention for Perioperative Screening and Management of Patients With Suspected Obstructive Sleep Apnea: A Hospital Registry Study. Anesthesia & Analgesia 2020, 130: 1415-1424. PMID: 31283617, DOI: 10.1213/ane.0000000000004294.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaInvasive mechanical ventilationBeth Israel Deaconess Medical CenterHospital registry studyMechanical ventilationRegistry studyPostoperative desaturationSleep apneaPeripheral oxygen saturation measurementsMinutes of extubationNoncardiac surgical casesPostoperative invasive ventilationPreoperative screening toolPostoperative mechanical ventilationKey secondary outcomesDay of surgeryManagement of patientsBody mass indexMultivariable logistic regressionHigh-risk casesLow-risk casesPatient-specific factorsClinical management pathwayOxygen saturation measurementsInvasive ventilation
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