2024
Progression of Gestational Subclinical Hypothyroidism and Hypothyroxinemia to Overt Hypothyroidism After Pregnancy: Pooled Analysis of Data from Two Randomized Controlled Trials
Varner M, Mele L, Casey B, Peaceman A, Reddy U, Wapner R, Thorp J, Saade G, Tita A, Rouse D, Sibai B, Costantine M, Mercer B, Caritis S, Bethesda. Progression of Gestational Subclinical Hypothyroidism and Hypothyroxinemia to Overt Hypothyroidism After Pregnancy: Pooled Analysis of Data from Two Randomized Controlled Trials. Thyroid 2024, 34: 1171-1176. PMID: 39028022, PMCID: PMC11563732, DOI: 10.1089/thy.2023.0616.Peer-Reviewed Original ResearchSubclinical hypothyroidismOvert hypothyroidismAssociated with higher ratesTPO levelsThyroid peroxidaseYear 5Gestational subclinical hypothyroidismNormal free T4Multicenter treatment trialThyroid replacement therapyYear of deliveryThyrotropin (TSHThyroid peroxidase levelsYear 1Randomized Controlled TrialsWeeks gestationPlacebo groupTSH valuesMaternal serumReplacement therapyFree T4Higher RatesHypothyroxinemiaThyroid functionHypothyroidism
2014
An airway epithelial iNOS–DUOX2–thyroid peroxidase metabolome drives Th1/Th2 nitrative stress in human severe asthma
Voraphani N, Gladwin MT, Contreras AU, Kaminski N, Tedrow JR, Milosevic J, Bleecker ER, Meyers DA, Ray A, Ray P, Erzurum SC, Busse WW, Zhao J, Trudeau JB, Wenzel SE. An airway epithelial iNOS–DUOX2–thyroid peroxidase metabolome drives Th1/Th2 nitrative stress in human severe asthma. Mucosal Immunology 2014, 7: 1175-1185. PMID: 24518246, PMCID: PMC4130801, DOI: 10.1038/mi.2014.6.Peer-Reviewed Original ResearchConceptsInducible nitric oxide synthaseHuman airway epithelial cellsDual oxidase 2Severe asthmaNitrative stressThyroid peroxidaseIL-13Ex vivoSevere refractory asthmaNitric oxide synthaseTh2 cytokine expressionAirway epithelial cellsRefractory asthmaLower interleukinHigher interferonCytokine expressionOxide synthaseOxidase 2AsthmaIFNEpithelial cellsEpithelial cell systemSuperoxide dismutaseRNA knockdownEndogenous peroxidase
1999
Escape from the acute Wolff-Chaikoff effect is associated with a decrease in thyroid sodium/iodide symporter messenger ribonucleic acid and protein.
Eng P, Cardona G, Fang S, Previti M, Alex S, Carrasco N, Chin W, Braverman L. Escape from the acute Wolff-Chaikoff effect is associated with a decrease in thyroid sodium/iodide symporter messenger ribonucleic acid and protein. Endocrinology 1999, 140: 3404-10. PMID: 10433193, DOI: 10.1210/endo.140.8.6893.Peer-Reviewed Original ResearchConceptsAcute Wolff-Chaikoff effectThyroid peroxidase mRNANIS mRNAIodide administrationWolff-Chaikoff effectThyroid peroxidaseIodide transportTSH receptorNIS proteinIodide ingestionIntrathyroidal iodine contentIodine-induced hypothyroidismSerum TSH levelsOrganification of iodideAcute experimentsIodide-induced changesMessenger ribonucleic acidPlasma iodide levelsTSH levelsHashimoto's thyroiditisChronic experimentsSerum T4Plasma iodide concentrationsSodium/iodide symporterHormone measurementsEscape from the Acute Wolff-Chaikoff Effect Is Associated with a Decrease in Thyroid Sodium/Iodide Symporter Messenger Ribonucleic Acid and Protein*
Eng P, Cardona G, Fang S, Previti M, Alex S, Carrasco N, Chin W, Braverman L. Escape from the Acute Wolff-Chaikoff Effect Is Associated with a Decrease in Thyroid Sodium/Iodide Symporter Messenger Ribonucleic Acid and Protein*. Endocrinology 1999, 140: 3404-3410. DOI: 10.1210/en.140.8.3404.Peer-Reviewed Original ResearchAcute Wolff-Chaikoff effectThyroid peroxidase mRNANIS mRNAIodide administrationWolff-Chaikoff effectThyroid peroxidaseIodide transportTSH receptorNIS proteinIodide ingestionIntrathyroidal iodine contentIodine-induced hypothyroidismSerum TSH levelsOrganification of iodideAcute experimentsIodide-induced changesMessenger ribonucleic acidPlasma iodide levelsTSH levelsHashimoto's thyroiditisChronic experimentsSerum T4Plasma iodide concentrationsSodium/iodide symporterCyclophilin mRNA
1998
Detection of thyroglobulin, thyroid peroxidase, and RET/PTC1 mRNA transcripts in the peripheral blood of patients with thyroid disease.
Tallini G, Ghossein RA, Emanuel J, Gill J, Kinder B, Dimich AB, Costa J, Robbins R, Burrow GN, Rosai J. Detection of thyroglobulin, thyroid peroxidase, and RET/PTC1 mRNA transcripts in the peripheral blood of patients with thyroid disease. Journal Of Clinical Oncology 1998, 16: 1158-66. PMID: 9508203, DOI: 10.1200/jco.1998.16.3.1158.Peer-Reviewed Original ResearchConceptsReverse transcription-polymerase chain reactionPeripheral bloodThyroid diseaseThyroid carcinomaBenign thyroid nodulesThyroid peroxidaseThyroid nodulesRT-PCR positivityPeripheral blood samplesDiagnosis of carcinomaTranscription-polymerase chain reactionPapillary thyroid carcinomaBenign thyroid lesionsRET/PTC1Cervical lymphInitial surgeryClinical evidenceExtrathyroid extensionNodular hyperplasiaBenign lesionsPatientsCarcinomaBlood collectionMRNA transcriptsThyroid lesions
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