2025
Stroke risk prediction in symptomatic anterior circulation ICAD: Analysis of regional QMRA flow from the MYRIAD study
Amin-Hanjani S, Elder T, Du X, Romano J, Liebeskind D, De Havenon A, Chatterjee A, Prabhakaran S. Stroke risk prediction in symptomatic anterior circulation ICAD: Analysis of regional QMRA flow from the MYRIAD study. Journal Of Stroke And Cerebrovascular Diseases 2025, 34: 108322. PMID: 40246039, PMCID: PMC12101060, DOI: 10.1016/j.jstrokecerebrovasdis.2025.108322.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlgorithmsBlood Flow VelocityCerebral AngiographyCerebrovascular CirculationCollateral CirculationFemaleHumansIntracranial ArteriosclerosisIschemic StrokeMagnetic Resonance AngiographyMaleMiddle AgedMiddle Cerebral ArteryPerfusion ImagingPredictive Value of TestsPrognosisProspective StudiesRecurrenceRisk AssessmentRisk FactorsStrokeTime FactorsConceptsMiddle cerebral arteryIntracranial atherosclerotic diseaseQuantitative MRAStroke riskRecurrent strokeFlow patientsIdentification of high-risk patientsIntracranial arteriesLow-flow patientsProximal intracranial arteriesHigh-risk patientsStroke risk predictionInvestigation of therapeutic interventionsRecurrent stroke riskRisk predictionRecurrence riskZ-score thresholdRegional hypoperfusionArtery territoryPrimary outcomeCerebral arteryLow flowsPatientsZ-scoreAtherosclerotic disease
2022
Comparative anatomy of the middle cerebral artery, rhinal and endorhinal sulci, piriform lobe, entorhinal cortex, olfactory tubercule, anterior perforate substance, and hippocampus: A dissection study
Kier E, Conlogue G. Comparative anatomy of the middle cerebral artery, rhinal and endorhinal sulci, piriform lobe, entorhinal cortex, olfactory tubercule, anterior perforate substance, and hippocampus: A dissection study. The Anatomical Record 2022, 306: 2030-2043. PMID: 36371781, DOI: 10.1002/ar.25124.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnatomy, ComparativeAnimalsCerebral CortexDogsEntorhinal CortexHippocampusHumansMiddle Cerebral ArteryRabbitsSheepTemporal LobeConceptsMiddle cerebral arteryRecurrent arteryPiriform lobeHuman fetal specimensOlfactory tuberculeLenticulostriate arteriesRhinal sulcusEndorhinal sulcusCerebral arteryTemporal lobeFetal specimensAnatomic modificationsHuman temporal lobeStriate nucleusMCA branchesArteryInferomedial regionHeubnerHippocampusComplex anatomyDissection studiesBrain dissectionCerebrumSulcusLobe
2021
Fetal cerebrovascular impedance is reduced in left congenital diaphragmatic hernia
Kosiv K, Moon‐Grady A, Hogan W, Keller R, Rapoport R, Rogers E, Feldstein V, Lee H, Peyvandi S. Fetal cerebrovascular impedance is reduced in left congenital diaphragmatic hernia. Ultrasound In Obstetrics And Gynecology 2021, 57: 386-391. PMID: 32068925, PMCID: PMC7431368, DOI: 10.1002/uog.21992.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalCardiography, ImpedanceCase-Control StudiesCerebrovascular CirculationEchocardiographyElectric ImpedanceFemaleFetal DevelopmentFetusFunctional LateralityGestational AgeHernias, Diaphragmatic, CongenitalHumansMiddle Cerebral ArteryNeurodevelopmental DisordersPregnancyPulsatile FlowUltrasonography, PrenatalUmbilical ArteriesConceptsLeft ventricular cardiac outputLeft-sided CDHCongenital diaphragmatic herniaMCA-PI Z-scoreMCA-PICerebral blood flowCardiac outputRight-sided CDHPulsatility indexHead circumferenceBiparietal diameterCDH survivorsBlood flowSmall left-sided cardiac structuresMiddle cerebral artery pulsatility indexRight-sided congenital diaphragmatic herniaLeft-sided congenital diaphragmatic herniaLeft-sided cardiac structuresPercentage of COCerebral artery pulsatility indexGestational age-matched controlsZ-scoreMCA PI valuesArtery pulsatility indexSignificant mass effectImpaired Distal Perfusion Predicts Length of Hospital Stay in Patients with Symptomatic Middle Cerebral Artery Stenosis
Yaghi S, de Havenon A, Honda T, Hinman JD, Raychev R, Sharma LK, Kim S, Feldmann E, Romano JG, Prabhakaran S, Liebeskind DS. Impaired Distal Perfusion Predicts Length of Hospital Stay in Patients with Symptomatic Middle Cerebral Artery Stenosis. Journal Of Neuroimaging 2021, 31: 475-479. PMID: 33565162, PMCID: PMC8119309, DOI: 10.1111/jon.12839.Peer-Reviewed Original ResearchConceptsTransient ischemic attackMCA stenosisPerfusion delayPerfusion imagingSymptomatic middle cerebral artery stenosisMiddle cerebral artery stenosisSymptomatic MCA stenosisComprehensive stroke centerSymptomatic intracranial stenosisCerebral artery stenosisContinuous variablesHospital stayIschemic attackIschemic strokeStenosis patientsStroke centersSymptom onsetConsecutive patientsArtery stenosisIntracranial stenosisProspective studyRetrospective studyPredicts LengthInclusion criteriaMismatch volume
2020
Benefit of endovascular thrombectomy for M2 middle cerebral artery occlusion in the ARISE II study
de Havenon A, Narata AP, Amelot A, Saver JL, Bozorgchami H, Mattle HP, Ribo M, Andersson T, Zaidat OO, investigators A. Benefit of endovascular thrombectomy for M2 middle cerebral artery occlusion in the ARISE II study. Journal Of NeuroInterventional Surgery 2020, 13: 779-783. PMID: 33219148, PMCID: PMC8134506, DOI: 10.1136/neurintsurg-2020-016427.Peer-Reviewed Original ResearchMeSH KeywordsBrain IschemiaEndovascular ProceduresHumansInfarction, Middle Cerebral ArteryMiddle Cerebral ArteryStrokeThrombectomyTreatment OutcomeConceptsMiddle cerebral artery occlusionM2 occlusionsCerebral artery occlusionM1 occlusionEndovascular thrombectomyAdverse eventsBetter outcomesArtery occlusionIschemic strokeReperfusion ratesM2-segment middle cerebral artery occlusionM2 middle cerebral artery occlusionsScale scoreHealth Stroke Scale scoreBaseline National InstitutesStroke Scale scoreAcute ischemic strokeMajor adverse eventsRankin Scale scorePaucity of dataLogistic regression modelsII trialSuccessful reperfusionII studyPrespecified analysisHypoperfusion Distal to Anterior Circulation Intracranial Atherosclerosis is Associated with Recurrent Stroke
de Havenon A, Khatri P, Prabhakaran S, Yeatts S, Peterson C, Sacchetti D, Alexander M, Cutting S, Mac Grory B, Furie K, Liebeskind D, Yaghi S. Hypoperfusion Distal to Anterior Circulation Intracranial Atherosclerosis is Associated with Recurrent Stroke. Journal Of Neuroimaging 2020, 30: 468-470. PMID: 32579278, PMCID: PMC8010594, DOI: 10.1111/jon.12710.Peer-Reviewed Original ResearchConceptsIntracranial atherosclerotic diseaseSymptomatic intracranial atherosclerotic diseaseDistal hypoperfusionRecurrent strokeComputed tomographyRetrospective study of patientsImpaired distal flowIntracranial atherosclerotic disease patientsSymptomatic ischemic strokeStudy of patientsAssociated with recurrent strokeMiddle cerebral arteryAssociated with stroke recurrenceIntracranial carotidSecondary stroke preventionRetrospective studySymptomatic arteryPerfusion statusHazard ratioPrimary outcomeCerebral arteryStroke preventionHypoperfusionPatientsInclusion criteriaFetal echocardiographic assessment of cardiovascular impact of prolonged support on EXTrauterine Environment for Neonatal Development (EXTEND) system
Ozawa K, Davey M, Tian Z, Hornick M, Mejaddam A, McGovern P, Flake A, Rychik J. Fetal echocardiographic assessment of cardiovascular impact of prolonged support on EXTrauterine Environment for Neonatal Development (EXTEND) system. Ultrasound In Obstetrics And Gynecology 2020, 55: 516-522. PMID: 30989734, PMCID: PMC7187205, DOI: 10.1002/uog.20295.Peer-Reviewed Original ResearchConceptsMean arterial pressureMiddle cerebral arteryPulsatility indexCardiac outputFetal sheepUmbilical arteryCardiac functionExtrauterine environmentHeart rateFetal middle cerebral arteryStudy periodMedian gestational ageGlobal longitudinal strainExtend systemUtero stateMCA-PIUA-PIArterial pressureCerebral arteryGestational agePlacental circulationProspective studyDiastolic flowDepressed contractilityFetal growth
2019
Higher Plaque Burden of Middle Cerebral Artery Is Associated With Recurrent Ischemic Stroke
Ran Y, Wang Y, Zhu M, Wu X, Malhotra A, Lei X, Zhang F, Wang X, Xie S, Zhou J, Zhu J, Cheng J, Zhu C. Higher Plaque Burden of Middle Cerebral Artery Is Associated With Recurrent Ischemic Stroke. Stroke 2019, 51: 659-662. PMID: 31856694, DOI: 10.1161/strokeaha.119.028405.Peer-Reviewed Original ResearchConceptsRecurrent ischemic strokeMiddle cerebral arteryMagnetic resonance vessel wall imagingPlaque burdenIschemic strokeVessel wall imagingAcute strokeCerebral arteryRecurrent strokeChronic strokeStroke patientsPlaque characteristicsMiddle cerebral artery plaqueRecurrent acute strokeRecurrent stroke groupRecurrent stroke patientsAcute stroke patientsHigher plaque burdenMethods One hundredDegree of stenosisClinical factorsStroke groupArtery plaquesFemale sexImaging featuresPoor Outcomes Related to Anterior Extension of Large Hemispheric Infarction: Topographic Analysis of GAMES-RP Trial MRI Scans
Payabvash S, Falcone GJ, Sze GK, Jain A, Beslow LA, Petersen NH, Sheth KN, Kimberly WT. Poor Outcomes Related to Anterior Extension of Large Hemispheric Infarction: Topographic Analysis of GAMES-RP Trial MRI Scans. Journal Of Stroke And Cerebrovascular Diseases 2019, 29: 104488. PMID: 31787498, PMCID: PMC8820410, DOI: 10.1016/j.jstrokecerebrovasdis.2019.104488.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, IntravenousAgedAnterior Cerebral ArteryCerebrovascular CirculationCerebrumClinical Trials as TopicClinical Trials, Phase II as TopicDiffusion Magnetic Resonance ImagingDisability EvaluationExtremitiesFemaleGlyburideHumansHypoglycemic AgentsInfarction, Anterior Cerebral ArteryInfarction, Middle Cerebral ArteryMaleMiddle AgedMiddle Cerebral ArteryPatient AdmissionPredictive Value of TestsRecovery of FunctionRisk FactorsTime FactorsTreatment OutcomeUnited StatesConceptsLarge hemispheric infarctionInfarct volumeIndependent predictorsInfarct lesionsHemispheric infarctionHealth Stroke Scale total scorePost-stroke day 3Anterior cerebral artery territoryTotal scoreLeft MCA infarctLeg motor functionNIHSS total scoreHours of onsetOnly independent predictorPoor functional outcomeBorder zoneScale total scoreAnterior extensionMultivariate regression analysisVoxel-wise analysisLHI patientsAdmission NIHSSArtery territoryGlibenclamide treatmentMCA infarct
2018
Depression Predicts Delirium After Coronary Artery Bypass Graft Surgery Independent of Cognitive Impairment and Cerebrovascular Disease: An Analysis of the Neuropsychiatric Outcomes After Heart Surgery Study
Oldham MA, Hawkins KA, Lin IH, Deng Y, Hao Q, Scoutt LM, Yuh DD, Lee HB. Depression Predicts Delirium After Coronary Artery Bypass Graft Surgery Independent of Cognitive Impairment and Cerebrovascular Disease: An Analysis of the Neuropsychiatric Outcomes After Heart Surgery Study. American Journal Of Geriatric Psychiatry 2018, 27: 476-486. PMID: 30709616, PMCID: PMC6443412, DOI: 10.1016/j.jagp.2018.12.025.Peer-Reviewed Original ResearchConceptsMiddle cerebral arteryMild cognitive impairmentCerebrovascular diseaseCognitive impairmentRisk factorsCoronary artery bypass graft surgeryStenosis severityProspective observational cohort studyArtery bypass graft surgeryBilateral middle cerebral arteriesTertiary care academic hospitalHeart Surgery studyPreoperative cognitive assessmentUndergoing CABG surgeryBypass graft surgeryConfusion Assessment MethodRisk of deliriumDelirium risk factorsObservational cohort studyPostoperative day 2Clinical Dementia RatingDepression InterviewPreoperative depressionStructured HamiltonStudy psychiatrist
2017
Transorbital endoscopic approach for exposure of the sylvian fissure, middle cerebral artery and crural cistern: an anatomical study
Almeida JP, Ruiz-Treviño AS, Shetty SR, Omay SB, Anand VK, Schwartz TH. Transorbital endoscopic approach for exposure of the sylvian fissure, middle cerebral artery and crural cistern: an anatomical study. Acta Neurochirurgica 2017, 159: 1893-1907. PMID: 28808799, DOI: 10.1007/s00701-017-3296-8.Peer-Reviewed Original ResearchMeSH KeywordsCerebral CortexDecompression, SurgicalDura MaterHumansMiddle Cerebral ArteryNatural Orifice Endoscopic SurgeryNeurosurgical ProceduresOrbitSkull BaseConceptsMiddle cerebral arteryTransorbital endoscopic approachLesser sphenoidal wingMesial temporal lobeSylvian fissureEndoscopic approachCerebral arteryCrural cisternSphenoidal wingEyelid incisionSphenoidal portionEndoscopic transorbital approachIntradural dissectionTemporal lobeTransorbital approachGreater sphenoidal wingAnatomical studyMedial orbital decompressionMiddle fossa duraInvasive skull base surgeryInferior orbital fissurePosterior orbital gyrusSkull base surgerySkull base pathologiesInjected cadaver heads
2016
Vessel wall MRI of an inflamed aneurysm with atherosclerosis in a patient with ischemic stroke
de Havenon A, Park M, McNally S. Vessel wall MRI of an inflamed aneurysm with atherosclerosis in a patient with ischemic stroke. Neurology 2016, 87: 741-742. PMID: 27527539, PMCID: PMC4999170, DOI: 10.1212/wnl.0000000000002990.Peer-Reviewed Original ResearchAdded Value of Vessel Wall Magnetic Resonance Imaging in the Differentiation of Moyamoya Vasculopathies in a Non-Asian Cohort
Mossa-Basha M, de Havenon A, Becker KJ, Hallam DK, Levitt MR, Cohen WA, Hippe DS, Alexander MD, Tirschwell DL, Hatsukami T, Amlie-Lefond C, Yuan C. Added Value of Vessel Wall Magnetic Resonance Imaging in the Differentiation of Moyamoya Vasculopathies in a Non-Asian Cohort. Stroke 2016, 47: 1782-1788. PMID: 27272486, PMCID: PMC4927346, DOI: 10.1161/strokeaha.116.013320.Peer-Reviewed Original ResearchConceptsVessel wall magnetic resonance imagingMagnetic resonance imagingMoyamoya diseaseLuminal imagingInter-reader agreementMoyamoya vasculopathyResonance imagingCarotid artery territoryNon-Asian cohortsMoyamoya disease casesPattern of involvementT2 signal characteristicsArtery territoryCarotid diseaseCollateral gradingConcentric lesionsCollateral extentPostcontrast enhancementMRI characteristicsHeterogeneous enhancementMulticontrast protocolClinical dataCarotid segmentsHeterogeneous lesionsT2 heterogeneity
2015
The North American Fetal Therapy Network Consensus Statement
Emery SP, Bahtiyar MO, Dashe JS, Wilkins-Haug LE, Johnson A, Paek BW, Moon-Grady AJ, Skupski DW, O'Brien BM, Harman CR, Simpson LL. The North American Fetal Therapy Network Consensus Statement. Obstetrics And Gynecology 2015, 125: 1236-1243. PMID: 25932853, DOI: 10.1097/aog.0000000000000723.Peer-Reviewed Original ResearchConceptsMonochorionic gestationsNorth American Fetal Therapy NetworkUnequal placental sharingDetection of complicationsUnique disease processDichorionic gestationsUltrasonographic surveillanceEarly referralPlacental sharingPermanent disabilityConsensus statementPrenatal managementBetter outcomesDisease processClinical practiceGestationSingle placentaTherapy NetworkEarly detectionComplicationsVascular connectionsDeathSurveillanceReferralAngioarchitectureCohort-Based Identification of Predictors of Symptomatic Intracerebral Hemorrhage After IV Thrombolysis
Asuzu D, Nyström K, Amin H, Schindler J, Wira C, Greer D, Chi NF, Halliday J, Sheth KN. Cohort-Based Identification of Predictors of Symptomatic Intracerebral Hemorrhage After IV Thrombolysis. Neurocritical Care 2015, 23: 394-400. PMID: 25691004, DOI: 10.1007/s12028-015-0121-1.Peer-Reviewed Original ResearchConceptsRt-PA therapyEarly CT hypodensityHyperdense MCA signCT hypodensityIschemic strokeIndependent predictorsRisk of sICHSymptomatic intracerebral hemorrhageAcute ischemic strokeVisual field deficitsNew independent predictorAdditional independent predictorsCase-control studyIdentification of predictorsLevel of consciousnessTwo-sample t-testMann-Whitney testAntithrombolytic therapyStroke centersField deficitsSerious complicationsIntracerebral hemorrhageClinical parametersIntracranial hemorrhageTherapy
2013
Vessel Wall Magnetic Resonance Imaging Identifies the Site of Rupture in Patients With Multiple Intracranial AneurysmsProof of Principle
Matouk CC, Mandell DM, Günel M, Bulsara KR, Malhotra A, Hebert R, Johnson MH, Mikulis DJ, Minja FJ. Vessel Wall Magnetic Resonance Imaging Identifies the Site of Rupture in Patients With Multiple Intracranial AneurysmsProof of Principle. Neurosurgery 2013, 72: 492-496. PMID: 23151622, DOI: 10.1227/neu.0b013e31827d1012.Peer-Reviewed Original ResearchConceptsAneurysmal subarachnoid hemorrhageSite of ruptureSubarachnoid hemorrhageMultiple intracranial aneurysmsMR-VWIHigh-resolution magnetic resonance vessel wall imagingIntracranial aneurysmsSteno-occlusive cerebrovascular diseaseVessel wall magnetic resonance imagingMR imaging findingsVessel wall enhancementMagnetic resonance vessel wall imagingMagnetic resonance imagingVessel wall imagingDefinitive treatmentCerebrovascular diseaseImaging findingsMedical recordsRuptured aneurysmsUnruptured aneurysmsPatientsAneurysmsWall enhancementResonance imagingRuptureUtilizing a cranial window to visualize the middle cerebral artery during endothelin-1 induced middle cerebral artery occlusion.
Regenhardt RW, Ansari S, Azari H, Caldwell KJ, Mecca AP. Utilizing a cranial window to visualize the middle cerebral artery during endothelin-1 induced middle cerebral artery occlusion. Journal Of Visualized Experiments 2013, e50015. PMID: 23463164, PMCID: PMC3605805, DOI: 10.3791/50015.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEndothelin-1Infarction, Middle Cerebral ArteryMaleMiddle Cerebral ArteryRatsRats, Sprague-DawleySkullConceptsCranial windowEndothelin-1Cerebral arteryBrain parenchymaMiddle cerebral artery occlusion modelMiddle cerebral artery occlusionCerebral artery occlusionArtery occlusion modelMiddle cerebral arteryArtery occlusionIschemic strokeVasoconstricting peptideOcclusion modelVisualized vesselsLateral aspectTemporal boneArteryProximal portionRat cerebrumDuraVessel diameterCortical surfaceMCAOParietal boneParenchymaEndothelin-1 induced middle cerebral artery occlusion model for ischemic stroke with laser Doppler flowmetry guidance in rat.
Ansari S, Azari H, Caldwell KJ, Regenhardt RW, Hedna VS, Waters MF, Hoh BL, Mecca AP. Endothelin-1 induced middle cerebral artery occlusion model for ischemic stroke with laser Doppler flowmetry guidance in rat. Journal Of Visualized Experiments 2013 PMID: 23438950, PMCID: PMC3601209, DOI: 10.3791/50014.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDisease Models, AnimalEndothelin-1Infarction, Middle Cerebral ArteryLaser-Doppler FlowmetryMaleMiddle Cerebral ArteryRatsRats, Sprague-DawleyStrokeConceptsEndothelin-1Laser Doppler flowmetryCerebral ischemiaIschemic strokeHuman strokeMiddle cerebral artery occlusion modelMiddle cerebral artery areaET-1 modelArtery occlusion modelET-1 infusionFocal cerebral ischemiaCause of deathDuration of occlusionNumber one causeArtery constrictionPartial reperfusionReperfusion ratesIschemic damageMCAO modelStereotaxic injectionArtery areaStroke volumeDoppler flowmetryExtracranial vesselsOcclusion model
2012
Rapid identification of a major diffusion/perfusion mismatch in distal internal carotid artery or middle cerebral artery ischemic stroke
Hakimelahi R, Yoo A, He J, Schwamm L, Lev M, Schaefer P, González R. Rapid identification of a major diffusion/perfusion mismatch in distal internal carotid artery or middle cerebral artery ischemic stroke. BMC Neurology 2012, 12: 132. PMID: 23121836, PMCID: PMC3519648, DOI: 10.1186/1471-2377-12-132.Peer-Reviewed Original ResearchConceptsDiffusion/perfusion mismatchDWI lesion volumeInternal carotid arteryLesion volumePerfusion mismatchConsecutive patientsCarotid arteryMiddle cerebral artery ischemic strokeDiffusion/perfusion MRITerminal internal carotid arteryProximal middle cerebral arteryDistal internal carotid arteryLarger mismatch volumeProximal MCA occlusionMiddle cerebral arteryDiffusion lesion volumeSame inclusion criteriaTerminal ICAArtery occlusionIschemic strokeMCA occlusionStroke onsetCerebral arteryStroke patientsPatient assessment
2011
Development of a Middle Cerebral Artery Occlusion Model in the Nonhuman Primate and a Safety Study of I.V. Infusion of Human Mesenchymal Stem Cells
Sasaki M, Honmou O, Radtke C, Kocsis JD. Development of a Middle Cerebral Artery Occlusion Model in the Nonhuman Primate and a Safety Study of I.V. Infusion of Human Mesenchymal Stem Cells. PLOS ONE 2011, 6: e26577. PMID: 22039510, PMCID: PMC3200343, DOI: 10.1371/journal.pone.0026577.Peer-Reviewed Original ResearchConceptsMiddle cerebral arteryMagnetic resonance imagingM1 occlusionCollateral circulationSevere groupVenous bloodOcclusion modelMesenchymal stem cellsMiddle cerebral artery occlusion modelM1 branchNHP stroke modelsExtensive collateral circulationArtery occlusion modelPost-operative courseMCA territory infarctionGreater functional improvementLeft sylvian fissureNonhuman primate modelFronto-temporal craniotomyExperimental stroke researchAfrican green monkeysStem cellsHMSC infusionTerritory infarctionNeurological examination
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